diff --git a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientBuilderImpl.java b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientBuilderImpl.java
index 12c830977b9c8..81c315c22837d 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientBuilderImpl.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientBuilderImpl.java
@@ -95,6 +95,11 @@ public RestClientBuilderImpl trustStore(KeyStore trustStore) {
         return this;
     }
 
+    public RestClientBuilderImpl trustStore(KeyStore trustStore, String trustStorePassword) {
+        clientBuilder.trustStore(trustStore, trustStorePassword.toCharArray());
+        return this;
+    }
+
     @Override
     public RestClientBuilderImpl keyStore(KeyStore keyStore, String keystorePassword) {
         clientBuilder.keyStore(keyStore, keystorePassword);
diff --git a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java
index 83e647ae666df..d5f998178a40c 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilder.java
@@ -182,7 +182,7 @@ private void configureShared(RestClientBuilder builder) {
         }
     }
 
-    private void configureSsl(RestClientBuilder builder) {
+    private void configureSsl(RestClientBuilderImpl builder) {
 
         Optional<String> maybeTrustStore = oneOf(clientConfigByClassName().trustStore, clientConfigByConfigKey().trustStore,
                 configRoot.trustStore);
@@ -249,7 +249,7 @@ private void registerKeyStore(String keyStorePath, RestClientBuilder builder) {
         }
     }
 
-    private void registerTrustStore(String trustStorePath, RestClientBuilder builder) {
+    private void registerTrustStore(String trustStorePath, RestClientBuilderImpl builder) {
         Optional<String> maybeTrustStorePassword = oneOf(clientConfigByClassName().trustStorePassword,
                 clientConfigByConfigKey().trustStorePassword, configRoot.trustStorePassword);
         Optional<String> maybeTrustStoreType = oneOf(clientConfigByClassName().trustStoreType,
@@ -269,7 +269,7 @@ private void registerTrustStore(String trustStorePath, RestClientBuilder builder
                         e);
             }
 
-            builder.trustStore(trustStore);
+            builder.trustStore(trustStore, password);
         } catch (KeyStoreException e) {
             throw new IllegalArgumentException("Failed to initialize trust store from " + trustStorePath, e);
         }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java
index 60f80120fb6a7..9a0ec4493673d 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/test/java/io/quarkus/rest/client/reactive/runtime/RestClientCDIDelegateBuilderTest.java
@@ -109,7 +109,7 @@ public void testClientSpecificConfigs() {
         Mockito.verify(restClientBuilderMock).register(MyResponseFilter1.class);
         Mockito.verify(restClientBuilderMock).queryParamStyle(QueryParamStyle.COMMA_SEPARATED);
 
-        Mockito.verify(restClientBuilderMock).trustStore(Mockito.any());
+        Mockito.verify(restClientBuilderMock).trustStore(Mockito.any(), Mockito.anyString());
         Mockito.verify(restClientBuilderMock).keyStore(Mockito.any(), Mockito.anyString());
     }
 
@@ -151,7 +151,7 @@ public void testGlobalConfigs() {
         Mockito.verify(restClientBuilderMock).register(MyResponseFilter2.class);
         Mockito.verify(restClientBuilderMock).queryParamStyle(QueryParamStyle.MULTI_PAIRS);
 
-        Mockito.verify(restClientBuilderMock).trustStore(Mockito.any());
+        Mockito.verify(restClientBuilderMock).trustStore(Mockito.any(), Mockito.anyString());
         Mockito.verify(restClientBuilderMock).keyStore(Mockito.any(), Mockito.anyString());
     }
 
diff --git a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/ClientBuilderImpl.java b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/ClientBuilderImpl.java
index e8020ea6c1547..6afe4fb4d6e52 100644
--- a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/ClientBuilderImpl.java
+++ b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/impl/ClientBuilderImpl.java
@@ -46,6 +46,7 @@ public class ClientBuilderImpl extends ClientBuilder {
     private char[] keystorePassword;
     private SSLContext sslContext;
     private KeyStore trustStore;
+    private char[] trustStorePassword;
 
     private String proxyHost;
     private int proxyPort;
@@ -88,7 +89,12 @@ public ClientBuilder keyStore(KeyStore keyStore, char[] password) {
 
     @Override
     public ClientBuilder trustStore(KeyStore trustStore) {
+        return trustStore(trustStore, null);
+    }
+
+    public ClientBuilder trustStore(KeyStore trustStore, char[] password) {
         this.trustStore = trustStore;
+        this.trustStorePassword = password;
         return this;
     }
 
@@ -164,7 +170,7 @@ public ClientBuilder clientLogger(ClientLogger clientLogger) {
     @Override
     public ClientImpl build() {
         Buffer keyStore = asBuffer(this.keyStore, keystorePassword);
-        Buffer trustStore = asBuffer(this.trustStore, EMPTY_CHAR_ARARAY);
+        Buffer trustStore = asBuffer(this.trustStore, this.trustStorePassword);
 
         HttpClientOptions options = Optional.ofNullable(configuration.getFromContext(HttpClientOptions.class))
                 .orElseGet(HttpClientOptions::new);
@@ -185,7 +191,7 @@ public ClientImpl build() {
             if (trustStore != null) {
                 JksOptions jks = new JksOptions();
                 jks.setValue(trustStore);
-                jks.setPassword("");
+                jks.setPassword(trustStorePassword == null ? "" : new String(trustStorePassword));
                 options.setTrustStoreOptions(jks);
             }
         }
diff --git a/integration-tests/rest-client-reactive/pom.xml b/integration-tests/rest-client-reactive/pom.xml
index 8889bbc39f7ad..d81583d01c89e 100644
--- a/integration-tests/rest-client-reactive/pom.xml
+++ b/integration-tests/rest-client-reactive/pom.xml
@@ -11,6 +11,11 @@
     <artifactId>quarkus-integration-test-rest-client-reactive</artifactId>
     <name>Quarkus - Integration Tests - REST Client Reactive</name>
 
+    <properties>
+        <self-signed.trust-store>${project.build.directory}/self-signed.p12</self-signed.trust-store>
+        <self-signed.trust-store-password>changeit</self-signed.trust-store-password>
+    </properties>
+
     <!--todo add ssl tests-->
 
     <dependencies>
@@ -165,6 +170,31 @@
                     </execution>
                 </executions>
             </plugin>
+
+            <plugin>
+                <groupId>uk.co.automatictester</groupId>
+                <artifactId>truststore-maven-plugin</artifactId>
+                <version>${truststore-maven-plugin.version}</version>
+                <executions>
+                    <execution>
+                        <id>self-signed-truststore</id>
+                        <phase>generate-test-resources</phase>
+                        <goals>
+                            <goal>generate-truststore</goal>
+                        </goals>
+                        <configuration>
+                            <truststoreFormat>PKCS12</truststoreFormat>
+                            <truststoreFile>${self-signed.trust-store}</truststoreFile>
+                            <truststorePassword>${self-signed.trust-store-password}</truststorePassword>
+                            <servers>
+                                <server>self-signed.badssl.com:443</server>
+                            </servers>
+                            <trustAllCertificates>true</trustAllCertificates>
+                            <includeCertificates>LEAF</includeCertificates>
+                        </configuration>
+                    </execution>
+                </executions>
+            </plugin>
         </plugins>
     </build>
 
diff --git a/integration-tests/rest-client-reactive/src/main/java/io/quarkus/it/rest/client/main/ClientCallingResource.java b/integration-tests/rest-client-reactive/src/main/java/io/quarkus/it/rest/client/main/ClientCallingResource.java
index 5b6252ce83a00..1e311fef17815 100644
--- a/integration-tests/rest-client-reactive/src/main/java/io/quarkus/it/rest/client/main/ClientCallingResource.java
+++ b/integration-tests/rest-client-reactive/src/main/java/io/quarkus/it/rest/client/main/ClientCallingResource.java
@@ -21,6 +21,7 @@
 
 import io.opentelemetry.sdk.testing.exporter.InMemorySpanExporter;
 import io.quarkus.it.rest.client.main.MyResponseExceptionMapper.MyException;
+import io.quarkus.it.rest.client.main.selfsigned.ExternalSelfSignedClient;
 import io.smallrye.mutiny.Uni;
 import io.vertx.core.Future;
 import io.vertx.core.json.Json;
@@ -44,6 +45,9 @@ public class ClientCallingResource {
     @RestClient
     FaultToleranceOnInterfaceClient faultToleranceOnInterfaceClient;
 
+    @RestClient
+    ExternalSelfSignedClient externalSelfSignedClient;
+
     @Inject
     InMemorySpanExporter inMemorySpanExporter;
 
@@ -165,6 +169,9 @@ void init(@Observes Router router) {
         });
 
         router.get("/with%20space").handler(rc -> rc.response().setStatusCode(200).end());
+
+        router.get("/self-signed").blockingHandler(
+                rc -> rc.response().setStatusCode(200).end(String.valueOf(externalSelfSignedClient.invoke().getStatus())));
     }
 
     private Future<Void> success(RoutingContext rc, String body) {
diff --git a/integration-tests/rest-client-reactive/src/main/java/io/quarkus/it/rest/client/main/selfsigned/ExternalSelfSignedClient.java b/integration-tests/rest-client-reactive/src/main/java/io/quarkus/it/rest/client/main/selfsigned/ExternalSelfSignedClient.java
new file mode 100644
index 0000000000000..7d2610f75b4be
--- /dev/null
+++ b/integration-tests/rest-client-reactive/src/main/java/io/quarkus/it/rest/client/main/selfsigned/ExternalSelfSignedClient.java
@@ -0,0 +1,15 @@
+package io.quarkus.it.rest.client.main.selfsigned;
+
+import javax.ws.rs.GET;
+import javax.ws.rs.core.Response;
+
+import org.eclipse.microprofile.faulttolerance.Retry;
+import org.eclipse.microprofile.rest.client.inject.RegisterRestClient;
+
+@RegisterRestClient(baseUri = "https://self-signed.badssl.com/", configKey = "self-signed")
+public interface ExternalSelfSignedClient {
+
+    @GET
+    @Retry(delay = 1000)
+    Response invoke();
+}
diff --git a/integration-tests/rest-client-reactive/src/main/resources/application.properties b/integration-tests/rest-client-reactive/src/main/resources/application.properties
index 392722ce0c912..03c013f85ce30 100644
--- a/integration-tests/rest-client-reactive/src/main/resources/application.properties
+++ b/integration-tests/rest-client-reactive/src/main/resources/application.properties
@@ -1,4 +1,7 @@
 w-exception-mapper/mp-rest/url=${test.url}
 w-fault-tolerance/mp-rest/url=${test.url}
 io.quarkus.it.rest.client.main.ParamClient/mp-rest/url=${test.url}
-io.quarkus.it.rest.client.multipart.MultipartClient/mp-rest/url=${test.url}
\ No newline at end of file
+io.quarkus.it.rest.client.multipart.MultipartClient/mp-rest/url=${test.url}
+# HTTPS
+quarkus.rest-client.self-signed.trust-store=${self-signed.trust-store}
+quarkus.rest-client.self-signed.trust-store-password=${self-signed.trust-store-password}
diff --git a/integration-tests/rest-client-reactive/src/test/java/io/quarkus/it/rest/client/selfsigned/ExternalSelfSignedTestCase.java b/integration-tests/rest-client-reactive/src/test/java/io/quarkus/it/rest/client/selfsigned/ExternalSelfSignedTestCase.java
new file mode 100644
index 0000000000000..1348f532290fc
--- /dev/null
+++ b/integration-tests/rest-client-reactive/src/test/java/io/quarkus/it/rest/client/selfsigned/ExternalSelfSignedTestCase.java
@@ -0,0 +1,21 @@
+package io.quarkus.it.rest.client.selfsigned;
+
+import static io.restassured.RestAssured.when;
+import static org.hamcrest.Matchers.is;
+
+import org.junit.jupiter.api.Test;
+
+import io.quarkus.test.junit.QuarkusTest;
+
+@QuarkusTest
+public class ExternalSelfSignedTestCase {
+
+    @Test
+    public void should_accept_self_signed_certs() {
+        when()
+                .get("/self-signed")
+                .then()
+                .statusCode(200)
+                .body(is("200"));
+    }
+}