diff --git a/extensions/jackson/deployment/src/main/java/io/quarkus/jackson/deployment/JacksonProcessor.java b/extensions/jackson/deployment/src/main/java/io/quarkus/jackson/deployment/JacksonProcessor.java
index dc7b382a921a4..d120cea847a9e 100644
--- a/extensions/jackson/deployment/src/main/java/io/quarkus/jackson/deployment/JacksonProcessor.java
+++ b/extensions/jackson/deployment/src/main/java/io/quarkus/jackson/deployment/JacksonProcessor.java
@@ -25,6 +25,7 @@
 import org.jboss.jandex.Type;
 
 import com.fasterxml.jackson.annotation.JsonAutoDetect;
+import com.fasterxml.jackson.annotation.JsonSubTypes;
 import com.fasterxml.jackson.annotation.SimpleObjectIdResolver;
 import com.fasterxml.jackson.databind.JsonDeserializer;
 import com.fasterxml.jackson.databind.JsonSerializer;
@@ -79,7 +80,7 @@ public class JacksonProcessor {
     private static final DotName JSON_AUTO_DETECT = DotName.createSimple(JsonAutoDetect.class.getName());
 
     private static final DotName JSON_TYPE_ID_RESOLVER = DotName.createSimple(JsonTypeIdResolver.class.getName());
-
+    private static final DotName JSON_SUBTYPES = DotName.createSimple(JsonSubTypes.class.getName());
     private static final DotName JSON_CREATOR = DotName.createSimple("com.fasterxml.jackson.annotation.JsonCreator");
 
     private static final DotName JSON_NAMING = DotName.createSimple("com.fasterxml.jackson.databind.annotation.JsonNaming");
@@ -98,6 +99,7 @@ public class JacksonProcessor {
     // this list can probably be enriched with more modules
     private static final List<String> MODULES_NAMES_TO_AUTO_REGISTER = Arrays.asList(TIME_MODULE, JDK8_MODULE,
             PARAMETER_NAMES_MODULE);
+    private static final String[] EMPTY_STRING = new String[0];
 
     @Inject
     CombinedIndexBuildItem combinedIndexBuildItem;
@@ -266,6 +268,25 @@ void register(
             }
         }
 
+        // register @JsonSubTypes.Type values for reflection
+        Set<String> subTypeTypesNames = new HashSet<>();
+        for (AnnotationInstance subTypeInstance : index.getAnnotations(JSON_SUBTYPES)) {
+            AnnotationValue subTypeValue = subTypeInstance.value();
+            if (subTypeValue != null) {
+                for (AnnotationInstance subTypeTypeInstance : subTypeValue.asNestedArray()) {
+                    AnnotationValue subTypeTypeValue = subTypeTypeInstance.value();
+                    if (subTypeTypeValue != null) {
+                        subTypeTypesNames.add(subTypeTypeValue.asClass().name().toString());
+                    }
+                }
+
+            }
+        }
+        if (!subTypeTypesNames.isEmpty()) {
+            reflectiveClass.produce(ReflectiveClassBuildItem.builder(subTypeTypesNames.toArray(EMPTY_STRING))
+                    .methods().fields().build());
+        }
+
         // this needs to be registered manually since the runtime module is not indexed by Jandex
         additionalBeans.produce(new AdditionalBeanBuildItem(ObjectMapperProducer.class));
     }