diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/ComputedHeader.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/ComputedHeader.java
new file mode 100644
index 0000000000000..3a796b6a0988d
--- /dev/null
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/ComputedHeader.java
@@ -0,0 +1,9 @@
+package io.quarkus.rest.client.reactive.registerclientheaders;
+
+public final class ComputedHeader {
+
+    public static String get() {
+        return "From " + ComputedHeader.class.getName();
+    }
+
+}
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/MultipleHeadersBindingClient.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/MultipleHeadersBindingClient.java
new file mode 100644
index 0000000000000..7a4e8012169dd
--- /dev/null
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/MultipleHeadersBindingClient.java
@@ -0,0 +1,20 @@
+package io.quarkus.rest.client.reactive.registerclientheaders;
+
+import javax.ws.rs.GET;
+import javax.ws.rs.HeaderParam;
+import javax.ws.rs.Path;
+
+import org.eclipse.microprofile.rest.client.annotation.ClientHeaderParam;
+import org.eclipse.microprofile.rest.client.annotation.RegisterClientHeaders;
+import org.eclipse.microprofile.rest.client.inject.RegisterRestClient;
+
+@RegisterRestClient
+@RegisterClientHeaders(MyHeadersFactory.class)
+@ClientHeaderParam(name = "my-header", value = "constant-header-value")
+@ClientHeaderParam(name = "computed-header", value = "{io.quarkus.rest.client.reactive.registerclientheaders.ComputedHeader.get}")
+public interface MultipleHeadersBindingClient {
+    @GET
+    @Path("/describe-request")
+    @ClientHeaderParam(name = "header-from-properties", value = "${header.value}")
+    RequestData call(@HeaderParam("jaxrs-style-header") String headerValue);
+}
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/MyHeadersFactory.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/MyHeadersFactory.java
index 8572362e62d2e..79068e1a0695f 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/MyHeadersFactory.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/MyHeadersFactory.java
@@ -19,8 +19,8 @@ public class MyHeadersFactory implements ClientHeadersFactory {
     public MultivaluedMap<String, String> update(MultivaluedMap<String, String> incomingHeaders,
             MultivaluedMap<String, String> clientOutgoingHeaders) {
         assertNotNull(beanManager);
-        incomingHeaders.add("foo", "bar");
-        return incomingHeaders;
+        clientOutgoingHeaders.add("foo", "bar");
+        return clientOutgoingHeaders;
     }
 
 }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/RegisterClientHeadersTest.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/RegisterClientHeadersTest.java
index 670e5213d8f3c..7d9488644b613 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/RegisterClientHeadersTest.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/registerclientheaders/RegisterClientHeadersTest.java
@@ -1,9 +1,13 @@
 package io.quarkus.rest.client.reactive.registerclientheaders;
 
 import static io.quarkus.rest.client.reactive.RestClientTestUtil.setUrlForClass;
+import static io.quarkus.rest.client.reactive.registerclientheaders.HeaderSettingClient.HEADER;
 import static org.assertj.core.api.Assertions.assertThat;
 import static org.junit.jupiter.api.Assertions.assertEquals;
 
+import java.util.List;
+import java.util.Map;
+
 import org.eclipse.microprofile.rest.client.inject.RestClient;
 import org.jboss.shrinkwrap.api.ShrinkWrap;
 import org.jboss.shrinkwrap.api.asset.StringAsset;
@@ -26,8 +30,9 @@ public class RegisterClientHeadersTest {
                                                 setUrlForClass(HeaderSettingClient.class) +
                                                 setUrlForClass(HeaderPassingClient.class) +
                                                 setUrlForClass(HeaderNoPassingClient.class) +
-                                                "org.eclipse.microprofile.rest.client.propagateHeaders="
-                                                + HeaderSettingClient.HEADER),
+                                                setUrlForClass(MultipleHeadersBindingClient.class) +
+                                                "org.eclipse.microprofile.rest.client.propagateHeaders=" + HEADER + "\n" +
+                                                "header.value=from property file"),
                                 "application.properties");
             });
 
@@ -37,6 +42,9 @@ public class RegisterClientHeadersTest {
     @RestClient
     HeaderSettingClient headerSettingClient;
 
+    @RestClient
+    MultipleHeadersBindingClient multipleHeadersBindingClient;
+
     @Test
     public void shouldUseHeadersFactory() {
         assertEquals("ping:bar", client.echo("ping:"));
@@ -47,14 +55,30 @@ public void shouldUseHeadersFactory() {
     public void shouldPassIncomingHeaders() {
         String headerValue = "my-header-value";
         RequestData requestData = headerSettingClient.setHeaderValue(headerValue);
-        assertThat(requestData.getHeaders().get(HeaderSettingClient.HEADER).get(0)).isEqualTo(headerValue);
+        assertThat(requestData.getHeaders().get(HEADER).get(0)).isEqualTo(headerValue);
     }
 
     @Test
     public void shouldNotPassIncomingHeaders() {
         String headerValue = "my-header-value";
         RequestData requestData = headerSettingClient.setHeaderValueNoPassing(headerValue);
-        assertThat(requestData.getHeaders().get(HeaderSettingClient.HEADER)).isNull();
+        assertThat(requestData.getHeaders().get(HEADER)).isNull();
+    }
+
+    @Test
+    public void shouldSetHeadersFromMultipleBindings() {
+        String headerValue = "my-header-value";
+        Map<String, List<String>> headers = multipleHeadersBindingClient.call(headerValue).getHeaders();
+        // Verify: @RegisterClientHeaders(MyHeadersFactory.class)
+        assertThat(headers.get("foo")).containsExactly("bar");
+        // Verify: @ClientHeaderParam(name = "my-header", value = "constant-header-value")
+        assertThat(headers.get("my-header")).containsExactly("constant-header-value");
+        // Verify: @ClientHeaderParam(name = "computed-header", value = "{...ComputedHeader.get}")
+        assertThat(headers.get("computed-header")).containsExactly("From " + ComputedHeader.class.getName());
+        // Verify: @ClientHeaderParam(name = "header-from-properties", value = "${header.value}")
+        assertThat(headers.get("header-from-properties")).containsExactly("from property file");
+        // Verify: @HeaderParam("jaxrs-style-header")
+        assertThat(headers.get("jaxrs-style-header")).containsExactly(headerValue);
     }
 
 }
diff --git a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientRequestFilter.java b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientRequestFilter.java
index 3a6c26f8405ed..89982a4c8caaa 100644
--- a/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientRequestFilter.java
+++ b/extensions/resteasy-reactive/rest-client-reactive/runtime/src/main/java/io/quarkus/rest/client/reactive/runtime/MicroProfileRestClientRequestFilter.java
@@ -10,7 +10,6 @@
 import javax.ws.rs.core.MultivaluedMap;
 
 import org.eclipse.microprofile.rest.client.ext.ClientHeadersFactory;
-import org.eclipse.microprofile.rest.client.ext.DefaultClientHeadersFactoryImpl;
 import org.jboss.resteasy.reactive.client.spi.ResteasyReactiveClientRequestContext;
 import org.jboss.resteasy.reactive.client.spi.ResteasyReactiveClientRequestFilter;
 
@@ -55,12 +54,9 @@ public void filter(ResteasyReactiveClientRequestContext requestContext) {
             }
         }
 
-        if (clientHeadersFactory instanceof DefaultClientHeadersFactoryImpl) {
-            // When using the default factory, pass the proposed outgoing headers onto the request context.
-            // Propagation with the default factory will then overwrite any values if required.
-            for (Map.Entry<String, List<String>> headerEntry : headers.entrySet()) {
-                requestContext.getHeaders().put(headerEntry.getKey(), castToListOfObjects(headerEntry.getValue()));
-            }
+        // Propagation with the default factory will then overwrite any values if required.
+        for (Map.Entry<String, List<String>> headerEntry : headers.entrySet()) {
+            requestContext.getHeaders().put(headerEntry.getKey(), castToListOfObjects(headerEntry.getValue()));
         }
 
         if (clientHeadersFactory != null) {
@@ -82,10 +78,6 @@ public void filter(ResteasyReactiveClientRequestContext requestContext) {
                     requestContext.getHeaders().put(headerEntry.getKey(), castToListOfObjects(headerEntry.getValue()));
                 }
             }
-        } else {
-            for (Map.Entry<String, List<String>> headerEntry : headers.entrySet()) {
-                requestContext.getHeaders().put(headerEntry.getKey(), castToListOfObjects(headerEntry.getValue()));
-            }
         }
     }