diff --git a/packages/grpc-js/src/server-interceptors.ts b/packages/grpc-js/src/server-interceptors.ts
index c03f3028c..405f526bf 100644
--- a/packages/grpc-js/src/server-interceptors.ts
+++ b/packages/grpc-js/src/server-interceptors.ts
@@ -39,6 +39,11 @@ function trace(text: string) {
   logging.trace(LogVerbosity.DEBUG, TRACER_NAME, text);
 }
 
+interface GrpcFrame {
+  infoBytes: Buffer;
+  payload: Buffer;
+}
+
 export interface ServerMetadataListener {
   (metadata: Metadata, next: (metadata: Metadata) => void): void;
 }
@@ -613,16 +618,15 @@ export class BaseServerInterceptingCall implements ServerInterceptingCallInterfa
    * @param value
    * @returns
    */
-  private serializeMessage(value: any) {
-    const messageBuffer = this.handler.serialize(value);
-    const byteLength = messageBuffer.byteLength;
-    const output = Buffer.allocUnsafe(byteLength + 5);
+  private serializeMessage(value: any): GrpcFrame {
+    const payload = this.handler.serialize(value);
+
+    const infoBytes = Buffer.allocUnsafe(5);
     /* Note: response compression is currently not supported, so this
      * compressed bit is always 0. */
-    output.writeUInt8(0, 0);
-    output.writeUInt32BE(byteLength, 1);
-    messageBuffer.copy(output, 5);
-    return output;
+    infoBytes.writeUInt8(0, 0);
+    infoBytes.writeUInt32BE(payload.byteLength, 1);
+    return { infoBytes, payload };
   }
 
   private decompressMessage(
@@ -740,47 +744,70 @@ export class BaseServerInterceptingCall implements ServerInterceptingCallInterfa
     };
     this.stream.respond(headers, defaultResponseOptions);
   }
+  private createFrameWriteErrorCallback(
+    callback: () => void
+  ): (err: unknown) => void {
+    let errored = false;
+    let written = 0;
+    return (error: unknown) => {
+      if (errored) {
+        return;
+      }
+      if (error) {
+        this.sendStatus({
+          code: Status.INTERNAL,
+          details: `Error writing message: ${getErrorMessage(error)}`,
+          metadata: null,
+        });
+        errored = true;
+        return;
+      }
+      written++;
+      if (written !== 2) {
+        return;
+      }
+      this.callEventTracker?.addMessageSent();
+      callback();
+    };
+  }
   sendMessage(message: any, callback: () => void): void {
     if (this.checkCancelled()) {
       return;
     }
-    let response: Buffer;
+    let frame: GrpcFrame;
     try {
-      response = this.serializeMessage(message);
+      frame = this.serializeMessage(message);
     } catch (e) {
       this.sendStatus({
         code: Status.INTERNAL,
         details: `Error serializing response: ${getErrorMessage(e)}`,
-        metadata: null
+        metadata: null,
       });
       return;
     }
 
     if (
       this.maxSendMessageSize !== -1 &&
-      response.length - 5 > this.maxSendMessageSize
+      frame.payload.length > this.maxSendMessageSize
     ) {
       this.sendStatus({
         code: Status.RESOURCE_EXHAUSTED,
-        details: `Sent message larger than max (${response.length} vs. ${this.maxSendMessageSize})`,
-        metadata: null
+        details: `Sent message larger than max (${frame.payload.length} vs. ${this.maxSendMessageSize})`,
+        metadata: null,
       });
       return;
     }
     this.maybeSendMetadata();
-    trace('Request to ' + this.handler.path + ' sent data frame of size ' + response.length);
-    this.stream.write(response, error => {
-      if (error) {
-        this.sendStatus({
-          code: Status.INTERNAL,
-          details: `Error writing message: ${getErrorMessage(error)}`,
-          metadata: null
-        });
-        return;
-      }
-      this.callEventTracker?.addMessageSent();
-      callback();
-    });
+    trace(
+      'Request to ' +
+        this.handler.path +
+        ' sent data frame of size ' +
+        frame.payload.length
+    );
+
+    const cb = this.createFrameWriteErrorCallback(callback);
+    this.stream.write(frame.infoBytes, cb);
+    this.stream.write(frame.payload, cb);
   }
   sendStatus(status: PartialStatusObject): void {
     if (this.checkCancelled()) {