From fc7f904a03585afc9df7c155f2c8ea71ca7692ee Mon Sep 17 00:00:00 2001 From: HM Rando Date: Tue, 11 Oct 2022 09:58:32 -0400 Subject: [PATCH] shorten abstract --- content/24.vaccines-novel.md | 16 +++++++--------- 1 file changed, 7 insertions(+), 9 deletions(-) diff --git a/content/24.vaccines-novel.md b/content/24.vaccines-novel.md index ae4084253..773f9d124 100644 --- a/content/24.vaccines-novel.md +++ b/content/24.vaccines-novel.md @@ -3,21 +3,19 @@ ### Abstract In the 21^st^ century, several emergent viruses have posed a global threat. -Each of these pathogens has emphasized the value of rapid and scalable vaccine development programs. +Each pathogen has emphasized the value of rapid and scalable vaccine development programs. The ongoing SARS-CoV-2 pandemic has made the importance of such efforts especially clear. -In particular, new biotechnological advances in vaccine design allowed for new advances in vaccines that provide only the nucleic acid building blocks of an antigen, eliminating many safety concerns. +New biotechnological advances in vaccinology allow for recent advances that provide only the nucleic acid building blocks of an antigen, eliminating many safety concerns. During the COVID-19 pandemic, these DNA and RNA vaccines have facilitated the development and deployment of vaccines at an unprecedented pace. -This success was attributable at least in part to broader shifts in scientific research relative to prior epidemics. -For example, the genome of SARS-CoV-2 was available as early as January 2020, allowing for global efforts in the development of DNA and RNA vaccines to begin within two weeks of the international community becoming aware of the new viral threat. -Additionally, these technologies that were previously only theoretical were found to be not only safe but also to have high vaccine efficacy. +This success was attributable at least in part to broader shifts in scientific research relative to prior epidemics; the genome of SARS-CoV-2 was available as early as January 2020, facilitating global efforts in the development of DNA and RNA vaccines within two weeks of the international community becoming aware of the new viral threat. +Additionally, these technologies that were previously only theoretical are not only safe but also to have highly efficacious. -Although historically a slow process, the rapid development of vaccines during the COVID-19 public health crisis reveals a major shift in vaccine technologies. -In this review, we provide historical context for the emergence of these paradigm-shifting vaccines. -Further context is provided in a companion review exploring more established vaccines platforms. +Although historically a slow process, the rapid development of vaccines during the COVID-19 crisis reveals a major shift in vaccine technologies. +Here, we provide historical context for the emergence of these paradigm-shifting vaccines. We describe several DNA and RNA vaccines and in terms of their efficacy, safety, and approval status. We also discuss patterns in worldwide distribution. -The advances made since early 2020 provide an exceptional illustration of how rapidly vaccine development technology has advanced in the last two decades in particular, and suggest a new era in vaccines against emerging pathogens. +The advances made since early 2020 provide an exceptional illustration of how rapidly vaccine development technology has advanced in the last two decades in particular and suggest a new era in vaccines against emerging pathogens. ### Importance