diff --git a/.github/workflows/opam.yml b/.github/workflows/opam.yml
index 27852d8..b8a8070 100644
--- a/.github/workflows/opam.yml
+++ b/.github/workflows/opam.yml
@@ -27,7 +27,6 @@ jobs:
 
       - name: Inspect depexts
         run: |
-          opam exec -- which python
           opam exec -- which cmake
 
       - name: Install local dependencies
diff --git a/README.md b/README.md
index cbabacd..48e5aee 100644
--- a/README.md
+++ b/README.md
@@ -19,14 +19,6 @@ Inside your dune file, you can depend on `libbinaryen` as such:
   (flags :standard -O2 -Wall -Wextra)))
 ```
 
-## Dependencies
-
-This project requires `CMake` and `python` (v3.5 or greater).
-
-When installing with opam, both of these dependencies will be checked using `conf-cmake` and `conf-python-3`.
-
-When installing with esy, CMake will be built from source, and, on Mac or Linux, Python must be globally installed within a location that esy knows about (those being `/usr/local/bin`, `/usr/bin`, `/bin`, `/usr/sbin`, or `/sbin`). On Windows, a suitable python is already available from esy-bash.
-
 ## MacOS C++ Compiler
 
 When including this library in your `dune` MacOS executables, you'll need to specify `-cc clang++` in your `(flags)` stanza. This is required because Binaryen will throw errors for itself to catch and using `clang++` is the only way to handle them correctly. You can find more info on this [ocaml issue](https://github.com/ocaml/ocaml/issues/10423).
diff --git a/binaryen b/binaryen
index 8010148..3168fa2 160000
--- a/binaryen
+++ b/binaryen
@@ -1 +1 @@
-Subproject commit 80101484099e9451072eb8c10df69499031b3475
+Subproject commit 3168fa227eeb3b964b6d3c773d95e0a2014b396a
diff --git a/libbinaryen.opam b/libbinaryen.opam
index c6c0f76..24beed6 100644
--- a/libbinaryen.opam
+++ b/libbinaryen.opam
@@ -13,7 +13,6 @@ build: [
 ]
 depends: [
   "conf-cmake" {build}
-  "conf-python-3" {build}
   "dune" {>= "2.9.1"}
   "dune-configurator" {>= "2.9.1"}
   "ocaml" {>= "4.12"}