diff --git a/CHANGELOG.md b/CHANGELOG.md
index bd60e4986ef..b6adba6557d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -31,6 +31,7 @@
   * `cortex_alertmanager_nflog_maintenance_errors_total`
   * `cortex_alertmanager_silences_maintenance_total`
   * `cortex_alertmanager_silences_maintenance_errors_total`
+* [ENHANCEMENT] Add native histogram support for `cortex_request_duration_seconds` metric family. #4987
 * [BUGFIX] Metadata API: Mimir will now return an empty object when no metadata is available, matching Prometheus. #4782
 * [BUGFIX] Store-gateway: add collision detection on expanded postings and individual postings cache keys. #4770
 * [BUGFIX] Ruler: Support the `type=alert|record` query parameter for the API endpoint `<prometheus-http-prefix>/api/v1/rules`. #4302
diff --git a/pkg/mimir/mimir.go b/pkg/mimir/mimir.go
index 60b70035f95..062a0a85425 100644
--- a/pkg/mimir/mimir.go
+++ b/pkg/mimir/mimir.go
@@ -138,6 +138,8 @@ type Config struct {
 func (c *Config) RegisterFlags(f *flag.FlagSet, logger log.Logger) {
 	c.ApplicationName = "Grafana Mimir"
 	c.Server.MetricsNamespace = "cortex"
+	// Enable native histograms for enabled scrapers with 10% bucket growth.
+	c.Server.MetricsNativeHistogramFactor = 1.1
 	c.Server.ExcludeRequestInLog = true
 	c.Server.DisableRequestSuccessLog = true