diff --git a/setup.py b/setup.py
index 772e26b..ec17bb4 100644
--- a/setup.py
+++ b/setup.py
@@ -24,7 +24,7 @@
 version = "1.63.0"
 release_status = "Development Status :: 5 - Production/Stable"
 dependencies = [
-    "protobuf>=3.19.5,<5.0.0.dev0,!=3.20.0,!=3.20.1,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+    "protobuf>=3.19.5,<6.0.0.dev0,!=3.20.0,!=3.20.1,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 
 extras_require = {"grpc": ["grpcio >= 1.44.0, <2.0.0.dev0"]}