diff --git a/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java b/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java
index 63318a090..8e50d0867 100644
--- a/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java
+++ b/google-cloud-datastore/src/main/java/com/google/cloud/datastore/StructuredQuery.java
@@ -272,7 +272,10 @@ public Operator apply(String constant) {
       static final Operator GREATER_THAN = type.createAndRegister("GREATER_THAN");
       static final Operator GREATER_THAN_OR_EQUAL = type.createAndRegister("GREATER_THAN_OR_EQUAL");
       static final Operator EQUAL = type.createAndRegister("EQUAL");
+      static final Operator IN = type.createAndRegister("IN");
+      static final Operator NOT_EQUAL = type.createAndRegister("NOT_EQUAL");
       static final Operator HAS_ANCESTOR = type.createAndRegister("HAS_ANCESTOR");
+      static final Operator NOT_IN = type.createAndRegister("NOT_IN");
 
       com.google.datastore.v1.PropertyFilter.Operator toPb() {
         return com.google.datastore.v1.PropertyFilter.Operator.valueOf(name());
@@ -502,6 +505,46 @@ public static PropertyFilter eq(String property, Blob value) {
       return new PropertyFilter(property, Operator.EQUAL, of(value));
     }
 
+    public static PropertyFilter neq(String property, Value<?> value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, value);
+    }
+
+    public static PropertyFilter neq(String property, String value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, long value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, double value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, boolean value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, Timestamp value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, Key value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter neq(String property, Blob value) {
+      return new PropertyFilter(property, Operator.NOT_EQUAL, of(value));
+    }
+
+    public static PropertyFilter in(String property, ListValue value) {
+      return new PropertyFilter(property, Operator.IN, value);
+    }
+
+    public static PropertyFilter not_in(String property, ListValue value) {
+      return new PropertyFilter(property, Operator.NOT_IN, value);
+    }
+
     public static PropertyFilter hasAncestor(Key key) {
       return new PropertyFilter(KEY_PROPERTY_NAME, Operator.HAS_ANCESTOR, of(key));
     }
diff --git a/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java b/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java
index 3db8cfe3e..ac9ede3e9 100644
--- a/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java
+++ b/google-cloud-datastore/src/test/java/com/google/cloud/datastore/it/ITDatastoreTest.java
@@ -582,6 +582,64 @@ public void testRunStructuredQuery() throws InterruptedException {
     assertFalse(results4.hasNext());
   }
 
+  @Test
+  public void testMoreQueryFilters() throws InterruptedException {
+    DATASTORE.put(ENTITY3);
+
+    Query<Entity> queryIn =
+        Query.newEntityQueryBuilder().setKind(KIND1)
+            .setFilter(PropertyFilter.in("age", ListValue.of(20, 30))).build();
+
+    Query<Entity> scQueryIn =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.hasAncestor(ROOT_KEY))
+            .setFilter(PropertyFilter.in("age", ListValue.of(20, 30)))
+            .build();
+
+    Iterator<Entity> resultIn = getStronglyConsistentResults(scQueryIn, queryIn);
+
+    assertTrue(resultIn.hasNext());
+    assertEquals(ENTITY2, resultIn.next());
+    assertFalse(resultIn.hasNext());
+
+    Query<Entity> queryNotIn =
+        Query.newEntityQueryBuilder().setKind(KIND1)
+            .setFilter(PropertyFilter.not_in("age", ListValue.of(20, 30))).build();
+
+    Query<Entity> scQueryNotIn =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.hasAncestor(ROOT_KEY))
+            .setFilter(PropertyFilter.not_in("age", ListValue.of(20, 30)))
+            .build();
+
+    Iterator<Entity> resultNotIn = getStronglyConsistentResults(scQueryNotIn, queryNotIn);
+    assertTrue(resultNotIn.hasNext());
+    assertEquals(ENTITY1, resultNotIn.next());
+    assertEquals(ENTITY3, resultIn.next());
+    assertFalse(resultNotIn.hasNext());
+
+    Query<Entity> queryNeq =
+        Query.newEntityQueryBuilder().setKind(KIND1)
+            .setFilter(PropertyFilter.neq("str", STR_VALUE)).build();
+
+    Query<Entity> scQueryNeq =
+        Query.newEntityQueryBuilder()
+            .setKind(KIND1)
+            .setFilter(PropertyFilter.hasAncestor(ROOT_KEY))
+            .setFilter(PropertyFilter.neq("str", STR_VALUE))
+            .build();
+
+    Iterator<Entity> resultNeq = getStronglyConsistentResults(scQueryNeq, queryNeq);
+    assertTrue(resultNeq.hasNext());
+    assertEquals(ENTITY2, resultNeq.next());
+    assertEquals(ENTITY3, resultNeq.next());
+    assertFalse(resultNeq.hasNext());
+
+    DATASTORE.delete(ENTITY3.getKey());
+  }
+
   @Test
   public void testAllocateId() {
     KeyFactory keyFactory = DATASTORE.newKeyFactory().setKind(KIND1);