diff --git a/packages/google-cloud-binary-authorization/.github/.OwlBot.lock.yaml b/packages/google-cloud-binary-authorization/.github/.OwlBot.lock.yaml
index c6acdf3f90c4..23e106b65770 100644
--- a/packages/google-cloud-binary-authorization/.github/.OwlBot.lock.yaml
+++ b/packages/google-cloud-binary-authorization/.github/.OwlBot.lock.yaml
@@ -13,5 +13,5 @@
 # limitations under the License.
 docker:
   image: gcr.io/cloud-devrel-public-resources/owlbot-python:latest
-  digest: sha256:562802bfac02e012a6ac34eda282f81d06e77326b82a32d7bbb1369ff552b387
-# created: 2022-08-24T17:07:22.006876712Z
+  digest: sha256:ce3c1686bc81145c81dd269bd12c4025c6b275b22d14641358827334fddb1d72
+# created: 2022-08-29T17:28:30.441852797Z
diff --git a/packages/google-cloud-binary-authorization/.kokoro/requirements.txt b/packages/google-cloud-binary-authorization/.kokoro/requirements.txt
index c4b824f247e3..4b29ef247bed 100644
--- a/packages/google-cloud-binary-authorization/.kokoro/requirements.txt
+++ b/packages/google-cloud-binary-authorization/.kokoro/requirements.txt
@@ -136,9 +136,9 @@ cryptography==37.0.4 \
     # via
     #   gcp-releasetool
     #   secretstorage
-distlib==0.3.5 \
-    --hash=sha256:a7f75737c70be3b25e2bee06288cec4e4c221de18455b2dd037fe2a795cab2fe \
-    --hash=sha256:b710088c59f06338ca514800ad795a132da19fda270e3ce4affc74abf955a26c
+distlib==0.3.6 \
+    --hash=sha256:14bad2d9b04d3a36127ac97f30b12a19268f211063d8f8ee4f47108896e11b46 \
+    --hash=sha256:f35c4b692542ca110de7ef0bea44d73981caeb34ca0b9b6b2e6d7790dda8f80e
     # via virtualenv
 docutils==0.19 \
     --hash=sha256:33995a6753c30b7f577febfc2c50411fec6aac7f7ffeb7c4cfe5991072dcf9e6 \
diff --git a/packages/google-cloud-binary-authorization/noxfile.py b/packages/google-cloud-binary-authorization/noxfile.py
index 70739b12dd8c..5f898a7a57c9 100644
--- a/packages/google-cloud-binary-authorization/noxfile.py
+++ b/packages/google-cloud-binary-authorization/noxfile.py
@@ -188,7 +188,9 @@ def unit(session):
 def install_systemtest_dependencies(session, *constraints):
 
     # Use pre-release gRPC for system tests.
-    session.install("--pre", "grpcio")
+    # Exclude version 1.49.0rc1 which has a known issue.
+    # See https://github.com/grpc/grpc/pull/30642
+    session.install("--pre", "grpcio!=1.49.0rc1")
 
     session.install(*SYSTEM_TEST_STANDARD_DEPENDENCIES, *constraints)
 
@@ -368,7 +370,8 @@ def prerelease_deps(session):
         # dependency of grpc
         "six",
         "googleapis-common-protos",
-        "grpcio",
+        # Exclude version 1.49.0rc1 which has a known issue. See https://github.com/grpc/grpc/pull/30642
+        "grpcio!=1.49.0rc1",
         "grpcio-status",
         "google-api-core",
         "proto-plus",