diff --git a/pw_allocator/py/setup.cfg b/pw_allocator/py/setup.cfg
index 4f1a6fdb3e..3aa3264a52 100644
--- a/pw_allocator/py/setup.cfg
+++ b/pw_allocator/py/setup.cfg
@@ -21,7 +21,7 @@ description = Pigweed heap allocator
 [options]
 packages = find:
 zip_safe = False
-install_requires = pw_cli
+install_requires =
 
 [options.package_data]
 pw_allocator = py.typed
diff --git a/pw_bloat/py/setup.cfg b/pw_bloat/py/setup.cfg
index b1f87faa93..65c184cb7f 100644
--- a/pw_bloat/py/setup.cfg
+++ b/pw_bloat/py/setup.cfg
@@ -22,7 +22,6 @@ description = Tools for generating binary size report cards
 packages = find:
 zip_safe = False
 install_requires =
-    pw_cli
     pyelftools
 
 [options.package_data]
diff --git a/pw_build/py/setup.cfg b/pw_build/py/setup.cfg
index 72f76984ae..df953ca29a 100644
--- a/pw_build/py/setup.cfg
+++ b/pw_build/py/setup.cfg
@@ -24,9 +24,6 @@ zip_safe = False
 install_requires =
     wheel
     coverage
-    pw_cli
-    pw_env_setup
-    pw_presubmit
 
 [options.entry_points]
 console_scripts =
diff --git a/pw_console/py/setup.cfg b/pw_console/py/setup.cfg
index d16c4734c4..4e7f0a8bbe 100644
--- a/pw_console/py/setup.cfg
+++ b/pw_console/py/setup.cfg
@@ -26,8 +26,6 @@ install_requires =
     Jinja2
     prompt_toolkit>=3.0.26
     ptpython>=3.0.20
-    pw_cli
-    pw_log_tokenized
     Pygments
     pygments-style-dracula
     pygments-style-tomorrow
diff --git a/pw_cpu_exception_cortex_m/py/setup.cfg b/pw_cpu_exception_cortex_m/py/setup.cfg
index 178a77a64c..d6fd9330c1 100644
--- a/pw_cpu_exception_cortex_m/py/setup.cfg
+++ b/pw_cpu_exception_cortex_m/py/setup.cfg
@@ -23,8 +23,6 @@ packages = find:
 zip_safe = False
 install_requires =
     protobuf
-    pw_cli
-    pw_protobuf_compiler
 
 [options.package_data]
 pw_cpu_exception_cortex_m = py.typed
diff --git a/pw_env_setup/BUILD.gn b/pw_env_setup/BUILD.gn
index af86dd92a5..44cce8b35b 100644
--- a/pw_env_setup/BUILD.gn
+++ b/pw_env_setup/BUILD.gn
@@ -65,13 +65,11 @@ _pigweed_python_deps = [
 ]
 
 pw_python_group("python") {
-  python_deps = []
+  python_deps = _pigweed_python_deps
   if (pw_build_USE_NEW_PYTHON_BUILD) {
     # This target creates and installs Python package named 'pigweed' including
     # every package listed in _pigweed_python_deps.
     python_deps += [ ":pip_install_pigweed_package" ]
-  } else {
-    python_deps += _pigweed_python_deps
   }
   python_deps += [
     # Standalone scripts
diff --git a/pw_hdlc/py/setup.cfg b/pw_hdlc/py/setup.cfg
index b3b18a3a12..e0447cda1e 100644
--- a/pw_hdlc/py/setup.cfg
+++ b/pw_hdlc/py/setup.cfg
@@ -23,10 +23,6 @@ packages = find:
 zip_safe = False
 install_requires =
     ipython
-    pw_console
-    pw_protobuf_compiler
-    pw_rpc
-tests_require = pw_build
 
 [options.package_data]
 pw_hdlc = py.typed
diff --git a/pw_presubmit/py/setup.cfg b/pw_presubmit/py/setup.cfg
index 14652af9d2..82dcf55081 100644
--- a/pw_presubmit/py/setup.cfg
+++ b/pw_presubmit/py/setup.cfg
@@ -24,8 +24,6 @@ zip_safe = False
 install_requires =
     scan-build==2.0.19
     yapf==0.31.0
-    pw_cli
-    pw_package
 
 [options.package_data]
 pw_presubmit = py.typed
diff --git a/pw_protobuf/py/setup.cfg b/pw_protobuf/py/setup.cfg
index a2bbc18056..f391b257f6 100644
--- a/pw_protobuf/py/setup.cfg
+++ b/pw_protobuf/py/setup.cfg
@@ -23,7 +23,6 @@ packages = find:
 zip_safe = False
 install_requires =
     protobuf
-    pw_cli
     graphlib-backport;python_version<'3.9'
 
 [options.entry_points]
diff --git a/pw_protobuf_compiler/py/setup.cfg b/pw_protobuf_compiler/py/setup.cfg
index 09b0f7b14d..a7e24b4a67 100644
--- a/pw_protobuf_compiler/py/setup.cfg
+++ b/pw_protobuf_compiler/py/setup.cfg
@@ -27,7 +27,6 @@ install_requires =
     # This must also be specified in //pw_protobuf_compiler/BUILD.gn
     mypy-protobuf==2.9
     protobuf
-    pw_cli
     types-protobuf
 
 [options.package_data]
diff --git a/pw_system/py/setup.cfg b/pw_system/py/setup.cfg
index b71b3b1598..989a099e1d 100644
--- a/pw_system/py/setup.cfg
+++ b/pw_system/py/setup.cfg
@@ -22,12 +22,6 @@ description = Pigweed System
 packages = find:
 zip_safe = False
 install_requires =
-    pw_cli
-    pw_console
-    pw_hdlc
-    pw_protobuf_compiler
-    pw_rpc
-    pw_tokenizer
 
 [options.entry_points]
 console_scripts = pw-system-console = pw_system.console:main
diff --git a/pw_tls_client/py/setup.cfg b/pw_tls_client/py/setup.cfg
index 6a52caeb4c..3fceb695c8 100644
--- a/pw_tls_client/py/setup.cfg
+++ b/pw_tls_client/py/setup.cfg
@@ -21,7 +21,8 @@ description = pw_tls_client python package
 [options]
 packages = find:
 zip_safe = False
-install_requires = cryptography
+install_requires =
+    cryptography
 
 [options.package_data]
 pw_tls_client = py.typed
diff --git a/pw_trace_tokenized/py/setup.cfg b/pw_trace_tokenized/py/setup.cfg
index 5a5cfb234d..6c643bb4ab 100644
--- a/pw_trace_tokenized/py/setup.cfg
+++ b/pw_trace_tokenized/py/setup.cfg
@@ -22,9 +22,6 @@ description = pw_trace backend to tokenize trace events
 packages = find:
 zip_safe = False
 install_requires =
-    pw_hdlc
-    pw_tokenizer
-    pw_trace
 
 [options.package_data]
 pw_trace_tokenized = py.typed
diff --git a/pw_unit_test/py/setup.cfg b/pw_unit_test/py/setup.cfg
index c73ce69221..27cce253af 100644
--- a/pw_unit_test/py/setup.cfg
+++ b/pw_unit_test/py/setup.cfg
@@ -21,7 +21,7 @@ description = Unit tests for Pigweed projects
 [options]
 packages = find:
 zip_safe = False
-install_requires = pw_cli; pw_rpc; pw_unit_test_proto
+install_requires =
 
 [options.package_data]
 pw_unit_test = py.typed
diff --git a/pw_watch/py/setup.cfg b/pw_watch/py/setup.cfg
index 504489c0b8..1d887576a4 100644
--- a/pw_watch/py/setup.cfg
+++ b/pw_watch/py/setup.cfg
@@ -21,7 +21,9 @@ description = Pigweed automatic builder
 [options]
 packages = find:
 zip_safe = False
-install_requires = httpwatcher; pw_cli; watchdog>=2.1.0
+install_requires =
+    httpwatcher
+    watchdog>=2.1.0
 
 [options.package_data]
 pw_watch = py.typed