diff --git a/CHANGELOG.md b/CHANGELOG.md
index c38172ad72..e53e934d6c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,6 +23,7 @@
 
 - Prevent pod install crash when visionos is not present ([#3548](https://github.com/getsentry/sentry-react-native/pull/3548))
 - Fetch Organization slug from `@sentry/react-native/expo` config when uploading artifacts ([#3557](https://github.com/getsentry/sentry-react-native/pull/3557))
+- Remove 404 Http Client Errors reports for Metro Dev Server Requests ([#3553](https://github.com/getsentry/sentry-react-native/pull/3553))
 
 ## 5.17.0
 
diff --git a/src/js/integrations/debugsymbolicator.ts b/src/js/integrations/debugsymbolicator.ts
index e449c605b6..970042f214 100644
--- a/src/js/integrations/debugsymbolicator.ts
+++ b/src/js/integrations/debugsymbolicator.ts
@@ -3,6 +3,7 @@ import { addContextToFrame, logger } from '@sentry/utils';
 
 import { getFramesToPop, isErrorLike } from '../utils/error';
 import { ReactNativeLibraries } from '../utils/rnlibraries';
+import { createStealthXhr, XHR_READYSTATE_DONE } from '../utils/xhr';
 import type * as ReactNative from '../vendor/react-native';
 
 const INTERNAL_CALLSITES_REGEX = new RegExp(['ReactNativeRenderer-dev\\.js$', 'MessageQueue\\.js$'].join('|'));
@@ -200,14 +201,30 @@ export class DebugSymbolicator implements Integration {
    * Get source context for segment
    */
   private async _fetchSourceContext(url: string, segments: Array<string>, start: number): Promise<string | null> {
-    const response = await fetch(`${url}${segments.slice(start).join('/')}`, {
-      method: 'GET',
-    });
+    return new Promise(resolve => {
+      const fullUrl = `${url}${segments.slice(start).join('/')}`;
 
-    if (response.ok) {
-      return response.text();
-    }
-    return null;
+      const xhr = createStealthXhr();
+      if (!xhr) {
+        resolve(null);
+        return;
+      }
+
+      xhr.open('GET', fullUrl, true);
+      xhr.send();
+
+      xhr.onreadystatechange = (): void => {
+        if (xhr.readyState === XHR_READYSTATE_DONE) {
+          if (xhr.status !== 200) {
+            resolve(null);
+          }
+          resolve(xhr.responseText);
+        }
+      };
+      xhr.onerror = (): void => {
+        resolve(null);
+      };
+    });
   }
 
   /**
diff --git a/src/js/utils/worldwide.ts b/src/js/utils/worldwide.ts
index 7c4e2ea4ec..debd6da3ab 100644
--- a/src/js/utils/worldwide.ts
+++ b/src/js/utils/worldwide.ts
@@ -16,6 +16,7 @@ export interface ReactNativeInternalGlobal extends InternalGlobal {
   nativeFabricUIManager: unknown;
   ErrorUtils?: ErrorUtils;
   expo?: ExpoGlobalObject;
+  XMLHttpRequest?: typeof XMLHttpRequest;
 }
 
 /** Get's the global object for the current JavaScript runtime */
diff --git a/src/js/utils/xhr.ts b/src/js/utils/xhr.ts
new file mode 100644
index 0000000000..c64d5a7a31
--- /dev/null
+++ b/src/js/utils/xhr.ts
@@ -0,0 +1,41 @@
+import { RN_GLOBAL_OBJ } from './worldwide';
+
+const __sentry_original__ = '__sentry_original__';
+
+type XMLHttpRequestWithSentryOriginal = XMLHttpRequest & {
+  open: typeof XMLHttpRequest.prototype.open & { [__sentry_original__]?: typeof XMLHttpRequest.prototype.open };
+  send: typeof XMLHttpRequest.prototype.send & { [__sentry_original__]?: typeof XMLHttpRequest.prototype.send };
+};
+
+/**
+ * The DONE ready state for XmlHttpRequest
+ *
+ * Defining it here as a constant b/c XMLHttpRequest.DONE is not always defined
+ * (e.g. during testing, it is `undefined`)
+ *
+ * @see {@link https://developer.mozilla.org/en-US/docs/Web/API/XMLHttpRequest/readyState}
+ */
+export const XHR_READYSTATE_DONE = 4;
+
+/**
+ * Creates a new XMLHttpRequest object which is not instrumented by the SDK.
+ *
+ * This request won't be captured by the HttpClient Errors integration
+ * and won't be added to breadcrumbs and won't be traced.
+ */
+export function createStealthXhr(
+  customGlobal: { XMLHttpRequest?: typeof XMLHttpRequest } = RN_GLOBAL_OBJ,
+): XMLHttpRequest | null {
+  if (!customGlobal.XMLHttpRequest) {
+    return null;
+  }
+
+  const xhr: XMLHttpRequestWithSentryOriginal = new customGlobal.XMLHttpRequest();
+  if (xhr.open.__sentry_original__) {
+    xhr.open = xhr.open.__sentry_original__;
+  }
+  if (xhr.send.__sentry_original__) {
+    xhr.send = xhr.send.__sentry_original__;
+  }
+  return xhr;
+}
diff --git a/test/utils/xhr.test.ts b/test/utils/xhr.test.ts
new file mode 100644
index 0000000000..2e9b16fc2a
--- /dev/null
+++ b/test/utils/xhr.test.ts
@@ -0,0 +1,76 @@
+import { createStealthXhr } from '../../src/js/utils/xhr';
+
+describe('xhr', () => {
+  it('creates xhr and calls monkey patched methods if original was not preserved', () => {
+    const XMLHttpRequestMock = getXhrMock();
+    const globalMock = createGlobalMock(XMLHttpRequestMock);
+
+    const xhr = createStealthXhr(globalMock);
+
+    xhr!.open('GET', 'https://example.com');
+    xhr!.send();
+
+    expect(xhr!.open).toHaveBeenCalledWith('GET', 'https://example.com');
+    expect(xhr!.send).toHaveBeenCalled();
+  });
+
+  it('monkey patched xhr is not called when original is preserved', () => {
+    const XMLHttpRequestMock = getXhrMock();
+    const globalMock = createGlobalMock(XMLHttpRequestMock);
+
+    const { xhrOpenMonkeyPatch, xhrSendMonkeyPatch } = mockSentryPatchWithOriginal(globalMock);
+
+    const xhr = createStealthXhr(globalMock);
+
+    xhr!.open('GET', 'https://example.com');
+    xhr!.send();
+
+    expect(xhrOpenMonkeyPatch).not.toHaveBeenCalled();
+    expect(xhrSendMonkeyPatch).not.toHaveBeenCalled();
+    expect(xhr!.open).toHaveBeenCalledWith('GET', 'https://example.com');
+    expect(xhr!.send).toHaveBeenCalled();
+  });
+});
+
+function createGlobalMock(xhr: unknown) {
+  return {
+    XMLHttpRequest: xhr as typeof XMLHttpRequest,
+  };
+}
+
+function getXhrMock() {
+  function XhrMock() {}
+
+  XhrMock.prototype.open = jest.fn();
+  XhrMock.prototype.send = jest.fn();
+
+  return XhrMock;
+}
+
+type WithSentryOriginal<T> = T & { __sentry_original__?: T };
+
+function mockSentryPatchWithOriginal(globalMock: { XMLHttpRequest: typeof XMLHttpRequest }): {
+  xhrOpenMonkeyPatch: jest.Mock;
+  xhrSendMonkeyPatch: jest.Mock;
+} {
+  const originalOpen = globalMock.XMLHttpRequest.prototype.open;
+  const originalSend = globalMock.XMLHttpRequest.prototype.send;
+
+  const xhrOpenMonkeyPatch = jest.fn();
+  const xhrSendMonkeyPatch = jest.fn();
+
+  globalMock.XMLHttpRequest.prototype.open = xhrOpenMonkeyPatch;
+  globalMock.XMLHttpRequest.prototype.send = xhrSendMonkeyPatch;
+
+  (
+    globalMock.XMLHttpRequest.prototype.open as WithSentryOriginal<typeof XMLHttpRequest.prototype.open>
+  ).__sentry_original__ = originalOpen;
+  (
+    globalMock.XMLHttpRequest.prototype.send as WithSentryOriginal<typeof XMLHttpRequest.prototype.send>
+  ).__sentry_original__ = originalSend;
+
+  return {
+    xhrOpenMonkeyPatch,
+    xhrSendMonkeyPatch,
+  };
+}