diff --git a/packages/node/src/sdk/client.ts b/packages/node/src/sdk/client.ts
index b4730ac0f07c..f8a775c15600 100644
--- a/packages/node/src/sdk/client.ts
+++ b/packages/node/src/sdk/client.ts
@@ -1,6 +1,7 @@
 import * as os from 'node:os';
 import type { Tracer } from '@opentelemetry/api';
 import { trace } from '@opentelemetry/api';
+import { registerInstrumentations } from '@opentelemetry/instrumentation';
 import type { BasicTracerProvider } from '@opentelemetry/sdk-trace-base';
 import type { Scope, ServerRuntimeClientOptions } from '@sentry/core';
 import { SDK_VERSION, ServerRuntimeClient, applySdkMetadata, logger } from '@sentry/core';
@@ -27,6 +28,12 @@ export class NodeClient extends ServerRuntimeClient<NodeClientOptions> {
       serverName: options.serverName || global.process.env.SENTRY_NAME || os.hostname(),
     };
 
+    if (options.openTelemetryInstrumentations) {
+      registerInstrumentations({
+        instrumentations: options.openTelemetryInstrumentations,
+      });
+    }
+
     applySdkMetadata(clientOptions, 'node');
 
     logger.log(
diff --git a/packages/node/src/types.ts b/packages/node/src/types.ts
index 7235e2057c34..15df14d59847 100644
--- a/packages/node/src/types.ts
+++ b/packages/node/src/types.ts
@@ -1,4 +1,5 @@
 import type { Span as WriteableSpan } from '@opentelemetry/api';
+import type { Instrumentation } from '@opentelemetry/instrumentation';
 import type { ReadableSpan } from '@opentelemetry/sdk-trace-base';
 import type { ClientOptions, Options, SamplingContext, Scope, Span, TracePropagationTargets } from '@sentry/types';
 
@@ -90,6 +91,13 @@ export interface BaseNodeOptions {
    */
   skipOpenTelemetrySetup?: boolean;
 
+  /**
+   * Provide an array of OpenTelemetry Instrumentations that should be registered.
+   *
+   * Use this option if you want to register OpenTelemetry instrumentation that the Sentry SDK does not yet have support for.
+   */
+  openTelemetryInstrumentations?: Instrumentation[];
+
   /**
    * The max. duration in seconds that the SDK will wait for parent spans to be finished before discarding a span.
    * The SDK will automatically clean up spans that have no finished parent after this duration.
@@ -156,7 +164,7 @@ export interface CurrentScopes {
  * The base `Span` type is basically a `WriteableSpan`.
  * There are places where we basically want to allow passing _any_ span,
  * so in these cases we type this as `AbstractSpan` which could be either a regular `Span` or a `ReadableSpan`.
- * You'll have to make sur to check revelant fields before accessing them.
+ * You'll have to make sur to check relevant fields before accessing them.
  *
  * Note that technically, the `Span` exported from `@opentelemetry/sdk-trace-base` matches this,
  * but we cannot be 100% sure that we are actually getting such a span, so this type is more defensive.
diff --git a/packages/node/test/sdk/client.test.ts b/packages/node/test/sdk/client.test.ts
index 1aa4cf14fdff..8f85c375592f 100644
--- a/packages/node/test/sdk/client.test.ts
+++ b/packages/node/test/sdk/client.test.ts
@@ -1,5 +1,6 @@
 import * as os from 'os';
 import { ProxyTracer } from '@opentelemetry/api';
+import * as opentelemetryInstrumentationPackage from '@opentelemetry/instrumentation';
 import {
   SDK_VERSION,
   SessionFlusher,
@@ -495,6 +496,21 @@ describe('NodeClient', () => {
       expect(sendEnvelopeSpy).toHaveBeenCalledTimes(0);
     });
   });
+
+  it('registers instrumentations provided with `openTelemetryInstrumentations`', () => {
+    const registerInstrumentationsSpy = jest
+      .spyOn(opentelemetryInstrumentationPackage, 'registerInstrumentations')
+      .mockImplementationOnce(() => () => undefined);
+    const instrumentationsArray = ['foobar'] as unknown as opentelemetryInstrumentationPackage.Instrumentation[];
+
+    new NodeClient(getDefaultNodeClientOptions({ openTelemetryInstrumentations: instrumentationsArray }));
+
+    expect(registerInstrumentationsSpy).toHaveBeenCalledWith(
+      expect.objectContaining({
+        instrumentations: instrumentationsArray,
+      }),
+    );
+  });
 });
 
 describe('flush/close', () => {