diff --git a/moto/secretsmanager/list_secrets/filters.py b/moto/secretsmanager/list_secrets/filters.py
index 659d4c636ce3..233550175499 100644
--- a/moto/secretsmanager/list_secrets/filters.py
+++ b/moto/secretsmanager/list_secrets/filters.py
@@ -9,7 +9,7 @@ def name_filter(secret: "FakeSecret", names: List[str]) -> bool:
 
 
 def description_filter(secret: "FakeSecret", descriptions: List[str]) -> bool:
-    return _matcher(descriptions, [secret.description])  # type: ignore
+    return _matcher(descriptions, [secret.description], match_prefix=False)  # type: ignore
 
 
 def tag_key(secret: "FakeSecret", tag_keys: List[str]) -> bool:
@@ -30,21 +30,31 @@ def filter_all(secret: "FakeSecret", values: List[str]) -> bool:
     return _matcher(values, attributes)  # type: ignore
 
 
-def _matcher(patterns: List[str], strings: List[str]) -> bool:
+def _matcher(
+    patterns: List[str], strings: List[str], match_prefix: bool = True
+) -> bool:
     for pattern in [p for p in patterns if p.startswith("!")]:
         for string in strings:
-            if _match_pattern(pattern[1:], string):
-                return False
+            if not _match_pattern(pattern[1:], string, match_prefix):
+                return True
 
     for pattern in [p for p in patterns if not p.startswith("!")]:
         for string in strings:
-            if _match_pattern(pattern, string):
+            if _match_pattern(pattern, string, match_prefix):
                 return True
     return False
 
 
-def _match_pattern(pattern: str, value: str) -> bool:
-    for word in pattern.split(" "):
-        if word not in value:
-            return False
+def _match_pattern(pattern: str, value: str, match_prefix: bool = True) -> bool:
+    if match_prefix:
+        return value.startswith(pattern)
+    else:
+        pattern_words = pattern.split(" ")
+        value_words = value.split(" ")
+        for pattern_word in pattern_words:
+            # all words in value must start with pattern_word
+            if not any(
+                value_word.startswith(pattern_word) for value_word in value_words
+            ):
+                return False
     return True
diff --git a/tests/test_secretsmanager/test_list_secrets.py b/tests/test_secretsmanager/test_list_secrets.py
index 32dadb7dc044..1acb8a9d3bdf 100644
--- a/tests/test_secretsmanager/test_list_secrets.py
+++ b/tests/test_secretsmanager/test_list_secrets.py
@@ -268,7 +268,13 @@ def test_with_filter_with_negation():
     )
 
     secret_names = list(map(lambda s: s["Name"], secrets["SecretList"]))
-    assert secret_names == ["baz"]
+    for secret_name in ["foo", "bar", "baz"]:
+        assert secret_name in secret_names
+
+    secrets = conn.list_secrets(Filters=[{"Key": "description", "Values": ["!o"]}])
+    secret_names = list(map(lambda s: s["Name"], secrets["SecretList"]))
+    for secret_name in ["qux", "none"]:
+        assert secret_name in secret_names
 
 
 @mock_aws