diff --git a/pkgs/development/python-modules/cleanlab/default.nix b/pkgs/development/python-modules/cleanlab/default.nix
index 7746a76ce1469..ad7a59d343e6b 100644
--- a/pkgs/development/python-modules/cleanlab/default.nix
+++ b/pkgs/development/python-modules/cleanlab/default.nix
@@ -2,6 +2,7 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
+  fetchpatch,
 
   # build-system
   setuptools,
@@ -42,8 +43,21 @@ buildPythonPackage rec {
     hash = "sha256-0kCEIHNOXIkdwDH5zCVWnR/W79ppc/1PFsJ/a4goGzk=";
   };
 
+  patches = [
+    # https://github.com/cleanlab/cleanlab/pull/1224
+    (fetchpatch {
+      name = "numpy2-compatibility";
+      url = "https://github.com/GaetanLepage/cleanlab/commit/7d4cef11cf8d58b0ca7dba78f4c64995ed709274.patch";
+      hash = "sha256-1mLEITYj30F9tJh8tajWnpGC5FANh8he/lgw1f+LAsI=";
+    })
+  ];
+
   build-system = [ setuptools ];
 
+  pythonRelaxDeps = [
+    "numpy"
+  ];
+
   dependencies = [
     numpy
     scikit-learn
@@ -79,6 +93,12 @@ buildPythonPackage rec {
     [
       # Requires the datasets we prevent from downloading
       "test_create_imagelab"
+
+      # Non-trivial numpy2 incompatibilities
+      # assert np.float64(0.492) == 0.491
+      "test_duplicate_points_have_similar_scores"
+      # AssertionError: assert 'Annotators [1] did not label any examples.'
+      "test_label_quality_scores_multiannotator"
     ]
     ++ lib.optionals (pythonAtLeast "3.12") [
       # AttributeError: 'called_once_with' is not a valid assertion.