diff --git a/extensions/resteasy-reactive/quarkus-resteasy-reactive-common/runtime/src/main/java/io/quarkus/resteasy/reactive/common/runtime/ArcBeanFactory.java b/extensions/resteasy-reactive/quarkus-resteasy-reactive-common/runtime/src/main/java/io/quarkus/resteasy/reactive/common/runtime/ArcBeanFactory.java
index 0808558c0ca57b..68c8faf9d1e7b2 100644
--- a/extensions/resteasy-reactive/quarkus-resteasy-reactive-common/runtime/src/main/java/io/quarkus/resteasy/reactive/common/runtime/ArcBeanFactory.java
+++ b/extensions/resteasy-reactive/quarkus-resteasy-reactive-common/runtime/src/main/java/io/quarkus/resteasy/reactive/common/runtime/ArcBeanFactory.java
@@ -22,17 +22,27 @@ public String toString() {
 
     @Override
     public BeanInstance<T> createInstance() {
-        BeanContainer.Instance<T> instance = factory.create();
-        return new BeanInstance<T>() {
-            @Override
-            public T getInstance() {
-                return instance.get();
+        BeanContainer.Instance<T> instance;
+        try {
+            instance = factory.create();
+            return new BeanInstance<T>() {
+                @Override
+                public T getInstance() {
+                    return instance.get();
+                }
+
+                @Override
+                public void close() {
+                    instance.close();
+                }
+            };
+        } catch (Exception e) {
+            if (factory.getClass().getName().contains("DefaultInstanceFactory")) {
+                throw new IllegalArgumentException(
+                        "Unable to create class '" + targetClassName + "'. To fix the problem, make this class is a CDI bean.",
+                        e);
             }
-
-            @Override
-            public void close() {
-                instance.close();
-            }
-        };
+            throw e;
+        }
     }
 }