diff --git a/packages/vite-plugin-cloudflare/package.json b/packages/vite-plugin-cloudflare/package.json
index 7fdc5b32..1eff92fb 100644
--- a/packages/vite-plugin-cloudflare/package.json
+++ b/packages/vite-plugin-cloudflare/package.json
@@ -36,6 +36,7 @@
 	},
 	"dependencies": {
 		"@hattip/adapter-node": "^0.0.49",
+		"@rollup/plugin-replace": "^6.0.1",
 		"miniflare": "^3.20241205.0"
 	},
 	"devDependencies": {
diff --git a/packages/vite-plugin-cloudflare/src/cloudflare-environment.ts b/packages/vite-plugin-cloudflare/src/cloudflare-environment.ts
index c4d93fc2..2876e33a 100644
--- a/packages/vite-plugin-cloudflare/src/cloudflare-environment.ts
+++ b/packages/vite-plugin-cloudflare/src/cloudflare-environment.ts
@@ -1,5 +1,6 @@
 import assert from 'node:assert';
 import { builtinModules } from 'node:module';
+import replace from '@rollup/plugin-replace';
 import * as vite from 'vite';
 import { getNodeCompatExternals } from './node-js-compat';
 import { INIT_PATH, UNKNOWN_HOST } from './shared';
@@ -153,6 +154,13 @@ export function createCloudflareEnvironmentOptions(
 				//       optimizeDeps.entries in the dev config)
 				input: workerConfig.main,
 				external: [...cloudflareBuiltInModules, ...getNodeCompatExternals()],
+				plugins: [
+					replace({
+						'process.env.NODE_ENV': JSON.stringify(
+							process.env.NODE_ENV ?? 'production',
+						),
+					}),
+				],
 			},
 		},
 		optimizeDeps: {
diff --git a/playground/module-resolution/__tests__/module-resolution.spec.ts b/playground/module-resolution/__tests__/module-resolution.spec.ts
index 3f90891a..836d97cc 100644
--- a/playground/module-resolution/__tests__/module-resolution.spec.ts
+++ b/playground/module-resolution/__tests__/module-resolution.spec.ts
@@ -76,9 +76,7 @@ describe('module resolution', async () => {
 	 *  special meaning to us.
 	 */
 	describe('third party packages resolutions', () => {
-		// TODO: we skip this test on build because a `ReferenceError: process is not defined` is thrown
-		//       (https://github.com/flarelabs-net/vite-plugin-cloudflare/issues/82)
-		test.skipIf(isBuild)('react', async () => {
+		test('react', async () => {
 			const result = await getJsonResponse('/third-party/react');
 			expect(result).toEqual({
 				'(react) reactVersionsMatch': true,
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index f7ea1670..5638e674 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -68,6 +68,9 @@ importers:
       '@hattip/adapter-node':
         specifier: ^0.0.49
         version: 0.0.49
+      '@rollup/plugin-replace':
+        specifier: ^6.0.1
+        version: 6.0.1(rollup@4.24.0)
       miniflare:
         specifier: ^3.20241205.0
         version: 3.20241205.0
@@ -1335,6 +1338,24 @@ packages:
       typescript:
         optional: true
 
+  '@rollup/plugin-replace@6.0.1':
+    resolution: {integrity: sha512-2sPh9b73dj5IxuMmDAsQWVFT7mR+yoHweBaXG2W/R8vQ+IWZlnaI7BR7J6EguVQUp1hd8Z7XuozpDjEKQAAC2Q==}
+    engines: {node: '>=14.0.0'}
+    peerDependencies:
+      rollup: ^1.20.0||^2.0.0||^3.0.0||^4.0.0
+    peerDependenciesMeta:
+      rollup:
+        optional: true
+
+  '@rollup/pluginutils@5.1.3':
+    resolution: {integrity: sha512-Pnsb6f32CD2W3uCaLZIzDmeFyQ2b8UWMFI7xtwUezpcGBDVDW6y9XgAWIlARiGAo6eNF5FK5aQTr0LFyNyqq5A==}
+    engines: {node: '>=14.0.0'}
+    peerDependencies:
+      rollup: ^1.20.0||^2.0.0||^3.0.0||^4.0.0
+    peerDependenciesMeta:
+      rollup:
+        optional: true
+
   '@rollup/rollup-android-arm-eabi@4.22.4':
     resolution: {integrity: sha512-Fxamp4aEZnfPOcGA8KSNEohV8hX7zVHOemC8jVBoBUHu5zpJK/Eu3uJwt6BMgy9fkvzxDaurgj96F/NiLukF2w==}
     cpu: [arm]
@@ -1836,6 +1857,9 @@ packages:
   estree-walker@0.6.1:
     resolution: {integrity: sha512-SqmZANLWS0mnatqbSfRP5g8OXZC12Fgg1IwNtLsyHDzJizORW4khDfjPqJZsemPWBB2uqykUah5YpQ6epsqC/w==}
 
+  estree-walker@2.0.2:
+    resolution: {integrity: sha512-Rfkk/Mp/DL7JVje3u18FxFujQlTNR2q6QfMSMB7AvCBx91NGj/ba3kCfza0f6dVDbw7YlRf/nDrn7pQrCCyQ/w==}
+
   estree-walker@3.0.3:
     resolution: {integrity: sha512-7RUKfXgSMMkzt6ZuXmqapOurLGPPfgj6l9uRZ7lRGolvk0y2yocc35LdcxKC5PQZdn2DMqioAQ2NoWcrTKmm6g==}
 
@@ -3627,6 +3651,21 @@ snapshots:
     optionalDependencies:
       typescript: 5.7.2
 
+  '@rollup/plugin-replace@6.0.1(rollup@4.24.0)':
+    dependencies:
+      '@rollup/pluginutils': 5.1.3(rollup@4.24.0)
+      magic-string: 0.30.12
+    optionalDependencies:
+      rollup: 4.24.0
+
+  '@rollup/pluginutils@5.1.3(rollup@4.24.0)':
+    dependencies:
+      '@types/estree': 1.0.6
+      estree-walker: 2.0.2
+      picomatch: 4.0.2
+    optionalDependencies:
+      rollup: 4.24.0
+
   '@rollup/rollup-android-arm-eabi@4.22.4':
     optional: true
 
@@ -4143,6 +4182,8 @@ snapshots:
 
   estree-walker@0.6.1: {}
 
+  estree-walker@2.0.2: {}
+
   estree-walker@3.0.3:
     dependencies:
       '@types/estree': 1.0.6