diff --git a/packages/react/src/ReactFetch.js b/packages/react/src/ReactFetch.js
index 7ceea672acd45..2a5637efc0d60 100644
--- a/packages/react/src/ReactFetch.js
+++ b/packages/react/src/ReactFetch.js
@@ -74,7 +74,13 @@ if (enableCache && enableFetchInstrumentation) {
         url = resource;
       } else {
         // Normalize the request.
-        const request = new Request(resource, options);
+        // if resource is not a string or a URL (its an instance of Request)
+        // then do not instantiate a new Request but instead
+        // reuse the request as to not disturb the body in the event it's a ReadableStream.
+        const request =
+          typeof resource === 'string' || resource instanceof URL
+            ? new Request(resource, options)
+            : resource;
         if (
           (request.method !== 'GET' && request.method !== 'HEAD') ||
           // $FlowFixMe[prop-missing]: keepalive is real
diff --git a/packages/react/src/__tests__/ReactFetch-test.js b/packages/react/src/__tests__/ReactFetch-test.js
index b3f8843b8856e..9558ead7c1bc4 100644
--- a/packages/react/src/__tests__/ReactFetch-test.js
+++ b/packages/react/src/__tests__/ReactFetch-test.js
@@ -135,6 +135,22 @@ describe('ReactFetch', () => {
     expect(fetchCount).toBe(1);
   });
 
+  // @gate enableFetchInstrumentation && enableCache
+  it('can dedupe fetches using URL and not', async () => {
+    const url = 'http://example.com/';
+    function Component() {
+      const response = use(fetch(url));
+      const text = use(response.text());
+      const response2 = use(fetch(new URL(url)));
+      const text2 = use(response2.text());
+      return text + ' ' + text2;
+    }
+    expect(await render(Component)).toMatchInlineSnapshot(
+      `"GET ${url} [] GET ${url} []"`,
+    );
+    expect(fetchCount).toBe(1);
+  });
+
   it('can opt-out of deduping fetches inside of render with custom signal', async () => {
     const controller = new AbortController();
     function useCustomHook() {