diff --git a/packages/react-reconciler/src/ReactFiberScheduler.js b/packages/react-reconciler/src/ReactFiberScheduler.js
index 20b2b4d4f8500..1a407aab55619 100644
--- a/packages/react-reconciler/src/ReactFiberScheduler.js
+++ b/packages/react-reconciler/src/ReactFiberScheduler.js
@@ -168,6 +168,18 @@ let didWarnSetStateChildContext;
 let warnAboutUpdateOnUnmounted;
 let warnAboutInvalidUpdates;
 
+if (enableSchedulerTracking) {
+  // Provide explicit error message when production+profiling bundle of e.g. react-dom
+  // is used with production (non-profiling) bundle of schedule/tracking
+  invariant(
+    __interactionsRef != null && __interactionsRef.current != null,
+    'It is not supported to run the profiling version of a renderer (for example, `react-dom/profiling`) ' +
+      'without also replacing the `schedule/tracking` module with `schedule/tracking-profiling`. ' +
+      'Your bundler might have a setting for aliasing both modules. ' +
+      'Learn more at http://fb.me/react-profiling',
+  );
+}
+
 if (__DEV__) {
   didWarnAboutStateTransition = false;
   didWarnSetStateChildContext = false;
diff --git a/packages/react-reconciler/src/__tests__/ReactTracking-test.internal.js b/packages/react-reconciler/src/__tests__/ReactTracking-test.internal.js
new file mode 100644
index 0000000000000..3168f6f778505
--- /dev/null
+++ b/packages/react-reconciler/src/__tests__/ReactTracking-test.internal.js
@@ -0,0 +1,28 @@
+/**
+ * Copyright (c) Facebook, Inc. and its affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ * @emails react-core
+ * @jest-environment node
+ */
+
+'use strict';
+
+describe('ReactTracking', () => {
+  it('should error if profiling renderer and non-profiling schedule/tracking bundles are combined', () => {
+    jest.resetModules();
+
+    const ReactFeatureFlags = require('shared/ReactFeatureFlags');
+    ReactFeatureFlags.enableSchedulerTracking = false;
+
+    require('schedule/tracking');
+
+    ReactFeatureFlags.enableSchedulerTracking = true;
+
+    expect(() => require('react-dom')).toThrow(
+      'Learn more at http://fb.me/react-profiling',
+    );
+  });
+});
diff --git a/packages/schedule/npm/tracking-profiling.js b/packages/schedule/npm/tracking-profiling.js
new file mode 100644
index 0000000000000..c90851e796d23
--- /dev/null
+++ b/packages/schedule/npm/tracking-profiling.js
@@ -0,0 +1,7 @@
+'use strict';
+
+if (process.env.NODE_ENV === 'production') {
+  module.exports = require('./cjs/schedule-tracking.profiling.min.js');
+} else {
+  module.exports = require('./cjs/schedule-tracking.development.js');
+}
diff --git a/packages/schedule/package.json b/packages/schedule/package.json
index db052a1edc91c..f0ce6c2a4c54c 100644
--- a/packages/schedule/package.json
+++ b/packages/schedule/package.json
@@ -20,6 +20,7 @@
     "README.md",
     "index.js",
     "tracking.js",
+    "tracking-profiling.js",
     "cjs/",
     "umd/"
   ]