diff --git a/packages/react-dom/src/__tests__/ReactDOMFizzServer-test.js b/packages/react-dom/src/__tests__/ReactDOMFizzServer-test.js
index 295e99b26a691..da9097c51d5e3 100644
--- a/packages/react-dom/src/__tests__/ReactDOMFizzServer-test.js
+++ b/packages/react-dom/src/__tests__/ReactDOMFizzServer-test.js
@@ -2811,4 +2811,65 @@ describe('ReactDOMFizzServer', () => {
       </ul>,
     );
   });
+
+  describe('bootstrapScriptContent escaping', () => {
+    // @gate experimental
+    it('the "S" in "</?[Ss]cript" strings are replaced with unicode escaped lowercase s or S depending on case, preserving case sensitivity of nearby characters', async () => {
+      window.__test_outlet = '';
+      const stringWithScriptsInIt =
+        'prescription pre<scription pre<Scription pre</scRipTion pre</ScripTion </script><script><!-- <script> -->';
+      await act(async () => {
+        const {pipe} = ReactDOMFizzServer.renderToPipeableStream(<div />, {
+          bootstrapScriptContent:
+            'window.__test_outlet = "This should have been replaced";var x = "' +
+            stringWithScriptsInIt +
+            '";\nwindow.__test_outlet = x;',
+        });
+        pipe(writable);
+      });
+      expect(window.__test_outlet).toMatch(stringWithScriptsInIt);
+    });
+
+    // @gate experimental
+    it('does not escape \\u2028, or \\u2029 characters', async () => {
+      // these characters are ignored in engines support https://github.com/tc39/proposal-json-superset
+      // in this test with JSDOM the characters are silently dropped and thus don't need to be encoded.
+      // if you send these characters to an older browser they could fail so it is a good idea to
+      // sanitize JSON input of these characters
+      window.__test_outlet = '';
+      const el = document.createElement('p');
+      el.textContent = '{"one":1,\u2028\u2029"two":2}';
+      const stringWithLSAndPSCharacters = el.textContent;
+      await act(async () => {
+        const {pipe} = ReactDOMFizzServer.renderToPipeableStream(<div />, {
+          bootstrapScriptContent:
+            'let x = ' +
+            stringWithLSAndPSCharacters +
+            '; window.__test_outlet = x;',
+        });
+        pipe(writable);
+      });
+      const outletString = JSON.stringify(window.__test_outlet);
+      expect(outletString).toBe(
+        stringWithLSAndPSCharacters.replace(/[\u2028\u2029]/g, ''),
+      );
+    });
+
+    // @gate experimental
+    it('does not escape <, >, or & characters', async () => {
+      // these characters valid javascript and may be necessary in scripts and won't be interpretted properly
+      // escaped outside of a string context within javascript
+      window.__test_outlet = null;
+      // this boolean expression will be cast to a number due to the bitwise &. we will look for a truthy value (1) below
+      const booleanLogicString = '1 < 2 & 3 > 1';
+      await act(async () => {
+        const {pipe} = ReactDOMFizzServer.renderToPipeableStream(<div />, {
+          bootstrapScriptContent:
+            'let x = ' + booleanLogicString + '; window.__test_outlet = x;',
+        });
+        pipe(writable);
+      });
+      expect(window.__test_outlet).toBe(1);
+    });
+  });
 });
diff --git a/packages/react-dom/src/server/ReactDOMServerFormatConfig.js b/packages/react-dom/src/server/ReactDOMServerFormatConfig.js
index a42cb3188722b..f41abe26cfff2 100644
--- a/packages/react-dom/src/server/ReactDOMServerFormatConfig.js
+++ b/packages/react-dom/src/server/ReactDOMServerFormatConfig.js
@@ -83,6 +83,17 @@ const startScriptSrc = stringToPrecomputedChunk('<script src="');
 const startModuleSrc = stringToPrecomputedChunk('<script type="module" src="');
 const endAsyncScript = stringToPrecomputedChunk('" async=""></script>');
 
+const scriptRegex = /(<\/|<)(s)(cript)/gi;
+const scriptReplacer = (match, prefix, s, suffix) =>
+  `${prefix}${s === 's' ? '\\u0073' : '\\u0053'}${suffix}`;
+
+function escapeBootstrapScriptContent(scriptText) {
+  if (__DEV__) {
+    checkHtmlStringCoercion(scriptText);
+  }
+  return ('' + scriptText).replace(scriptRegex, scriptReplacer);
+}
+
 // Allows us to keep track of what we've already written so we can refer back to it.
 export function createResponseState(
   identifierPrefix: string | void,
@@ -102,7 +113,7 @@ export function createResponseState(
   if (bootstrapScriptContent !== undefined) {
     bootstrapChunks.push(
       inlineScriptWithNonce,
-      stringToChunk(escapeTextForBrowser(bootstrapScriptContent)),
+      stringToChunk(escapeBootstrapScriptContent(bootstrapScriptContent)),
       endInlineScript,
     );
   }