diff --git a/extensions/resteasy-reactive/quarkus-resteasy-reactive/runtime/src/main/java/io/quarkus/resteasy/reactive/server/runtime/ResteasyReactiveRuntimeRecorder.java b/extensions/resteasy-reactive/quarkus-resteasy-reactive/runtime/src/main/java/io/quarkus/resteasy/reactive/server/runtime/ResteasyReactiveRuntimeRecorder.java
index d071a33698b4ce..af2fa0ff05c17c 100644
--- a/extensions/resteasy-reactive/quarkus-resteasy-reactive/runtime/src/main/java/io/quarkus/resteasy/reactive/server/runtime/ResteasyReactiveRuntimeRecorder.java
+++ b/extensions/resteasy-reactive/quarkus-resteasy-reactive/runtime/src/main/java/io/quarkus/resteasy/reactive/server/runtime/ResteasyReactiveRuntimeRecorder.java
@@ -35,6 +35,7 @@ public Supplier<RuntimeConfiguration> runtimeConfiguration(RuntimeValue<Deployme
 
         RuntimeConfiguration runtimeConfiguration = new DefaultRuntimeConfiguration(httpConf.readTimeout,
                 httpConf.body.deleteUploadedFilesOnEnd, httpConf.body.uploadsDirectory,
+                httpConf.body.multipart.fileContentTypes.orElse(null),
                 runtimeConf.multipart.inputPart.defaultCharset, maxBodySize,
                 httpConf.limits.maxFormAttributeSize.asLongValue());
 
diff --git a/extensions/vertx-http/runtime/src/main/java/io/quarkus/vertx/http/runtime/BodyConfig.java b/extensions/vertx-http/runtime/src/main/java/io/quarkus/vertx/http/runtime/BodyConfig.java
index 144033f305561f..1c8723f7f33e41 100644
--- a/extensions/vertx-http/runtime/src/main/java/io/quarkus/vertx/http/runtime/BodyConfig.java
+++ b/extensions/vertx-http/runtime/src/main/java/io/quarkus/vertx/http/runtime/BodyConfig.java
@@ -55,4 +55,10 @@ public class BodyConfig {
      */
     @ConfigItem
     public boolean preallocateBodyBuffer;
+
+    /**
+     * HTTP multipart request related settings
+     */
+    @ConfigItem
+    public MultiPartConfig multipart;
 }
diff --git a/extensions/vertx-http/runtime/src/main/java/io/quarkus/vertx/http/runtime/MultiPartConfig.java b/extensions/vertx-http/runtime/src/main/java/io/quarkus/vertx/http/runtime/MultiPartConfig.java
new file mode 100644
index 00000000000000..a0e262b28d6e58
--- /dev/null
+++ b/extensions/vertx-http/runtime/src/main/java/io/quarkus/vertx/http/runtime/MultiPartConfig.java
@@ -0,0 +1,23 @@
+package io.quarkus.vertx.http.runtime;
+
+import java.util.List;
+import java.util.Optional;
+
+import io.quarkus.runtime.annotations.ConfigGroup;
+import io.quarkus.runtime.annotations.ConfigItem;
+import io.quarkus.runtime.annotations.ConvertWith;
+import io.quarkus.runtime.configuration.TrimmedStringConverter;
+
+/**
+ * A {@link ConfigGroup} for the settings related to HTTP multipart request handling.
+ */
+@ConfigGroup
+public class MultiPartConfig {
+
+    /**
+     * A list of {@code ContentType} to indicate whether a given multipart field should be handled as a file part.
+     */
+    @ConfigItem
+    @ConvertWith(TrimmedStringConverter.class)
+    public Optional<List<String>> fileContentTypes;
+}
diff --git a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/core/multipart/MultiPartParserDefinition.java b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/core/multipart/MultiPartParserDefinition.java
index 216da2f1965f6e..ef77e6a026c52c 100644
--- a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/core/multipart/MultiPartParserDefinition.java
+++ b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/core/multipart/MultiPartParserDefinition.java
@@ -53,6 +53,7 @@ public class MultiPartParserDefinition implements FormParserFactory.ParserDefini
 
     private long maxAttributeSize = 2048;
     private long maxEntitySize = -1;
+    private List<String> fileContentTypes;
 
     public MultiPartParserDefinition(Supplier<Executor> executorSupplier) {
         this.executorSupplier = executorSupplier;
@@ -152,6 +153,15 @@ public MultiPartParserDefinition setMaxEntitySize(long maxEntitySize) {
         return this;
     }
 
+    public List<String> getFileContentTypes() {
+        return fileContentTypes;
+    }
+
+    public MultiPartParserDefinition setFileContentTypes(List<String> fileContentTypes) {
+        this.fileContentTypes = fileContentTypes;
+        return this;
+    }
+
     private final class MultiPartUploadHandler implements FormDataParser, MultipartParser.PartHandler {
 
         private final ResteasyReactiveRequestContext exchange;
@@ -236,7 +246,8 @@ public void beginPart(final CaseInsensitiveMap<String> headers) {
                 if (disposition.startsWith("form-data")) {
                     currentName = HeaderUtil.extractQuotedValueFromHeader(disposition, "name");
                     fileName = HeaderUtil.extractQuotedValueFromHeaderWithEncoding(disposition, "filename");
-                    if (fileName != null && fileSizeThreshold == 0) {
+                    String contentType = headers.getFirst(HttpHeaders.CONTENT_TYPE);
+                    if ((fileName != null || isFileContentType(contentType)) && fileSizeThreshold == 0) {
                         try {
                             if (tempFileLocation != null) {
                                 Files.createDirectories(tempFileLocation);
@@ -254,6 +265,14 @@ public void beginPart(final CaseInsensitiveMap<String> headers) {
             }
         }
 
+        private boolean isFileContentType(String contentType) {
+            if (contentType == null || fileContentTypes == null) {
+                return false;
+            }
+
+            return fileContentTypes.contains(contentType);
+        }
+
         @Override
         public void data(final ByteBuffer buffer) throws IOException {
             this.currentFileSize += buffer.remaining();
diff --git a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/handlers/FormBodyHandler.java b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/handlers/FormBodyHandler.java
index b7f12b58df2692..196d76632a83a8 100644
--- a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/handlers/FormBodyHandler.java
+++ b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/handlers/FormBodyHandler.java
@@ -46,6 +46,7 @@ public void configure(RuntimeConfiguration configuration) {
                         .setMaxAttributeSize(configuration.limits().maxFormAttributeSize())
                         .setMaxEntitySize(configuration.limits().maxBodySize().orElse(-1L))
                         .setDeleteUploadsOnEnd(configuration.body().deleteUploadedFilesOnEnd())
+                        .setFileContentTypes(configuration.body().multiPart().fileContentTypes())
                         .setDefaultCharset(configuration.body().defaultCharset().name())
                         .setTempFileLocation(Path.of(configuration.body().uploadsDirectory())))
 
diff --git a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/DefaultRuntimeConfiguration.java b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/DefaultRuntimeConfiguration.java
index 6fe9c4a290ab18..958c6e55b7f8fe 100644
--- a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/DefaultRuntimeConfiguration.java
+++ b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/DefaultRuntimeConfiguration.java
@@ -2,6 +2,7 @@
 
 import java.nio.charset.Charset;
 import java.time.Duration;
+import java.util.List;
 import java.util.Optional;
 
 public class DefaultRuntimeConfiguration implements RuntimeConfiguration {
@@ -10,9 +11,16 @@ public class DefaultRuntimeConfiguration implements RuntimeConfiguration {
     private final Limits limits;
 
     public DefaultRuntimeConfiguration(Duration readTimeout, boolean deleteUploadedFilesOnEnd, String uploadsDirectory,
-            Charset defaultCharset, Optional<Long> maxBodySize, long maxFormAttributeSize) {
+            List<String> fileContentTypes, Charset defaultCharset, Optional<Long> maxBodySize, long maxFormAttributeSize) {
         this.readTimeout = readTimeout;
         body = new Body() {
+            Body.MultiPart multiPart = new Body.MultiPart() {
+                @Override
+                public List<String> fileContentTypes() {
+                    return fileContentTypes;
+                }
+            };
+
             @Override
             public boolean deleteUploadedFilesOnEnd() {
                 return deleteUploadedFilesOnEnd;
@@ -27,6 +35,11 @@ public String uploadsDirectory() {
             public Charset defaultCharset() {
                 return defaultCharset;
             }
+
+            @Override
+            public MultiPart multiPart() {
+                return multiPart;
+            }
         };
         limits = new Limits() {
             @Override
diff --git a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/RuntimeConfiguration.java b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/RuntimeConfiguration.java
index 5bdd06534a5371..6ccfdcee9dd508 100644
--- a/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/RuntimeConfiguration.java
+++ b/independent-projects/resteasy-reactive/server/runtime/src/main/java/org/jboss/resteasy/reactive/server/spi/RuntimeConfiguration.java
@@ -2,6 +2,7 @@
 
 import java.nio.charset.Charset;
 import java.time.Duration;
+import java.util.List;
 import java.util.Optional;
 
 public interface RuntimeConfiguration {
@@ -19,6 +20,12 @@ interface Body {
         String uploadsDirectory();
 
         Charset defaultCharset();
+
+        MultiPart multiPart();
+
+        interface MultiPart {
+            List<String> fileContentTypes();
+        }
     }
 
     interface Limits {
diff --git a/independent-projects/resteasy-reactive/server/vertx/src/test/java/org/jboss/resteasy/reactive/server/vertx/test/framework/ResteasyReactiveUnitTest.java b/independent-projects/resteasy-reactive/server/vertx/src/test/java/org/jboss/resteasy/reactive/server/vertx/test/framework/ResteasyReactiveUnitTest.java
index 92d770aeb910ae..b996daf921ddce 100644
--- a/independent-projects/resteasy-reactive/server/vertx/src/test/java/org/jboss/resteasy/reactive/server/vertx/test/framework/ResteasyReactiveUnitTest.java
+++ b/independent-projects/resteasy-reactive/server/vertx/src/test/java/org/jboss/resteasy/reactive/server/vertx/test/framework/ResteasyReactiveUnitTest.java
@@ -121,6 +121,7 @@ public boolean isBlockingAllowed() {
     static Vertx vertx;
     static ExecutorService executor;
     boolean deleteUploadedFilesOnEnd = true;
+    List<String> fileContentTypes;
     Path uploadPath;
 
     private List<Consumer<ResteasyReactiveDeploymentManager.ScanStep>> scanCustomizers = new ArrayList<>();
@@ -149,6 +150,11 @@ public ResteasyReactiveUnitTest setDeleteUploadedFilesOnEnd(boolean deleteUpload
         return this;
     }
 
+    public ResteasyReactiveUnitTest setFileContentTypes(List<String> fileContentTypes) {
+        this.fileContentTypes = fileContentTypes;
+        return this;
+    }
+
     public ResteasyReactiveUnitTest setUploadPath(Path uploadPath) {
         this.uploadPath = uploadPath;
         return this;
@@ -391,7 +397,7 @@ public Thread newThread(Runnable r) {
         DefaultRuntimeConfiguration runtimeConfiguration = new DefaultRuntimeConfiguration(Duration.ofMinutes(1),
                 deleteUploadedFilesOnEnd,
                 uploadPath != null ? uploadPath.toAbsolutePath().toString() : System.getProperty("java.io.tmpdir"),
-                defaultCharset, Optional.empty(), maxFormAttributeSize);
+                fileContentTypes, defaultCharset, Optional.empty(), maxFormAttributeSize);
         ResteasyReactiveDeploymentManager.RunnableApplication application = prepared.createApplication(runtimeConfiguration,
                 new VertxRequestContextFactory(), executor);
         fieldInjectionSupport.runtimeInit(testClassLoader, application.getDeployment());
diff --git a/independent-projects/resteasy-reactive/server/vertx/src/test/java/org/jboss/resteasy/reactive/server/vertx/test/multipart/MultipartFileContentTypeTest.java b/independent-projects/resteasy-reactive/server/vertx/src/test/java/org/jboss/resteasy/reactive/server/vertx/test/multipart/MultipartFileContentTypeTest.java
new file mode 100644
index 00000000000000..85157244a79b00
--- /dev/null
+++ b/independent-projects/resteasy-reactive/server/vertx/src/test/java/org/jboss/resteasy/reactive/server/vertx/test/multipart/MultipartFileContentTypeTest.java
@@ -0,0 +1,86 @@
+package org.jboss.resteasy.reactive.server.vertx.test.multipart;
+
+import java.io.File;
+import java.io.IOException;
+import java.nio.file.Files;
+import java.nio.file.Path;
+import java.nio.file.Paths;
+import java.util.List;
+import java.util.function.Supplier;
+
+import javax.ws.rs.core.MediaType;
+
+import org.jboss.resteasy.reactive.server.vertx.test.framework.ResteasyReactiveUnitTest;
+import org.jboss.resteasy.reactive.server.vertx.test.multipart.other.OtherPackageFormDataBase;
+import org.jboss.shrinkwrap.api.ShrinkWrap;
+import org.jboss.shrinkwrap.api.spec.JavaArchive;
+import org.junit.jupiter.api.AfterEach;
+import org.junit.jupiter.api.Assertions;
+import org.junit.jupiter.api.BeforeEach;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import io.restassured.RestAssured;
+
+public class MultipartFileContentTypeTest extends AbstractMultipartTest {
+
+    private static final Path uploadDir = Paths.get("file-uploads");
+
+    @RegisterExtension
+    static ResteasyReactiveUnitTest test = new ResteasyReactiveUnitTest()
+            .setDeleteUploadedFilesOnEnd(false)
+            .setUploadPath(uploadDir)
+            .setFileContentTypes(List.of(MediaType.APPLICATION_OCTET_STREAM, MediaType.APPLICATION_SVG_XML))
+            .setArchiveProducer(new Supplier<>() {
+                @Override
+                public JavaArchive get() {
+                    return ShrinkWrap.create(JavaArchive.class)
+                            .addClasses(FormDataBase.class, OtherPackageFormDataBase.class, FormData.class, Status.class,
+                                    OtherFormData.class, FormDataSameFileName.class,
+                                    OtherFormDataBase.class,
+                                    MultipartResource.class, OtherMultipartResource.class);
+                }
+
+            });
+
+    private final File FILE = new File("./src/test/resources/test.html");
+
+    @BeforeEach
+    public void assertEmptyUploads() {
+        Assertions.assertTrue(isDirectoryEmpty(uploadDir));
+    }
+
+    @AfterEach
+    public void clearDirectory() {
+        clearDirectory(uploadDir);
+    }
+
+    @Test
+    public void testFilePartWithExpectedContentType() throws IOException {
+        RestAssured.given()
+                .multiPart("octetStream", null, Files.readAllBytes(FILE.toPath()), MediaType.APPLICATION_OCTET_STREAM)
+                .multiPart("svgXml", null, Files.readAllBytes(FILE.toPath()), MediaType.APPLICATION_SVG_XML)
+                .accept("text/plain")
+                .when()
+                .post("/multipart/optional")
+                .then()
+                .statusCode(200);
+
+        // ensure that the 2 uploaded files where created on disk
+        Assertions.assertEquals(2, uploadDir.toFile().listFiles().length);
+    }
+
+    @Test
+    public void testFilePartWithUnexpectedContentType() throws IOException {
+        RestAssured.given()
+                .multiPart("xmlFile", null, Files.readAllBytes(FILE.toPath()), MediaType.APPLICATION_XML)
+                .accept("text/plain")
+                .when()
+                .post("/multipart/optional")
+                .then()
+                .statusCode(200);
+
+        // ensure that no files are created as the content-type is not supported as a file part
+        Assertions.assertEquals(0, uploadDir.toFile().listFiles().length);
+    }
+}