diff --git a/x-pack/test/fleet_api_integration/apis/epm/install_integration_in_multiple_spaces.ts b/x-pack/test/fleet_api_integration/apis/epm/install_integration_in_multiple_spaces.ts
index d6023ae0492e1..b0be168685d89 100644
--- a/x-pack/test/fleet_api_integration/apis/epm/install_integration_in_multiple_spaces.ts
+++ b/x-pack/test/fleet_api_integration/apis/epm/install_integration_in_multiple_spaces.ts
@@ -67,7 +67,8 @@ export default function (providerContext: FtrProviderContext) {
       })
       .catch(() => {});
 
-  describe('When installing system integration in multiple spaces', async () => {
+  // FLAKY: https://github.com/elastic/kibana/issues/161624
+  describe.skip('When installing system integration in multiple spaces', async () => {
     skipIfNoDockerRegistry(providerContext);
     setupFleetAndAgents(providerContext);