diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments.cy.ts
index 5dbf14796c583..2d12aed3151b6 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments.cy.ts
@@ -17,7 +17,7 @@ import {
 } from '../../../../../tasks/alerts';
 import { createRule } from '../../../../../tasks/api_calls/rules';
 import { deleteAlertsAndRules } from '../../../../../tasks/api_calls/common';
-import { login } from '../../../../../tasks/login';
+import { activateUser, login } from '../../../../../tasks/login';
 import { ALERTS_URL } from '../../../../../urls/navigation';
 import { waitForAlertsToPopulate } from '../../../../../tasks/create_new_rule';
 import {
@@ -43,17 +43,19 @@ import {
 import { ALERTS_COUNT } from '../../../../../screens/alerts';
 
 // Failing: See https://github.com/elastic/kibana/issues/173429
-describe.skip('Alert user assignment - ESS & Serverless', { tags: ['@ess', '@serverless'] }, () => {
+describe('Alert user assignment - ESS & Serverless', { tags: ['@ess', '@serverless'] }, () => {
   before(() => {
     cy.task('esArchiverLoad', { archiveName: 'auditbeat_multiple' });
 
-    // Login into accounts so that they got activated and visible in user profiles list
-    login(ROLES.t1_analyst);
-    login(ROLES.t2_analyst);
-    login(ROLES.t3_analyst);
-    login(ROLES.soc_manager);
-    login(ROLES.detections_admin);
-    login(ROLES.platform_engineer);
+    login();
+
+    // Activate accounts so that they got visible in user profiles list
+    activateUser(ROLES.t1_analyst);
+    activateUser(ROLES.t2_analyst);
+    activateUser(ROLES.t3_analyst);
+    activateUser(ROLES.soc_manager);
+    activateUser(ROLES.detections_admin);
+    activateUser(ROLES.platform_engineer);
   });
 
   after(() => {
diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_complete.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_complete.cy.ts
index 72afcb304f893..e106cfbd7bab8 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_complete.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_complete.cy.ts
@@ -10,7 +10,7 @@ import { getNewRule } from '../../../../../objects/rule';
 import { refreshAlertPageFilter, selectFirstPageAlerts } from '../../../../../tasks/alerts';
 import { createRule } from '../../../../../tasks/api_calls/rules';
 import { deleteAlertsAndRules } from '../../../../../tasks/api_calls/common';
-import { login } from '../../../../../tasks/login';
+import { activateUser, login } from '../../../../../tasks/login';
 import { ALERTS_URL } from '../../../../../urls/navigation';
 import { waitForAlertsToPopulate } from '../../../../../tasks/create_new_rule';
 import {
@@ -21,7 +21,7 @@ import {
 } from '../../../../../tasks/alert_assignments';
 
 // FLAKY: https://github.com/elastic/kibana/issues/172557
-describe.skip(
+describe(
   'Alert user assignment - Serverless Complete',
   {
     tags: ['@serverless'],
@@ -38,13 +38,15 @@ describe.skip(
     before(() => {
       cy.task('esArchiverLoad', { archiveName: 'auditbeat_multiple' });
 
-      // Login into accounts so that they got activated and visible in user profiles list
-      login(ROLES.t1_analyst);
-      login(ROLES.t2_analyst);
-      login(ROLES.t3_analyst);
-      login(ROLES.soc_manager);
-      login(ROLES.detections_admin);
-      login(ROLES.platform_engineer);
+      login();
+
+      // Activate accounts so that they got visible in user profiles list
+      activateUser(ROLES.t1_analyst);
+      activateUser(ROLES.t2_analyst);
+      activateUser(ROLES.t3_analyst);
+      activateUser(ROLES.soc_manager);
+      activateUser(ROLES.detections_admin);
+      activateUser(ROLES.platform_engineer);
     });
 
     after(() => {
diff --git a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_essentials.cy.ts b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_essentials.cy.ts
index 5ae60a01a0e8b..d25919c9ee978 100644
--- a/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_essentials.cy.ts
+++ b/x-pack/test/security_solution_cypress/cypress/e2e/detection_response/detection_engine/detection_alerts/assignments/assignments_serverless_essentials.cy.ts
@@ -10,7 +10,7 @@ import { getNewRule } from '../../../../../objects/rule';
 import { refreshAlertPageFilter, selectFirstPageAlerts } from '../../../../../tasks/alerts';
 import { createRule } from '../../../../../tasks/api_calls/rules';
 import { deleteAlertsAndRules } from '../../../../../tasks/api_calls/common';
-import { login } from '../../../../../tasks/login';
+import { activateUser, login } from '../../../../../tasks/login';
 import { ALERTS_URL } from '../../../../../urls/navigation';
 import { waitForAlertsToPopulate } from '../../../../../tasks/create_new_rule';
 import {
@@ -21,7 +21,7 @@ import {
 } from '../../../../../tasks/alert_assignments';
 
 // FLAKY: https://github.com/elastic/kibana/issues/172520
-describe.skip(
+describe(
   'Alert user assignment - Serverless Essentials',
   {
     tags: ['@serverless'],
@@ -38,13 +38,15 @@ describe.skip(
     before(() => {
       cy.task('esArchiverLoad', { archiveName: 'auditbeat_multiple' });
 
-      // Login into accounts so that they got activated and visible in user profiles list
-      login(ROLES.t1_analyst);
-      login(ROLES.t2_analyst);
-      login(ROLES.t3_analyst);
-      login(ROLES.soc_manager);
-      login(ROLES.detections_admin);
-      login(ROLES.platform_engineer);
+      login();
+
+      // Activate accounts so that they got visible in user profiles list
+      activateUser(ROLES.t1_analyst);
+      activateUser(ROLES.t2_analyst);
+      activateUser(ROLES.t3_analyst);
+      activateUser(ROLES.soc_manager);
+      activateUser(ROLES.detections_admin);
+      activateUser(ROLES.platform_engineer);
     });
 
     after(() => {
diff --git a/x-pack/test/security_solution_cypress/cypress/tasks/login.ts b/x-pack/test/security_solution_cypress/cypress/tasks/login.ts
index 90c9d245c3bba..22c0efe3f4239 100644
--- a/x-pack/test/security_solution_cypress/cypress/tasks/login.ts
+++ b/x-pack/test/security_solution_cypress/cypress/tasks/login.ts
@@ -90,3 +90,23 @@ export const loginWithUser = (user: User): void => {
 export const logout = (): void => {
   cy.visit(LOGOUT_URL);
 };
+
+export const activateUser = (role?: SecurityRoleName): void => {
+  const user = role
+    ? {
+        username: role,
+        password: 'changeme',
+      }
+    : defaultUser;
+
+  cy.request({
+    url: `${Cypress.env('ELASTICSEARCH_URL')}/_security/profile/_activate`,
+    method: 'POST',
+    body: {
+      grant_type: 'password',
+      username: user.username,
+      password: user.password,
+    },
+    headers: API_HEADERS,
+  });
+};