diff --git a/i18ntokens.json b/i18ntokens.json
index 6f882e1ab85..e76b31697d5 100644
--- a/i18ntokens.json
+++ b/i18ntokens.json
@@ -4241,7 +4241,7 @@
   },
   {
     "token": "euiSuperSelect.screenReaderAnnouncement",
-    "defString": "You are in a form selector and must select a single option.\n              Use the up and down keys to navigate or escape to close.",
+    "defString": "You are in a form selector and must select a single option.\n              Use the Up and Down arrow keys to navigate or Escape to close.",
     "highlighting": "string",
     "loc": {
       "start": {
@@ -6143,4 +6143,4 @@
     },
     "filepath": "src/components/tree_view/tree_view.tsx"
   }
-]
\ No newline at end of file
+]
diff --git a/src/components/form/super_select/__snapshots__/super_select.test.tsx.snap b/src/components/form/super_select/__snapshots__/super_select.test.tsx.snap
index 48224aab1ca..30c6d0a2f67 100644
--- a/src/components/form/super_select/__snapshots__/super_select.test.tsx.snap
+++ b/src/components/form/super_select/__snapshots__/super_select.test.tsx.snap
@@ -179,7 +179,7 @@ exports[`EuiSuperSelect props custom display is propagated to dropdown 1`] = `
               class="emotion-euiScreenReaderOnly"
               id="euiSuperSelect__generated-id__screenreaderDescribeId"
             >
-              You are in a form selector and must select a single option. Use the up and down keys to navigate or escape to close.
+              You are in a form selector and must select a single option. Use the Up and Down arrow keys to navigate or Escape to close.
             </p>
             <div
               aria-describedby="euiSuperSelect__generated-id__screenreaderDescribeId"
@@ -442,7 +442,7 @@ exports[`EuiSuperSelect props more props are propogated to each option 1`] = `
               class="emotion-euiScreenReaderOnly"
               id="euiSuperSelect__generated-id__screenreaderDescribeId"
             >
-              You are in a form selector and must select a single option. Use the up and down keys to navigate or escape to close.
+              You are in a form selector and must select a single option. Use the Up and Down arrow keys to navigate or Escape to close.
             </p>
             <div
               aria-activedescendant="1"
@@ -594,7 +594,7 @@ exports[`EuiSuperSelect props options are rendered when select is open 1`] = `
               class="emotion-euiScreenReaderOnly"
               id="euiSuperSelect__generated-id__screenreaderDescribeId"
             >
-              You are in a form selector and must select a single option. Use the up and down keys to navigate or escape to close.
+              You are in a form selector and must select a single option. Use the Up and Down arrow keys to navigate or Escape to close.
             </p>
             <div
               aria-describedby="euiSuperSelect__generated-id__screenreaderDescribeId"
@@ -745,7 +745,7 @@ exports[`EuiSuperSelect props renders popoverProps on the underlying EuiPopover
               class="emotion-euiScreenReaderOnly"
               id="euiSuperSelect__generated-id__screenreaderDescribeId"
             >
-              You are in a form selector and must select a single option. Use the up and down keys to navigate or escape to close.
+              You are in a form selector and must select a single option. Use the Up and Down arrow keys to navigate or Escape to close.
             </p>
             <div
               aria-activedescendant="2"
diff --git a/src/components/form/super_select/super_select.tsx b/src/components/form/super_select/super_select.tsx
index a9d266708e5..c5eac43ca6b 100644
--- a/src/components/form/super_select/super_select.tsx
+++ b/src/components/form/super_select/super_select.tsx
@@ -339,7 +339,7 @@ export class EuiSuperSelect<T extends string> extends Component<
             <EuiI18n
               token="euiSuperSelect.screenReaderAnnouncement"
               default="You are in a form selector and must select a single option.
-              Use the up and down keys to navigate or escape to close."
+              Use the Up and Down arrow keys to navigate or Escape to close."
             />
           </p>
         </EuiScreenReaderOnly>
diff --git a/upcoming_changelogs/6549.md b/upcoming_changelogs/6549.md
new file mode 100644
index 00000000000..ec7315412d8
--- /dev/null
+++ b/upcoming_changelogs/6549.md
@@ -0,0 +1 @@
+- Updated `EuiSuperSelect` screen reader instructions to be more specific