diff --git a/src-docs/src/views/combo_box/combo_box.js b/src-docs/src/views/combo_box/combo_box.js
index bd01a4bae0b..db4e89f720b 100644
--- a/src-docs/src/views/combo_box/combo_box.js
+++ b/src-docs/src/views/combo_box/combo_box.js
@@ -13,6 +13,7 @@ export default class extends Component {
       'data-test-subj': 'titanOption',
     }, {
       label: 'Enceladus',
+      disabled: true,
     }, {
       label: 'Mimas',
     }, {
diff --git a/src/components/combo_box/combo_box_options_list/_combo_box_option.scss b/src/components/combo_box/combo_box_options_list/_combo_box_option.scss
index 7f37487eb80..6afefe9431a 100644
--- a/src/components/combo_box/combo_box_options_list/_combo_box_option.scss
+++ b/src/components/combo_box/combo_box_options_list/_combo_box_option.scss
@@ -16,4 +16,8 @@
     color: $euiColorPrimary;
     background-color: $euiFocusBackgroundColor;
   }
+  &:disabled {
+    color: $euiColorMediumShade;
+    cursor: not-allowed;
+  }
 }
diff --git a/src/components/combo_box/combo_box_options_list/combo_box_option.js b/src/components/combo_box/combo_box_options_list/combo_box_option.js
index e3f9a77b568..e09d7219e1f 100644
--- a/src/components/combo_box/combo_box_options_list/combo_box_option.js
+++ b/src/components/combo_box/combo_box_options_list/combo_box_option.js
@@ -38,6 +38,7 @@ export class EuiComboBoxOption extends Component {
       option, // eslint-disable-line no-unused-vars
       onClick, // eslint-disable-line no-unused-vars
       onEnterKey, // eslint-disable-line no-unused-vars
+      disabled,
       ...rest
     } = this.props;
 
@@ -54,6 +55,7 @@ export class EuiComboBoxOption extends Component {
         onKeyDown={this.onKeyDown}
         ref={optionRef}
         tabIndex="-1"
+        disabled={disabled}
         {...rest}
       >
         {children}