diff --git a/src/coreclr/configurecompiler.cmake b/src/coreclr/configurecompiler.cmake
index 39c2e7e410bd1..c893e442823d5 100644
--- a/src/coreclr/configurecompiler.cmake
+++ b/src/coreclr/configurecompiler.cmake
@@ -485,6 +485,7 @@ if (CLR_CMAKE_PLATFORM_UNIX)
     add_compile_options(-Wno-unused-variable)
     add_compile_options(-Wno-unused-but-set-variable)
     add_compile_options(-fms-extensions)
+    add_compile_options(-Wno-unknown-pragmas)
   endif()
 
   # Some architectures (e.g., ARM) assume char type is unsigned while CoreCLR assumes char is signed
diff --git a/src/coreclr/src/debug/daccess/daccess.cpp b/src/coreclr/src/debug/daccess/daccess.cpp
index a5e1387caf074..237a9b67daefb 100644
--- a/src/coreclr/src/debug/daccess/daccess.cpp
+++ b/src/coreclr/src/debug/daccess/daccess.cpp
@@ -7554,8 +7554,8 @@ BOOL OutOfProcessExceptionEventGetProcessIdAndThreadId(HANDLE hProcess, HANDLE h
 
 #ifdef FEATURE_PAL
     // UNIXTODO: mikem 1/13/15 Need appropriate PAL functions for getting ids
-    *pPId = (DWORD)hProcess;
-    *pThreadId = (DWORD)hThread;
+    *pPId = (DWORD)(SIZE_T)hProcess;
+    *pThreadId = (DWORD)(SIZE_T)hThread;
 #else
 #if !defined(FEATURE_CORESYSTEM)
     HMODULE hKernel32 = WszGetModuleHandle(W("kernel32.dll"));
diff --git a/src/coreclr/src/debug/ee/debugger.cpp b/src/coreclr/src/debug/ee/debugger.cpp
index d1eabb2d0096b..cb083c32145fd 100644
--- a/src/coreclr/src/debug/ee/debugger.cpp
+++ b/src/coreclr/src/debug/ee/debugger.cpp
@@ -11100,7 +11100,7 @@ bool Debugger::HandleIPCEvent(DebuggerIPCEvent * pEvent)
             {
                 // Get the appdomain
                 IGCHandleManager *mgr = GCHandleUtilities::GetGCHandleManager();
-                ADIndex appDomainIndex = ADIndex(reinterpret_cast<DWORD>(mgr->GetHandleContext(objectHandle)));
+                ADIndex appDomainIndex = ADIndex((DWORD)(SIZE_T)(mgr->GetHandleContext(objectHandle)));
                 pAppDomain = SystemDomain::GetAppDomainAtIndex(appDomainIndex);
 
                 _ASSERTE(pAppDomain != NULL);
diff --git a/src/coreclr/src/gc/unix/gcenv.unix.cpp b/src/coreclr/src/gc/unix/gcenv.unix.cpp
index ed09e89f26413..572fc3b12f6d1 100644
--- a/src/coreclr/src/gc/unix/gcenv.unix.cpp
+++ b/src/coreclr/src/gc/unix/gcenv.unix.cpp
@@ -449,7 +449,7 @@ the processors enabled.
 --*/
 static uintptr_t GetFullAffinityMask(int cpuCount)
 {
-    if (cpuCount < sizeof(uintptr_t) * 8)
+    if ((size_t)cpuCount < sizeof(uintptr_t) * 8)
     {
         return ((uintptr_t)1 << cpuCount) - 1;
     }
diff --git a/src/coreclr/src/nativeresources/rctocpp.awk b/src/coreclr/src/nativeresources/rctocpp.awk
index 6f8d597cf4a48..cef49ce4a559c 100644
--- a/src/coreclr/src/nativeresources/rctocpp.awk
+++ b/src/coreclr/src/nativeresources/rctocpp.awk
@@ -62,7 +62,7 @@ function writeheader(arrayName, tableName)
     print "// This code was generated by rctocpp.awk and is not meant to be modified manually."
     print "#include <resourcestring.h>";
     print "";
-    print "extern const NativeStringResourceTable " tableName ";";
+    print "extern NativeStringResourceTable " tableName ";";
     print "const NativeStringResource " arrayName "[] = {";
 }
 
@@ -78,7 +78,7 @@ function writefooter(arrayName, tableName)
     print "};";
     print "";
 
-    print "const NativeStringResourceTable " tableName " __attribute__((visibility(\"default\"))) = {";
+    print "NativeStringResourceTable " tableName " __attribute__((visibility(\"default\"))) = {";
     print numEntries ",";
     print arrayName "};";
 }
diff --git a/src/coreclr/src/pal/src/numa/numa.cpp b/src/coreclr/src/pal/src/numa/numa.cpp
index 8793a09b85002..9283a044da540 100644
--- a/src/coreclr/src/pal/src/numa/numa.cpp
+++ b/src/coreclr/src/pal/src/numa/numa.cpp
@@ -166,7 +166,7 @@ the processors enabled.
 --*/
 KAFFINITY GetFullAffinityMask(int cpuCount)
 {
-    if (cpuCount < sizeof(KAFFINITY) * 8)
+    if ((size_t)cpuCount < sizeof(KAFFINITY) * 8)
     {
         return ((KAFFINITY)1 << (cpuCount)) - 1;
     }
diff --git a/src/coreclr/src/vm/gchandleutilities.cpp b/src/coreclr/src/vm/gchandleutilities.cpp
index 220445a1cc31d..a4fdec3c3fc69 100644
--- a/src/coreclr/src/vm/gchandleutilities.cpp
+++ b/src/coreclr/src/vm/gchandleutilities.cpp
@@ -33,7 +33,7 @@ void ValidateHandleAssignment(OBJECTHANDLE handle, OBJECTREF objRef)
 #endif
 
     IGCHandleManager *mgr = GCHandleUtilities::GetGCHandleManager();
-    ADIndex appDomainIndex = ADIndex(reinterpret_cast<DWORD>(mgr->GetHandleContext(handle)));
+    ADIndex appDomainIndex = ADIndex((DWORD)((SIZE_T)mgr->GetHandleContext(handle)));
 
     ValidateObjectAndAppDomain(objRef, appDomainIndex);
 #endif // _DEBUG_IMPL
diff --git a/src/coreclr/src/vm/gchandleutilities.h b/src/coreclr/src/vm/gchandleutilities.h
index 86227cdd6a0c2..8c267372845c2 100644
--- a/src/coreclr/src/vm/gchandleutilities.h
+++ b/src/coreclr/src/vm/gchandleutilities.h
@@ -42,7 +42,7 @@ inline OBJECTREF ObjectFromHandle(OBJECTHANDLE handle)
 
 #if defined(_DEBUG_IMPL) && !defined(DACCESS_COMPILE)
     // not allowed to dispatch virtually on a IGCHandleManager when compiling for DAC
-    DWORD context = (DWORD)GCHandleUtilities::GetGCHandleManager()->GetHandleContext(handle);
+    DWORD context = (DWORD)(SIZE_T)GCHandleUtilities::GetGCHandleManager()->GetHandleContext(handle);
     OBJECTREF objRef = ObjectToOBJECTREF(*(Object**)handle);
 
     ValidateObjectAndAppDomain(objRef, ADIndex(context));
diff --git a/src/coreclr/src/vm/threadpoolrequest.h b/src/coreclr/src/vm/threadpoolrequest.h
index 17df7a790f901..0eb037523eb78 100644
--- a/src/coreclr/src/vm/threadpoolrequest.h
+++ b/src/coreclr/src/vm/threadpoolrequest.h
@@ -163,7 +163,7 @@ class ManagedPerAppDomainTPCount : public IPerAppDomainTPCount {
 private:
     ADID m_id;
     TPIndex m_index;
-    DECLSPEC_ALIGN(MAX_CACHE_LINE_SIZE) struct {
+    struct DECLSPEC_ALIGN(MAX_CACHE_LINE_SIZE) {
         BYTE m_padding1[MAX_CACHE_LINE_SIZE - sizeof(LONG)];
         // Only use with VolatileLoad+VolatileStore+FastInterlockCompareExchange
         LONG m_numRequestsPending;
@@ -256,7 +256,7 @@ class UnManagedPerAppDomainTPCount : public IPerAppDomainTPCount {
 private:
     SpinLock m_lock;
     ULONG m_NumRequests;
-    DECLSPEC_ALIGN(MAX_CACHE_LINE_SIZE) struct {
+    struct DECLSPEC_ALIGN(MAX_CACHE_LINE_SIZE) {
         BYTE m_padding1[MAX_CACHE_LINE_SIZE - sizeof(LONG)];
         // Only use with VolatileLoad+VolatileStore+FastInterlockCompareExchange
         LONG m_outstandingThreadRequestCount;
diff --git a/src/coreclr/src/zap/zapimport.cpp b/src/coreclr/src/zap/zapimport.cpp
index d84ea79e8a4ea..9bdc1d94995bd 100644
--- a/src/coreclr/src/zap/zapimport.cpp
+++ b/src/coreclr/src/zap/zapimport.cpp
@@ -1831,7 +1831,7 @@ ZapImport * ZapImportTable::GetDictionaryLookupCell(CORCOMPILE_FIXUP_BLOB_KIND k
         ThrowHR(E_NOTIMPL);
     }
 
-    _ASSERTE(((DWORD)pResolvedToken->tokenContext & 1) == 0);
+    _ASSERTE(((DWORD)(SIZE_T)pResolvedToken->tokenContext & 1) == 0);
 
     return GetImportForSignature<ZapDynamicHelperCell, ZapNodeType_DynamicHelperCell>((void*)pResolvedToken->tokenContext, &sigBuilder);
 }
@@ -1894,12 +1894,12 @@ class ZapIndirectHelperThunk : public ZapImport
 
     ReadyToRunHelper GetReadyToRunHelper()
     {
-        return (ReadyToRunHelper)((DWORD)GetHandle() & ~READYTORUN_HELPER_FLAG_VSD);
+        return (ReadyToRunHelper)((DWORD)(SIZE_T)GetHandle() & ~READYTORUN_HELPER_FLAG_VSD);
     }
 
     DWORD GetSectionIndex()
     {
-        return (DWORD)GetHandle2();
+        return (DWORD)(SIZE_T)GetHandle2();
     }
 
     BOOL IsDelayLoadHelper()
@@ -1919,7 +1919,7 @@ class ZapIndirectHelperThunk : public ZapImport
 
     BOOL IsVSD()
     {
-        return ((DWORD)GetHandle() & READYTORUN_HELPER_FLAG_VSD) != 0;
+        return ((DWORD)(SIZE_T)GetHandle() & READYTORUN_HELPER_FLAG_VSD) != 0;
     }
 
     BOOL IsLazyHelper()