diff --git a/src/libraries/Microsoft.CSharp/tests/DefaultParameterTests.cs b/src/libraries/Microsoft.CSharp/tests/DefaultParameterTests.cs
index beae75bc5dea9..e6b7d359bd7e9 100644
--- a/src/libraries/Microsoft.CSharp/tests/DefaultParameterTests.cs
+++ b/src/libraries/Microsoft.CSharp/tests/DefaultParameterTests.cs
@@ -9,7 +9,6 @@
 
 namespace Microsoft.CSharp.RuntimeBinder.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class DefaultParameterTests
     {
 
diff --git a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsBuilderTest.cs b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsBuilderTest.cs
index 819d80dbf7887..7e00f530ed10a 100644
--- a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsBuilderTest.cs
+++ b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsBuilderTest.cs
@@ -12,7 +12,6 @@
 
 namespace Microsoft.Extensions.Options.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class OptionsBuilderTest
     {
         [Fact]
diff --git a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsFactoryTests.cs b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsFactoryTests.cs
index 0c8748dd5c7d7..fb06ea00d5245 100644
--- a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsFactoryTests.cs
+++ b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsFactoryTests.cs
@@ -7,7 +7,6 @@
 
 namespace Microsoft.Extensions.Options.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class OptionsFactoryTest
     {
         [Fact]
diff --git a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsMonitorTest.cs b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsMonitorTest.cs
index f253d1efd251a..858b90dccd7ee 100644
--- a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsMonitorTest.cs
+++ b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsMonitorTest.cs
@@ -11,7 +11,6 @@
 
 namespace Microsoft.Extensions.Options.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class OptionsMonitorTest
     {
         [Fact]
diff --git a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsSnapshotTest.cs b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsSnapshotTest.cs
index 0dfa2c2095c02..adb63a5c6913c 100644
--- a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsSnapshotTest.cs
+++ b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsSnapshotTest.cs
@@ -10,7 +10,6 @@
 
 namespace Microsoft.Extensions.Options.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class OptionsSnapshotTest
     {
         [Fact]
diff --git a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsTest.cs b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsTest.cs
index 7f5ed8fc052a7..bb76bb9d7fc21 100644
--- a/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsTest.cs
+++ b/src/libraries/Microsoft.Extensions.Options/tests/Microsoft.Extensions.Options.Tests/OptionsTest.cs
@@ -12,7 +12,6 @@
 
 namespace Microsoft.Extensions.Options.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class OptionsTest
     {
         [Fact]
diff --git a/src/libraries/Microsoft.Extensions.Primitives/tests/CompositeChangeTokenTest.cs b/src/libraries/Microsoft.Extensions.Primitives/tests/CompositeChangeTokenTest.cs
index 549cfcc6138e3..07bb99b3ffc3f 100644
--- a/src/libraries/Microsoft.Extensions.Primitives/tests/CompositeChangeTokenTest.cs
+++ b/src/libraries/Microsoft.Extensions.Primitives/tests/CompositeChangeTokenTest.cs
@@ -103,7 +103,6 @@ public void ActiveChangeCallbacks_IsFalse_IfNoTokenHasActiveChangeCallbacks()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public async Task RegisteredCallbackGetsInvokedExactlyOnce_WhenMultipleConcurrentChangeEventsOccur()
         {
             // Arrange
diff --git a/src/libraries/Microsoft.VisualBasic.Core/tests/FileSystemTests.cs b/src/libraries/Microsoft.VisualBasic.Core/tests/FileSystemTests.cs
index 1ce09841b0770..d9f981b242598 100644
--- a/src/libraries/Microsoft.VisualBasic.Core/tests/FileSystemTests.cs
+++ b/src/libraries/Microsoft.VisualBasic.Core/tests/FileSystemTests.cs
@@ -43,7 +43,6 @@ public void ChDir()
         //   public static void ChDrive(string Drive){ throw null; }
 
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void CloseAllFiles()
         {
             var fileName1 = GetTestFilePath();
diff --git a/src/libraries/System.Collections.Immutable/tests/ImmutableDictionaryTestBase.nonnetstandard.cs b/src/libraries/System.Collections.Immutable/tests/ImmutableDictionaryTestBase.nonnetstandard.cs
index 36615bb91963e..3ea83edeba4f6 100644
--- a/src/libraries/System.Collections.Immutable/tests/ImmutableDictionaryTestBase.nonnetstandard.cs
+++ b/src/libraries/System.Collections.Immutable/tests/ImmutableDictionaryTestBase.nonnetstandard.cs
@@ -75,7 +75,6 @@ public void EqualsTest()
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void AddRangeTest()
         {
             var map = Empty<int, GenericParameterHelper>();
diff --git a/src/libraries/System.Collections.Immutable/tests/ImmutableSortedDictionaryTest.cs b/src/libraries/System.Collections.Immutable/tests/ImmutableSortedDictionaryTest.cs
index eba271b2f418a..c0ba89103cd09 100644
--- a/src/libraries/System.Collections.Immutable/tests/ImmutableSortedDictionaryTest.cs
+++ b/src/libraries/System.Collections.Immutable/tests/ImmutableSortedDictionaryTest.cs
@@ -102,7 +102,6 @@ public void AddExistingKeyDifferentValueTest()
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void ToUnorderedTest()
         {
             var sortedMap = Empty<int, GenericParameterHelper>().AddRange(Enumerable.Range(1, 100).Select(n => new KeyValuePair<int, GenericParameterHelper>(n, new GenericParameterHelper(n))));
diff --git a/src/libraries/System.ComponentModel.Composition/tests/System/ComponentModel/Composition/CompositionContainerTests.cs b/src/libraries/System.ComponentModel.Composition/tests/System/ComponentModel/Composition/CompositionContainerTests.cs
index 9fa75345a1534..93432aa8789fe 100644
--- a/src/libraries/System.ComponentModel.Composition/tests/System/ComponentModel/Composition/CompositionContainerTests.cs
+++ b/src/libraries/System.ComponentModel.Composition/tests/System/ComponentModel/Composition/CompositionContainerTests.cs
@@ -1699,7 +1699,6 @@ public void GetExports1_TypeAsMetadataViewTypeArgument_IsUsedAsMetadataConstrain
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void GetExports2_TypeAsMetadataViewTypeArgument_IsUsedAsMetadataConstraint()
         {
             var metadata = new Dictionary<string, object>();
diff --git a/src/libraries/System.Composition.Hosting/tests/System/Composition/Hosting/Core/CompositionHostTests.cs b/src/libraries/System.Composition.Hosting/tests/System/Composition/Hosting/Core/CompositionHostTests.cs
index 3024c07ae2072..f703345120442 100644
--- a/src/libraries/System.Composition.Hosting/tests/System/Composition/Hosting/Core/CompositionHostTests.cs
+++ b/src/libraries/System.Composition.Hosting/tests/System/Composition/Hosting/Core/CompositionHostTests.cs
@@ -133,7 +133,6 @@ public override IEnumerable<ExportDescriptorPromise> GetExportDescriptors(Compos
         [InlineData(typeof(Lazy<int, IDictionary<string, string>>))]
         [InlineData(typeof(Lazy<int, PrivateConstructor>))]
         [InlineData(typeof(Lazy<int, NoParameterlessConstructor>))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void GetExport_InvalidMetadata_ThrowsComposititionFailedException(Type type)
         {
             using (CompositionHost host = CompositionHost.CreateCompositionHost(new ExportDescriptorProvider[0]))
diff --git a/src/libraries/System.Console/tests/NonStandardConfiguration.Unix.cs b/src/libraries/System.Console/tests/NonStandardConfiguration.Unix.cs
index c9d2b09fe5e1c..35067d2067b09 100644
--- a/src/libraries/System.Console/tests/NonStandardConfiguration.Unix.cs
+++ b/src/libraries/System.Console/tests/NonStandardConfiguration.Unix.cs
@@ -12,7 +12,6 @@ public partial class NonStandardConfigurationTests
     {
         [PlatformSpecific(TestPlatforms.AnyUnix)] // Uses P/Invokes
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void NonBlockingStdout_AllDataReceived()
         {
             RemoteInvokeHandle remote = RemoteExecutor.Invoke(() =>
diff --git a/src/libraries/System.Console/tests/ReadKey.cs b/src/libraries/System.Console/tests/ReadKey.cs
index e0429983e7a70..42481f367a6a3 100644
--- a/src/libraries/System.Console/tests/ReadKey.cs
+++ b/src/libraries/System.Console/tests/ReadKey.cs
@@ -23,7 +23,6 @@ public static void KeyAvailable()
     }
 
     [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public static void RedirectedConsole_ReadKey()
     {
         RunRemote(() => { Assert.Throws<InvalidOperationException>(() => Console.ReadKey()); return 42; }, new ProcessStartInfo() { RedirectStandardInput = true });
diff --git a/src/libraries/System.Console/tests/RedirectedStream.cs b/src/libraries/System.Console/tests/RedirectedStream.cs
index ee2afb9bbd6e6..578824c8cce01 100644
--- a/src/libraries/System.Console/tests/RedirectedStream.cs
+++ b/src/libraries/System.Console/tests/RedirectedStream.cs
@@ -11,7 +11,6 @@
 using Microsoft.DotNet.XUnitExtensions;
 using Xunit;
 
-[ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
 public class RedirectedStream
 {
     [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))] // the CI system redirects stdout, so we can only really test the redirected behavior.
diff --git a/src/libraries/System.Diagnostics.DiagnosticSource/tests/ActivityTests.cs b/src/libraries/System.Diagnostics.DiagnosticSource/tests/ActivityTests.cs
index ed7e2f82101c9..39171dfab00b4 100644
--- a/src/libraries/System.Diagnostics.DiagnosticSource/tests/ActivityTests.cs
+++ b/src/libraries/System.Diagnostics.DiagnosticSource/tests/ActivityTests.cs
@@ -1547,7 +1547,6 @@ public void TestIsAllDataRequested()
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void TestTagObjects()
         {
             Activity activity = new Activity("TagObjects");
@@ -1608,7 +1607,6 @@ public void TestTagObjects()
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void TestGetTagItem()
         {
             Activity a = new Activity("GetTagItem");
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessCollectionTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessCollectionTests.cs
index 90acc19d048d7..3ac20166921f3 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessCollectionTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessCollectionTests.cs
@@ -8,7 +8,6 @@
 
 namespace System.Diagnostics.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class ProcessCollectionTests : ProcessTestBase
     {
         [Fact]
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessModuleTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessModuleTests.cs
index e127633db8c36..2631cb8b1a3dc 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessModuleTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessModuleTests.cs
@@ -72,7 +72,6 @@ public ModuleCollectionSubClass() : base() { }
         }
 
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void ModulesAreDisposedWhenProcessIsDisposed()
         {
             Process process = CreateDefaultProcess();
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessStartInfoTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessStartInfoTests.cs
index 1ffe9f0f24ca4..b061bf43d54af 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessStartInfoTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessStartInfoTests.cs
@@ -22,7 +22,6 @@
 
 namespace System.Diagnostics.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class ProcessStartInfoTests : ProcessTestBase
     {
         private const string ItemSeparator = "CAFF9451396B4EEF8A5155A15BDC2080"; // random string that shouldn't be in any env vars; used instead of newline to separate env var strings
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessStreamReadTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessStreamReadTests.cs
index 2620f965411e0..3cbab6c843fbe 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessStreamReadTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessStreamReadTests.cs
@@ -14,7 +14,6 @@
 
 namespace System.Diagnostics.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class ProcessStreamReadTests : ProcessTestBase
     {
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
index 47c538af8077f..9921aac3e947c 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
@@ -21,7 +21,6 @@
 
 namespace System.Diagnostics.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public partial class ProcessTests : ProcessTestBase
     {
         private class FinalizingProcess : Process
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessThreadTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessThreadTests.cs
index 46305d91ac865..2266582ac5190 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessThreadTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessThreadTests.cs
@@ -10,7 +10,6 @@
 
 namespace System.Diagnostics.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public partial class ProcessThreadTests : ProcessTestBase
     {
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessWaitingTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessWaitingTests.cs
index 8bd7985a218fd..5cbd89d5a7705 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessWaitingTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessWaitingTests.cs
@@ -11,7 +11,6 @@
 
 namespace System.Diagnostics.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class ProcessWaitingTests : ProcessTestBase
     {
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
diff --git a/src/libraries/System.Dynamic.Runtime/tests/Dynamic.DynamicType/Conformance.dynamic.dynamicType.conversions.cs b/src/libraries/System.Dynamic.Runtime/tests/Dynamic.DynamicType/Conformance.dynamic.dynamicType.conversions.cs
index a345456c53b8f..d27e05bff2864 100644
--- a/src/libraries/System.Dynamic.Runtime/tests/Dynamic.DynamicType/Conformance.dynamic.dynamicType.conversions.cs
+++ b/src/libraries/System.Dynamic.Runtime/tests/Dynamic.DynamicType/Conformance.dynamic.dynamicType.conversions.cs
@@ -397,7 +397,6 @@ private static bool NullableUlongTypeWithNullableNumbericConversionFromUintInAss
 
         #endregion
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public static void DynamicCSharpRunTest()
         {
             Assert.Equal(0, MainMethod());
diff --git a/src/libraries/System.Dynamic.Runtime/tests/Dynamic.NamedAndOptional/Conformance.dynamic.namedandoptional.usage.executeOrder.cs b/src/libraries/System.Dynamic.Runtime/tests/Dynamic.NamedAndOptional/Conformance.dynamic.namedandoptional.usage.executeOrder.cs
index a9b0ebba2ebeb..b0a5792306e26 100644
--- a/src/libraries/System.Dynamic.Runtime/tests/Dynamic.NamedAndOptional/Conformance.dynamic.namedandoptional.usage.executeOrder.cs
+++ b/src/libraries/System.Dynamic.Runtime/tests/Dynamic.NamedAndOptional/Conformance.dynamic.namedandoptional.usage.executeOrder.cs
@@ -1035,7 +1035,6 @@ public static int Bar3()
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public static void DynamicCSharpRunTest()
         {
             Assert.Equal(0, MainMethod());
diff --git a/src/libraries/System.Dynamic.Runtime/tests/Dynamic.OverloadResolution/Conformance.dynamic.overloadResolution.Methods.1class2methods.cs b/src/libraries/System.Dynamic.Runtime/tests/Dynamic.OverloadResolution/Conformance.dynamic.overloadResolution.Methods.1class2methods.cs
index af1b08aa772d2..5cf0a1ffe9dfd 100644
--- a/src/libraries/System.Dynamic.Runtime/tests/Dynamic.OverloadResolution/Conformance.dynamic.overloadResolution.Methods.1class2methods.cs
+++ b/src/libraries/System.Dynamic.Runtime/tests/Dynamic.OverloadResolution/Conformance.dynamic.overloadResolution.Methods.1class2methods.cs
@@ -2966,7 +2966,6 @@ public void Method(short? s)
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public static void DynamicCSharpRunTest()
         {
             Assert.Equal(0, MainMethod());
@@ -2998,7 +2997,6 @@ public void Method(short? s)
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public static void DynamicCSharpRunTest()
         {
             Assert.Equal(0, MainMethod());
diff --git a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CrossProcess.cs b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CrossProcess.cs
index 61e5b9eb92b89..fa8f454e3052e 100644
--- a/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CrossProcess.cs
+++ b/src/libraries/System.IO.MemoryMappedFiles/tests/MemoryMappedFile.CrossProcess.cs
@@ -9,7 +9,6 @@ namespace System.IO.MemoryMappedFiles.Tests
     public class CrossProcessTests : FileCleanupTestBase
     {
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void DataShared()
         {
             // Create a new file and load it into an MMF
diff --git a/src/libraries/System.IO.Pipes/tests/AnonymousPipeTests/AnonymousPipeTest.CrossProcess.cs b/src/libraries/System.IO.Pipes/tests/AnonymousPipeTests/AnonymousPipeTest.CrossProcess.cs
index ff475367616d6..9a68529796319 100644
--- a/src/libraries/System.IO.Pipes/tests/AnonymousPipeTests/AnonymousPipeTest.CrossProcess.cs
+++ b/src/libraries/System.IO.Pipes/tests/AnonymousPipeTests/AnonymousPipeTest.CrossProcess.cs
@@ -8,7 +8,6 @@
 
 namespace System.IO.Pipes.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class AnonymousPipeTest_CrossProcess
     {
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
diff --git a/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.CrossProcess.cs b/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.CrossProcess.cs
index 6e4fbc02c3494..83e52342abd5b 100644
--- a/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.CrossProcess.cs
+++ b/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.CrossProcess.cs
@@ -11,7 +11,6 @@
 
 namespace System.IO.Pipes.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public sealed class NamedPipeTest_CrossProcess
     {
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
diff --git a/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.Specific.cs b/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.Specific.cs
index 4eb889567c6fb..220be9d65ca8a 100644
--- a/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.Specific.cs
+++ b/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.Specific.cs
@@ -346,7 +346,6 @@ public async Task Windows_GetImpersonationUserName_Succeed(TokenImpersonationLev
 
         [Fact]
         [PlatformSpecific(TestPlatforms.AnyUnix)]  // Uses P/Invoke to verify the user name
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public async Task Unix_GetImpersonationUserName_Succeed()
         {
             string pipeName = PipeStreamConformanceTests.GetUniquePipeName();
diff --git a/src/libraries/System.Net.Http/tests/UnitTests/HttpEnvironmentProxyTest.cs b/src/libraries/System.Net.Http/tests/UnitTests/HttpEnvironmentProxyTest.cs
index d6c3d12237c86..8c0669f6e62ba 100644
--- a/src/libraries/System.Net.Http/tests/UnitTests/HttpEnvironmentProxyTest.cs
+++ b/src/libraries/System.Net.Http/tests/UnitTests/HttpEnvironmentProxyTest.cs
@@ -10,7 +10,6 @@
 
 namespace System.Net.Http.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class HttpEnvironmentProxyTest
     {
         private readonly ITestOutputHelper _output;
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
index b3b056df5ec95..7360975078aba 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
@@ -45,7 +45,6 @@ public void RelativeSearchPath_Is_Null()
 
         [Fact]
         [SkipOnPlatform(TestPlatforms.Browser, "throws pNSE")]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/49868", TestPlatforms.Android)]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/36896", TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
         public void TargetFrameworkTest()
@@ -212,7 +211,6 @@ public void ProcessExit_Add_Remove()
         }
 
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void ProcessExit_Called()
         {
             string path = GetTestFilePath();
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs b/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs
index 626aa3ac8ee05..f6ef6cef9f463 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs
@@ -22,7 +22,6 @@ public class Environment_Exit
 
         [ConditionalTheory(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
         [MemberData(nameof(ExitCodeValues))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public static void CheckExitCode(int expectedExitCode)
         {
             RemoteExecutor.Invoke(s => int.Parse(s), expectedExitCode.ToString(), new RemoteInvokeOptions { ExpectedExitCode = expectedExitCode }).Dispose();
@@ -43,7 +42,6 @@ public static void ExitCode_Roundtrips(int exitCode)
         [InlineData(2)] // setting ExitCode both from Main and from an Unloading event handler.
         [InlineData(3)] // using Exit(exitCode)
         [SkipOnPlatform(TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.MacCatalyst | TestPlatforms.tvOS, "Not supported on Browser, iOS, MacCatalyst, or tvOS.")]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/49868", TestPlatforms.Android)]
         public static void ExitCode_VoidMainAppReturnsSetValue(int mode)
         {
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/Environment.GetCommandLineArgs.cs b/src/libraries/System.Runtime.Extensions/tests/System/Environment.GetCommandLineArgs.cs
index ae0d4a68e1f18..695af6b8f2567 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/Environment.GetCommandLineArgs.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/Environment.GetCommandLineArgs.cs
@@ -23,7 +23,6 @@ public static IEnumerable<object[]> GetCommandLineArgs_TestData()
 
         [ConditionalTheory(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
         [MemberData(nameof(GetCommandLineArgs_TestData))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void GetCommandLineArgs_Invoke_ReturnsExpected(string[] args)
         {
             switch (args.Length)
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
index b192b0900acd0..ed12573ab7d98 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
@@ -83,7 +83,6 @@ public void ProcessId_Idempotent()
         }
 
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void ProcessId_MatchesExpectedValue()
         {
             using RemoteInvokeHandle handle = RemoteExecutor.Invoke(() => Console.WriteLine(Environment.ProcessId), new RemoteInvokeOptions { StartInfo = new ProcessStartInfo { RedirectStandardOutput = true } });
@@ -97,7 +96,6 @@ public void ProcessPath_Idempotent()
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void ProcessPath_MatchesExpectedValue()
         {
             string expectedProcessPath = PlatformDetection.IsBrowser ? null : Process.GetCurrentProcess().MainModule.FileName;
@@ -268,7 +266,6 @@ public void FailFast_ExpectFailureExitCode()
 
         [Trait(XunitConstants.Category, XunitConstants.IgnoreForCI)] // fail fast crashes the process
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void FailFast_ExceptionStackTrace_ArgumentException()
         {
             var psi = new ProcessStartInfo();
@@ -290,7 +287,6 @@ public void FailFast_ExceptionStackTrace_ArgumentException()
 
         [Trait(XunitConstants.Category, XunitConstants.IgnoreForCI)] // fail fast crashes the process
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void FailFast_ExceptionStackTrace_StackOverflowException()
         {
             // Test using another type of exception
@@ -313,7 +309,6 @@ public void FailFast_ExceptionStackTrace_StackOverflowException()
 
         [Trait(XunitConstants.Category, XunitConstants.IgnoreForCI)] // fail fast crashes the process
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void FailFast_ExceptionStackTrace_InnerException()
         {
             // Test if inner exception details are also logged
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/Runtime/ProfileOptimization.cs b/src/libraries/System.Runtime.Extensions/tests/System/Runtime/ProfileOptimization.cs
index 7f980ffc9ff57..530661c9762ea 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/Runtime/ProfileOptimization.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/Runtime/ProfileOptimization.cs
@@ -14,7 +14,6 @@ public class ProfileOptimizationTest : FileCleanupTestBase
         [InlineData(false)]
         [InlineData(true)]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/31853", TestRuntimes.Mono)]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void ProfileOptimization_CheckFileExists(bool stopProfile)
         {
             string profileFile = GetTestFileName();
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/UnloadingAndProcessExitTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/UnloadingAndProcessExitTests.cs
index 7e37f41de4739..577b5262d7bc3 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/UnloadingAndProcessExitTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/UnloadingAndProcessExitTests.cs
@@ -12,7 +12,6 @@ namespace System.Tests
     public class UnloadingAndProcessExitTests : FileCleanupTestBase
     {
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void UnloadingEventMustHappenBeforeProcessExitEvent()
         {
             string fileName = GetTestFilePath();
diff --git a/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterEventSourceTests.cs b/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterEventSourceTests.cs
index d955b831e45a6..805b1ad4df481 100644
--- a/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterEventSourceTests.cs
+++ b/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterEventSourceTests.cs
@@ -12,7 +12,6 @@
 namespace System.Runtime.Serialization.Formatters.Tests
 {
     [ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsBinaryFormatterSupported))]
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public static class BinaryFormatterEventSourceTests
     {
         private const string BinaryFormatterEventSourceName = "System.Runtime.Serialization.Formatters.Binary.BinaryFormatterEventSource";
diff --git a/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterTests.cs b/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterTests.cs
index b4076482fcb8f..7bd5ede42c51b 100644
--- a/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterTests.cs
+++ b/src/libraries/System.Runtime.Serialization.Formatters/tests/BinaryFormatterTests.cs
@@ -19,7 +19,6 @@
 namespace System.Runtime.Serialization.Formatters.Tests
 {
     [ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsBinaryFormatterSupported))]
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public partial class BinaryFormatterTests : FileCleanupTestBase
     {
         // On 32-bit we can't test these high inputs as they cause OutOfMemoryExceptions.
diff --git a/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterServicesTests.cs b/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterServicesTests.cs
index 6d2bca0f36660..0a04f250a3f8a 100644
--- a/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterServicesTests.cs
+++ b/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterServicesTests.cs
@@ -9,7 +9,6 @@
 
 namespace System.Runtime.Serialization.Formatters.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public partial class FormatterServicesTests
     {
         [Fact]
diff --git a/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterTests.cs b/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterTests.cs
index e1195cd5908e7..68ca34ee79d6a 100644
--- a/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterTests.cs
+++ b/src/libraries/System.Runtime.Serialization.Formatters/tests/FormatterTests.cs
@@ -8,7 +8,6 @@
 
 namespace System.Runtime.Serialization.Formatters.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class FormatterTests
     {
         [Fact]
diff --git a/src/libraries/System.Runtime.Serialization.Formatters/tests/SerializationInfoTests.cs b/src/libraries/System.Runtime.Serialization.Formatters/tests/SerializationInfoTests.cs
index e135157920a7b..30b72ce09fc54 100644
--- a/src/libraries/System.Runtime.Serialization.Formatters/tests/SerializationInfoTests.cs
+++ b/src/libraries/System.Runtime.Serialization.Formatters/tests/SerializationInfoTests.cs
@@ -6,7 +6,6 @@
 
 namespace System.Runtime.Serialization.Formatters.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public class SerializationInfoTests
     {
         [Fact]
diff --git a/src/libraries/System.Runtime.Serialization.Xml/tests/DataContractSerializer.cs b/src/libraries/System.Runtime.Serialization.Xml/tests/DataContractSerializer.cs
index d1ce413b3dfac..a576fcf1c872a 100644
--- a/src/libraries/System.Runtime.Serialization.Xml/tests/DataContractSerializer.cs
+++ b/src/libraries/System.Runtime.Serialization.Xml/tests/DataContractSerializer.cs
@@ -21,7 +21,6 @@
 using System.Runtime.Serialization.Tests;
 
 
-[ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
 public static partial class DataContractSerializerTests
 {
 #if ReflectionOnly
diff --git a/src/libraries/System.Text.Encodings.Web/tests/EncoderCommonTests.cs b/src/libraries/System.Text.Encodings.Web/tests/EncoderCommonTests.cs
index 8169576630ae3..239a6299d407f 100644
--- a/src/libraries/System.Text.Encodings.Web/tests/EncoderCommonTests.cs
+++ b/src/libraries/System.Text.Encodings.Web/tests/EncoderCommonTests.cs
@@ -13,7 +13,6 @@ public class EncoderCommonTests
         [InlineData(5000, 3, 15000)] // haven't exceeded the 16k cap
         [InlineData(40000, 3, 40000)] // if we spill over the LOH, we still allocate an output buffer equivalent in length to the input buffer
         [InlineData(512, int.MaxValue, 16 * 1024)] // make sure we can handle numeric overflow
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void GetCapacityOfOutputStringBuilder(int numCharsToEncode, int worstCaseOutputCharsPerInputChar, int expectedResult)
         {
             Assert.Equal(expectedResult, EncoderCommon.GetCapacityOfOutputStringBuilder(numCharsToEncode, worstCaseOutputCharsPerInputChar));
diff --git a/src/libraries/System.Text.Encodings.Web/tests/HtmlEncoderTests.cs b/src/libraries/System.Text.Encodings.Web/tests/HtmlEncoderTests.cs
index 0621653036a48..4321a99e2c03d 100644
--- a/src/libraries/System.Text.Encodings.Web/tests/HtmlEncoderTests.cs
+++ b/src/libraries/System.Text.Encodings.Web/tests/HtmlEncoderTests.cs
@@ -16,7 +16,6 @@ public class HtmlEncoderTests
         [InlineData("&#x1F602; 21", "\U0001F602 21")]
         [InlineData("x&#x1F602;y", "x\U0001F602y")]
         [InlineData("&#x1F602;x&#x1F602;y", "\U0001F602x\U0001F602y")]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void TestSurrogate(string expected, string actual)
         {
             Assert.Equal(expected, HtmlEncoder.Default.Encode(actual));
@@ -96,7 +95,6 @@ public void Default_EquivalentToBasicLatin()
         [InlineData("'", "&#x27;")]
         [InlineData("\"", "&quot;")]
         [InlineData("+", "&#x2B;")]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void HtmlEncode_AllRangesAllowed_StillEncodesForbiddenChars_Simple(string input, string expected)
         {
             // Arrange
diff --git a/src/libraries/System.Text.Encodings.Web/tests/JavaScriptEncoderTests.cs b/src/libraries/System.Text.Encodings.Web/tests/JavaScriptEncoderTests.cs
index 161ba615ae244..c57a84e0af3d0 100644
--- a/src/libraries/System.Text.Encodings.Web/tests/JavaScriptEncoderTests.cs
+++ b/src/libraries/System.Text.Encodings.Web/tests/JavaScriptEncoderTests.cs
@@ -11,7 +11,6 @@
 
 namespace System.Text.Encodings.Web.Tests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
     public partial class JavaScriptEncoderTests
     {
         [Fact]
diff --git a/src/libraries/System.Text.Encodings.Web/tests/TextEncoderTests.cs b/src/libraries/System.Text.Encodings.Web/tests/TextEncoderTests.cs
index 35166fb19c13c..cb26b483e7ce3 100644
--- a/src/libraries/System.Text.Encodings.Web/tests/TextEncoderTests.cs
+++ b/src/libraries/System.Text.Encodings.Web/tests/TextEncoderTests.cs
@@ -53,7 +53,6 @@ public void EncodeIntoBuffer_SurrogatePairs()
         [InlineData(10, 10)]
         [InlineData(11, 11)]
         [InlineData(12, 11)]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void EncodeUtf8_WellFormedInput_DoesNotRequireEncoding_CopiedToDestinationCorrectly(int destinationSize, int expectedBytesCopied)
         {
             // This test considers input which is well-formed and doesn't need to be encoded.
@@ -258,7 +257,6 @@ public void FindFirstCharToEncodeUtf8_WellFormedData_SomeCharsDisallowed()
         [InlineData(new byte[] { 0xF1, 0x80, 0x80 }, 0)]
         [InlineData(new byte[] { 0xF1, 0x80, 0x80, 0x80, 0xFF }, 4)]
         [InlineData(new byte[] { 0xFF, 0x80, 0x80, 0x80, 0xFF }, 0)]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void FindFirstCharToEncodeUtf8_IllFormedData_ReturnsIndexOfIllFormedSubsequence(byte[] utf8Data, int expectedIndex)
         {
             // Arrange
diff --git a/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangeTests.cs b/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangeTests.cs
index c54b770e7df93..51d1d9adc4b3f 100644
--- a/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangeTests.cs
+++ b/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangeTests.cs
@@ -12,7 +12,6 @@ public class UnicodeRangeTests
         [Theory]
         [InlineData(-1, 16)]
         [InlineData(0x10000, 16)]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void Ctor_FailureCase_FirstCodePoint(int firstCodePoint, int rangeSize)
         {
             AssertExtensions.Throws<ArgumentOutOfRangeException>("firstCodePoint", () => new UnicodeRange(firstCodePoint, rangeSize));
@@ -21,7 +20,6 @@ public void Ctor_FailureCase_FirstCodePoint(int firstCodePoint, int rangeSize)
         [Theory]
         [InlineData(0x0100, -1)]
         [InlineData(0x0100, 0x10000)]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void Ctor_FailureCase_RangeSize(int firstCodePoint, int rangeSize)
         {
             AssertExtensions.Throws<ArgumentOutOfRangeException>("length", () => new UnicodeRange(firstCodePoint, rangeSize));
diff --git a/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangesTests.cs b/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangesTests.cs
index 4217d130ff5e2..efa50bff2f8ee 100644
--- a/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangesTests.cs
+++ b/src/libraries/System.Text.Encodings.Web/tests/UnicodeRangesTests.cs
@@ -27,7 +27,6 @@ public static void Range_All()
 
         [Theory]
         [MemberData(nameof(UnicodeRanges_GeneratedData))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public static void Range_Unicode(ushort first, ushort last, string blockName)
         {
             Assert.Equal(0x0, first & 0xF); // first char in any block should be U+nnn0
diff --git a/src/libraries/System.Threading.Tasks.Dataflow/tests/Dataflow/ActionBlockTests.cs b/src/libraries/System.Threading.Tasks.Dataflow/tests/Dataflow/ActionBlockTests.cs
index 35668423bd37d..55f7c4f0b5d63 100644
--- a/src/libraries/System.Threading.Tasks.Dataflow/tests/Dataflow/ActionBlockTests.cs
+++ b/src/libraries/System.Threading.Tasks.Dataflow/tests/Dataflow/ActionBlockTests.cs
@@ -366,7 +366,6 @@ public async Task TestFault()
         }
 
         [Fact]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public async Task TestFaulting()
         {
             for (int trial = 0; trial < 3; trial++)
diff --git a/src/libraries/System.Threading.Thread/tests/ThreadTests.cs b/src/libraries/System.Threading.Thread/tests/ThreadTests.cs
index acfd85eebc9c0..23a9c0d7c4896 100644
--- a/src/libraries/System.Threading.Thread/tests/ThreadTests.cs
+++ b/src/libraries/System.Threading.Thread/tests/ThreadTests.cs
@@ -169,7 +169,6 @@ public static IEnumerable<object[]> ApartmentStateTest_MemberData()
         [InlineData("MTAMain.exe", "SetApartmentStateTest")]
         [InlineData("DefaultApartmentStateMain.exe", "GetApartmentStateTest")]
         [InlineData("DefaultApartmentStateMain.exe", "SetApartmentStateTest")]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/50577", TestPlatforms.Android)]
         [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.MacCatalyst | TestPlatforms.tvOS, "Not supported on iOS, MacCatalyst, or tvOS.")]
         public static void ApartmentState_AttributePresent(string appName, string testName)
diff --git a/src/libraries/System.Threading/tests/MutexTests.cs b/src/libraries/System.Threading/tests/MutexTests.cs
index c7fea3554ac33..a893662df1519 100644
--- a/src/libraries/System.Threading/tests/MutexTests.cs
+++ b/src/libraries/System.Threading/tests/MutexTests.cs
@@ -406,7 +406,6 @@ public static IEnumerable<object[]> CrossProcess_NamedMutex_ProtectedFileAccessA
         [ConditionalTheory(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/36307", TestRuntimes.Mono)]
         [MemberData(nameof(CrossProcess_NamedMutex_ProtectedFileAccessAtomic_MemberData))]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
         public void CrossProcess_NamedMutex_ProtectedFileAccessAtomic(string prefix)
         {
             string fileName = GetTestFilePath();