diff --git a/.github/workflows/continuous-integration.yml b/.github/workflows/continuous-integration.yml
index 423cdecdbe..df65f5ff4b 100644
--- a/.github/workflows/continuous-integration.yml
+++ b/.github/workflows/continuous-integration.yml
@@ -66,7 +66,7 @@ jobs:
           php-version: "${{ matrix.php-version }}"
           extensions: "apcu, pdo, ${{ matrix.extension }}"
           coverage: "pcov"
-          ini-values: "zend.assertions=1"
+          ini-values: "zend.assertions=1, apc.enable_cli=1"
 
       - name: "Require specific DBAL version"
         run: "composer require doctrine/dbal ^${{ matrix.dbal-version }} --no-update"
@@ -139,7 +139,7 @@ jobs:
         with:
           php-version: "${{ matrix.php-version }}"
           coverage: "pcov"
-          ini-values: "zend.assertions=1"
+          ini-values: "zend.assertions=1, apc.enable_cli=1"
 
       - name: "Require specific DBAL version"
         run: "composer require doctrine/dbal ^${{ matrix.dbal-version }} --no-update"
@@ -211,7 +211,7 @@ jobs:
         with:
           php-version: "${{ matrix.php-version }}"
           coverage: "pcov"
-          ini-values: "zend.assertions=1"
+          ini-values: "zend.assertions=1, apc.enable_cli=1"
           extensions: "${{ matrix.extension }}"
 
       - name: "Install dependencies with Composer"
@@ -276,7 +276,7 @@ jobs:
         with:
           php-version: "${{ matrix.php-version }}"
           coverage: "pcov"
-          ini-values: "zend.assertions=1"
+          ini-values: "zend.assertions=1, apc.enable_cli=1"
           extensions: "${{ matrix.extension }}"
 
       - name: "Require specific DBAL version"
@@ -327,7 +327,7 @@ jobs:
         uses: "shivammathur/setup-php@v2"
         with:
           php-version: "${{ matrix.php-version }}"
-          ini-values: "zend.assertions=1"
+          ini-values: "zend.assertions=1, apc.enable_cli=1"
 
       - name: "Install dependencies with Composer"
         uses: "ramsey/composer-install@v2"
diff --git a/.github/workflows/phpbench.yml b/.github/workflows/phpbench.yml
index c22e1c778f..5fcc3f53ed 100644
--- a/.github/workflows/phpbench.yml
+++ b/.github/workflows/phpbench.yml
@@ -45,7 +45,7 @@ jobs:
         with:
           php-version: "${{ matrix.php-version }}"
           coverage: "pcov"
-          ini-values: "zend.assertions=1"
+          ini-values: "zend.assertions=1, apc.enable_cli=1"
 
       - name: "Cache dependencies installed with composer"
         uses: "actions/cache@v3"
diff --git a/lib/Doctrine/ORM/ORMSetup.php b/lib/Doctrine/ORM/ORMSetup.php
index 3213431d73..5a561c90e1 100644
--- a/lib/Doctrine/ORM/ORMSetup.php
+++ b/lib/Doctrine/ORM/ORMSetup.php
@@ -20,6 +20,7 @@
 use Symfony\Component\Cache\Adapter\MemcachedAdapter;
 use Symfony\Component\Cache\Adapter\RedisAdapter;
 
+use function apcu_enabled;
 use function class_exists;
 use function extension_loaded;
 use function md5;
@@ -181,7 +182,7 @@ private static function createCacheInstance(
 
         $namespace = 'dc2_' . md5($proxyDir);
 
-        if (extension_loaded('apcu')) {
+        if (extension_loaded('apcu') && apcu_enabled()) {
             return new ApcuAdapter($namespace);
         }
 
diff --git a/lib/Doctrine/ORM/Tools/Setup.php b/lib/Doctrine/ORM/Tools/Setup.php
index 51930d95ee..f07053f719 100644
--- a/lib/Doctrine/ORM/Tools/Setup.php
+++ b/lib/Doctrine/ORM/Tools/Setup.php
@@ -27,6 +27,7 @@
 use Symfony\Component\Cache\Adapter\MemcachedAdapter;
 use Symfony\Component\Cache\Adapter\RedisAdapter;
 
+use function apcu_enabled;
 use function class_exists;
 use function dirname;
 use function extension_loaded;
@@ -236,7 +237,7 @@ private static function createCacheInstance(bool $isDevMode, ?Cache $cache): Cac
 
         if ($isDevMode === true) {
             $cache = class_exists(ArrayCache::class) ? new ArrayCache() : new ArrayAdapter();
-        } elseif (extension_loaded('apcu')) {
+        } elseif (extension_loaded('apcu') && apcu_enabled()) {
             $cache = class_exists(ApcuCache::class) ? new ApcuCache() : new ApcuAdapter();
         } elseif (extension_loaded('memcached') && (class_exists(MemcachedCache::class) || MemcachedAdapter::isSupported())) {
             $memcached = new Memcached();