diff --git a/packages/dnb-design-system-portal/src/docs/uilib/components/upload/Examples.tsx b/packages/dnb-design-system-portal/src/docs/uilib/components/upload/Examples.tsx
index ed3ce133a2d..349c14ec012 100644
--- a/packages/dnb-design-system-portal/src/docs/uilib/components/upload/Examples.tsx
+++ b/packages/dnb-design-system-portal/src/docs/uilib/components/upload/Examples.tsx
@@ -12,6 +12,7 @@ import {
   Section,
   Upload,
 } from '@dnb/eufemia/src'
+import { UploadValue } from '@dnb/eufemia/src/extensions/forms/Field/Upload'
 
 export function createMockFile(name: string, size: number, type: string) {
   const file = new File([], name, { type })
@@ -34,6 +35,46 @@ const useMockFiles = (setFiles, extend) => {
   }, [])
 }
 
+export async function mockAsyncFileUpload(
+  newFiles: UploadValue,
+): Promise<UploadValue> {
+  const promises = newFiles.map(async (file, index) => {
+    const formData = new FormData()
+    formData.append('file', file.file, file.file.name)
+
+    await new Promise((resolve) =>
+      setTimeout(resolve, Math.floor(Math.random() * 2000) + 1000),
+    )
+
+    const mockResponse = {
+      ok: (index + 2) % 2 === 0, // Every other request will fail
+      json: async () => ({
+        server_generated_id: `${file.file.name}_${crypto.randomUUID()}`,
+      }),
+    }
+
+    return await Promise.resolve(mockResponse)
+      .then((res) => {
+        if (res.ok) return res.json()
+        throw new Error('Unable to upload this file')
+      })
+      .then((data) => {
+        return {
+          ...file,
+          id: data.server_generated_id,
+        }
+      })
+      .catch((error) => {
+        return {
+          ...file,
+          errorMessage: error.message,
+        }
+      })
+  })
+
+  return await Promise.all(promises)
+}
+
 export const UploadPrefilledFileList = () => (
   <ComponentBox
     data-visual-test="upload-file-list"
diff --git a/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/Examples.tsx b/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/Examples.tsx
index 785b9e4a226..805e4d682a3 100644
--- a/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/Examples.tsx
+++ b/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/Examples.tsx
@@ -1,7 +1,11 @@
 import { Flex } from '@dnb/eufemia/src'
 import ComponentBox from '../../../../../../../shared/tags/ComponentBox'
-import { Field, Form } from '@dnb/eufemia/src/extensions/forms'
-import { createMockFile } from '../../../../../../../docs/uilib/components/upload/Examples'
+import { Field, Form, Tools } from '@dnb/eufemia/src/extensions/forms'
+import {
+  createMockFile,
+  mockAsyncFileUpload,
+} from '../../../../../../../docs/uilib/components/upload/Examples'
+import useUpload from '@dnb/eufemia/src/components/upload/useUpload'
 
 export const BasicUsage = () => {
   return (
@@ -78,3 +82,36 @@ export const WithPath = () => {
     </ComponentBox>
   )
 }
+
+export const WithAsyncFileHandler = () => {
+  return (
+    <ComponentBox scope={{ mockAsyncFileUpload, useUpload, Tools }}>
+      {() => {
+        const MyForm = () => {
+          return (
+            <Form.Handler onSubmit={async (form) => console.log(form)}>
+              <Flex.Stack>
+                <Field.Upload
+                  id="async_upload_context_id"
+                  path="/attachments"
+                  labelDescription="Upload multiple files at once to see the upload error message. This demo has been set up so that every other file in a batch will fail."
+                  asyncFileHandler={mockAsyncFileUpload}
+                  required
+                />
+                <Form.SubmitButton />
+              </Flex.Stack>
+              <Output />
+            </Form.Handler>
+          )
+        }
+
+        const Output = () => {
+          const { files } = useUpload('async_upload_context_id')
+          return <Tools.Log data={files} top />
+        }
+
+        return <MyForm />
+      }}
+    </ComponentBox>
+  )
+}
diff --git a/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/demos.mdx b/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/demos.mdx
index 58b2f44838d..d8cce0a083d 100644
--- a/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/demos.mdx
+++ b/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/demos.mdx
@@ -25,3 +25,7 @@ import * as Examples from './Examples'
 ### Customized
 
 <Examples.Customized />
+
+### With asynchronous file handler
+
+<Examples.WithAsyncFileHandler />
diff --git a/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/info.mdx b/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/info.mdx
index 58eeb8a6b50..2c5ac985757 100644
--- a/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/info.mdx
+++ b/packages/dnb-design-system-portal/src/docs/uilib/extensions/forms/feature-fields/more-fields/Upload/info.mdx
@@ -58,3 +58,36 @@ The `value` property represents an array with an object described above:
 ```tsx
 render(<Field.Upload value={files} />)
 ```
+
+## About the `asyncFileHandler` property
+
+The `asyncFileHandler` is an asynchronous handler function that takes newly added files as a parameter and returns a promise containing the processed files. The component will automatically handle loading states during the upload process. This feature is useful for tasks like uploading files to a virus checker, which returns a new file ID if the file passes the check. To indicate a failed upload, set the `errorMessage` on the specific file object with the desired message to display next to the file in the upload list.
+
+```js
+async function virusCheck(newFiles) {
+  const promises = newFiles.map(async (file) => {
+    const formData = new FormData()
+    formData.append('file', file.file, file.file.name)
+
+    return await fetch('/', { method: 'POST', body: formData })
+      .then((response) => {
+        if (response.ok) return response.json()
+        throw new Error('Unable to upload this file')
+      })
+      .then((data) => {
+        return {
+          ...file,
+          id: data.server_generated_id,
+        }
+      })
+      .catch((error) => {
+        return {
+          ...file,
+          errorMessage: error.message,
+        }
+      })
+  })
+
+  return await Promise.all(promises)
+}
+```
diff --git a/packages/dnb-eufemia/src/extensions/forms/Field/Upload/Upload.tsx b/packages/dnb-eufemia/src/extensions/forms/Field/Upload/Upload.tsx
index f6447fb4be1..38fb9cf1510 100644
--- a/packages/dnb-eufemia/src/extensions/forms/Field/Upload/Upload.tsx
+++ b/packages/dnb-eufemia/src/extensions/forms/Field/Upload/Upload.tsx
@@ -34,7 +34,9 @@ export type Props = FieldHelpProps &
     | 'fileMaxSize'
     | 'onFileDelete'
     | 'skeleton'
-  >
+  > & {
+    asyncFileHandler?: (newFiles: UploadValue) => Promise<UploadValue>
+  }
 
 const validateRequired = (
   value: UploadValue,
@@ -53,6 +55,13 @@ const validateRequired = (
   return undefined
 }
 
+const updateFileLoadingState = (
+  files: UploadValue,
+  isLoading: boolean
+) => {
+  return files.map((file) => ({ ...file, isLoading }))
+}
+
 function UploadComponent(props: Props) {
   const sharedTr = useSharedTranslation().Upload
   const formsTr = useFormsTranslation().Upload
@@ -82,6 +91,7 @@ function UploadComponent(props: Props) {
     handleChange,
     handleFocus,
     handleBlur,
+    asyncFileHandler,
     ...rest
   } = useFieldProps(preparedProps, {
     executeOnChangeRegardlessOfError: true,
@@ -98,20 +108,53 @@ function UploadComponent(props: Props) {
     onFileDelete,
   } = rest
 
-  const { setFiles } = useUpload(id)
+  const { files: fileContext, setFiles } = useUpload(id)
 
   useEffect(() => {
     setFiles(value)
   }, [setFiles, value])
 
+  const handleChangeAsync = useCallback(
+    async (files: UploadValue) => {
+      // Filter out existing files
+      const existingFileIds = fileContext?.map((file) => file.id) || []
+      const newFiles = files.filter(
+        (file) => !existingFileIds.includes(file.id)
+      )
+
+      if (newFiles.length > 0) {
+        // Set loading
+        setFiles([
+          ...fileContext,
+          ...updateFileLoadingState(newFiles, true),
+        ])
+
+        const uploadedFiles = updateFileLoadingState(
+          await asyncFileHandler(newFiles),
+          false
+        )
+
+        handleChange([...fileContext, ...uploadedFiles])
+      } else {
+        handleChange(files)
+      }
+    },
+    [fileContext, asyncFileHandler, setFiles, updateFileLoadingState]
+  )
+
   const changeHandler = useCallback(
     ({ files }: { files: UploadValue }) => {
       // Prevents the form-status from showing up
       handleBlur()
       handleFocus()
-      handleChange(files)
+
+      if (asyncFileHandler) {
+        handleChangeAsync(files)
+      } else {
+        handleChange(files)
+      }
     },
-    [handleBlur, handleChange, handleFocus]
+    [handleBlur, handleChange, handleFocus, asyncFileHandler, fileContext]
   )
 
   const width = widthProp as FieldBlockWidth