diff --git a/.circleci/config.yml b/.circleci/config.yml
index 2fbc6acd7f..bcd6fa17d9 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -139,6 +139,16 @@ jobs:
       - <<: *restore_dependency_cache_unix
       - run: npm run test:rule-help-version
 
+  # Test node API
+  test_node:
+    <<: *defaults
+    <<: *unix_box
+    steps:
+      - checkout
+      - <<: *restore_dependency_cache_unix
+      - run: npm run build
+      - run: npm run test:node
+
   # Release a "next" version
   next_release:
     <<: *defaults
@@ -208,6 +218,9 @@ workflows:
       - test_rule_help_version:
           requires:
             - test_unix
+      - test_node:
+          requires:
+            - test_unix
       # Hold for approval
       - hold:
           type: approval
@@ -218,6 +231,7 @@ workflows:
             - test_locales
             - build_api_docs
             - test_rule_help_version
+            - test_node
           filters:
             branches:
               only:
@@ -242,6 +256,7 @@ workflows:
             - test_locales
             - build_api_docs
             - test_rule_help_version
+            - test_node
             - hold
           filters:
             branches:
diff --git a/lib/core/public/run-rules.js b/lib/core/public/run-rules.js
index b0ae7af490..2d49a4bb41 100644
--- a/lib/core/public/run-rules.js
+++ b/lib/core/public/run-rules.js
@@ -1,9 +1,17 @@
 import Context from '../base/context';
+import cache from '../base/cache';
 
 // Clean up after resolve / reject
 function cleanup() {
+	if (cache.get('globalDocumentSet')) {
+		document = null;
+	}
+	if (cache.get('globalWindowSet')) {
+		window = null;
+	}
+
 	axe._memoizedFns.forEach(fn => fn.clear());
-	axe._cache.clear();
+	cache.clear();
 	axe._tree = undefined;
 	axe._selectorData = undefined;
 }
diff --git a/lib/core/public/run.js b/lib/core/public/run.js
index 3560aa5cfa..b9ec8abda4 100644
--- a/lib/core/public/run.js
+++ b/lib/core/public/run.js
@@ -1,4 +1,5 @@
 import { getReporter } from './reporter';
+import cache from '../base/cache';
 
 function isContext(potential) {
 	'use strict';
@@ -102,10 +103,12 @@ function run(context, options, callback) {
 		}
 
 		if (!hasDoc) {
+			cache.set('globalDocumentSet', true);
 			document = context.ownerDocument;
 		}
 
 		if (!hasWindow) {
+			cache.set('globalWindowSet', true);
 			window = document.defaultView;
 		}
 	}
diff --git a/package-lock.json b/package-lock.json
index f28a6f315b..91463cb5c3 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -1312,6 +1312,12 @@
 				"through": ">=2.2.7 <3"
 			}
 		},
+		"abab": {
+			"version": "2.0.3",
+			"resolved": "https://registry.npmjs.org/abab/-/abab-2.0.3.tgz",
+			"integrity": "sha512-tsFzPpcttalNjFBCFMqsKYQcWxxen1pgJR56by//QwvJc4/OUS3kPOOttx2tSIfjsylB0pYu7f5D3K1RCxUnUg==",
+			"dev": true
+		},
 		"abbrev": {
 			"version": "1.1.1",
 			"resolved": "https://registry.npmjs.org/abbrev/-/abbrev-1.1.1.tgz",
@@ -1334,6 +1340,24 @@
 			"integrity": "sha1-yM4n3grMdtiW0rH6099YjZ6C8BQ=",
 			"dev": true
 		},
+		"acorn-globals": {
+			"version": "6.0.0",
+			"resolved": "https://registry.npmjs.org/acorn-globals/-/acorn-globals-6.0.0.tgz",
+			"integrity": "sha512-ZQl7LOWaF5ePqqcX4hLuv/bLXYQNfNWw2c0/yX/TsPRKamzHcTGQnlCjHT3TsmkOUVEPS3crCxiPfdzE/Trlhg==",
+			"dev": true,
+			"requires": {
+				"acorn": "^7.1.1",
+				"acorn-walk": "^7.1.1"
+			},
+			"dependencies": {
+				"acorn": {
+					"version": "7.3.1",
+					"resolved": "https://registry.npmjs.org/acorn/-/acorn-7.3.1.tgz",
+					"integrity": "sha512-tLc0wSnatxAQHVHUapaHdz72pi9KUyHjq5KyHjGg9Y8Ifdc79pTh2XvI6I1/chZbnM7QtNKzh66ooDogPZSleA==",
+					"dev": true
+				}
+			}
+		},
 		"acorn-jsx": {
 			"version": "5.2.0",
 			"resolved": "https://registry.npmjs.org/acorn-jsx/-/acorn-jsx-5.2.0.tgz",
@@ -1586,6 +1610,15 @@
 			"integrity": "sha512-3duEwti880xqi4eAMN8AyR4a0ByT90zoYdLlevfrvU43vb0YZwZVfxOgxWrLXXXpyugL0hNZc9G6BiB5B3nUug==",
 			"dev": true
 		},
+		"asn1": {
+			"version": "0.2.4",
+			"resolved": "https://registry.npmjs.org/asn1/-/asn1-0.2.4.tgz",
+			"integrity": "sha512-jxwzQpLQjSmWXgwaCZE9Nz+glAG01yF1QnWgbhGwHI5A6FRIEY6IVqtHhIepHqI7/kyEyQEagBC5mBEFlIYvdg==",
+			"dev": true,
+			"requires": {
+				"safer-buffer": "~2.1.0"
+			}
+		},
 		"asn1.js": {
 			"version": "4.10.1",
 			"resolved": "https://registry.npmjs.org/asn1.js/-/asn1.js-4.10.1.tgz",
@@ -1632,6 +1665,12 @@
 				}
 			}
 		},
+		"assert-plus": {
+			"version": "1.0.0",
+			"resolved": "https://registry.npmjs.org/assert-plus/-/assert-plus-1.0.0.tgz",
+			"integrity": "sha1-8S4PPF13sLHN2RRpQuTpbB5N1SU=",
+			"dev": true
+		},
 		"assertion-error": {
 			"version": "1.1.0",
 			"resolved": "https://registry.npmjs.org/assertion-error/-/assertion-error-1.1.0.tgz",
@@ -1675,12 +1714,30 @@
 			"integrity": "sha512-csOlWGAcRFJaI6m+F2WKdnMKr4HhdhFVBk0H/QbJFMCr+uO2kwohwXQPxw/9OCxp05r5ghVBFSyioixx3gfkNQ==",
 			"dev": true
 		},
+		"asynckit": {
+			"version": "0.4.0",
+			"resolved": "https://registry.npmjs.org/asynckit/-/asynckit-0.4.0.tgz",
+			"integrity": "sha1-x57Zf380y48robyXkLzDZkdLS3k=",
+			"dev": true
+		},
 		"atob": {
 			"version": "2.1.2",
 			"resolved": "https://registry.npmjs.org/atob/-/atob-2.1.2.tgz",
 			"integrity": "sha512-Wm6ukoaOGJi/73p/cl2GvLjTI5JM1k/O14isD73YML8StrH/7/lRFgmg8nICZgD3bZZvjwCGxtMOD3wWNAu8cg==",
 			"dev": true
 		},
+		"aws-sign2": {
+			"version": "0.7.0",
+			"resolved": "https://registry.npmjs.org/aws-sign2/-/aws-sign2-0.7.0.tgz",
+			"integrity": "sha1-tG6JCTSpWR8tL2+G1+ap8bP+dqg=",
+			"dev": true
+		},
+		"aws4": {
+			"version": "1.10.0",
+			"resolved": "https://registry.npmjs.org/aws4/-/aws4-1.10.0.tgz",
+			"integrity": "sha512-3YDiu347mtVtjpyV3u5kVqQLP242c06zwDOgpeRnybmXlYYsLbtTrUBUm8i8srONt+FWobl5aibnU1030PeeuA==",
+			"dev": true
+		},
 		"axios": {
 			"version": "0.19.2",
 			"resolved": "https://registry.npmjs.org/axios/-/axios-0.19.2.tgz",
@@ -1787,6 +1844,15 @@
 			"integrity": "sha1-3DQxT05nkxgJP8dgJyUl+UvyXBY=",
 			"dev": true
 		},
+		"bcrypt-pbkdf": {
+			"version": "1.0.2",
+			"resolved": "https://registry.npmjs.org/bcrypt-pbkdf/-/bcrypt-pbkdf-1.0.2.tgz",
+			"integrity": "sha1-pDAdOJtqQ/m2f/PKEaP2Y342Dp4=",
+			"dev": true,
+			"requires": {
+				"tweetnacl": "^0.14.3"
+			}
+		},
 		"big.js": {
 			"version": "5.2.2",
 			"resolved": "https://registry.npmjs.org/big.js/-/big.js-5.2.2.tgz",
@@ -1887,6 +1953,12 @@
 				"umd": "^3.0.0"
 			}
 		},
+		"browser-process-hrtime": {
+			"version": "1.0.0",
+			"resolved": "https://registry.npmjs.org/browser-process-hrtime/-/browser-process-hrtime-1.0.0.tgz",
+			"integrity": "sha512-9o5UecI3GhkpM6DrXr69PblIuWxPKk9Y0jHBRhdocZ2y7YECBFCsHm79Pr3OyR2AvjhDkabFJaDJMYRazHgsow==",
+			"dev": true
+		},
 		"browser-resolve": {
 			"version": "1.11.3",
 			"resolved": "https://registry.npmjs.org/browser-resolve/-/browser-resolve-1.11.3.tgz",
@@ -2219,6 +2291,12 @@
 			"integrity": "sha512-PFTw9UyVfbkcMEFs82q8XVlRayj7HKvnhu5BLcmjGpv+SNyiWasCcWXPGJuO0rK0dhLRDJmtZcJ+LHUfypbw1w==",
 			"dev": true
 		},
+		"caseless": {
+			"version": "0.12.0",
+			"resolved": "https://registry.npmjs.org/caseless/-/caseless-0.12.0.tgz",
+			"integrity": "sha1-G2gcIf+EAzyCZUMJBolCDRhxUdw=",
+			"dev": true
+		},
 		"catharsis": {
 			"version": "0.8.11",
 			"resolved": "https://registry.npmjs.org/catharsis/-/catharsis-0.8.11.tgz",
@@ -2484,6 +2562,15 @@
 				}
 			}
 		},
+		"combined-stream": {
+			"version": "1.0.8",
+			"resolved": "https://registry.npmjs.org/combined-stream/-/combined-stream-1.0.8.tgz",
+			"integrity": "sha512-FQN4MRfuJeHf7cBbBMJFXhKSDq+2kAArBlmRBvcvFE5BB1HZKXtSFASDhdlz9zOYwxh8lDdnvmMOe/+5cdoEdg==",
+			"dev": true,
+			"requires": {
+				"delayed-stream": "~1.0.0"
+			}
+		},
 		"commander": {
 			"version": "2.20.3",
 			"resolved": "https://registry.npmjs.org/commander/-/commander-2.20.3.tgz",
@@ -3154,6 +3241,29 @@
 			"integrity": "sha512-HYPSb7y/Z7BNDCOrakL4raGO2zltZkbeXyAd6Tg9obzix6QhzxCotdBl6VT0Dv4vZfJGVz3WL/xaEI9Ly3ul0g==",
 			"dev": true
 		},
+		"cssom": {
+			"version": "0.4.4",
+			"resolved": "https://registry.npmjs.org/cssom/-/cssom-0.4.4.tgz",
+			"integrity": "sha512-p3pvU7r1MyyqbTk+WbNJIgJjG2VmTIaB10rI93LzVPrmDJKkzKYMtxxyAvQXR/NS6otuzveI7+7BBq3SjBS2mw==",
+			"dev": true
+		},
+		"cssstyle": {
+			"version": "2.3.0",
+			"resolved": "https://registry.npmjs.org/cssstyle/-/cssstyle-2.3.0.tgz",
+			"integrity": "sha512-AZL67abkUzIuvcHqk7c09cezpGNcxUxU4Ioi/05xHk4DQeTkWmGYftIE6ctU6AEt+Gn4n1lDStOtj7FKycP71A==",
+			"dev": true,
+			"requires": {
+				"cssom": "~0.3.6"
+			},
+			"dependencies": {
+				"cssom": {
+					"version": "0.3.8",
+					"resolved": "https://registry.npmjs.org/cssom/-/cssom-0.3.8.tgz",
+					"integrity": "sha512-b0tGHbfegbhPJpxpiBPU2sCkigAqtM9O121le6bbOlgyV+NyGyCmVfJ6QW9eRjz8CpNfWEOYBIMIGRYkLwsIYg==",
+					"dev": true
+				}
+			}
+		},
 		"currently-unhandled": {
 			"version": "0.4.1",
 			"resolved": "https://registry.npmjs.org/currently-unhandled/-/currently-unhandled-0.4.1.tgz",
@@ -3194,6 +3304,26 @@
 			"integrity": "sha512-Vy4dx7gquTeMcQR/hDkYLGUnwVil6vk4FOOct+djUnHOUWt+zJPJAaRIXaAFkPXtJjvlY7o3rfRu0/3hpnwoUA==",
 			"dev": true
 		},
+		"dashdash": {
+			"version": "1.14.1",
+			"resolved": "https://registry.npmjs.org/dashdash/-/dashdash-1.14.1.tgz",
+			"integrity": "sha1-hTz6D3y+L+1d4gMmuN1YEDX24vA=",
+			"dev": true,
+			"requires": {
+				"assert-plus": "^1.0.0"
+			}
+		},
+		"data-urls": {
+			"version": "2.0.0",
+			"resolved": "https://registry.npmjs.org/data-urls/-/data-urls-2.0.0.tgz",
+			"integrity": "sha512-X5eWTSXO/BJmpdIKCRuKUgSCgAN0OwliVK3yPKbwIWU1Tdw5BRajxlzMidvh+gwko9AfQ9zIj52pzF91Q3YAvQ==",
+			"dev": true,
+			"requires": {
+				"abab": "^2.0.3",
+				"whatwg-mimetype": "^2.3.0",
+				"whatwg-url": "^8.0.0"
+			}
+		},
 		"date-fns": {
 			"version": "1.30.1",
 			"resolved": "https://registry.npmjs.org/date-fns/-/date-fns-1.30.1.tgz",
@@ -3248,6 +3378,12 @@
 				}
 			}
 		},
+		"decimal.js": {
+			"version": "10.2.0",
+			"resolved": "https://registry.npmjs.org/decimal.js/-/decimal.js-10.2.0.tgz",
+			"integrity": "sha512-vDPw+rDgn3bZe1+F/pyEwb1oMG2XTlRVgAa6B4KccTEpYgF8w6eQllVbQcfIJnZyvzFtFpxnpGtx8dd7DJp/Rw==",
+			"dev": true
+		},
 		"decode-uri-component": {
 			"version": "0.2.0",
 			"resolved": "https://registry.npmjs.org/decode-uri-component/-/decode-uri-component-0.2.0.tgz",
@@ -3367,6 +3503,12 @@
 				}
 			}
 		},
+		"delayed-stream": {
+			"version": "1.0.0",
+			"resolved": "https://registry.npmjs.org/delayed-stream/-/delayed-stream-1.0.0.tgz",
+			"integrity": "sha1-3zrhmayt+31ECqrgsp4icrJOxhk=",
+			"dev": true
+		},
 		"depd": {
 			"version": "2.0.0",
 			"resolved": "https://registry.npmjs.org/depd/-/depd-2.0.0.tgz",
@@ -3500,6 +3642,23 @@
 			"integrity": "sha512-jnjyiM6eRyZl2H+W8Q/zLMA481hzi0eszAaBUzIVnmYVDBbnLxVNnfu1HgEBvCbL+71FrxMl3E6lpKH7Ge3OXA==",
 			"dev": true
 		},
+		"domexception": {
+			"version": "2.0.1",
+			"resolved": "https://registry.npmjs.org/domexception/-/domexception-2.0.1.tgz",
+			"integrity": "sha512-yxJ2mFy/sibVQlu5qHjOkf9J3K6zgmCxgJ94u2EdvDOV09H+32LtRswEcUsmUWN72pVLOEnTSRaIVVzVQgS0dg==",
+			"dev": true,
+			"requires": {
+				"webidl-conversions": "^5.0.0"
+			},
+			"dependencies": {
+				"webidl-conversions": {
+					"version": "5.0.0",
+					"resolved": "https://registry.npmjs.org/webidl-conversions/-/webidl-conversions-5.0.0.tgz",
+					"integrity": "sha512-VlZwKPCkYKxQgeSbH5EyngOmRp7Ww7I9rQLERETtf5ofd9pGeswWiOtogpEO850jziPRarreGxn5QIiTqpb2wA==",
+					"dev": true
+				}
+			}
+		},
 		"dot-prop": {
 			"version": "3.0.0",
 			"resolved": "https://registry.npmjs.org/dot-prop/-/dot-prop-3.0.0.tgz",
@@ -3582,6 +3741,16 @@
 				"stream-shift": "^1.0.0"
 			}
 		},
+		"ecc-jsbn": {
+			"version": "0.1.2",
+			"resolved": "https://registry.npmjs.org/ecc-jsbn/-/ecc-jsbn-0.1.2.tgz",
+			"integrity": "sha1-OoOpBOVDUyh4dMVkt1SThoSamMk=",
+			"dev": true,
+			"requires": {
+				"jsbn": "~0.1.0",
+				"safer-buffer": "^2.1.0"
+			}
+		},
 		"ee-first": {
 			"version": "1.1.1",
 			"resolved": "https://registry.npmjs.org/ee-first/-/ee-first-1.1.1.tgz",
@@ -3852,6 +4021,28 @@
 			"integrity": "sha1-G2HAViGQqN/2rjuyzwIAyhMLhtQ=",
 			"dev": true
 		},
+		"escodegen": {
+			"version": "1.14.3",
+			"resolved": "https://registry.npmjs.org/escodegen/-/escodegen-1.14.3.tgz",
+			"integrity": "sha512-qFcX0XJkdg+PB3xjZZG/wKSuT1PnQWx57+TVSjIMmILd2yC/6ByYElPwJnslDsuWuSAp4AwJGumarAAmJch5Kw==",
+			"dev": true,
+			"requires": {
+				"esprima": "^4.0.1",
+				"estraverse": "^4.2.0",
+				"esutils": "^2.0.2",
+				"optionator": "^0.8.1",
+				"source-map": "~0.6.1"
+			},
+			"dependencies": {
+				"source-map": {
+					"version": "0.6.1",
+					"resolved": "https://registry.npmjs.org/source-map/-/source-map-0.6.1.tgz",
+					"integrity": "sha512-UjgapumWlbMhkBgzT7Ykc5YXUT46F0iKu8SGXq0bcwP5dz/h0Plj6enJqjz1Zbq2l5WaqYnrVbwWOWMyF3F47g==",
+					"dev": true,
+					"optional": true
+				}
+			}
+		},
 		"escope": {
 			"version": "3.6.0",
 			"resolved": "https://registry.npmjs.org/escope/-/escope-3.6.0.tgz",
@@ -4350,6 +4541,12 @@
 				}
 			}
 		},
+		"extsprintf": {
+			"version": "1.3.0",
+			"resolved": "https://registry.npmjs.org/extsprintf/-/extsprintf-1.3.0.tgz",
+			"integrity": "sha1-lpGEQOMEGnpBT4xS48V06zw+HgU=",
+			"dev": true
+		},
 		"falafel": {
 			"version": "1.2.0",
 			"resolved": "https://registry.npmjs.org/falafel/-/falafel-1.2.0.tgz",
@@ -4721,6 +4918,23 @@
 			"integrity": "sha1-C+4AUBiusmDQo6865ljdATbsG5k=",
 			"dev": true
 		},
+		"forever-agent": {
+			"version": "0.6.1",
+			"resolved": "https://registry.npmjs.org/forever-agent/-/forever-agent-0.6.1.tgz",
+			"integrity": "sha1-+8cfDEGt6zf5bFd60e1C2P2sypE=",
+			"dev": true
+		},
+		"form-data": {
+			"version": "2.3.3",
+			"resolved": "https://registry.npmjs.org/form-data/-/form-data-2.3.3.tgz",
+			"integrity": "sha512-1lLKB2Mu3aGP1Q/2eCOx0fNbRMe7XdwktwOruhfqqd0rIJWwN4Dh+E3hrPSlDCXnSR7UtZ1N38rVXm+6+MEhJQ==",
+			"dev": true,
+			"requires": {
+				"asynckit": "^0.4.0",
+				"combined-stream": "^1.0.6",
+				"mime-types": "^2.1.12"
+			}
+		},
 		"fragment-cache": {
 			"version": "0.2.1",
 			"resolved": "https://registry.npmjs.org/fragment-cache/-/fragment-cache-0.2.1.tgz",
@@ -5021,6 +5235,15 @@
 			"integrity": "sha1-BHpEl4n6Fg0Bj1SG7ZEyC27HiFw=",
 			"dev": true
 		},
+		"getpass": {
+			"version": "0.1.7",
+			"resolved": "https://registry.npmjs.org/getpass/-/getpass-0.1.7.tgz",
+			"integrity": "sha1-Xv+OPmhNVprkyysSgmBOi6YhSfo=",
+			"dev": true,
+			"requires": {
+				"assert-plus": "^1.0.0"
+			}
+		},
 		"git-raw-commits": {
 			"version": "2.0.0",
 			"resolved": "https://registry.npmjs.org/git-raw-commits/-/git-raw-commits-2.0.0.tgz",
@@ -5647,6 +5870,22 @@
 				}
 			}
 		},
+		"har-schema": {
+			"version": "2.0.0",
+			"resolved": "https://registry.npmjs.org/har-schema/-/har-schema-2.0.0.tgz",
+			"integrity": "sha1-qUwiJOvKwEeCoNkDVSHyRzW37JI=",
+			"dev": true
+		},
+		"har-validator": {
+			"version": "5.1.3",
+			"resolved": "https://registry.npmjs.org/har-validator/-/har-validator-5.1.3.tgz",
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 		"stream-browserify": {
 			"version": "2.0.2",
 			"resolved": "https://registry.npmjs.org/stream-browserify/-/stream-browserify-2.0.2.tgz",
@@ -10555,6 +11074,12 @@
 			"integrity": "sha512-e900nM8RRtGhlV36KGEU9k65K3mPb1WV70OdjfxlG2EAuM1noi/E/BaW/uMhL7bPEssK8QV57vN3esixjUvcXQ==",
 			"dev": true
 		},
+		"symbol-tree": {
+			"version": "3.2.4",
+			"resolved": "https://registry.npmjs.org/symbol-tree/-/symbol-tree-3.2.4.tgz",
+			"integrity": "sha512-9QNk5KwDF+Bvz+PyObkmSYjI5ksVUYtjW7AU22r2NKcfLJcXp96hkDWU3+XndOsUb+AQ9QhfzfCT2O+CNWT5Tw==",
+			"dev": true
+		},
 		"syntax-error": {
 			"version": "1.4.0",
 			"resolved": "https://registry.npmjs.org/syntax-error/-/syntax-error-1.4.0.tgz",
@@ -10812,6 +11337,42 @@
 			"integrity": "sha512-yaOH/Pk/VEhBWWTlhI+qXxDFXlejDGcQipMlyxda9nthulaxLZUNcUqFxokp0vcYnvteJln5FNQDRrxj3YcbVw==",
 			"dev": true
 		},
+		"tough-cookie": {
+			"version": "3.0.1",
+			"resolved": "https://registry.npmjs.org/tough-cookie/-/tough-cookie-3.0.1.tgz",
+			"integrity": "sha512-yQyJ0u4pZsv9D4clxO69OEjLWYw+jbgspjTue4lTQZLfV0c5l1VmK2y1JK8E9ahdpltPOaAThPcp5nKPUgSnsg==",
+			"dev": true,
+			"requires": {
+				"ip-regex": "^2.1.0",
+				"psl": "^1.1.28",
+				"punycode": "^2.1.1"
+			},
+			"dependencies": {
+				"punycode": {
+					"version": "2.1.1",
+					"resolved": "https://registry.npmjs.org/punycode/-/punycode-2.1.1.tgz",
+					"integrity": "sha512-XRsRjdf+j5ml+y/6GKHPZbrF/8p2Yga0JPtdqTIY2Xe5ohJPD9saDJJLPvp9+NSBprVvevdXZybnj2cv8OEd0A==",
+					"dev": true
+				}
+			}
+		},
+		"tr46": {
+			"version": "2.0.2",
+			"resolved": "https://registry.npmjs.org/tr46/-/tr46-2.0.2.tgz",
+			"integrity": "sha512-3n1qG+/5kg+jrbTzwAykB5yRYtQCTqOGKq5U5PE3b0a1/mzo6snDhjGS0zJVJunO0NrT3Dg1MLy5TjWP/UJppg==",
+			"dev": true,
+			"requires": {
+				"punycode": "^2.1.1"
+			},
+			"dependencies": {
+				"punycode": {
+					"version": "2.1.1",
+					"resolved": "https://registry.npmjs.org/punycode/-/punycode-2.1.1.tgz",
+					"integrity": "sha512-XRsRjdf+j5ml+y/6GKHPZbrF/8p2Yga0JPtdqTIY2Xe5ohJPD9saDJJLPvp9+NSBprVvevdXZybnj2cv8OEd0A==",
+					"dev": true
+				}
+			}
+		},
 		"trim-newlines": {
 			"version": "3.0.0",
 			"resolved": "https://registry.npmjs.org/trim-newlines/-/trim-newlines-3.0.0.tgz",
@@ -10836,6 +11397,21 @@
 			"integrity": "sha512-C3TaO7K81YvjCgQH9Q1S3R3P3BtN3RIM8n+OvX4il1K1zgE8ZhI0op7kClgkxtutIE8hQrcrHBXvIheqKUUCxw==",
 			"dev": true
 		},
+		"tunnel-agent": {
+			"version": "0.6.0",
+			"resolved": "https://registry.npmjs.org/tunnel-agent/-/tunnel-agent-0.6.0.tgz",
+			"integrity": "sha1-J6XeoGs2sEoKmWZ3SykIaPD8QP0=",
+			"dev": true,
+			"requires": {
+				"safe-buffer": "^5.0.1"
+			}
+		},
+		"tweetnacl": {
+			"version": "0.14.5",
+			"resolved": "https://registry.npmjs.org/tweetnacl/-/tweetnacl-0.14.5.tgz",
+			"integrity": "sha1-WuaBd/GS1EViadEIr6k/+HQ/T2Q=",
+			"dev": true
+		},
 		"type": {
 			"version": "1.2.0",
 			"resolved": "https://registry.npmjs.org/type/-/type-1.2.0.tgz",
@@ -11170,12 +11746,41 @@
 				"spdx-expression-parse": "^3.0.0"
 			}
 		},
+		"verror": {
+			"version": "1.10.0",
+			"resolved": "https://registry.npmjs.org/verror/-/verror-1.10.0.tgz",
+			"integrity": "sha1-OhBcoXBTr1XW4nDB+CiGguGNpAA=",
+			"dev": true,
+			"requires": {
+				"assert-plus": "^1.0.0",
+				"core-util-is": "1.0.2",
+				"extsprintf": "^1.2.0"
+			}
+		},
 		"vm-browserify": {
 			"version": "1.1.2",
 			"resolved": "https://registry.npmjs.org/vm-browserify/-/vm-browserify-1.1.2.tgz",
 			"integrity": "sha512-2ham8XPWTONajOR0ohOKOHXkm3+gaBmGut3SRuu75xLd/RRaY6vqgh8NBYYk7+RW3u5AtzPQZG8F10LHkl0lAQ==",
 			"dev": true
 		},
+		"w3c-hr-time": {
+			"version": "1.0.2",
+			"resolved": "https://registry.npmjs.org/w3c-hr-time/-/w3c-hr-time-1.0.2.tgz",
+			"integrity": "sha512-z8P5DvDNjKDoFIHK7q8r8lackT6l+jo/Ye3HOle7l9nICP9lf1Ci25fy9vHd0JOWewkIFzXIEig3TdKT7JQ5fQ==",
+			"dev": true,
+			"requires": {
+				"browser-process-hrtime": "^1.0.0"
+			}
+		},
+		"w3c-xmlserializer": {
+			"version": "2.0.0",
+			"resolved": "https://registry.npmjs.org/w3c-xmlserializer/-/w3c-xmlserializer-2.0.0.tgz",
+			"integrity": "sha512-4tzD0mF8iSiMiNs30BiLO3EpfGLZUT2MSX/G+o7ZywDzliWQ3OPtTZ0PTC3B3ca1UAf4cJMHB+2Bf56EriJuRA==",
+			"dev": true,
+			"requires": {
+				"xml-name-validator": "^3.0.0"
+			}
+		},
 		"watchpack": {
 			"version": "1.7.2",
 			"resolved": "https://registry.npmjs.org/watchpack/-/watchpack-1.7.2.tgz",
@@ -11424,6 +12029,12 @@
 			"integrity": "sha512-Lyc5GL7aY3E91T5upv+0fd+OZe8gpTa4gyFo+9J5k6HGfYQpLGTAUg/TmAKFoSf+3F05iXLbqd2wIxV9ztr6ig==",
 			"dev": true
 		},
+		"webidl-conversions": {
+			"version": "6.1.0",
+			"resolved": "https://registry.npmjs.org/webidl-conversions/-/webidl-conversions-6.1.0.tgz",
+			"integrity": "sha512-qBIvFLGiBpLjfwmYAaHPXsn+ho5xZnGvyGvsarywGNc8VyQJUMHJ8OBKGGrPER0okBeMDaan4mNBlgBROxuI8w==",
+			"dev": true
+		},
 		"webpack": {
 			"version": "4.43.0",
 			"resolved": "https://registry.npmjs.org/webpack/-/webpack-4.43.0.tgz",
@@ -11625,6 +12236,40 @@
 				"xtend": "^4.0.0"
 			}
 		},
+		"whatwg-encoding": {
+			"version": "1.0.5",
+			"resolved": "https://registry.npmjs.org/whatwg-encoding/-/whatwg-encoding-1.0.5.tgz",
+			"integrity": "sha512-b5lim54JOPN9HtzvK9HFXvBma/rnfFeqsic0hSpjtDbVxR3dJKLc+KB4V6GgiGOvl7CY/KNh8rxSo9DKQrnUEw==",
+			"dev": true,
+			"requires": {
+				"iconv-lite": "0.4.24"
+			}
+		},
+		"whatwg-mimetype": {
+			"version": "2.3.0",
+			"resolved": "https://registry.npmjs.org/whatwg-mimetype/-/whatwg-mimetype-2.3.0.tgz",
+			"integrity": "sha512-M4yMwr6mAnQz76TbJm914+gPpB/nCwvZbJU28cUD6dR004SAxDLOOSUaB1JDRqLtaOV/vi0IC5lEAGFgrjGv/g==",
+			"dev": true
+		},
+		"whatwg-url": {
+			"version": "8.1.0",
+			"resolved": "https://registry.npmjs.org/whatwg-url/-/whatwg-url-8.1.0.tgz",
+			"integrity": "sha512-vEIkwNi9Hqt4TV9RdnaBPNt+E2Sgmo3gePebCRgZ1R7g6d23+53zCTnuB0amKI4AXq6VM8jj2DUAa0S1vjJxkw==",
+			"dev": true,
+			"requires": {
+				"lodash.sortby": "^4.7.0",
+				"tr46": "^2.0.2",
+				"webidl-conversions": "^5.0.0"
+			},
+			"dependencies": {
+				"webidl-conversions": {
+					"version": "5.0.0",
+					"resolved": "https://registry.npmjs.org/webidl-conversions/-/webidl-conversions-5.0.0.tgz",
+					"integrity": "sha512-VlZwKPCkYKxQgeSbH5EyngOmRp7Ww7I9rQLERETtf5ofd9pGeswWiOtogpEO850jziPRarreGxn5QIiTqpb2wA==",
+					"dev": true
+				}
+			}
+		},
 		"which": {
 			"version": "1.3.1",
 			"resolved": "https://registry.npmjs.org/which/-/which-1.3.1.tgz",
@@ -11767,6 +12412,12 @@
 				"ultron": "~1.1.0"
 			}
 		},
+		"xml-name-validator": {
+			"version": "3.0.0",
+			"resolved": "https://registry.npmjs.org/xml-name-validator/-/xml-name-validator-3.0.0.tgz",
+			"integrity": "sha512-A5CUptxDsvxKJEU3yO6DuWBSJz/qizqzJKOMIfUJHETbBw/sFaDxgd6fxm1ewUaM0jZ444Fc5vC5ROYurg/4Pw==",
+			"dev": true
+		},
 		"xml2js": {
 			"version": "0.4.23",
 			"resolved": "https://registry.npmjs.org/xml2js/-/xml2js-0.4.23.tgz",
@@ -11783,6 +12434,12 @@
 			"integrity": "sha512-fDlsI/kFEx7gLvbecc0/ohLG50fugQp8ryHzMTuW9vSa1GJ0XYWKnhsUx7oie3G98+r56aTQIUB4kht42R3JvA==",
 			"dev": true
 		},
+		"xmlchars": {
+			"version": "2.2.0",
+			"resolved": "https://registry.npmjs.org/xmlchars/-/xmlchars-2.2.0.tgz",
+			"integrity": "sha512-JZnDKK8B0RCDw84FNdDAIpZK+JuJw+s7Lz8nksI7SIuU3UXJJslUthsi+uWBUYOwPFwW7W7PRLRfUKpxjtjFCw==",
+			"dev": true
+		},
 		"xmlcreate": {
 			"version": "2.0.3",
 			"resolved": "https://registry.npmjs.org/xmlcreate/-/xmlcreate-2.0.3.tgz",
diff --git a/package.json b/package.json
index e9f0255710..ba0154738e 100644
--- a/package.json
+++ b/package.json
@@ -67,6 +67,7 @@
 		"test:examples": "node ./doc/examples/test-examples",
 		"test:locales": "mocha test/test-locales.js",
 		"test:rule-help-version": "mocha test/test-rule-help-version.js",
+		"test:node": "mocha test/node/*.js",
 		"version": "echo \"use 'npm run release' to bump axe-core version\" && exit 1",
 		"prepublishOnly": "grunt build && grunt file-exists",
 		"release": "standard-version -a",
@@ -115,6 +116,7 @@
 		"husky": "^3.0.0",
 		"jquery": "^3.0.0",
 		"jsdoc": "^3.5.5",
+		"jsdom": "^16.3.0",
 		"lint-staged": "^9.2.1",
 		"make-dir": "^3.0.0",
 		"markdown-table": "^1.1.2",
diff --git a/test/node/jsdom.js b/test/node/jsdom.js
new file mode 100644
index 0000000000..37b2d80ade
--- /dev/null
+++ b/test/node/jsdom.js
@@ -0,0 +1,52 @@
+var axe = require('../../');
+var jsdom = require('jsdom');
+var assert = require('assert');
+
+var domStr =
+	'<!DOCTYPE html>' +
+	'<html lang="en">' +
+	'<head>' +
+	'<meta charset="UTF-8">' +
+	'<meta name="viewport" content="width=device-width, initial-scale=1.0">' +
+	'<title>Document</title>' +
+	'</head>' +
+	'<body>' +
+	'Hello' +
+	'</body>' +
+	'</html>';
+
+describe('jsdom axe-core', function() {
+	it('should run without setting globals', function() {
+		var dom = new jsdom.JSDOM(domStr);
+
+		return axe
+			.run(dom.window.document.documentElement, {
+				rules: { 'color-contrast': { enabled: false } }
+			})
+			.then(function(results) {
+				assert.notEqual(results.violations.length, 0);
+			});
+	});
+
+	it('should unset globals so it can run with a new set of globals', function() {
+		var dom = new jsdom.JSDOM(domStr);
+
+		return axe
+			.run(dom.window.document.documentElement, {
+				rules: { 'color-contrast': { enabled: false } }
+			})
+			.then(function(results) {
+				assert.notEqual(results.violations.length, 0);
+
+				var dom = new jsdom.JSDOM(domStr);
+
+				return axe
+					.run(dom.window.document.documentElement, {
+						rules: { 'color-contrast': { enabled: false } }
+					})
+					.then(function(results) {
+						assert.notEqual(results.violations.length, 0);
+					});
+			});
+	});
+});