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filter -f germline #391

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thedam opened this issue Nov 5, 2024 · 1 comment
Open

filter -f germline #391

thedam opened this issue Nov 5, 2024 · 1 comment
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@thedam
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thedam commented Nov 5, 2024

hey,
How does this filter work?

delly filter -f germline -o germline.bcf merged.bcf
What criteria it uses?

With some set of samples I get no output, so I wonder if I could write my own filter directly on the output files from this command:
delly call -g $ref38 -x $dellyexc $bam -o ${sname}.bcf

Cheers

@tobiasrausch
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The germline filter compares SV carriers with SV non-carriers for various parameters (such as read-depth or paired-end support) to distinguish likely false positive and likely true positive germline SVs. This works better with increasing numbers of samples (definitely >25).

@tobiasrausch tobiasrausch self-assigned this Nov 6, 2024
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