diff --git a/CHANGELOG.md b/CHANGELOG.md
index 3c316d8f8c40..12122532d11e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -14,10 +14,16 @@ This is a patch release that:
 - Fixes an issue in dart2wasm compiler that can result in incorrect nullability
   of type parameter (see [#55741])
 
+- Disallows `dart:ffi` imports in user code in dart2wasm (e.g. issue [#53910]) as
+  dart2wasm's currently only supports a small subset of `dart:ffi` (tracking
+  issue [#46690]).
+
 [#55767]: https://github.com/dart-lang/sdk/issues/55767
 [#55872]: https://github.com/dart-lang/sdk/issues/55872
 [#55876]: https://github.com/dart-lang/sdk/issues/55876
 [#55741]: https://github.com/dart-lang/sdk/issues/55741
+[#55733]: https://github.com/dart-lang/sdk/issues/53910
+[#46690]: https://github.com/dart-lang/sdk/issues/46690
 
 ## 3.4.2 - 2024-05-29
 
diff --git a/pkg/_fe_analyzer_shared/lib/src/messages/codes_generated.dart b/pkg/_fe_analyzer_shared/lib/src/messages/codes_generated.dart
index 0bbd8926aa22..5ba5d9296b3d 100644
--- a/pkg/_fe_analyzer_shared/lib/src/messages/codes_generated.dart
+++ b/pkg/_fe_analyzer_shared/lib/src/messages/codes_generated.dart
@@ -2742,6 +2742,16 @@ Message _withArgumentsCyclicTypedef(String name) {
   );
 }
 
+// DO NOT EDIT. THIS FILE IS GENERATED. SEE TOP OF FILE.
+const Code<Null> codeDartFfiLibraryInDart2Wasm =
+    messageDartFfiLibraryInDart2Wasm;
+
+// DO NOT EDIT. THIS FILE IS GENERATED. SEE TOP OF FILE.
+const MessageCode messageDartFfiLibraryInDart2Wasm = const MessageCode(
+  "DartFfiLibraryInDart2Wasm",
+  problemMessage: r"""'dart:ffi' can't be imported when compiling to Wasm.""",
+);
+
 // DO NOT EDIT. THIS FILE IS GENERATED. SEE TOP OF FILE.
 const Template<Message Function(String name, String string)>
     templateDebugTrace =
diff --git a/pkg/_js_interop_checks/lib/js_interop_checks.dart b/pkg/_js_interop_checks/lib/js_interop_checks.dart
index 02151ef99246..4cbd3363659d 100644
--- a/pkg/_js_interop_checks/lib/js_interop_checks.dart
+++ b/pkg/_js_interop_checks/lib/js_interop_checks.dart
@@ -8,6 +8,7 @@ import 'package:_fe_analyzer_shared/src/messages/codes.dart'
     show
         Message,
         LocatedMessage,
+        messageDartFfiLibraryInDart2Wasm,
         messageJsInteropDartJsInteropAnnotationForStaticInteropOnly,
         messageJsInteropEnclosingClassJSAnnotation,
         messageJsInteropEnclosingClassJSAnnotationContext,
@@ -134,7 +135,8 @@ class JsInteropChecks extends RecursiveVisitor {
     'package:js/js.dart',
     'package:js/js_util.dart',
     'dart:js_util',
-    'dart:js'
+    'dart:js',
+    'dart:ffi',
   ];
 
   /// Libraries that use `external` to exclude from checks on external.
@@ -550,12 +552,12 @@ class JsInteropChecks extends RecursiveVisitor {
             _allowedUseOfDart2WasmDisallowedInteropLibrariesTestPatterns
                 .any((pattern) => uri.path.contains(pattern));
         if (allowedToImport) return;
-        _reporter.report(
-            templateJsInteropDisallowedInteropLibraryInDart2Wasm
-                .withArguments(dependencyUriString),
-            dependency.fileOffset,
-            dependencyUriString.length,
-            node.fileUri);
+        final message = dependencyUriString == 'dart:ffi'
+            ? messageDartFfiLibraryInDart2Wasm
+            : templateJsInteropDisallowedInteropLibraryInDart2Wasm
+                .withArguments(dependencyUriString);
+        _reporter.report(message, dependency.fileOffset,
+            dependencyUriString.length, node.fileUri);
       }
     }
   }
diff --git a/pkg/front_end/messages.status b/pkg/front_end/messages.status
index 4cb0eccf3bae..095ca6af6aba 100644
--- a/pkg/front_end/messages.status
+++ b/pkg/front_end/messages.status
@@ -188,6 +188,8 @@ CyclicRedirectingFactoryConstructors/part_wrapped_script: Fail # Error is report
 CyclicRedirectingFactoryConstructors/script: Fail # Error is reported for each factory involved in the cycle.
 CyclicRepresentationDependency/analyzerCode: Fail
 CyclicTypedef/example: Fail
+DartFfiLibraryInDart2Wasm/analyzerCode: Fail
+DartFfiLibraryInDart2Wasm/example: Fail
 DeferredAfterPrefix/example: Fail
 DeferredExtensionImport/analyzerCode: Fail
 DeferredExtensionImport/part_wrapped_script: Fail
diff --git a/pkg/front_end/messages.yaml b/pkg/front_end/messages.yaml
index 98df5912b784..6c70c9a8d040 100644
--- a/pkg/front_end/messages.yaml
+++ b/pkg/front_end/messages.yaml
@@ -7528,3 +7528,6 @@ NoMacroApplicationTarget:
 MacroDefinitionApplicationSameLibraryCycle:
   problemMessage: "The macro '#name' can't be applied in the same library cycle where it is defined."
   correctionMessage: Try moving it to a different library that does not import the one where it is applied.
+
+DartFfiLibraryInDart2Wasm:
+  problemMessage: "'dart:ffi' can't be imported when compiling to Wasm."
diff --git a/tests/lib/js/static_interop_test/disallowed_interop_libraries_test.dart b/tests/lib/js/static_interop_test/disallowed_interop_libraries_test.dart
index 37cb8bc4e8f5..a8f6c4b9f54c 100644
--- a/tests/lib/js/static_interop_test/disallowed_interop_libraries_test.dart
+++ b/tests/lib/js/static_interop_test/disallowed_interop_libraries_test.dart
@@ -20,4 +20,8 @@
 //   ^
 // [web] JS interop library 'package:js/js_util.dart' can't be imported when compiling to Wasm.
 
+/**/ import 'dart:ffi';
+//   ^
+// [web] 'dart:ffi' can't be imported when compiling to Wasm.
+
 void main() {}