diff --git a/Lib/test/libregrtest/cmdline.py b/Lib/test/libregrtest/cmdline.py
index 608b12bb6f2a38..2cf63330366aed 100644
--- a/Lib/test/libregrtest/cmdline.py
+++ b/Lib/test/libregrtest/cmdline.py
@@ -164,6 +164,7 @@ def __init__(self, **kwargs) -> None:
         self.match_tests: TestFilter = []
         self.pgo = False
         self.pgo_extended = False
+        self.tsan = False
         self.worker_json = None
         self.start = None
         self.timeout = None
@@ -333,6 +334,8 @@ def _create_parser():
                        help='enable Profile Guided Optimization (PGO) training')
     group.add_argument('--pgo-extended', action='store_true',
                        help='enable extended PGO training (slower training)')
+    group.add_argument('--tsan', dest='tsan', action='store_true',
+                       help='enable TSAN test')
     group.add_argument('--fail-env-changed', action='store_true',
                        help='if a test file alters the environment, mark '
                             'the test as failed')
diff --git a/Lib/test/libregrtest/main.py b/Lib/test/libregrtest/main.py
index 126daca388fd7f..28f3c5abd0bc2e 100644
--- a/Lib/test/libregrtest/main.py
+++ b/Lib/test/libregrtest/main.py
@@ -18,6 +18,7 @@
 from .runtests import RunTests, HuntRefleak
 from .setup import setup_process, setup_test_dir
 from .single import run_single_test, PROGRESS_MIN_TIME
+from .tsan import setup_tsan_tests
 from .utils import (
     StrPath, StrJSON, TestName, TestList, TestTuple, TestFilter,
     strip_py_suffix, count, format_duration,
@@ -56,6 +57,7 @@ def __init__(self, ns: Namespace, _add_python_opts: bool = False):
         self.quiet: bool = ns.quiet
         self.pgo: bool = ns.pgo
         self.pgo_extended: bool = ns.pgo_extended
+        self.tsan: bool = ns.tsan
 
         # Test results
         self.results: TestResults = TestResults()
@@ -87,7 +89,11 @@ def __init__(self, ns: Namespace, _add_python_opts: bool = False):
 
         # Workers
         if ns.use_mp is None:
-            num_workers = 0  # run sequentially
+            if ns.tsan:
+                # For TSAN tests, use number of CPU of the current process.
+                num_workers = os.process_cpu_count()
+            else:
+                num_workers = 0  # run sequentially
         elif ns.use_mp <= 0:
             num_workers = -1  # use the number of CPUs
         else:
@@ -183,6 +189,9 @@ def find_tests(self, tests: TestList | None = None) -> tuple[TestTuple, TestList
             # add default PGO tests if no tests are specified
             setup_pgo_tests(self.cmdline_args, self.pgo_extended)
 
+        if self.tsan:
+            setup_tsan_tests(self.cmdline_args)
+
         exclude_tests = set()
         if self.exclude:
             for arg in self.cmdline_args:
diff --git a/Lib/test/libregrtest/tsan.py b/Lib/test/libregrtest/tsan.py
new file mode 100644
index 00000000000000..53c7957b5efed2
--- /dev/null
+++ b/Lib/test/libregrtest/tsan.py
@@ -0,0 +1,43 @@
+# Set of tests run by default if --tsan is specified.  The tests below were
+# chosen to run a thread sanitizer in a reasonable executable time.
+
+TSAN_TESTS = [
+    'test_asyncio',
+    'test_capi',
+    'test_code',
+    'test_compilerall',
+    'test_concurrent_futures',
+    'test_enum',
+    'test_fork1',
+    'test_functools',
+    'test_httpservers',
+    'test_imaplib',
+    'test_import',
+    'test_importlib',
+    'test_io',
+    'test_logging',
+    'test_multiprocessing_forkserver',
+    'test_multiprocessing_spawn',
+    'test_pickle',
+    'test_queue',
+    'test_list',
+    'test_dict',
+    'test_set',
+    'test_tuple',
+    'test_smtpnet',
+    'test_socketserver',
+    'test_ssl',
+    'test_syslog',
+    'test_thread',
+    'test_threadedtempfile',
+    'test_threading',
+    'test_threading_local',
+    'test_threadsignals',
+    'test_urllib2net',
+    'test_weakref'
+]
+
+
+def setup_tsan_tests(cmdline_args):
+    if not cmdline_args:
+        cmdline_args[:] = TSAN_TESTS[:]
diff --git a/Tools/tsan/supressions.txt b/Tools/tsan/supressions.txt
new file mode 100644
index 00000000000000..b70dcc30d3aaf5
--- /dev/null
+++ b/Tools/tsan/supressions.txt
@@ -0,0 +1,3 @@
+## reference: https://github.com/google/sanitizers/wiki/ThreadSanitizerSuppressions
+race:get_allocator_unlocked
+race:set_allocator_unlocked