diff --git a/recipe/gen_patch_json.py b/recipe/gen_patch_json.py
index fd11fa2af..10a1a1d1f 100644
--- a/recipe/gen_patch_json.py
+++ b/recipe/gen_patch_json.py
@@ -1805,6 +1805,13 @@ def _gen_new_index_per_key(repodata, subdir, index_key):
             pkg_resources.parse_version("2.7.1")):
             if record.get("timestamp", 0) <= 1654360235233:
                 _replace_pin("scipy >=0.14,<1.8.0", "scipy >=0.14", record["depends"], record)
+            if (
+                pkg_resources.parse_version(record["version"]) >=
+                pkg_resources.parse_version("2.5.0") and
+                pkg_resources.parse_version(record["version"]) <=
+                pkg_resources.parse_version("2.7.3")
+            ):
+                _replace_pin('setuptools', 'setuptools !=65.0.*', deps, record)
 
         if record_name == "aesara-base":
             if (
@@ -1814,6 +1821,15 @@ def _gen_new_index_per_key(repodata, subdir, index_key):
                 record["build_number"] == 1 and subdir.startswith("win-")
             ):
                 record["depends"].append("libpython >=2.2")
+            if record["version"] in ["2.7.8", "2.7.9"]:
+                _replace_pin('setuptools >=45.0.0', 'setuptools >=48.0.0,!=65.0.*', deps, record)
+            if (
+                pkg_resources.parse_version(record["version"]) >=
+                pkg_resources.parse_version("2.7.4") and
+                pkg_resources.parse_version(record["version"]) <=
+                pkg_resources.parse_version("2.7.7")
+            ):
+                record["depends"].append("setuptools !=65.0.*")
 
         if record_name == "requests" and (
             pkg_resources.parse_version(record["version"]) >=