diff --git a/ChangeLog.md b/ChangeLog.md
index 238fa566fd..4c77719c10 100644
--- a/ChangeLog.md
+++ b/ChangeLog.md
@@ -174,6 +174,8 @@ Bug fixes:
   See [#4453](https://github.com/commercialhaskell/stack/issues/4453).
 * Extra include and lib dirs are now order-dependent. See
   [#4527](https://github.com/commercialhaskell/stack/issues/4527).
+* Apply GHC options when building a `Setup.hs` file. See
+  [#4526](https://github.com/commercialhaskell/stack/issues/4526).
 
 ## v1.9.3
 
diff --git a/src/Stack/Build/Execute.hs b/src/Stack/Build/Execute.hs
index 9950ab400f..31d72621ea 100644
--- a/src/Stack/Build/Execute.hs
+++ b/src/Stack/Build/Execute.hs
@@ -1246,7 +1246,17 @@ withSingleContext ActionContext {..} ExecuteEnv {..} task@Task {..} mdeps msuffi
                                 ] ++
                                 (case compiler of
                                     Ghc -> []
-                                    Ghcjs -> ["-build-runner"])
+                                    Ghcjs -> ["-build-runner"]) ++
+
+                                -- Apply GHC options
+                                -- https://github.com/commercialhaskell/stack/issues/4526
+                                map T.unpack (
+                                  Map.findWithDefault [] AGOEverything (configGhcOptionsByCat config) ++
+                                  case configApplyGhcOptions config of
+                                    AGOEverything -> boptsCLIGhcOptions eeBuildOptsCLI
+                                    AGOTargets -> []
+                                    AGOLocals -> [])
+
                             liftIO $ atomicModifyIORef' eeCustomBuilt $
                                 \oldCustomBuilt -> (Set.insert (packageName package) oldCustomBuilt, ())
                             return outputFile