diff --git a/pkg/sql/alter_table.go b/pkg/sql/alter_table.go
index 5a465fc44699..4a8e29d1c0c5 100644
--- a/pkg/sql/alter_table.go
+++ b/pkg/sql/alter_table.go
@@ -333,7 +333,7 @@ func (n *alterTableNode) startExec(params runParams) error {
 				return err
 			}
 
-			if err := params.p.dropSequencesOwnedByCol(params.ctx, colToDrop); err != nil {
+			if err := params.p.dropSequencesOwnedByCol(params.ctx, colToDrop, true /* queueJob */); err != nil {
 				return err
 			}
 
diff --git a/pkg/sql/drop_table.go b/pkg/sql/drop_table.go
index 22b616620230..095952992f17 100644
--- a/pkg/sql/drop_table.go
+++ b/pkg/sql/drop_table.go
@@ -291,7 +291,7 @@ func (p *planner) dropTableImpl(
 
 	// Drop sequences that the columns of the table own
 	for _, col := range tableDesc.Columns {
-		if err := p.dropSequencesOwnedByCol(ctx, &col); err != nil {
+		if err := p.dropSequencesOwnedByCol(ctx, &col, queueJob); err != nil {
 			return droppedViews, err
 		}
 	}
@@ -338,7 +338,7 @@ func (p *planner) initiateDropTable(
 	drainName bool,
 ) error {
 	if tableDesc.Dropped() {
-		return fmt.Errorf("table %q is being dropped", tableDesc.Name)
+		return errors.Errorf("table %q is already being dropped", tableDesc.Name)
 	}
 
 	// If the table is not interleaved , use the delayed GC mechanism to
diff --git a/pkg/sql/logictest/testdata/logic_test/sequences b/pkg/sql/logictest/testdata/logic_test/sequences
index 2bf2292603f0..46d72702117f 100644
--- a/pkg/sql/logictest/testdata/logic_test/sequences
+++ b/pkg/sql/logictest/testdata/logic_test/sequences
@@ -1,3 +1,4 @@
+# LogicTest: !3node-tenant(50840)
 # see also files `drop_sequence`, `alter_sequence`, `rename_sequence`
 
 # USING THE `lastval` FUNCTION
@@ -1095,3 +1096,89 @@ DROP SEQUENCE seq_50649
 
 statement ok
 DROP TABLE t_50649
+
+subtest regression_50712
+
+statement ok
+CREATE DATABASE db_50712
+
+statement ok
+CREATE TABLE db_50712.t_50712(a INT PRIMARY KEY)
+
+statement ok
+CREATE SEQUENCE db_50712.seq_50712 OWNED BY db_50712.t_50712.a
+
+statement ok
+DROP DATABASE db_50712 CASCADE
+
+# Same test like above, except the table is lexicographically less than the
+# sequence, which results in drop database dropping the table before the
+# sequence.
+statement ok
+CREATE DATABASE db_50712
+
+statement ok
+CREATE TABLE db_50712.a_50712(a INT PRIMARY KEY)
+
+statement ok
+CREATE SEQUENCE db_50712.seq_50712 OWNED BY db_50712.a_50712.a
+
+statement ok
+DROP DATABASE db_50712 CASCADE
+
+# Same test like above, except the db is switched as the current db
+statement ok
+CREATE DATABASE db_50712
+
+statement ok
+SET DATABASE = db_50712
+
+statement ok
+CREATE TABLE a_50712(a INT PRIMARY KEY)
+
+statement ok
+CREATE SEQUENCE seq_50712 OWNED BY a_50712.a
+
+statement ok
+DROP DATABASE db_50712
+
+statement ok
+SET DATABASE = test
+
+# Tests db drop.
+# Sequence: outside db.
+# Owner: inside db.
+# The sequence should be automatically dropped.
+statement ok
+CREATE DATABASE db_50712
+
+statement ok
+CREATE TABLE db_50712.t_50712(a INT PRIMARY KEY)
+
+statement ok
+CREATE SEQUENCE seq_50712 OWNED BY db_50712.t_50712.a
+
+statement ok
+DROP DATABASE db_50712 CASCADE
+
+statement error pq: relation "seq_50712" does not exist
+SELECT * FROM seq_50712
+
+# Tests db drop.
+# Sequence: inside db
+# Owner: outside db
+# It should be possible to drop the table later.
+statement ok
+CREATE DATABASE db_50712
+
+statement ok
+CREATE TABLE t_50712(a INT PRIMARY KEY)
+
+statement ok
+CREATE SEQUENCE db_50712.seq_50712 OWNED BY t_50712.a
+
+statement ok
+DROP DATABASE db_50712 CASCADE
+
+statement ok
+DROP TABLE t_50712
diff --git a/pkg/sql/sequence.go b/pkg/sql/sequence.go
index 84868b7c40f9..6c86d6c4157a 100644
--- a/pkg/sql/sequence.go
+++ b/pkg/sql/sequence.go
@@ -335,6 +335,11 @@ func removeSequenceOwnerIfExists(
 	if err != nil {
 		return err
 	}
+	// If the table descriptor has already been dropped, there is no need to
+	// remove the reference.
+	if tableDesc.Dropped() {
+		return nil
+	}
 	col, err := tableDesc.FindColumnByID(opts.SequenceOwner.OwnerColumnID)
 	if err != nil {
 		return err
@@ -469,17 +474,21 @@ func maybeAddSequenceDependencies(
 // dropSequencesOwnedByCol drops all the sequences from col.OwnsSequenceIDs.
 // Called when the respective column (or the whole table) is being dropped.
 func (p *planner) dropSequencesOwnedByCol(
-	ctx context.Context, col *sqlbase.ColumnDescriptor,
+	ctx context.Context, col *sqlbase.ColumnDescriptor, queueJob bool,
 ) error {
 	for _, sequenceID := range col.OwnsSequenceIds {
 		seqDesc, err := p.Tables().GetMutableTableVersionByID(ctx, sequenceID, p.txn)
 		if err != nil {
 			return err
 		}
+		// This sequence is already getting dropped. Don't do it twice.
+		if seqDesc.Dropped() {
+			continue
+		}
 		jobDesc := fmt.Sprintf("removing sequence %q dependent on column %q which is being dropped",
 			seqDesc.Name, col.ColName())
 		if err := p.dropSequenceImpl(
-			ctx, seqDesc, true /* queueJob */, jobDesc, tree.DropRestrict,
+			ctx, seqDesc, queueJob, jobDesc, tree.DropRestrict,
 		); err != nil {
 			return err
 		}
diff --git a/pkg/sql/table.go b/pkg/sql/table.go
index 7339ca387bbd..650f34ad7952 100644
--- a/pkg/sql/table.go
+++ b/pkg/sql/table.go
@@ -12,7 +12,6 @@ package sql
 
 import (
 	"context"
-	"fmt"
 	"strings"
 
 	"github.com/cockroachdb/cockroach/pkg/clusterversion"
@@ -209,7 +208,8 @@ func (p *planner) writeSchemaChange(
 	}
 	if tableDesc.Dropped() {
 		// We don't allow schema changes on a dropped table.
-		return fmt.Errorf("table %q is being dropped", tableDesc.Name)
+		return errors.Errorf("no schema changes allowed on table %q as it is being dropped",
+			tableDesc.Name)
 	}
 	if err := p.createOrUpdateSchemaChangeJob(ctx, tableDesc, jobDesc, mutationID); err != nil {
 		return err
@@ -225,7 +225,8 @@ func (p *planner) writeSchemaChangeToBatch(
 	}
 	if tableDesc.Dropped() {
 		// We don't allow schema changes on a dropped table.
-		return fmt.Errorf("table %q is being dropped", tableDesc.Name)
+		return errors.Errorf("no schema changes allowed on table %q as it is being dropped",
+			tableDesc.Name)
 	}
 	return p.writeTableDescToBatch(ctx, tableDesc, b)
 }