diff --git a/pkg/sql/create_table.go b/pkg/sql/create_table.go
index 69954750b5d1..8fafc599f905 100644
--- a/pkg/sql/create_table.go
+++ b/pkg/sql/create_table.go
@@ -39,6 +39,7 @@ import (
 	"github.com/cockroachdb/cockroach/pkg/sql/catalog/resolver"
 	"github.com/cockroachdb/cockroach/pkg/sql/catalog/schemaexpr"
 	"github.com/cockroachdb/cockroach/pkg/sql/catalog/tabledesc"
+	"github.com/cockroachdb/cockroach/pkg/sql/catalog/typedesc"
 	"github.com/cockroachdb/cockroach/pkg/sql/paramparse"
 	"github.com/cockroachdb/cockroach/pkg/sql/parser"
 	"github.com/cockroachdb/cockroach/pkg/sql/pgwire/pgcode"
@@ -1223,6 +1224,27 @@ func newTableDescIfAs(
 		}
 	}
 
+	// Check if there is any reference to a user defined type that belongs to
+	// another database which is not allowed.
+	for _, def := range p.Defs {
+		if d, ok := def.(*tree.ColumnTableDef); ok {
+			// In CTAS, ColumnTableDef are generated from resultColumns which are
+			// resolved already. So we may cast it to *types.T directly without
+			// resolving it again.
+			typ := d.Type.(*types.T)
+			if typ.UserDefined() {
+				tn, typDesc, err := params.p.GetTypeDescriptor(params.ctx, typedesc.UserDefinedTypeOIDToID(typ.Oid()))
+				if err != nil {
+					return nil, err
+				}
+				if typDesc.GetParentID() != db.GetID() {
+					return nil, pgerror.Newf(
+						pgcode.FeatureNotSupported, "cross database type references are not supported: %s", tn.String())
+				}
+			}
+		}
+	}
+
 	desc, err = newTableDesc(
 		params,
 		p,
diff --git a/pkg/sql/logictest/testdata/logic_test/create_as b/pkg/sql/logictest/testdata/logic_test/create_as
index 2aeb3b033081..6c74254bea15 100644
--- a/pkg/sql/logictest/testdata/logic_test/create_as
+++ b/pkg/sql/logictest/testdata/logic_test/create_as
@@ -382,3 +382,29 @@ query I
 SELECT * FROM tab_from_seq
 ----
 2
+
+# Regression test for #105393
+subtest regression_105393
+
+statement ok
+CREATE DATABASE db105393_1;
+CREATE DATABASE db105393_2;
+USE db105393_1;
+CREATE TYPE e105393 AS ENUM ('a');
+CREATE TABLE t105393 (a INT PRIMARY KEY, b e105393);
+USE db105393_2;
+
+statement error pq: cross database type references are not supported: db105393_1.public.e105393
+CREATE TABLE e105393 AS TABLE db105393_1.public.t105393;
+
+statement error pq: cross database type references are not supported: db105393_1.public.e105393
+CREATE TABLE e105393 AS SELECT * FROM db105393_1.public.t105393;
+
+statement error pq: cross database type references are not supported: db105393_1.public.e105393
+CREATE TABLE e105393 AS SELECT b FROM db105393_1.public.t105393;
+
+statement error pq: cross database type references are not supported: db105393_1.public.e105393
+CREATE TABLE e105393 (a PRIMARY KEY, b) AS TABLE db105393_1.public.t105393;
+
+statement error pq: cross database type references are not supported: db105393_1.public.e105393
+CREATE TABLE e105393 (b) AS SELECT b FROM db105393_1.public.t105393;