diff --git a/pkg/sql/drop_sequence.go b/pkg/sql/drop_sequence.go
index d25c976310e9..506d452fbffa 100644
--- a/pkg/sql/drop_sequence.go
+++ b/pkg/sql/drop_sequence.go
@@ -107,6 +107,9 @@ func (p *planner) dropSequenceImpl(
 	jobDesc string,
 	behavior tree.DropBehavior,
 ) error {
+	if err := removeSequenceOwnerIfExists(ctx, p, seqDesc.ID, seqDesc.GetSequenceOpts()); err != nil {
+		return err
+	}
 	return p.initiateDropTable(ctx, seqDesc, queueJob, jobDesc, true /* drainName */)
 }
 
diff --git a/pkg/sql/logictest/testdata/logic_test/sequences b/pkg/sql/logictest/testdata/logic_test/sequences
index f503ff0b1c29..2bf2292603f0 100644
--- a/pkg/sql/logictest/testdata/logic_test/sequences
+++ b/pkg/sql/logictest/testdata/logic_test/sequences
@@ -1081,3 +1081,17 @@ CREATE TABLE c(a INT DEFAULT(currval('currval_dep_test')))
 
 statement error pq: cannot drop sequence currval_dep_test because other objects depend on it
 DROP SEQUENCE currval_dep_test
+
+subtest regression_50649
+
+statement ok
+CREATE TABLE t_50649(a INT PRIMARY KEY)
+
+statement ok
+CREATE SEQUENCE seq_50649 OWNED BY t_50649.a
+
+statement ok
+DROP SEQUENCE seq_50649
+
+statement ok
+DROP TABLE t_50649