diff --git a/pkg/ccl/backupccl/restore_planning.go b/pkg/ccl/backupccl/restore_planning.go
index e70644201a5f..49544afd1285 100644
--- a/pkg/ccl/backupccl/restore_planning.go
+++ b/pkg/ccl/backupccl/restore_planning.go
@@ -546,17 +546,30 @@ func allocateDescriptorRewrites(
 				}
 
 				// Check privileges.
-				{
-					parentDB, err := catalogkv.MustGetDatabaseDescByID(ctx, txn, p.ExecCfg().Codec, parentID)
-					if err != nil {
-						return errors.Wrapf(err,
-							"failed to lookup parent DB %d", errors.Safe(parentID))
-					}
+				parentDB, err := catalogkv.MustGetDatabaseDescByID(ctx, txn, p.ExecCfg().Codec, parentID)
+				if err != nil {
+					return errors.Wrapf(err,
+						"failed to lookup parent DB %d", errors.Safe(parentID))
+				}
+				if err := p.CheckPrivilege(ctx, parentDB, privilege.CREATE); err != nil {
+					return err
+				}
 
-					if err := p.CheckPrivilege(ctx, parentDB, privilege.CREATE); err != nil {
-						return err
-					}
+				// We're restoring a table and not its parent database.  If the
+				// new database we're placing the table in is a multi-region database,
+				// block the restore. We do this because we currently have no way to
+				// modify this table and make it multi-region friendly. Long-term we'd
+				// want to modify the table so that it can exist in the multi-region
+				// database.
+				// https://github.com/cockroachdb/cockroach/issues/59804
+				if parentDB.GetRegionConfig() != nil {
+					return pgerror.Newf(pgcode.FeatureNotSupported,
+						"cannot restore individual table %d into multi-region database %d",
+						table.GetID(),
+						parentDB.GetID(),
+					)
 				}
+
 				// Create the table rewrite with the new parent ID. We've done all the
 				// up-front validation that we can.
 				descriptorRewrites[table.ID] = &jobspb.RestoreDetails_DescriptorRewrite{ParentID: parentID}
diff --git a/pkg/ccl/logictestccl/testdata/logic_test/multi_region_backup b/pkg/ccl/logictestccl/testdata/logic_test/multi_region_backup
index f9a5f80e5561..31d03aff6741 100644
--- a/pkg/ccl/logictestccl/testdata/logic_test/multi_region_backup
+++ b/pkg/ccl/logictestccl/testdata/logic_test/multi_region_backup
@@ -969,3 +969,16 @@ BACKUP TABLE regional_by_table_in_ca_central_1 TO 'nodelocal://1/rbr_table/';
 
 statement error cannot backup individual table
 BACKUP TABLE global_table TO 'nodelocal://1/rbr_table/';
+
+statement ok
+CREATE DATABASE non_mr_backup;
+USE non_mr_backup
+
+statement ok
+CREATE TABLE non_mr_table (i int)
+
+statement ok
+BACKUP TABLE non_mr_table TO 'nodelocal://1/non_mr_table/'
+
+statement error cannot restore individual table
+RESTORE TABLE non_mr_table FROM 'nodelocal://1/non_mr_table/' WITH into_db = 'mr-backup-1'