diff --git a/pkg/sql/conn_executor_exec.go b/pkg/sql/conn_executor_exec.go
index 97afdc251c4c..8086d12fcb71 100644
--- a/pkg/sql/conn_executor_exec.go
+++ b/pkg/sql/conn_executor_exec.go
@@ -1473,7 +1473,7 @@ func (ex *connExecutor) dispatchToExecutionEngine(
 	var err error
 	if ppInfo := getPausablePortalInfo(); ppInfo != nil {
 		if !ppInfo.dispatchToExecutionEngine.cleanup.isComplete {
-			err = ex.makeExecPlan(ctx, planner)
+			err = ex.makeExecPlan(ctx, planner, res)
 			ppInfo.dispatchToExecutionEngine.planTop = planner.curPlan
 			ppInfo.dispatchToExecutionEngine.cleanup.appendFunc(namedFunc{
 				fName: "close planTop",
@@ -1485,7 +1485,7 @@ func (ex *connExecutor) dispatchToExecutionEngine(
 	} else {
 		// Prepare the plan. Note, the error is processed below. Everything
 		// between here and there needs to happen even if there's an error.
-		err = ex.makeExecPlan(ctx, planner)
+		err = ex.makeExecPlan(ctx, planner, res)
 		defer planner.curPlan.close(ctx)
 	}
 
@@ -1978,7 +1978,7 @@ func (ex *connExecutor) handleTxnRowsWrittenReadLimits(ctx context.Context) erro
 
 // makeExecPlan creates an execution plan and populates planner.curPlan using
 // the cost-based optimizer.
-func (ex *connExecutor) makeExecPlan(ctx context.Context, planner *planner) error {
+func (ex *connExecutor) makeExecPlan(ctx context.Context, planner *planner, res RestrictedCommandResult) error {
 	if tree.CanModifySchema(planner.stmt.AST) {
 		if planner.Txn().IsoLevel().ToleratesWriteSkew() {
 			if planner.extendedEvalCtx.TxnIsSingleStmt && planner.extendedEvalCtx.TxnImplicit {
@@ -2001,6 +2001,21 @@ func (ex *connExecutor) makeExecPlan(ctx context.Context, planner *planner) erro
 
 	flags := planner.curPlan.flags
 
+	if flags.IsSet(planFlagContainsMutation) && planner.pausablePortal != nil {
+		telemetry.Inc(sqltelemetry.NotReadOnlyStmtsTriedWithPausablePortals)
+		// We don't allow mutations in a pausable portal. Set it back to an
+		// un-pausable (normal) portal.
+		// With pauseInfo is nil, no cleanup function will be added to the stack
+		// and all clean-up steps will be performed as for normal portals.
+		planner.pausablePortal.pauseInfo = nil
+		// We need this so that the result consumption for this portal cannot be
+		// paused either.
+		if err := res.RevokePortalPausability(); err != nil {
+			res.SetError(err)
+			return nil
+		}
+	}
+
 	if flags.IsSet(planFlagContainsFullIndexScan) || flags.IsSet(planFlagContainsFullTableScan) {
 		if ex.executorType == executorTypeExec && planner.EvalContext().SessionData().DisallowFullTableScans {
 			hasLargeScan := flags.IsSet(planFlagContainsLargeFullIndexScan) || flags.IsSet(planFlagContainsLargeFullTableScan)
diff --git a/pkg/sql/pgwire/testdata/pgtest/portals_crbugs b/pkg/sql/pgwire/testdata/pgtest/portals_crbugs
index 8c682a98e330..7928f5b58513 100644
--- a/pkg/sql/pgwire/testdata/pgtest/portals_crbugs
+++ b/pkg/sql/pgwire/testdata/pgtest/portals_crbugs
@@ -301,4 +301,72 @@ ReadyForQuery
 {"Type":"ReadyForQuery","TxStatus":"I"}
 
 
+subtest end
+
+subtest functions_not_supported
+
+# We don't support UDFs in pausable portals since we don't allow mutations, and
+# UDFs may contain mutations. The following test results in a duplicate key
+# violation in postgres.
+
+send
+Query {"String": "SET multiple_active_portals_enabled = true"}
+----
+
+send
+Query {"String": "DROP TABLE IF EXISTS xy;"}
+Query {"String": "DROP FUNCTION IF EXISTS f;"}
+Query {"String": "DROP FUNCTION IF EXISTS g;"}
+Query {"String": "DEALLOCATE ALL;"}
+Query {"String": "CREATE TABLE xy (x INT PRIMARY KEY, y INT);"}
+Query {"String": "CREATE FUNCTION f() RETURNS SETOF RECORD LANGUAGE SQL AS $$ INSERT INTO xy VALUES (1, 1), (2, 2) RETURNING *; $$"}
+Query {"String": "CREATE FUNCTION g() RETURNS SETOF RECORD LANGUAGE SQL AS $$ INSERT INTO xy VALUES (2, 1), (3, 3) RETURNING *; $$"}
+Parse {"Name": "q1", "Query": "SELECT f();"}
+Parse {"Name": "q2", "Query": "SELECT g();"}
+Bind {"DestinationPortal": "p1", "PreparedStatement": "q1"}
+Bind {"DestinationPortal": "p2", "PreparedStatement": "q2"}
+Execute {"Portal": "p1", "MaxRows": 1}
+Execute {"Portal": "p2", "MaxRows": 1}
+Execute {"Portal": "p1", "MaxRows": 1}
+Execute {"Portal": "p2", "MaxRows": 1}
+Sync
+----
+
+until keepErrMessage
+ReadyForQuery
+ReadyForQuery
+ReadyForQuery
+ReadyForQuery
+ReadyForQuery
+ReadyForQuery
+ReadyForQuery
+ReadyForQuery
+ReadyForQuery
+ErrorResponse
+----
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"SET"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"DROP TABLE"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"DROP FUNCTION"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"DROP FUNCTION"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"DEALLOCATE ALL"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"CREATE TABLE"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"CREATE FUNCTION"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"CommandComplete","CommandTag":"CREATE FUNCTION"}
+{"Type":"ReadyForQuery","TxStatus":"I"}
+{"Type":"ParseComplete"}
+{"Type":"ParseComplete"}
+{"Type":"BindComplete"}
+{"Type":"BindComplete"}
+{"Type":"DataRow","Values":[{"text":"(1,1)"}]}
+{"Type":"PortalSuspended"}
+{"Type":"ErrorResponse","Code":"0A000","Message":"unimplemented: the statement for a pausable portal must be a read-only SELECT query with no sub-queries or post-queries","Detail":"cannot execute a portal while a different one is open","Hint":"You have attempted to use a feature that is not yet implemented.\nSee: https://go.crdb.dev/issue-v/98911/v23.2"}
+
 subtest end