diff --git a/pkg/cmd/roachtest/tests/registry.go b/pkg/cmd/roachtest/tests/registry.go
index 6a360326a1f2..69e03f9fc9e4 100644
--- a/pkg/cmd/roachtest/tests/registry.go
+++ b/pkg/cmd/roachtest/tests/registry.go
@@ -99,6 +99,7 @@ func RegisterTests(r registry.Registry) {
 	registerSequelize(r)
 	registerSQLAlchemy(r)
 	registerSQLSmith(r)
+	registerSSTableCorruption(r)
 	registerSyncTest(r)
 	registerSysbench(r)
 	registerTLP(r)
diff --git a/pkg/cmd/roachtest/tests/sstable_corruption.go b/pkg/cmd/roachtest/tests/sstable_corruption.go
new file mode 100644
index 000000000000..06d640e95b94
--- /dev/null
+++ b/pkg/cmd/roachtest/tests/sstable_corruption.go
@@ -0,0 +1,111 @@
+// Copyright 2021 The Cockroach Authors.
+//
+// Use of this software is governed by the Business Source License
+// included in the file licenses/BSL.txt.
+//
+// As of the Change Date specified in that file, in accordance with
+// the Business Source License, use of this software will be governed
+// by the Apache License, Version 2.0, included in the file
+// licenses/APL.txt.
+
+package tests
+
+import (
+	"context"
+	"fmt"
+	"strconv"
+	"strings"
+	"time"
+
+	"github.com/cockroachdb/cockroach/pkg/cmd/roachtest/cluster"
+	"github.com/cockroachdb/cockroach/pkg/cmd/roachtest/registry"
+	"github.com/cockroachdb/cockroach/pkg/cmd/roachtest/test"
+	"github.com/stretchr/testify/require"
+)
+
+func runSSTableCorruption(ctx context.Context, t test.Test, c cluster.Cluster) {
+	crdbNodes := c.Range(1, c.Spec().NodeCount)
+	workloadNode := c.Node(1)
+	const corruptNode = 3
+
+	t.Status("installing cockroach")
+	c.Put(ctx, t.Cockroach(), "./cockroach", crdbNodes)
+	c.Start(ctx, crdbNodes)
+
+	{
+		m := c.NewMonitor(ctx, crdbNodes)
+
+		m.Go(func(ctx context.Context) error {
+			// We don't really need tpcc, we just need a good amount of data. Enough
+			// to have multiple ranges, and some sstables with only table keys.
+			t.Status("importing tpcc fixture")
+			c.Run(ctx, workloadNode,
+				"./cockroach workload fixtures import tpcc --warehouses=100 --fks=false --checks=false")
+			return nil
+		})
+		m.Wait()
+	}
+
+	c.Stop(ctx, crdbNodes)
+
+	tableSSTs, err := c.RunWithBuffer(ctx, t.L(), c.Node(corruptNode),
+		"./cockroach debug pebble manifest dump {store-dir}/MANIFEST-* | grep -v added | grep -v deleted | grep \"\\[/Table\"")
+	if err != nil {
+		t.Fatal(err)
+	}
+	strTableSSTs := strings.Split(string(tableSSTs), "\n")
+	if len(strTableSSTs) == 0 {
+		t.Fatal("expected at least one sst containing table keys only, got none")
+	}
+	// Corrupt up to 6 SSTs containing table keys.
+	corruptedFiles := 0
+	for _, sstLine := range strTableSSTs {
+		sstLine = strings.TrimSpace(sstLine)
+		firstFileIdx := strings.Index(sstLine, ":")
+		_, err = strconv.Atoi(sstLine[:firstFileIdx])
+		if err != nil {
+			t.Fatal("error when converting %s to int: %s", sstLine[:firstFileIdx], err.Error())
+		}
+
+		t.Status(fmt.Sprintf("corrupting sstable %s on node %d", sstLine[:firstFileIdx], corruptNode))
+		c.Run(ctx, c.Node(corruptNode), fmt.Sprintf("dd if=/dev/urandom of={store-dir}/%s.sst seek=256 count=128 bs=1 conv=notrunc", sstLine[:firstFileIdx]))
+		corruptedFiles++
+		if corruptedFiles >= 6 {
+			break
+		}
+	}
+
+	if err := c.StartE(ctx, crdbNodes); err != nil {
+		// Node detected corruption on start and crashed. This is good. No need
+		// to run workload; the test is complete.
+		return
+	}
+
+	{
+		m := c.NewMonitor(ctx)
+		// Run a workload to try to get the node to notice corruption and crash.
+		m.Go(func(ctx context.Context) error {
+			_ = c.RunE(ctx, workloadNode,
+				fmt.Sprintf("./cockroach workload run tpcc --warehouses=100 --tolerate-errors --duration=%s", 2*time.Minute))
+			// Don't return an error from the workload. We want outcome of WaitE to be
+			// determined by the monitor noticing that a node died. The workload may
+			// also fail, despite --tolerate-errors, if a node crashes too early.
+			return nil
+		})
+		require.Error(t, m.WaitE())
+	}
+
+	// Exempt corrupted node from roachtest harness' post-test liveness checks.
+	_ = c.WipeE(ctx, t.L(), c.Node(corruptNode))
+}
+
+func registerSSTableCorruption(r registry.Registry) {
+	r.Add(registry.TestSpec{
+		Name:    "sstable-corruption/table",
+		Owner:   registry.OwnerStorage,
+		Cluster: r.MakeClusterSpec(3),
+		Run: func(ctx context.Context, t test.Test, c cluster.Cluster) {
+			runSSTableCorruption(ctx, t, c)
+		},
+	})
+}