Cov19Expression

Covid-19 Gene Expression Working Group

Hackathon team: gene expression analysis for Covid-19 Virtual Biohackathon (vBH)

Link to vBH Github

https://github.com/virtual-biohackathons/covid-19-bh20

Official Gene Expression Work Group Page

https://github.com/virtual-biohackathons/covid-19-bh20/wiki/GeneExpression

Main Objective

As part of the virtual BioHackathon 2020, we formed a working group that focused on the analysis of gene expression in the context of COVID-19. More specifically, we performed transcriptome analyses on published datasets in order to better understand the interaction between the human host and the SARS-CoV-2 virus.

Fig. 1. Project structure and interaction. Project 1 and 2 along with literature research will provide a list of candidate genes for Project 3 and 4 that will take into account external factors (comorbidities, and potential drug treatments). All data analyzed during this project are fully available to the medical community and meet the FAIR principles. Finally, Project 5 allows the efforts of all of the previous projects to be clearly detailed into workflows for increased reproducibility.

Deliverables

Biological: Perform a global RNA-Seq analysis with SARS-CoV-2 infected datasets to search for new candidate genes for testing experimentally