diff --git a/packages/react-resizable-panels/src/utils/computePercentagePanelConstraints.test.ts b/packages/react-resizable-panels/src/utils/computePercentagePanelConstraints.test.ts
index 8be84c2c4..0c8d485e6 100644
--- a/packages/react-resizable-panels/src/utils/computePercentagePanelConstraints.test.ts
+++ b/packages/react-resizable-panels/src/utils/computePercentagePanelConstraints.test.ts
@@ -68,4 +68,31 @@ describe("computePercentagePanelConstraints", () => {
 }
 `);
   });
+
+  it("should compute reasonable percentage based constraints from pixels if group size is negative", () => {
+    jest.spyOn(console, "warn").mockImplementation(() => {});
+
+    expect(
+      computePercentagePanelConstraints(
+        [
+          {
+            minSizePixels: 25,
+            maxSizePixels: 100,
+          },
+        ],
+
+        0,
+        -100
+      )
+    ).toMatchInlineSnapshot(`
+{
+  "collapsedSizePercentage": 0,
+  "defaultSizePercentage": undefined,
+  "maxSizePercentage": 0,
+  "minSizePercentage": 0,
+}
+`);
+
+    expect(console.warn).toHaveBeenCalledTimes(1);
+  });
 });
diff --git a/packages/react-resizable-panels/src/utils/convertPixelConstraintsToPercentages.test.ts b/packages/react-resizable-panels/src/utils/convertPixelConstraintsToPercentages.test.ts
new file mode 100644
index 000000000..1065e577c
--- /dev/null
+++ b/packages/react-resizable-panels/src/utils/convertPixelConstraintsToPercentages.test.ts
@@ -0,0 +1,47 @@
+import { convertPixelConstraintsToPercentages } from "./convertPixelConstraintsToPercentages";
+
+describe("convertPixelConstraintsToPercentages", () => {
+  it("should respect percentage panel constraints if group size is negative", () => {
+    jest.spyOn(console, "warn").mockImplementation(() => {});
+
+    expect(
+      convertPixelConstraintsToPercentages(
+        {
+          minSizePercentage: 25,
+          defaultSizePercentage: 50,
+          maxSizePercentage: 75,
+        },
+        -100
+      )
+    ).toEqual({
+      collapsedSizePercentage: 0,
+      defaultSizePercentage: 50,
+      maxSizePercentage: 75,
+      minSizePercentage: 25,
+    });
+
+    expect(console.warn).toHaveBeenCalledTimes(0);
+  });
+
+  // Edge case test (issues/206)
+  it("should ignore pixel panel constraints if group size is negative", () => {
+    jest.spyOn(console, "warn").mockImplementation(() => {});
+
+    expect(
+      convertPixelConstraintsToPercentages(
+        {
+          minSizePixels: 25,
+          maxSizePixels: 75,
+        },
+        -100
+      )
+    ).toEqual({
+      collapsedSizePercentage: 0,
+      defaultSizePercentage: undefined,
+      maxSizePercentage: 0,
+      minSizePercentage: 0,
+    });
+
+    expect(console.warn).toHaveBeenCalledTimes(1);
+  });
+});
diff --git a/packages/react-resizable-panels/src/utils/convertPixelConstraintsToPercentages.ts b/packages/react-resizable-panels/src/utils/convertPixelConstraintsToPercentages.ts
index d4348f3ff..ce682370b 100644
--- a/packages/react-resizable-panels/src/utils/convertPixelConstraintsToPercentages.ts
+++ b/packages/react-resizable-panels/src/utils/convertPixelConstraintsToPercentages.ts
@@ -21,6 +21,23 @@ export function convertPixelConstraintsToPercentages(
     minSizePixels,
   } = panelConstraints;
 
+  const hasPixelConstraints =
+    collapsedSizePixels != null ||
+    defaultSizePixels != null ||
+    minSizePixels != null ||
+    maxSizePixels != null;
+
+  if (hasPixelConstraints && groupSizePixels <= 0) {
+    console.warn(`WARNING: Invalid group size: ${groupSizePixels}px`);
+
+    return {
+      collapsedSizePercentage: 0,
+      defaultSizePercentage,
+      maxSizePercentage: 0,
+      minSizePercentage: 0,
+    };
+  }
+
   if (collapsedSizePixels != null) {
     collapsedSizePercentage = convertPixelsToPercentage(
       collapsedSizePixels,
diff --git a/packages/react-resizable-panels/src/utils/resizePanel.test.ts b/packages/react-resizable-panels/src/utils/resizePanel.test.ts
new file mode 100644
index 000000000..907a0c21e
--- /dev/null
+++ b/packages/react-resizable-panels/src/utils/resizePanel.test.ts
@@ -0,0 +1,45 @@
+import { resizePanel } from "./resizePanel";
+
+describe("resizePanel", () => {
+  // Edge case test (issues/206)
+  fit("should respect percentage panel constraints if group size is negative", () => {
+    jest.spyOn(console, "warn").mockImplementation(() => {});
+
+    expect(
+      resizePanel({
+        groupSizePixels: -100,
+        panelConstraints: [
+          {
+            minSizePercentage: 25,
+            maxSizePercentage: 75,
+          },
+        ],
+        panelIndex: 0,
+        size: 50,
+      })
+    ).toBe(50);
+
+    expect(console.warn).toHaveBeenCalledTimes(0);
+  });
+
+  // Edge case test (issues/206)
+  it("should handle pixel panel constraints if group size is negative", () => {
+    jest.spyOn(console, "warn").mockImplementation(() => {});
+
+    expect(
+      resizePanel({
+        groupSizePixels: -100,
+        panelConstraints: [
+          {
+            minSizePixels: 25,
+            maxSizePixels: 75,
+          },
+        ],
+        panelIndex: 0,
+        size: 50,
+      })
+    ).toBe(0);
+
+    expect(console.warn).toHaveBeenCalledTimes(1);
+  });
+});
diff --git a/packages/react-resizable-panels/src/utils/resizePanel.ts b/packages/react-resizable-panels/src/utils/resizePanel.ts
index c8bc51789..2d526cb59 100644
--- a/packages/react-resizable-panels/src/utils/resizePanel.ts
+++ b/packages/react-resizable-panels/src/utils/resizePanel.ts
@@ -5,7 +5,7 @@ import { fuzzyCompareNumbers } from "./numbers/fuzzyCompareNumbers";
 // Panel size must be in percentages; pixel values should be pre-converted
 export function resizePanel({
   groupSizePixels,
-  panelConstraints,
+  panelConstraints: panelConstraintsArray,
   panelIndex,
   size,
 }: {
@@ -14,14 +14,39 @@ export function resizePanel({
   panelIndex: number;
   size: number;
 }) {
-  let { collapsible } = panelConstraints[panelIndex]!;
-
-  const { collapsedSizePercentage, maxSizePercentage, minSizePercentage } =
-    computePercentagePanelConstraints(
-      panelConstraints,
-      panelIndex,
-      groupSizePixels
-    );
+  const hasPixelConstraints = panelConstraintsArray.some(
+    ({
+      collapsedSizePixels,
+      defaultSizePixels,
+      minSizePixels,
+      maxSizePixels,
+    }) =>
+      collapsedSizePixels != null ||
+      defaultSizePixels != null ||
+      minSizePixels != null ||
+      maxSizePixels != null
+  );
+
+  if (hasPixelConstraints && groupSizePixels <= 0) {
+    console.warn(`WARNING: Invalid group size: ${groupSizePixels}px`);
+
+    return 0;
+  }
+
+  const panelConstraints = panelConstraintsArray[panelIndex]!;
+  let { collapsible } = panelConstraints;
+
+  const {
+    collapsedSizePercentage = 0,
+    maxSizePercentage,
+    minSizePercentage,
+  } = hasPixelConstraints
+    ? computePercentagePanelConstraints(
+        panelConstraintsArray,
+        panelIndex,
+        groupSizePixels
+      )
+    : panelConstraints;
 
   if (minSizePercentage != null) {
     if (fuzzyCompareNumbers(size, minSizePercentage) < 0) {