diff --git a/browser/ipfs/test/ipns_keys_manager_browsertest.cc b/browser/ipfs/test/ipns_keys_manager_browsertest.cc
index 3acb7e789308..abe07251f27a 100644
--- a/browser/ipfs/test/ipns_keys_manager_browsertest.cc
+++ b/browser/ipfs/test/ipns_keys_manager_browsertest.cc
@@ -18,6 +18,7 @@
 #include "chrome/test/base/ui_test_utils.h"
 #include "components/network_session_configurator/common/network_switches.h"
 #include "content/public/test/browser_test.h"
+#include "net/base/net_errors.h"
 #include "net/test/embedded_test_server/http_request.h"
 #include "net/test/embedded_test_server/http_response.h"
 
@@ -229,4 +230,18 @@ IN_PROC_BROWSER_TEST_F(IpnsManagerBrowserTest, ImportKey) {
   run_loop.Run();
 }
 
+IN_PROC_BROWSER_TEST_F(IpnsManagerBrowserTest, LoadKeysRetry) {
+  base::RunLoop run_loop;
+  auto* ipns_manager = ipfs_service()->GetIpnsKeysManager();
+  ipns_manager->LoadKeys(base::BindOnce(
+      [](base::OnceCallback<void(void)> launch_callback, const bool success) {
+        ASSERT_FALSE(success);
+        if (launch_callback)
+          std::move(launch_callback).Run();
+      },
+      run_loop.QuitClosure()));
+  run_loop.Run();
+  EXPECT_EQ(ipns_manager->GetLastLoadRetryForTest(), 0);
+}
+
 }  // namespace ipfs
diff --git a/components/ipfs/keys/ipns_keys_manager.cc b/components/ipfs/keys/ipns_keys_manager.cc
index dde0125e3ebd..fc2d01679644 100644
--- a/components/ipfs/keys/ipns_keys_manager.cc
+++ b/components/ipfs/keys/ipns_keys_manager.cc
@@ -9,6 +9,7 @@
 #include <string>
 #include <utility>
 
+#include "base/rand_util.h"
 #include "base/task/post_task.h"
 #include "base/task/thread_pool.h"
 #include "brave/components/ipfs/blob_context_getter_factory.h"
@@ -26,6 +27,29 @@
 #include "storage/browser/blob/blob_data_builder.h"
 #include "storage/browser/blob/blob_data_handle.h"
 
+namespace {
+
+// Retry after some time If local node responded with error.
+// The keys are often called immediately after startup
+// and node initialization may take some time.
+constexpr int kDefaultRetries = 5;
+
+// Used to retry requests if we got error from ipfs node,
+// it may fail requests sometimes right after launch,
+// Actual value will be generated randomly in range
+// (kMinimalRequestRetryIntervalMs,
+//  kRequetsRetryRate*kMinimalRequestRetryIntervalMs)
+const int kMinimalRequestRetryIntervalMs = 350;
+const int kRequetsRetryRate = 3;
+
+base::TimeDelta CalculateKeysRetryTime() {
+  return base::TimeDelta::FromMilliseconds(
+      base::RandInt(kMinimalRequestRetryIntervalMs,
+                    kRequetsRetryRate * kMinimalRequestRetryIntervalMs));
+}
+
+}  // namespace
+
 namespace ipfs {
 
 IpnsKeysManager::IpnsKeysManager(
@@ -164,13 +188,17 @@ void IpnsKeysManager::LoadKeys(LoadKeysCallback callback) {
   if (callback)
     pending_load_callbacks_.push(std::move(callback));
 
+  LoadKeysInternal(kDefaultRetries);
+}
+
+void IpnsKeysManager::LoadKeysInternal(int retries) {
   auto url_loader =
       CreateURLLoader(server_endpoint_.Resolve(kAPIKeyListEndpoint), "POST");
   auto iter = url_loaders_.insert(url_loaders_.begin(), std::move(url_loader));
-
   iter->get()->DownloadToStringOfUnboundedSizeUntilCrashAndDie(
-      url_loader_factory_, base::BindOnce(&IpnsKeysManager::OnKeysLoaded,
-                                          weak_factory_.GetWeakPtr(), iter));
+      url_loader_factory_,
+      base::BindOnce(&IpnsKeysManager::OnKeysLoaded, weak_factory_.GetWeakPtr(),
+                     iter, retries));
 }
 
 void IpnsKeysManager::UploadData(
@@ -226,6 +254,7 @@ void IpnsKeysManager::OnIpfsShutdown() {
 }
 
 void IpnsKeysManager::OnKeysLoaded(SimpleURLLoaderList::iterator iter,
+                                   int retry_number,
                                    std::unique_ptr<std::string> response_body) {
   auto* url_loader = iter->get();
   int error_code = url_loader->NetError();
@@ -233,6 +262,15 @@ void IpnsKeysManager::OnKeysLoaded(SimpleURLLoaderList::iterator iter,
   if (url_loader->ResponseInfo() && url_loader->ResponseInfo()->headers)
     response_code = url_loader->ResponseInfo()->headers->response_code();
   url_loaders_.erase(iter);
+  last_load_retry_value_for_test_ = retry_number;
+  if (error_code == net::ERR_CONNECTION_REFUSED && retry_number) {
+    base::SequencedTaskRunnerHandle::Get()->PostDelayedTask(
+        FROM_HERE,
+        base::BindOnce(&IpnsKeysManager::LoadKeysInternal,
+                       weak_factory_.GetWeakPtr(), retry_number - 1),
+        CalculateKeysRetryTime());
+    return;
+  }
 
   bool success = (error_code == net::OK && response_code == net::HTTP_OK);
   std::unordered_map<std::string, std::string> new_keys;
@@ -247,6 +285,10 @@ void IpnsKeysManager::OnKeysLoaded(SimpleURLLoaderList::iterator iter,
   NotifyKeysLoaded(success);
 }
 
+int IpnsKeysManager::GetLastLoadRetryForTest() const {
+  return last_load_retry_value_for_test_;
+}
+
 void IpnsKeysManager::SetLoadCallbackForTest(LoadKeysCallback callback) {
   if (callback)
     pending_load_callbacks_.push(std::move(callback));
diff --git a/components/ipfs/keys/ipns_keys_manager.h b/components/ipfs/keys/ipns_keys_manager.h
index 23fc3ca97463..5fc4c67f9c58 100644
--- a/components/ipfs/keys/ipns_keys_manager.h
+++ b/components/ipfs/keys/ipns_keys_manager.h
@@ -62,6 +62,7 @@ class IpnsKeysManager : public IpfsServiceObserver {
                  ImportKeyCallback callback);
   void SetServerEndpointForTest(const GURL& gurl);
   void SetLoadCallbackForTest(LoadKeysCallback callback);
+  int GetLastLoadRetryForTest() const;
 
  private:
   using SimpleURLLoaderList =
@@ -81,14 +82,16 @@ class IpnsKeysManager : public IpfsServiceObserver {
                     RemoveKeyCallback callback,
                     std::unique_ptr<std::string> response_body);
   void OnKeysLoaded(SimpleURLLoaderList::iterator iter,
+                    int retry_number,
                     std::unique_ptr<std::string> response_body);
 
   void NotifyKeysLoaded(bool result);
-
+  void LoadKeysInternal(int retries);
   void UploadData(ImportKeyCallback callback,
                   const std::string& name,
                   std::unique_ptr<network::ResourceRequest> request);
 
+  int last_load_retry_value_for_test_ = -1;
   BlobContextGetterFactory* blob_context_getter_factory_ = nullptr;
   network::mojom::URLLoaderFactory* url_loader_factory_;
   SimpleURLLoaderList url_loaders_;