diff --git a/browser/greaselion/greaselion_browsertest.cc b/browser/greaselion/greaselion_browsertest.cc
index ba7ca78d2f64..90d3e92aeed1 100644
--- a/browser/greaselion/greaselion_browsertest.cc
+++ b/browser/greaselion/greaselion_browsertest.cc
@@ -129,6 +129,7 @@ class GreaselionServiceTest : public BaseLocalDataFilesBrowserTest {
     BaseLocalDataFilesBrowserTest::SetUpOnMainThread();
     base::ScopedAllowBlockingForTesting allow_blocking;
     response_->LoadMocks();
+    profile()->GetPrefs()->SetBoolean(brave_rewards::prefs::kEnabled, true);
   }
 
   // BaseLocalDataFilesBrowserTest overrides
diff --git a/browser/greaselion/greaselion_service_factory.cc b/browser/greaselion/greaselion_service_factory.cc
index 0b6ba14300b5..b0f470879028 100644
--- a/browser/greaselion/greaselion_service_factory.cc
+++ b/browser/greaselion/greaselion_service_factory.cc
@@ -12,9 +12,11 @@
 #include "base/no_destructor.h"
 #include "base/path_service.h"
 #include "brave/browser/brave_browser_process.h"
+#include "brave/components/brave_rewards/common/pref_names.h"
 #include "brave/components/greaselion/browser/greaselion_service.h"
 #include "brave/components/greaselion/browser/greaselion_service_impl.h"
 #include "chrome/browser/extensions/extension_service.h"
+#include "chrome/browser/profiles/profile.h"
 #include "chrome/common/chrome_paths.h"
 #include "components/keyed_service/content/browser_context_dependency_manager.h"
 #include "components/keyed_service/core/keyed_service.h"
@@ -36,6 +38,19 @@ class GreaselionServiceDelegateImpl
       content::BrowserContext* browser_context)
       : browser_context_(browser_context) {
     DCHECK(browser_context_);
+    pref_change_registrar_.Init(
+        Profile::FromBrowserContext(browser_context)->GetPrefs());
+    pref_change_registrar_.Add(
+        brave_rewards::prefs::kEnabled,
+        base::BindRepeating(
+            &GreaselionServiceDelegateImpl::UpdateGreaselionExtensions,
+            base::Unretained(this)));
+  }
+
+  bool IsEnabled() const override {
+    return Profile::FromBrowserContext(browser_context_)
+        ->GetPrefs()
+        ->GetBoolean(brave_rewards::prefs::kEnabled);
   }
 
   void AddExtension(extensions::Extension* extension) override {
@@ -56,7 +71,16 @@ class GreaselionServiceDelegateImpl
   }
 
  private:
+  void UpdateGreaselionExtensions() {
+    auto* service =
+        GreaselionServiceFactory::GetForBrowserContext(browser_context_);
+    if (service) {
+      service->UpdateInstalledExtensions();
+    }
+  }
+
   raw_ptr<content::BrowserContext> browser_context_;  // Not owned
+  PrefChangeRegistrar pref_change_registrar_;
 };
 
 }  // namespace
diff --git a/browser/greaselion/sources.gni b/browser/greaselion/sources.gni
index 4dc7b7242621..15a865cd4a68 100644
--- a/browser/greaselion/sources.gni
+++ b/browser/greaselion/sources.gni
@@ -13,7 +13,9 @@ if (enable_greaselion) {
 
   brave_browser_greaselion_deps += [
     "//base",
+    "//brave/components/brave_rewards/common",
     "//brave/components/greaselion/browser",
+    "//chrome/browser/profiles:profile",
     "//chrome/common",
     "//components/keyed_service/content",
     "//extensions/browser",
diff --git a/components/greaselion/browser/greaselion_service.h b/components/greaselion/browser/greaselion_service.h
index 9f3372179cd1..c031ea5cfab0 100644
--- a/components/greaselion/browser/greaselion_service.h
+++ b/components/greaselion/browser/greaselion_service.h
@@ -42,6 +42,7 @@ class GreaselionService : public KeyedService,
   class Delegate {
    public:
     virtual ~Delegate() = default;
+    virtual bool IsEnabled() const = 0;
     virtual void AddExtension(extensions::Extension* extension) = 0;
     virtual void UnloadExtension(const std::string& extension_id) = 0;
   };
diff --git a/components/greaselion/browser/greaselion_service_impl.cc b/components/greaselion/browser/greaselion_service_impl.cc
index 781645461d16..1564ae2b2bc7 100644
--- a/components/greaselion/browser/greaselion_service_impl.cc
+++ b/components/greaselion/browser/greaselion_service_impl.cc
@@ -270,6 +270,9 @@ GreaselionServiceImpl::GetExtensionIdsForTesting() {
 }
 
 void GreaselionServiceImpl::UpdateInstalledExtensions() {
+  if (!delegate_->IsEnabled()) {
+    return;
+  }
   if (update_in_progress_) {
     update_pending_ = true;
     return;