diff --git a/data/templates/Chem-decreases-Gene/decrease-another-gene-that-upregs.json b/data/templates/Chem-decreases-Gene/decrease-another-gene-that-upregs.json
index 95fcfeb5..7ff51ce3 100644
--- a/data/templates/Chem-decreases-Gene/decrease-another-gene-that-upregs.json
+++ b/data/templates/Chem-decreases-Gene/decrease-another-gene-that-upregs.json
@@ -27,19 +27,7 @@
                                 },
                                 {
                                     "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "activity"
-                                }
-                            ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "decreased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "abundance"
+                                    "qualifier_value": "activity_or_abundance"
                                 }
                             ]
                         }
diff --git a/data/templates/Chem-decreases-Gene/direct-decrease.json b/data/templates/Chem-decreases-Gene/direct-decrease.json
index ed1dc878..64a376b7 100644
--- a/data/templates/Chem-decreases-Gene/direct-decrease.json
+++ b/data/templates/Chem-decreases-Gene/direct-decrease.json
@@ -26,30 +26,6 @@
                                     "qualifier_value": "activity_or_abundance"
                                 }
                             ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "decreased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "activity"
-                                }
-                            ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "decreased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "abundance"
-                                }
-                            ]
                         }
                     ]
                 }
diff --git a/data/templates/Chem-decreases-Gene/increase-another-gene-that-downregs.json b/data/templates/Chem-decreases-Gene/increase-another-gene-that-downregs.json
index 05941133..5e1c5b09 100644
--- a/data/templates/Chem-decreases-Gene/increase-another-gene-that-downregs.json
+++ b/data/templates/Chem-decreases-Gene/increase-another-gene-that-downregs.json
@@ -27,19 +27,7 @@
                                 },
                                 {
                                     "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "activity"
-                                }
-                            ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "increased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "abundance"
+                                    "qualifier_value": "activity_or_abundance"
                                 }
                             ]
                         }
diff --git a/data/templates/Chem-increases-Gene/decrease-another-gene-that-downregs.json b/data/templates/Chem-increases-Gene/decrease-another-gene-that-downregs.json
index a5bc6f38..9099b453 100644
--- a/data/templates/Chem-increases-Gene/decrease-another-gene-that-downregs.json
+++ b/data/templates/Chem-increases-Gene/decrease-another-gene-that-downregs.json
@@ -27,19 +27,7 @@
                                 },
                                 {
                                     "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "activity"
-                                }
-                            ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "decreased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "abundance"
+                                    "qualifier_value": "activity_or_abundance"
                                 }
                             ]
                         }
diff --git a/data/templates/Chem-increases-Gene/direct-increase.json b/data/templates/Chem-increases-Gene/direct-increase.json
index f3a3b790..b8e8dcef 100644
--- a/data/templates/Chem-increases-Gene/direct-increase.json
+++ b/data/templates/Chem-increases-Gene/direct-increase.json
@@ -26,30 +26,6 @@
                                     "qualifier_value": "activity_or_abundance"
                                 }
                             ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "increased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "activity"
-                                }
-                            ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "increased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "abundance"
-                                }
-                            ]
                         }
                     ]
                 }
diff --git a/data/templates/Chem-increases-Gene/increase-another-gene-that-upregs.json b/data/templates/Chem-increases-Gene/increase-another-gene-that-upregs.json
index 8944f54a..515cdfb0 100644
--- a/data/templates/Chem-increases-Gene/increase-another-gene-that-upregs.json
+++ b/data/templates/Chem-increases-Gene/increase-another-gene-that-upregs.json
@@ -27,19 +27,7 @@
                                 },
                                 {
                                     "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "activity"
-                                }
-                            ]
-                        },
-                        {
-                            "qualifier_set": [
-                                {
-                                    "qualifier_type_id": "biolink:object_direction_qualifier",
-                                    "qualifier_value": "increased"
-                                },
-                                {
-                                    "qualifier_type_id": "biolink:object_aspect_qualifier",
-                                    "qualifier_value": "abundance"
+                                    "qualifier_value": "activity_or_abundance"
                                 }
                             ]
                         }
diff --git a/data/templates/Drug-treats-Disease/m4-Chem-Gene-DoP.json b/data/templates/Drug-treats-Disease/m4-Chem-Gene-DoP.json
index 2a9d9a10..b7e39755 100644
--- a/data/templates/Drug-treats-Disease/m4-Chem-Gene-DoP.json
+++ b/data/templates/Drug-treats-Disease/m4-Chem-Gene-DoP.json
@@ -22,7 +22,11 @@
                 "eB": {
                     "subject": "nA",
                     "object": "creativeQueryObject",
-                    "predicates": ["biolink:causes"]
+                    "predicates": [
+                        "biolink:affects",
+                        "biolink:causes",
+                        "biolink:contributes_to"
+                    ]
                 }
             }
         }