diff --git a/data/templates/Chem-decreases-Gene/interacts-with-another-gene-that-downregs.json b/data/templates/Chem-decreases-Gene/interacts-with-another-gene-that-downregs.json
index f71b512d..af52b986 100644
--- a/data/templates/Chem-decreases-Gene/interacts-with-another-gene-that-downregs.json
+++ b/data/templates/Chem-decreases-Gene/interacts-with-another-gene-that-downregs.json
@@ -17,7 +17,7 @@
                 "eA": {
                     "subject": "creativeQuerySubject",
                     "object": "nA",
-                    "predicates": ["biolink:physically_interacts_with"]
+                    "predicates": ["biolink:interacts_with"]
                 },
                 "eB": {
                     "subject": "nA",
diff --git a/data/templates/Chem-increases-Gene/interacts-with-another-gene-that-upregs.json b/data/templates/Chem-increases-Gene/interacts-with-another-gene-that-upregs.json
index a4282b18..669c8e88 100644
--- a/data/templates/Chem-increases-Gene/interacts-with-another-gene-that-upregs.json
+++ b/data/templates/Chem-increases-Gene/interacts-with-another-gene-that-upregs.json
@@ -17,7 +17,7 @@
                 "eA": {
                     "subject": "creativeQuerySubject",
                     "object": "nA",
-                    "predicates": ["biolink:physically_interacts_with"]
+                    "predicates": ["biolink:interacts_with"]
                 },
                 "eB": {
                     "subject": "nA",
diff --git a/data/templates/Chem-interacts-with-Gene.json b/data/templates/Chem-interacts-with-Gene.json
index ea54293b..d7b83857 100644
--- a/data/templates/Chem-interacts-with-Gene.json
+++ b/data/templates/Chem-interacts-with-Gene.json
@@ -13,7 +13,7 @@
                 "eA": {
                     "subject": "creativeQuerySubject",
                     "object": "creativeQueryObject",
-                    "predicates": ["biolink:physically_interacts_with"]
+                    "predicates": ["biolink:interacts_with"]
                 }
             }
         }