diff --git a/recipes/rmats/build_failure.osx-64.yaml b/recipes/rmats/build_failure.osx-64.yaml
deleted file mode 100644
index 758d8e8d7dee2..0000000000000
--- a/recipes/rmats/build_failure.osx-64.yaml
+++ /dev/null
@@ -1,104 +0,0 @@
-recipe_sha: eb225f3a61251bb54e69e31c1b3d4ffe1b70c2f7cc8c20ac6a9433238022c11d  # The hash of the recipe's meta.yaml at which this recipe failed to build.
-skiplist: true # Set to true to skiplist this recipe so that it will be ignored as long as its latest commit is the one given above.
-log: |-
-  [  3%] Building CXX object src/api/CMakeFiles/BamTools.dir/BamWriter.cpp.o
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-  [ 28%] Building CXX object src/api/CMakeFiles/BamTools.dir/internal/io/HttpHeader_p.cpp.o
-  [ 29%] Building CXX object src/api/CMakeFiles/BamTools.dir/internal/io/ILocalIODevice_p.cpp.o
-  [ 30%] Building CXX object src/api/CMakeFiles/BamTools.dir/internal/io/RollingBuffer_p.cpp.o
-  [ 31%] Building CXX object src/api/CMakeFiles/BamTools.dir/internal/io/TcpSocket_p.cpp.o
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-  [ 35%] Building CXX object src/api/CMakeFiles/BamTools.dir/internal/sam/SamFormatPrinter_p.cpp.o
-  [ 36%] Building CXX object src/api/CMakeFiles/BamTools.dir/internal/sam/SamHeaderValidator_p.cpp.o
-  [ 37%] Building CXX object src/api/CMakeFiles/BamTools.dir/internal/utils/BamException_p.cpp.o
-  [ 38%] Linking CXX shared library $SRC_DIR/bamtools/lib/libbamtools.dylib
-  make[3]: Leaving directory '$SRC_DIR/bamtools/build'
-  [ 38%] Built target BamTools
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-  [ 39%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/BamAlignment.cpp.o
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-  [ 50%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/bam/BamMultiReader_p.cpp.o
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-  [ 54%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/index/BamIndexFactory_p.cpp.o
-  [ 55%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/index/BamStandardIndex_p.cpp.o
-  [ 56%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/index/BamToolsIndex_p.cpp.o
-  [ 57%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/BamDeviceFactory_p.cpp.o
-  [ 58%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/BamFile_p.cpp.o
-  [ 59%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/BamFtp_p.cpp.o
-  [ 60%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/BamHttp_p.cpp.o
-  [ 61%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/BamPipe_p.cpp.o
-  [ 62%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/BgzfStream_p.cpp.o
-  [ 63%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/ByteArray_p.cpp.o
-  [ 64%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/HostAddress_p.cpp.o
-  [ 65%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/HostInfo_p.cpp.o
-  [ 66%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/HttpHeader_p.cpp.o
-  [ 67%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/ILocalIODevice_p.cpp.o
-  [ 68%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/RollingBuffer_p.cpp.o
-  [ 69%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/TcpSocket_p.cpp.o
-  [ 70%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/TcpSocketEngine_p.cpp.o
-  [ 71%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/io/TcpSocketEngine_unix_p.cpp.o
-  [ 72%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/sam/SamFormatParser_p.cpp.o
-  [ 73%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/sam/SamFormatPrinter_p.cpp.o
-  [ 74%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/sam/SamHeaderValidator_p.cpp.o
-  [ 75%] Building CXX object src/api/CMakeFiles/BamTools-static.dir/internal/utils/BamException_p.cpp.o
-  [ 76%] Linking CXX static library $SRC_DIR/bamtools/lib/libbamtools.a
-  make[3]: Leaving directory '$SRC_DIR/bamtools/build'
-  [ 76%] Built target BamTools-static
-  make[3]: Entering directory '$SRC_DIR/bamtools/build'
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-  make[3]: Entering directory '$SRC_DIR/bamtools/build'
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-  [ 76%] Built target APIHeaders
-  make[3]: Entering directory '$SRC_DIR/bamtools/build'
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-  [ 76%] Built target AlgorithmsHeaders
-  make[3]: Entering directory '$SRC_DIR/bamtools/build'
-  make[3]: Leaving directory '$SRC_DIR/bamtools/build'
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-  [ 77%] Building CXX object src/third_party/jsoncpp/CMakeFiles/jsoncpp.dir/json_reader.cpp.o
-  [ 78%] Building CXX object src/third_party/jsoncpp/CMakeFiles/jsoncpp.dir/json_value.cpp.o
-  make[3]: Leaving directory '$SRC_DIR/bamtools/build'
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-  make[1]: Leaving directory '$SRC_DIR/bamtools/build'
-# Last 100 lines of the build log.
diff --git a/recipes/rmats/meta.yaml b/recipes/rmats/meta.yaml
index 6f36f750e1005..b09b14db10e21 100644
--- a/recipes/rmats/meta.yaml
+++ b/recipes/rmats/meta.yaml
@@ -8,9 +8,12 @@ package:
 source:
   sha256: c78e6411b7c6634cc31511b69d37a6a3da2e2e076e87609679818debd513aa7a
   url: https://github.com/Xinglab/rmats-turbo/releases/download/v{{ version }}/rmats_turbo_v{{ version|replace(".","_") }}.tar.gz
+  patches:
+    # remove patch when a release includes: https://github.com/Xinglab/rmats-turbo/pull/453
+    - rmats_pipeline_setup.patch
 
 build:
-  number: 3
+  number: 4
   run_exports:
     - {{ pin_subpackage(name, max_pin="x") }}
 
@@ -26,16 +29,17 @@ requirements:
     - python
     - cython
     - numpy
-    - gsl 2.5
+    - gsl
     - zlib
     - libblas
     - liblapack
+    - setuptools
   run:
     - python
     - numpy
-    - gsl 2.5
+    - gsl
     - zlib
-    - star >=2.5
+    - star >=2.5  # [not (osx and arm64)]
 
 test:
   commands:
@@ -51,3 +55,4 @@ about:
 extra:
   additional-platforms:
     - linux-aarch64
+    - osx-arm64
diff --git a/recipes/rmats/rmats_pipeline_setup.patch b/recipes/rmats/rmats_pipeline_setup.patch
new file mode 100644
index 0000000000000..eb31d6abbece5
--- /dev/null
+++ b/recipes/rmats/rmats_pipeline_setup.patch
@@ -0,0 +1,11 @@
+--- rMATS_pipeline/setup.py	2024-11-19 14:12:11.355314000 -0500
++++ rMATS_pipeline/setup.py	2024-11-19 14:12:11.355314000 -0500
+@@ -1,6 +1,6 @@
+ import os
+-from distutils.core import setup
+-from distutils.extension import Extension
++from setuptools import setup
++from setuptools import Extension
+ from Cython import __version__ as cython_version
+ from Cython.Build import cythonize
+ from Cython.Distutils import build_ext