From 08b697358ca82e371c175c71325b8318403f8b9c Mon Sep 17 00:00:00 2001
From: Manuel Holtgrewe <manuel.holtgrewe@bih-charite.de>
Date: Tue, 9 Jan 2024 09:33:11 +0100
Subject: [PATCH] feat: integrate new gnomAD v4 data

---
 .../GeneDetails/PathogenicityCard.vue         |  2 +-
 .../FreqsCard/AutosomalFreqs.vue              | 20 +++++++++----------
 2 files changed, 11 insertions(+), 11 deletions(-)

diff --git a/frontend/src/components/GeneDetails/PathogenicityCard.vue b/frontend/src/components/GeneDetails/PathogenicityCard.vue
index 03d8b301..e95666f0 100644
--- a/frontend/src/components/GeneDetails/PathogenicityCard.vue
+++ b/frontend/src/components/GeneDetails/PathogenicityCard.vue
@@ -70,7 +70,7 @@ const props = withDefaults(defineProps<Props>(), {
               <template v-if="geneInfo?.gnomadConstraints">
                 <div class="text-subtitle-1">
                   gnomAD
-                  <small> v2.1.1 </small>
+                  <small> v4.0 </small>
                   <small v-if="geneInfo?.hgnc?.ensemblGeneId?.length">
                     <a
                       :href="`https://gnomad.broadinstitute.org/gene/${geneInfo?.hgnc.ensemblGeneId}?dataset=gnomad_r4`"
diff --git a/frontend/src/components/SeqvarDetails/FreqsCard/AutosomalFreqs.vue b/frontend/src/components/SeqvarDetails/FreqsCard/AutosomalFreqs.vue
index aca5afed..bac38310 100644
--- a/frontend/src/components/SeqvarDetails/FreqsCard/AutosomalFreqs.vue
+++ b/frontend/src/components/SeqvarDetails/FreqsCard/AutosomalFreqs.vue
@@ -33,8 +33,8 @@ const noCohort = computed(() => {
 
 const byPop = computed(() => {
   const res: any = {}
-  for (const record of noCohort.value?.byPopulation ?? []) {
-    res[record.population] = record
+  for (const record of noCohort.value?.byPopulation ?? noCohort.value?.byAncestryGroup ?? []) {
+    res[record.population ?? record.ancestryGroup] = record
   }
   return res
 })
@@ -47,7 +47,8 @@ const allPopLabels = {
   nfe: 'European (North-Western)',
   amr: 'Latino/Admixed American',
   sas: 'South Asian',
-  oth: 'Other'
+  oth: 'Other',
+  remaining: 'Remaining'
 }
 
 const idKey = (token: string): string => {
@@ -81,7 +82,7 @@ const sexExpanded: any = ref({})
             v-if="seqvar.genomeBuild == 'grch38'"
             :href="`https://gnomad.broadinstitute.org/variant/${seqvar.chrom.replace(/^chr/, '')}-${
               seqvar.pos
-            }-${seqvar.del}-${seqvar.ins}?dataset=gnomad_r3`"
+            }-${seqvar.del}-${seqvar.ins}?dataset=gnomad_r4`"
             target="_blank"
           >
             <v-icon>mdi-launch</v-icon>
@@ -146,13 +147,12 @@ const sexExpanded: any = ref({})
                   {{ sep(byPop[key]?.counts?.xx?.an ?? 0) }}
                 </td>
                 <td class="text-right text-no-wrap">
-                  {{ sep(byPop[key]?.counts?.xx?.nhomal ?? 0) }}
+                  {{ sep(byPop[key]?.counts?.xx?.ac ?? 0) }}
+                </td>
+                <td class="text-right text-no-wrap">
+                  {{ sep(byPop[key]?.counts?.xx?.nhomhalt ?? 0) }}
                 </td>
                 <!-- eslint-disable vue/no-v-html -->
-                <td
-                  class="text-right text-no-wrap"
-                  v-html="roundIt(byPop[key]?.counts?.xx?.af ?? 0.0, FREQ_DIGITS)"
-                />
                 <td
                   class="text-right text-no-wrap"
                   v-html="roundIt(byPop[key]?.counts?.xx?.af, FREQ_DIGITS)"
@@ -259,7 +259,7 @@ const sexExpanded: any = ref({})
           v-if="seqvar.genomeBuild == 'grch38'"
           :href="`https://gnomad.broadinstitute.org/variant/${seqvar.chrom.replace(/^chr/, '')}-${
             seqvar.pos
-          }-${seqvar.del}-${seqvar.ins}?dataset=gnomad_r3`"
+          }-${seqvar.del}-${seqvar.ins}?dataset=gnomad_r4`"
         >
           <v-icon>mdi-launch</v-icon>
           gnomAD