diff --git a/.storybook/preview.ts b/.storybook/preview.ts
index 025d977..4d23e28 100644
--- a/.storybook/preview.ts
+++ b/.storybook/preview.ts
@@ -1,9 +1,11 @@
 import { type Preview, setup } from '@storybook/vue3'
+import { createPinia } from 'pinia'
+import { type App } from 'vue'
 
 import { registerPlugins } from '../src/plugins'
 import { withVuetifyTheme } from './withVuetifyTheme.decorator'
 
-// import type { StoryIdentifier } from "@storybook/types"
+export const pinia = createPinia()
 
 const preview: Preview = {
   parameters: {
@@ -27,7 +29,10 @@ const preview: Preview = {
   }
 }
 
-setup((app) => {
+setup((app: App) => {
+  // Use pinia for state management, also in pinia.
+  console.log('Using pinia for state management')
+  app.use(pinia)
   // Registers your app's plugins into Storybook
   registerPlugins(app)
 })
diff --git a/package-lock.json b/package-lock.json
index f98f66b..0202cd2 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -10,6 +10,8 @@
       "dependencies": {
         "@mdi/font": "^7.4.47",
         "@protobuf-ts/runtime": "^2.9.3",
+        "@types/luxon": "^3.4.2",
+        "luxon": "^3.4.4",
         "title-case": "^4.3.1",
         "vega": "^5.27.0",
         "vega-embed": "^6.24.0",
@@ -5928,6 +5930,11 @@
       "integrity": "sha512-OvlIYQK9tNneDlS0VN54LLd5uiPCBOp7gS5Z0f1mjoJYBrtStzgmJBxONW3U6OZqdtNzZPmn9BS/7WI7BFFcFQ==",
       "dev": true
     },
+    "node_modules/@types/luxon": {
+      "version": "3.4.2",
+      "resolved": "https://registry.npmjs.org/@types/luxon/-/luxon-3.4.2.tgz",
+      "integrity": "sha512-TifLZlFudklWlMBfhubvgqTXRzLDI5pCbGa4P8a3wPyUQSW+1xQ5eDsreP9DWHX3tjq1ke96uYG/nwundroWcA=="
+    },
     "node_modules/@types/mdast": {
       "version": "3.0.15",
       "resolved": "https://registry.npmjs.org/@types/mdast/-/mdast-3.0.15.tgz",
@@ -13073,6 +13080,14 @@
         "yallist": "^3.0.2"
       }
     },
+    "node_modules/luxon": {
+      "version": "3.4.4",
+      "resolved": "https://registry.npmjs.org/luxon/-/luxon-3.4.4.tgz",
+      "integrity": "sha512-zobTr7akeGHnv7eBOXcRgMeCP6+uyYsczwmeRCauvpvaAltgNyTbLH/+VaEAPUeWBT+1GuNmz4wC/6jtQzbbVA==",
+      "engines": {
+        "node": ">=12"
+      }
+    },
     "node_modules/lz-string": {
       "version": "1.5.0",
       "resolved": "https://registry.npmjs.org/lz-string/-/lz-string-1.5.0.tgz",
diff --git a/package.json b/package.json
index 0d62c08..dd5b9aa 100644
--- a/package.json
+++ b/package.json
@@ -48,6 +48,8 @@
   "dependencies": {
     "@mdi/font": "^7.4.47",
     "@protobuf-ts/runtime": "^2.9.3",
+    "@types/luxon": "^3.4.2",
+    "luxon": "^3.4.4",
     "title-case": "^4.3.1",
     "vega": "^5.27.0",
     "vega-embed": "^6.24.0",
diff --git a/src/api/pubtator/index.ts b/src/api/pubtator/index.ts
new file mode 100644
index 0000000..1fe8cf3
--- /dev/null
+++ b/src/api/pubtator/index.ts
@@ -0,0 +1,69 @@
+import { SearchResult } from './types'
+
+export * from './types'
+
+/** API base URL to use. */
+const API_BASE_URL = '/internal/proxy/pubtator3-api'
+
+/**
+ * Client for PubTator V3 API queries.
+ */
+export class PubtatorClient {
+  /** API base URL to use in this client instance. */
+  private apiBaseUrl: string
+
+  /**
+   * Create a new PubTator client.
+   *
+   * @param apiBaseUrl The API base URL to use, defaults to `API_BASE_URL`.
+   */
+  constructor(apiBaseUrl?: string) {
+    this.apiBaseUrl = apiBaseUrl ?? API_BASE_URL
+  }
+
+  /**
+   * Perform search for the given HGNC symbol.
+   *
+   * @param hgncSymbol HGNC symbol to search for.
+   * @returns Promise for the search results.
+   * @throws Error if the search fails.
+   */
+  async performSearch(hgncSymbol: string): Promise<{ [key: string]: SearchResult }> {
+    const url = `${this.apiBaseUrl}/search/?text=@GENE_${hgncSymbol}`
+    const searchRes = await fetch(url, {
+      method: 'GET'
+    })
+    if (!searchRes.ok) {
+      throw new Error(`Error running PubTator 3 search: ${searchRes.statusText}`)
+    }
+    const searchData = await searchRes.json()
+
+    // Then, extract PMID list and retrieve biocjson for the PMIDs
+    const pmids: string[] = searchData!.results!.map((doc: any) => doc.pmid)
+    const exportRes = await fetch(
+      `${this.apiBaseUrl}}/publications/export/biocjson` + `?pmids=${pmids.join(',')}`
+    )
+    if (!exportRes.ok) {
+      throw new Error(`Error running PubTator 3 export: ${exportRes.statusText}`)
+    }
+    const exportDataText = await exportRes.text()
+    const exportDataLines = exportDataText.split(/\n/)
+
+    // Zip search results and exports into searchResults
+    const searchResults: { [key: string]: SearchResult } = {}
+    for (const searchDataRecord of searchData.results) {
+      searchResults[searchDataRecord.pmid] = {
+        searchResult: searchDataRecord,
+        abstract: undefined
+      }
+    }
+    for (const exportDataLine of exportDataLines) {
+      if (exportDataLine) {
+        const exportDataRecord = JSON.parse(exportDataLine)
+        searchResults[exportDataRecord.pmid].abstract = exportDataRecord
+      }
+    }
+
+    return searchResults
+  }
+}
diff --git a/src/api/pubtator/types.ts b/src/api/pubtator/types.ts
new file mode 100644
index 0000000..c54e344
--- /dev/null
+++ b/src/api/pubtator/types.ts
@@ -0,0 +1,7 @@
+/** Interface for search result entry plus PubMed abstract. */
+export interface SearchResult {
+  /** The search result record. */
+  searchResult: any
+  /** The PubMed abstract. */
+  abstract: any
+}
diff --git a/src/components/GeneLiteratureCard/GeneLiteratureCard.spec.ts b/src/components/GeneLiteratureCard/GeneLiteratureCard.spec.ts
new file mode 100644
index 0000000..7bdf6db
--- /dev/null
+++ b/src/components/GeneLiteratureCard/GeneLiteratureCard.spec.ts
@@ -0,0 +1,62 @@
+import fs from 'fs'
+import path from 'path'
+import { describe, expect, test } from 'vitest'
+
+import { setupMountedComponents } from '../../lib/testUtils'
+import { Record as GeneInfoRecord } from '../../pbs/annonars/genes/base'
+import { SearchResults } from '../../store/pubtator'
+import { StoreState } from '../../store/types'
+import GeneLiteratureCard from './GeneLiteratureCard.vue'
+
+// Load fixture data for gene TGDS (little data) and BRCA1 (lots of data).
+const geneInfoTgds = GeneInfoRecord.fromJsonString(
+  fs.readFileSync(
+    path.resolve(__dirname, '../GenePathogenicityCard/fixture.geneInfo.TGDS.json'),
+    'utf8'
+  )
+)
+const geneInfoBrca1 = GeneInfoRecord.fromJsonString(
+  fs.readFileSync(
+    path.resolve(__dirname, '../GenePathogenicityCard/fixture.geneInfo.BRCA1.json'),
+    'utf8'
+  )
+)
+const searchResultsTgds = JSON.parse(
+  fs.readFileSync(path.resolve(__dirname, './fixture.pubtatorResults.TGDS.json'), 'utf8')
+) as SearchResults
+const searchResultsBrca1 = JSON.parse(
+  fs.readFileSync(path.resolve(__dirname, './fixture.pubtatorResults.BRCA1.json'), 'utf8')
+) as SearchResults
+
+describe.concurrent('GeneLiteratureCard.vue', async () => {
+  test.each([
+    ['BRCA1', geneInfoBrca1, searchResultsBrca1],
+    ['TGDS', geneInfoTgds, searchResultsTgds]
+  ])(
+    'renders for gene %s',
+    async (hgncSymbol: string, geneInfo: GeneInfoRecord, searchResults: SearchResults) => {
+      // arrange:
+      const { wrapper } = await setupMountedComponents(
+        { component: GeneLiteratureCard },
+        {
+          props: {
+            geneInfo
+          },
+          initialStoreState: {
+            pubtatorStore: {
+              storeState: StoreState.Active,
+              hgncSymbol,
+              searchResults
+            }
+          }
+        }
+      )
+
+      // act: nothing, only test rendering
+
+      // assert:
+      const vCards = wrapper.findAllComponents({ name: 'VCard' })
+      expect(vCards.length).toBe(1)
+    }
+  )
+})
diff --git a/src/components/GeneLiteratureCard/GeneLiteratureCard.stories.ts b/src/components/GeneLiteratureCard/GeneLiteratureCard.stories.ts
new file mode 100644
index 0000000..656d419
--- /dev/null
+++ b/src/components/GeneLiteratureCard/GeneLiteratureCard.stories.ts
@@ -0,0 +1,65 @@
+import { JsonValue } from '@protobuf-ts/runtime'
+import type { Meta, StoryObj } from '@storybook/vue3'
+
+import { Record as GeneInfoRecord } from '../../pbs/annonars/genes/base'
+import { StoreState } from '../../store'
+import { usePubtatorStore } from '../../store/pubtator'
+import geneInfoBrca1Json from '../GenePathogenicityCard/fixture.geneInfo.BRCA1.json'
+import geneInfoTgdsJson from '../GenePathogenicityCard/fixture.geneInfo.TGDS.json'
+import GeneLiteratureCard from './GeneLiteratureCard.vue'
+import searchResultsBrca1Json from './fixture.pubtatorResults.BRCA1.json'
+import searchResultsTgdsJson from './fixture.pubtatorResults.TGDS.json'
+
+// Here, fixture data is loaded via `import` from JSON file.  Reading the file
+// as in the tests fails with "process is not defined" error in the browser.
+
+// @ts-ignore
+const geneInfoTgds = GeneInfoRecord.fromJson(geneInfoTgdsJson as JsonValue)
+// @ts-ignore
+const geneInfoBrca1 = GeneInfoRecord.fromJson(geneInfoBrca1Json as JsonValue)
+
+const meta = {
+  title: 'Gene/GeneLiteratureCard',
+  component: GeneLiteratureCard,
+  tags: ['autodocs'],
+  argTypes: {
+    geneInfo: { control: { type: 'object' } }
+  },
+  args: {
+    geneInfo: geneInfoTgds,
+    skipLoadViaStore: true
+  }
+} satisfies Meta<typeof GeneLiteratureCard>
+
+export default meta
+
+type Story = StoryObj<typeof meta>
+
+export const TGDS: Story = {
+  args: {
+    geneInfo: geneInfoTgds
+  },
+  play: async () => {
+    // Setup the store contents after story selection.
+    const pubtatorStore = usePubtatorStore()
+    pubtatorStore.storeState = StoreState.Loading
+    pubtatorStore.hgncSymbol = 'TGDS'
+    pubtatorStore.searchResults = searchResultsTgdsJson
+    pubtatorStore.storeState = StoreState.Active
+  }
+}
+
+export const BRCA1: Story = {
+  args: {
+    geneInfo: geneInfoBrca1
+  },
+  play: async () => {
+    console.log('play...')
+    // Setup the store contents after story selection.
+    const pubtatorStore = usePubtatorStore()
+    pubtatorStore.storeState = StoreState.Loading
+    pubtatorStore.hgncSymbol = 'BRCA1'
+    pubtatorStore.searchResults = searchResultsBrca1Json
+    pubtatorStore.storeState = StoreState.Active
+  }
+}
diff --git a/src/components/GeneLiteratureCard/GeneLiteratureCard.vue b/src/components/GeneLiteratureCard/GeneLiteratureCard.vue
new file mode 100644
index 0000000..85dce9d
--- /dev/null
+++ b/src/components/GeneLiteratureCard/GeneLiteratureCard.vue
@@ -0,0 +1,320 @@
+<!--
+This component displays related literature using the PubTator 3 API.
+-->
+<script setup lang="ts">
+import { DateTime } from 'luxon'
+import { onMounted, ref, watch } from 'vue'
+import { useTheme } from 'vuetify'
+
+import { Record as GeneInfoRecord } from '../../pbs/annonars/genes/base'
+import {
+  type Annotation,
+  type AnnotationLocation,
+  AnnotationType,
+  usePubtatorStore
+} from '../../store/pubtator'
+import { StoreState } from '../../store/types'
+import DocsLink from '../DocsLink/DocsLink.vue'
+
+/** This component's props. */
+const props = withDefaults(
+  defineProps<{
+    /** Gene information */
+    geneInfo?: GeneInfoRecord
+    /** Disable loading via `pubtatorStore` (e.g., for use in storybooks) */
+    skipLoadViaStore?: boolean
+  }>(),
+  {
+    geneInfo: undefined,
+    skipLoadViaStore: false
+  }
+)
+
+/** Vuetify theme. */
+const theme = useTheme()
+
+/** The PubTator store. */
+const pubtatorStore = usePubtatorStore()
+
+/** Any error message to display. */
+const errorMessage = ref<string | undefined>(undefined)
+
+/** Mapping from annotation type to VChip color. */
+const TYPE_TO_CHIP_COLOR: { [key: string]: string } = {
+  [AnnotationType.Disease]: 'orange',
+  [AnnotationType.Gene]: '#8B2595',
+  [AnnotationType.Chemical]: 'green',
+  [AnnotationType.Species]: 'blue',
+  [AnnotationType.Variant]: 'red',
+  [AnnotationType.CellLine]: 'teal'
+}
+
+/** Mapping from annotation type to raw CSS color in light mode. */
+const TYPE_TO_RAW_COLOR_LIGHT: { [key: string]: string } = {
+  [AnnotationType.Disease]: '#FFF2E0',
+  [AnnotationType.Gene]: '#C9B7CB',
+  [AnnotationType.Chemical]: '#E9F5EA',
+  [AnnotationType.Species]: '#E4F2FE',
+  [AnnotationType.Variant]: '#FEE8E7',
+  [AnnotationType.CellLine]: '#E0FDFD'
+}
+
+/** Mapping from annotation type to raw CSS color in dark mode. */
+const TYPE_TO_RAW_COLOR_DARK: { [key: string]: string } = {
+  [AnnotationType.Disease]: '#9c6b24',
+  [AnnotationType.Gene]: '#743d7d',
+  [AnnotationType.Chemical]: '#5c7d5e',
+  [AnnotationType.Species]: '#577c99',
+  [AnnotationType.Variant]: '#853a3a',
+  [AnnotationType.CellLine]: '#4e8c94'
+}
+
+/** Mapping from annotation type to raw CSS color. */
+let TYPE_TO_RAW_COLOR =
+  theme.global.current.value.dark === true
+    ? { ...TYPE_TO_RAW_COLOR_DARK }
+    : { ...TYPE_TO_RAW_COLOR_LIGHT }
+
+/** Helper that returns `Annotation.text` if name is just a number or empty. */
+const annotationName = (annotation: Annotation) => {
+  if (!annotation?.name?.length || annotation.name.match(/^\d+$/)) {
+    return annotation.text
+  }
+  return annotation.name
+}
+
+/** Extract and normalize annotation from passage. */
+const extractPassageAnnotations = (passage: any): Annotation[] => {
+  const result: Annotation[] = []
+  for (const annotation of passage.annotations) {
+    result.push({
+      type: annotation.infons.type as AnnotationType,
+      name: annotation.infons.name,
+      text: annotation.text,
+      locations: annotation.locations as AnnotationLocation[]
+    })
+  }
+  return result
+}
+
+/** Extract and normalize annotations from abstract. */
+const extractAnnotations = (abstract: any): Annotation[] => {
+  const seen: Set<string> = new Set()
+  const annotations: Annotation[] = []
+  for (const passage of abstract?.passages ?? []) {
+    for (const annotation of extractPassageAnnotations(passage)) {
+      if (seen.has(annotation.name ?? annotation.text ?? '')) {
+        continue
+      }
+      annotations.push(annotation)
+      seen.add(annotation.name ?? annotation.text ?? '')
+    }
+  }
+  return annotations
+}
+
+/** Load the information from PubTator 3 API via local proxy. */
+const loadPubTator = async () => {
+  if (props.skipLoadViaStore) {
+    return // data is set into store elsewhere, e.g., storybook
+  }
+  try {
+    await pubtatorStore.initialize(props.geneInfo?.hgnc?.symbol)
+  } catch (e) {
+    errorMessage.value = `Error loading PubTator 3 data: ${e}`
+  }
+}
+
+/** Local type for storing Location and annotation, location on top level. */
+interface LocationAnnotation {
+  /** The location of the annotation. */
+  location: AnnotationLocation
+  /** The annotation. */
+  annotation: Annotation
+}
+
+/** Returns "inner" HTML with highlighting for annotation. */
+const highlight = (text: string, annotations: Annotation[], baseOffset: number): string => {
+  // get list of all annotations
+  const locationAnnotations: LocationAnnotation[] = []
+  for (const annotation of annotations) {
+    for (const location of annotation.locations) {
+      locationAnnotations.push({
+        location: location,
+        annotation: annotation
+      })
+    }
+  }
+  locationAnnotations.sort((a, b) => a.location.offset - b.location.offset)
+
+  // now process all annotations
+  const arr: string[] = []
+  let prevEnd = 0
+  for (const locationAnnotation of locationAnnotations) {
+    if (prevEnd > locationAnnotation.location.offset) {
+      continue // skip overlapping annotations
+    }
+
+    // push text before annotation
+    const textStart = prevEnd
+    const textEnd = locationAnnotation.location.offset
+    if (textStart != textEnd) {
+      arr.push(text.slice(textStart - baseOffset, textEnd - baseOffset))
+    }
+
+    // push annotation
+    const annoStart = locationAnnotation.location.offset
+    const annoEnd = locationAnnotation.location.offset + locationAnnotation.location.length
+    arr.push(
+      `<span style="background-color: ${TYPE_TO_RAW_COLOR[locationAnnotation.annotation.type]};">`
+    )
+    arr.push(text.slice(annoStart - baseOffset, annoEnd - baseOffset))
+    arr.push('</span>')
+
+    prevEnd = annoEnd
+  }
+
+  // push remaining text
+  if (prevEnd < text.length) {
+    arr.push(text.slice(prevEnd - baseOffset))
+  }
+
+  return arr.join('')
+}
+
+// Load information on mount.
+onMounted(loadPubTator)
+// Load information when the gene symbol changes.
+watch(() => props.geneInfo?.hgnc?.symbol, loadPubTator)
+// Reload template when theme changes.
+watch(
+  () => theme.global.current.value,
+  () => {
+    TYPE_TO_RAW_COLOR =
+      theme.global.current.value.dark === true
+        ? { ...TYPE_TO_RAW_COLOR_DARK }
+        : { ...TYPE_TO_RAW_COLOR_LIGHT }
+  }
+)
+</script>
+
+<template>
+  <!-- no HGNC symbol => display loader -->
+  <template v-if="!geneInfo?.hgnc?.symbol">
+    <v-skeleton-loader class="mt-3 mx-auto border" type="heading,subtitle,text,text" />
+  </template>
+
+  <!-- otherwise, display actual card -->
+  <template v-else>
+    <v-card>
+      <v-card-title class="pb-0 pr-2">
+        Literature
+        <DocsLink anchor="literature" />
+      </v-card-title>
+      <v-card-subtitle class="text-overline"> Top 10 from PubTator 3 </v-card-subtitle>
+      <v-card-text class="pt-3">
+        <v-alert v-if="errorMessage" type="error" dismissible>
+          {{ errorMessage }}
+        </v-alert>
+        <div
+          v-if="!errorMessage && pubtatorStore.storeState !== StoreState.Active"
+          class="text-center"
+        >
+          <v-progress-circular indeterminate />
+        </div>
+        <div v-else>
+          <div
+            v-for="(pmid, idx) in Object.keys(pubtatorStore.searchResults)"
+            :key="pmid"
+            :class="{ 'mt-3 pt-3 border-top': idx > 0 }"
+          >
+            <span>
+              #{{ idx + 1 }}
+              &middot;
+              <a
+                :href="`https://pubmed.ncbi.nlm.nih.gov/${pubtatorStore.searchResults[pmid]?.abstract.pmid}/`"
+                target="_blank"
+              >
+                {{ pubtatorStore.searchResults[pmid]?.abstract.pmid }}
+                <small><v-icon>mdi-launch</v-icon></small>
+              </a>
+              &middot;
+              {{ pubtatorStore.searchResults[pmid]?.abstract.journal }}
+              &middot;
+              {{
+                DateTime.fromISO(pubtatorStore.searchResults[pmid]?.abstract.date).toFormat(
+                  'yyyy/MM/dd'
+                )
+              }}
+            </span>
+
+            <div
+              v-for="passage in pubtatorStore.searchResults[pmid]?.abstract.passages"
+              :key="passage.offset"
+            >
+              <div v-if="passage.infons.type === 'title'">
+                <div class="text-h6">
+                  <!-- eslint-disable vue/no-v-html -->
+                  <span
+                    v-html="
+                      highlight(passage.text, extractPassageAnnotations(passage), passage.offset)
+                    "
+                  />
+                  <!-- eslint-enable -->
+                </div>
+                <div class="text-body-2 text-grey-darken-1">
+                  {{ pubtatorStore.searchResults[pmid]?.abstract?.authors.join(', ') }}
+                </div>
+              </div>
+              <div v-else-if="passage.infons.type === 'abstract'">
+                <div class="text-body-2">
+                  <!-- eslint-disable vue/no-v-html -->
+                  <span
+                    v-html="
+                      highlight(passage.text, extractPassageAnnotations(passage), passage.offset)
+                    "
+                  />
+                  <!-- eslint-enable -->
+                </div>
+              </div>
+            </div>
+
+            <div v-if="extractAnnotations(pubtatorStore.searchResults[pmid]?.abstract).length > 0">
+              <template
+                v-for="(annotation, idxInner) in extractAnnotations(
+                  pubtatorStore.searchResults[pmid]?.abstract
+                )"
+                :key="idxInner"
+              >
+                <v-chip
+                  rounded="xl"
+                  :text="annotationName(annotation)"
+                  :title="`'${annotation.text}' (${annotation.type})`"
+                  :color="TYPE_TO_CHIP_COLOR[annotation.type]"
+                  class="mt-3"
+                  :class="{ 'ml-1': idxInner > 0 }"
+                />
+              </template>
+            </div>
+          </div>
+        </div>
+      </v-card-text>
+
+      <v-card-actions>
+        <v-btn
+          :href="`https://www.ncbi.nlm.nih.gov/research/pubtator3/docsum?text=@GENE_${geneInfo?.hgnc?.symbol}`"
+          target="_blank"
+          prepend-icon="mdi-launch"
+        >
+          PubTator 3
+        </v-btn>
+      </v-card-actions>
+    </v-card>
+  </template>
+</template>
+
+<style scoped>
+.border-top {
+  border-top: 1px solid #bbb;
+}
+</style>
diff --git a/src/components/GeneLiteratureCard/fixture.pubtatorResults.BRCA1.json b/src/components/GeneLiteratureCard/fixture.pubtatorResults.BRCA1.json
new file mode 100644
index 0000000..0d35d93
--- /dev/null
+++ b/src/components/GeneLiteratureCard/fixture.pubtatorResults.BRCA1.json
@@ -0,0 +1,4850 @@
+{
+  "30293211": {
+    "searchResult": {
+      "_id": "30293211",
+      "pmid": 30293211,
+      "title": "BRCA mutations: is everything said?",
+      "journal": "Breast Cancer Res Treat",
+      "authors": [
+        "López-Urrutia E",
+        "Salazar-Rojas V",
+        "Brito-Elías L",
+        "Coca-González M",
+        "Silva-García J",
+        "Sánchez-Marín D",
+        "Campos-Parra AD",
+        "Pérez-Plasencia C"
+      ],
+      "date": "2019-01-01T00:00:00Z",
+      "doi": "10.1007/s10549-018-4986-5",
+      "meta_date_publication": "2019 Jan",
+      "meta_volume": "173",
+      "meta_issue": "1",
+      "meta_pages": "49-54",
+      "score": 252.99637,
+      "text_hl": "@<m>GENE_BRCA1</m> @@@BRCA@@@ mutations: is everything said?",
+      "citations": {
+        "NLM": "López-Urrutia E, Salazar-Rojas V, Brito-Elías L, Coca-González M, Silva-García J, Sánchez-Marín D, Campos-Parra AD, Pérez-Plasencia C. BRCA mutations: is everything said? Breast Cancer Res Treat. 2019 Jan;173(1):49-54. PMID: 30293211",
+        "BibTeX": "@article{30293211, title={BRCA mutations: is everything said?}, author={López-Urrutia E and Salazar-Rojas V and Brito-Elías L and Coca-González M and Silva-García J and Sánchez-Marín D and Campos-Parra AD and Pérez-Plasencia C}, journal={Breast Cancer Res Treat}, volume={173}, number={1}, pages={49-54}}"
+      }
+    },
+    "abstract": {
+      "_id": "30293211|None",
+      "id": "30293211",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Breast Cancer Res Treat. 2019 Jan;173(1):49-54. doi: 10.1007/s10549-018-4986-5. ",
+            "year": "2019",
+            "type": "title",
+            "authors": "Lopez-Urrutia E, Salazar-Rojas V, Brito-Elias L, Coca-Gonzalez M, Silva-Garcia J, Sanchez-Marin D, Campos-Parra AD, Perez-Plasencia C"
+          },
+          "offset": 0,
+          "text": "BRCA mutations: is everything said?",
+          "sentences": [],
+          "annotations": [
+            {
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+              "text": "BRCA",
+              "locations": [{ "offset": 0, "length": 4 }]
+            }
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+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 36,
+          "text": "BACKGROUND: Mutations in the BRCA1 and BRCA2 genes constitute a risk factor for breast cancer development. BRCA mutation research has been an active field since the discovery of the genes, and new mutations in both genes are constantly described and classified according to several systems. AIM: We intend to provide an overview of the current state of BRCA1 and BRCA2 mutation description and classification. We wanted to know whether there was a trend towards a more frequently described mutation type and what the proportion of pathogenic mutations was. RESULTS: We found that, although new mutations are described each year as reflected in current database records, very few of them are reported in papers. Classification systems are highly heterogeneous and a consensus among them is still under development. Regarding their function, a large number of mutations are yet to be analyzed, a very complex task, due to the great number of possible variations and their diverse effect in the BRCA gene functions. After individual analysis, many variants of unknown significance turn out to be pathogenic, and many can disrupt interactions with other proteins involved in mechanisms such as DNA damage repair pathways. Recent data suggest that looking for mutation patterns or combinations would shed a wider light on BRCA-derived cancer susceptibility in the upcoming years.",
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+              "text": "BRCA1",
+              "locations": [{ "offset": 65, "length": 5 }]
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+              "text": "BRCA2",
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+              },
+              "text": "breast cancer",
+              "locations": [{ "offset": 116, "length": 13 }]
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+              "text": "BRCA",
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+                "name": "BRCA2",
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+              },
+              "text": "BRCA2",
+              "locations": [{ "offset": 399, "length": 5 }]
+            },
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+              },
+              "text": "BRCA",
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+                "accession": "@DISEASE_Neoplasms"
+              },
+              "text": "cancer",
+              "locations": [{ "offset": 1366, "length": 6 }]
+            }
+          ],
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+      ],
+      "pmid": 30293211,
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+      "meta": {},
+      "date": "2019-01-01T00:00:00Z",
+      "journal": "Breast Cancer Res Treat",
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+        "López-Urrutia E",
+        "Salazar-Rojas V",
+        "Brito-Elías L",
+        "Coca-González M",
+        "Silva-García J",
+        "Sánchez-Marín D",
+        "Campos-Parra AD",
+        "Pérez-Plasencia C"
+      ],
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+        { "name": "associate|@DISEASE_Breast_Neoplasms|@GENE_BRCA2" },
+        { "name": "associate|@DISEASE_Breast_Neoplasms|@GENE_BRCA1" }
+      ]
+    }
+  },
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+      "title": "BRCA Exchange Launches.",
+      "journal": "Cancer Discov",
+      "date": "2019-03-01T00:00:00Z",
+      "doi": "10.1158/2159-8290.CD-NB2019-008",
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+            "type": "title"
+          },
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+          "text": "BRCA Exchange Launches.",
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+              },
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+              "locations": [{ "offset": 0, "length": 4 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 24,
+          "text": "The newly launched BRCA Exchange website and mobile app include data on more than 20,000 unique, inherited BRCA variants. Clinicians, researchers, and patients are expected to benefit from being able to access comprehensive, quality information on BRCA variants in a single place.",
+          "sentences": [],
+          "annotations": [
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+              },
+              "text": "BRCA",
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+                "biotype": "species",
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+              "text": "patients",
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+      "_id": "30992324",
+      "pmid": 30992324,
+      "pmcid": "PMC6497576",
+      "title": "BRCA1-No Matter How You Splice It.",
+      "journal": "Cancer Res",
+      "authors": ["Li D", "Harlan-Williams LM", "Kumaraswamy E", "Jensen RA"],
+      "date": "2019-05-01T00:00:00Z",
+      "doi": "10.1158/0008-5472.CAN-18-3190",
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+      }
+    },
+    "abstract": {
+      "_id": "30992324|None",
+      "id": "30992324",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Cancer Res. 2019 May 1;79(9):2091-2098. doi: 10.1158/0008-5472.CAN-18-3190. Epub ",
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+            "type": "title",
+            "authors": "Li D, Harlan-Williams LM, Kumaraswamy E, Jensen RA"
+          },
+          "offset": 0,
+          "text": "BRCA1-No Matter How You Splice It.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "1",
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+                "identifier": "672",
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+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 0, "length": 5 }]
+            }
+          ],
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+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 35,
+          "text": "BRCA1 (breast cancer 1, early onset), a well-known breast cancer susceptibility gene, is a highly alternatively spliced gene. BRCA1 alternative splicing may serve as an alternative regulatory mechanism for the inactivation of the BRCA1 gene in both hereditary and sporadic breast cancers, and other BRCA1-associated cancers. The alternative transcripts of BRCA1 can mimic known functions, possess unique functions compared with the full-length BRCA1 transcript, and in some cases, appear to function in opposition to full-length BRCA1 In this review, we will summarize the functional \"naturally occurring\" alternative splicing transcripts of BRCA1 and then discuss the latest next-generation sequencing-based detection methods and techniques to detect alternative BRCA1 splicing patterns and their potential use in cancer diagnosis, prognosis, and therapy.",
+          "sentences": [],
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+                "name": "BRCA1",
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+              },
+              "text": "BRCA1",
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+                "name": "Breast Neoplasms",
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+              },
+              "text": "breast cancer",
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+                "biotype": "gene",
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+              },
+              "text": "BRCA1",
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+            },
+            {
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+                "biotype": "disease",
+                "name": "Breast Neoplasms",
+                "accession": "@DISEASE_Breast_Neoplasms"
+              },
+              "text": "hereditary and sporadic breast cancers",
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+            },
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+                "biotype": "disease",
+                "name": "Breast Neoplasms",
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+              },
+              "text": "BRCA1-associated cancers",
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+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
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+              "text": "BRCA1",
+              "locations": [{ "offset": 391, "length": 5 }]
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+                "biotype": "gene",
+                "name": "BRCA1",
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+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 564, "length": 5 }]
+            },
+            {
+              "id": "23",
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+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 677, "length": 5 }]
+            },
+            {
+              "id": "24",
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+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 799, "length": 5 }]
+            },
+            {
+              "id": "25",
+              "infons": {
+                "identifier": "MESH:D009369",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D009369"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009369",
+                "biotype": "disease",
+                "name": "Neoplasms",
+                "accession": "@DISEASE_Neoplasms"
+              },
+              "text": "cancer",
+              "locations": [{ "offset": 850, "length": 6 }]
+            }
+          ],
+          "relations": []
+        }
+      ],
+      "relations": [
+        {
+          "id": "R1",
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+              "name": "Breast Neoplasms",
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+            },
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+            },
+            "type": "Negative_Correlation"
+          },
+          "nodes": [{ "refid": "1", "role": "2,1" }]
+        }
+      ],
+      "pmid": 30992324,
+      "pmcid": null,
+      "meta": {},
+      "date": "2019-05-01T00:00:00Z",
+      "journal": "Cancer Res",
+      "authors": ["Li D", "Harlan-Williams LM", "Kumaraswamy E", "Jensen RA"],
+      "relations_display": [
+        { "name": "associate|@DISEASE_Neoplasms|@GENE_BRCA1" },
+        { "name": "inhibit|@DISEASE_Breast_Neoplasms|@GENE_BRCA1" }
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+    "searchResult": {
+      "_id": "31672679",
+      "pmid": 31672679,
+      "pmcid": "PMC6934897",
+      "title": "Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study.",
+      "journal": "J Am Coll Surg",
+      "authors": [
+        "Cao CX",
+        "Sharib JM",
+        "Blanco AM",
+        "Goldberg D",
+        "Bracci P",
+        "Mukhtar RA",
+        "Esserman LJ",
+        "Kirkwood KS"
+      ],
+      "date": "2020-01-01T00:00:00Z",
+      "doi": "10.1016/j.jamcollsurg.2019.09.019",
+      "meta_date_publication": "2020 Jan",
+      "meta_volume": "230",
+      "meta_issue": "1",
+      "meta_pages": "53-63.e1",
+      "score": 251.35635,
+      "text_hl": "...BACKGROUND: Direct-to-consumer @<m>GENE_BRCA1</m> @@@BRCA@@@ testing will increase @<m>GENE_BRCA1</m> @@@BRCA@@@ diagnoses and subsequent abdominal imaging. ",
+      "citations": {
+        "NLM": "Cao CX, Sharib JM, Blanco AM, Goldberg D, Bracci P, Mukhtar RA, Esserman LJ, Kirkwood KS. Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study. J Am Coll Surg. 2020 Jan;230(1):53-63.e1. PMID: 31672679",
+        "BibTeX": "@article{31672679, title={Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study.}, author={Cao CX and Sharib JM and Blanco AM and Goldberg D and Bracci P and Mukhtar RA and Esserman LJ and Kirkwood KS}, journal={J Am Coll Surg}, volume={230}, number={1}, pages={53-63.e1}}"
+      }
+    },
+    "abstract": {
+      "_id": "31672679|None",
+      "id": "31672679",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "J Am Coll Surg. 2020 Jan;230(1):53-63.e1. doi: 10.1016/j.jamcollsurg.2019.09.019. ",
+            "year": "2020",
+            "article-id_pmc": "PMC6934897",
+            "type": "title",
+            "authors": "Cao CX, Sharib JM, Blanco AM, Goldberg D, Bracci P, Mukhtar RA, Esserman LJ, Kirkwood KS"
+          },
+          "offset": 0,
+          "text": "Abdominal Imaging of Pancreatic Cysts and Cyst-Associated Pancreatic Cancer in BRCA1/2 Mutation Carriers: A Retrospective Cross-Sectional Study.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "3",
+              "infons": {
+                "identifier": "MESH:D010181",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "Pancreatic Cysts",
+              "locations": [{ "offset": 21, "length": 16 }]
+            },
+            {
+              "id": "4",
+              "infons": {
+                "identifier": "MESH:D010190",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010190"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010190",
+                "biotype": "disease",
+                "name": "Pancreatic Neoplasms",
+                "accession": "@DISEASE_Pancreatic_Neoplasms"
+              },
+              "text": "Cyst-Associated Pancreatic Cancer",
+              "locations": [{ "offset": 42, "length": 33 }]
+            },
+            {
+              "id": "5",
+              "infons": {
+                "identifier": "672;675",
+                "type": "Gene",
+                "ncbi_homologene": "5276;41",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1/2",
+              "locations": [{ "offset": 79, "length": 7 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 145,
+          "text": "BACKGROUND: Direct-to-consumer BRCA testing will increase BRCA diagnoses and subsequent abdominal imaging. It is unclear whether BRCA carriers are at higher risk of developing pancreatic cysts (PCs) or cyst-associated pancreatic ductal adenocarcinoma (PDAC). We investigated the prevalence of PCs in BRCA-tested patients, and whether BRCA-carriers have higher rates of PDAC when PCs are found. STUDY DESIGN: This is a retrospective cross-sectional study of patients with BRCA testing and abdominal imaging between 1996 and 2018. Pancreatic cysts were identified on original imaging reports. Prevalence and risk characteristics of PCs, as well as incidence of PDAC, were compared between BRCA+, BRCA-, and BRCA-untested patients. RESULTS: Pancreatic cysts were identified in 4,045 patients among 128,164 unique patients with abdominal imaging, including 33 patients with PCs in 1,113 BRCA-tested patients. There was no difference in PC prevalence between BRCA+, BRCA-, and untested patients (3.6%, 2.6%, 3.2%, respectively; p = 0.64). Pancreatic cysts were diagnosed in BRCA+ patients at a younger age (57.1 vs 65.3 years, p < 0.001); however, there was no difference in risk stratification compared with BRCA- or untested patients by consensus criteria. Across the population of imaged patients, patients with PCs had significantly higher rates of PDAC compared with those without PCs (18.2% vs 2.4%, p < 0.001). Incidence of cyst-associated PDAC was similar in BRCA+ and BRCA- patients (13.3% vs 22.2%, p = 0.84). CONCLUSIONS: BRCA+ patients have similar rates of PCs, high-risk features in their cysts, and PDAC as BRCA- and untested patients. BRCA+ patients likely do not require dedicated abdominal imaging to evaluate for PCs and should follow management guidelines similar to those as the untested general population if an incidental PC is identified.",
+          "sentences": [],
+          "annotations": [
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+              "infons": {
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+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 176, "length": 4 }]
+            },
+            {
+              "id": "67",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 203, "length": 4 }]
+            },
+            {
+              "id": "68",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 274, "length": 4 }]
+            },
+            {
+              "id": "69",
+              "infons": {
+                "identifier": "MESH:D010181",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "pancreatic cysts",
+              "locations": [{ "offset": 321, "length": 16 }]
+            },
+            {
+              "id": "70",
+              "infons": {
+                "identifier": "MESH:D010181",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "PCs",
+              "locations": [{ "offset": 339, "length": 3 }]
+            },
+            {
+              "id": "71",
+              "infons": {
+                "identifier": "MESH:D003560",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D003560"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D003560",
+                "biotype": "disease",
+                "name": "Cysts",
+                "accession": "@DISEASE_Cysts"
+              },
+              "text": "cyst",
+              "locations": [{ "offset": 347, "length": 4 }]
+            },
+            {
+              "id": "72",
+              "infons": {
+                "identifier": "MESH:D021441",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D021441"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D021441",
+                "biotype": "disease",
+                "name": "Carcinoma Pancreatic Ductal",
+                "accession": "@DISEASE_Carcinoma_Pancreatic_Ductal"
+              },
+              "text": "pancreatic ductal adenocarcinoma",
+              "locations": [{ "offset": 363, "length": 32 }]
+            },
+            {
+              "id": "73",
+              "infons": {
+                "identifier": "MESH:D021441",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D021441"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D021441",
+                "biotype": "disease",
+                "name": "Carcinoma Pancreatic Ductal",
+                "accession": "@DISEASE_Carcinoma_Pancreatic_Ductal"
+              },
+              "text": "PDAC",
+              "locations": [{ "offset": 397, "length": 4 }]
+            },
+            {
+              "id": "74",
+              "infons": {
+                "identifier": "MESH:D010181",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "PCs",
+              "locations": [{ "offset": 438, "length": 3 }]
+            },
+            {
+              "id": "75",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 445, "length": 4 }]
+            },
+            {
+              "id": "76",
+              "infons": {
+                "identifier": "9606",
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+                "valid": true,
+                "normalized": [9606],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 9606,
+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patients",
+              "locations": [{ "offset": 457, "length": 8 }]
+            },
+            {
+              "id": "77",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 479, "length": 4 }]
+            },
+            {
+              "id": "78",
+              "infons": {
+                "identifier": "MESH:D021441",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D021441"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D021441",
+                "biotype": "disease",
+                "name": "Carcinoma Pancreatic Ductal",
+                "accession": "@DISEASE_Carcinoma_Pancreatic_Ductal"
+              },
+              "text": "PDAC",
+              "locations": [{ "offset": 514, "length": 4 }]
+            },
+            {
+              "id": "79",
+              "infons": {
+                "identifier": "MESH:D010181",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "PCs",
+              "locations": [{ "offset": 524, "length": 3 }]
+            },
+            {
+              "id": "80",
+              "infons": {
+                "identifier": "9606",
+                "type": "Species",
+                "valid": true,
+                "normalized": [9606],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 9606,
+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patients",
+              "locations": [{ "offset": 602, "length": 8 }]
+            },
+            {
+              "id": "81",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 616, "length": 4 }]
+            },
+            {
+              "id": "82",
+              "infons": {
+                "identifier": "MESH:D010181",
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+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "Pancreatic cysts",
+              "locations": [{ "offset": 674, "length": 16 }]
+            },
+            {
+              "id": "83",
+              "infons": {
+                "identifier": "MESH:D010181",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "PCs",
+              "locations": [{ "offset": 775, "length": 3 }]
+            },
+            {
+              "id": "84",
+              "infons": {
+                "identifier": "MESH:D021441",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D021441"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D021441",
+                "biotype": "disease",
+                "name": "Carcinoma Pancreatic Ductal",
+                "accession": "@DISEASE_Carcinoma_Pancreatic_Ductal"
+              },
+              "text": "PDAC",
+              "locations": [{ "offset": 804, "length": 4 }]
+            },
+            {
+              "id": "85",
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+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 832, "length": 4 }]
+            },
+            {
+              "id": "86",
+              "infons": {
+                "identifier": "672",
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+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 839, "length": 4 }]
+            },
+            {
+              "id": "87",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 850, "length": 4 }]
+            },
+            {
+              "id": "88",
+              "infons": {
+                "identifier": "9606",
+                "type": "Species",
+                "valid": true,
+                "normalized": [9606],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 9606,
+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patients",
+              "locations": [{ "offset": 864, "length": 8 }]
+            },
+            {
+              "id": "89",
+              "infons": {
+                "identifier": "MESH:D010181",
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+                "valid": true,
+                "normalized": ["D010181"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010181",
+                "biotype": "disease",
+                "name": "Pancreatic Cyst",
+                "accession": "@DISEASE_Pancreatic_Cyst"
+              },
+              "text": "Pancreatic cysts",
+              "locations": [{ "offset": 883, "length": 16 }]
+            },
+            {
+              "id": "90",
+              "infons": {
+                "identifier": "9606",
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+                "valid": true,
+                "normalized": [9606],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 9606,
+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patients",
+              "locations": [{ "offset": 925, "length": 8 }]
+            },
+            {
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+      "text_hl": "@<m>GENE_BRCA1</m> @@@BRCA1@@@-BRCT Mutations Alter the Subcellular Localization of @<m>GENE_BRCA1</m> @@@BRCA1@@@ In Vitro.",
+      "citations": {
+        "NLM": "Drikos I, Boutou E, Kastritis PL, Vorgias CE. BRCA1-BRCT Mutations Alter the Subcellular Localization of BRCA1 In Vitro. Anticancer Res. 2021 Jun;41(6):2953-2962. PMID: 34083286",
+        "BibTeX": "@article{34083286, title={BRCA1-BRCT Mutations Alter the Subcellular Localization of BRCA1 In Vitro.}, author={Drikos I and Boutou E and Kastritis PL and Vorgias CE}, journal={Anticancer Res}, volume={41}, number={6}, pages={2953-2962}}"
+      }
+    },
+    "abstract": {
+      "_id": "34083286|None",
+      "id": "34083286",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Anticancer Res. 2021 Jun;41(6):2953-2962. doi: 10.21873/anticanres.15077.",
+            "year": "2021",
+            "type": "title",
+            "authors": "Drikos I, Boutou E, Kastritis PL, Vorgias CE"
+          },
+          "offset": 0,
+          "text": "BRCA1-BRCT Mutations Alter the Subcellular Localization of BRCA1 In Vitro.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "2",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 0, "length": 5 }]
+            },
+            {
+              "id": "3",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 59, "length": 5 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 75,
+          "text": "BACKGROUND/AIM: Numerous missense mutations have been determined in the BRCT domain of the BRCA1 gene, affecting localization and interaction of BRCA1 with other proteins. MATERIALS AND METHODS: We examined whether the M1775K and V1809F mutations in the BRCT domain affect BRCA1 cellular localization. Cells were transfected with pEGFP-C3-BRCA1 and detected by fluorescence microscopy. RESULTS: Following induction of DNA damage, cytoplasmic mislocalization was observed for both M1775K and V1809F mutants compared to EGFP-BRCA1wt and the less common variant M1652I. These results indicate that M1775K and V1809F mutations may change the function of the protein by affecting BRCA1 localization. CONCLUSION: There is a correlation between subcellular localization of BRCA1 and diminished DNA repair observed in breast cancer cells, which may be explained by structural variations and altered binding properties of phosphopeptides.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "20",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 166, "length": 5 }]
+            },
+            {
+              "id": "21",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 220, "length": 5 }]
+            },
+            {
+              "id": "22",
+              "infons": {
+                "identifier": "tmVar:p|SUB|M|1775|K;HGVS:p.M1775K;VariantGroup:0;CorrespondingGene:672;RS#:41293463;CorrespondingSpecies:9606;CA#:3476",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.M1775K",
+                "gene_ids": [672],
+                "gene_id": 672,
+                "rsids": ["rs41293463"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA3476",
+                "rsid": "rs41293463",
+                "normalized": ["rs41293463##", "#672#", "CA3476#rs41293463##"],
+                "normalized_id": "rs41293463##",
+                "biotype": "variant",
+                "name": "p.M1775K",
+                "accession": "@VARIANT_p.M1775R_BRCA1_human"
+              },
+              "text": "M1775K",
+              "locations": [{ "offset": 294, "length": 6 }]
+            },
+            {
+              "id": "23",
+              "infons": {
+                "identifier": "tmVar:p|SUB|V|1809|F;HGVS:p.V1809F;VariantGroup:2;CorrespondingGene:672;RS#:28897698;CorrespondingSpecies:9606;CA#:3588",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.V1809F",
+                "gene_ids": [672],
+                "gene_id": 672,
+                "rsids": ["rs28897698"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA3588",
+                "rsid": "rs28897698",
+                "normalized": ["rs28897698##", "#672#", "CA3588#rs28897698##"],
+                "normalized_id": "rs28897698##",
+                "biotype": "variant",
+                "name": "p.V1809F",
+                "accession": "@VARIANT_p.V1809F_BRCA1_human"
+              },
+              "text": "V1809F",
+              "locations": [{ "offset": 305, "length": 6 }]
+            },
+            {
+              "id": "24",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 348, "length": 5 }]
+            },
+            {
+              "id": "25",
+              "infons": {
+                "identifier": "CVCL:1098",
+                "type": "CellLine",
+                "valid": true,
+                "normalized": ["1098"],
+                "database": "cvcl",
+                "normalized_id": "1098",
+                "biotype": "cellline",
+                "name": "1098",
+                "accession": null
+              },
+              "text": "-C3",
+              "locations": [{ "offset": 410, "length": 3 }]
+            },
+            {
+              "id": "26",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 414, "length": 5 }]
+            },
+            {
+              "id": "27",
+              "infons": {
+                "identifier": "tmVar:p|SUB|M|1775|K;HGVS:p.M1775K;VariantGroup:0;CorrespondingGene:672;RS#:41293463;CorrespondingSpecies:9606;CA#:3476",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.M1775K",
+                "gene_ids": [672],
+                "gene_id": 672,
+                "rsids": ["rs41293463"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA3476",
+                "rsid": "rs41293463",
+                "normalized": ["rs41293463##", "#672#", "CA3476#rs41293463##"],
+                "normalized_id": "rs41293463##",
+                "biotype": "variant",
+                "name": "p.M1775K",
+                "accession": "@VARIANT_p.M1775R_BRCA1_human"
+              },
+              "text": "M1775K",
+              "locations": [{ "offset": 555, "length": 6 }]
+            },
+            {
+              "id": "28",
+              "infons": {
+                "identifier": "tmVar:p|SUB|V|1809|F;HGVS:p.V1809F;VariantGroup:2;CorrespondingGene:672;RS#:28897698;CorrespondingSpecies:9606;CA#:3588",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.V1809F",
+                "gene_ids": [672],
+                "gene_id": 672,
+                "rsids": ["rs28897698"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA3588",
+                "rsid": "rs28897698",
+                "normalized": ["rs28897698##", "#672#", "CA3588#rs28897698##"],
+                "normalized_id": "rs28897698##",
+                "biotype": "variant",
+                "name": "p.V1809F",
+                "accession": "@VARIANT_p.V1809F_BRCA1_human"
+              },
+              "text": "V1809F",
+              "locations": [{ "offset": 566, "length": 6 }]
+            },
+            {
+              "id": "29",
+              "infons": {
+                "identifier": "tmVar:p|SUB|M|1652|I;HGVS:p.M1652I;VariantGroup:1;CorrespondingGene:672;RS#:1799967;CorrespondingSpecies:9606;CA#:3103",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.M1652I",
+                "gene_ids": [672],
+                "gene_id": 672,
+                "rsids": ["rs1799967"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA3103",
+                "rsid": "rs1799967",
+                "normalized": ["rs1799967##", "#672#", "CA3103#rs1799967##"],
+                "normalized_id": "rs1799967##",
+                "biotype": "variant",
+                "name": "p.M1652I",
+                "accession": "@VARIANT_p.M1652I_BRCA1_human"
+              },
+              "text": "M1652I",
+              "locations": [{ "offset": 634, "length": 6 }]
+            },
+            {
+              "id": "30",
+              "infons": {
+                "identifier": "tmVar:p|SUB|M|1775|K;HGVS:p.M1775K;VariantGroup:0;CorrespondingGene:672;RS#:41293463;CorrespondingSpecies:9606;CA#:3476",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.M1775K",
+                "gene_ids": [672],
+                "gene_id": 672,
+                "rsids": ["rs41293463"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA3476",
+                "rsid": "rs41293463",
+                "normalized": ["rs41293463##", "#672#", "CA3476#rs41293463##"],
+                "normalized_id": "rs41293463##",
+                "biotype": "variant",
+                "name": "p.M1775K",
+                "accession": "@VARIANT_p.M1775R_BRCA1_human"
+              },
+              "text": "M1775K",
+              "locations": [{ "offset": 670, "length": 6 }]
+            },
+            {
+              "id": "31",
+              "infons": {
+                "identifier": "tmVar:p|SUB|V|1809|F;HGVS:p.V1809F;VariantGroup:2;CorrespondingGene:672;RS#:28897698;CorrespondingSpecies:9606;CA#:3588",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.V1809F",
+                "gene_ids": [672],
+                "gene_id": 672,
+                "rsids": ["rs28897698"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA3588",
+                "rsid": "rs28897698",
+                "normalized": ["rs28897698##", "#672#", "CA3588#rs28897698##"],
+                "normalized_id": "rs28897698##",
+                "biotype": "variant",
+                "name": "p.V1809F",
+                "accession": "@VARIANT_p.V1809F_BRCA1_human"
+              },
+              "text": "V1809F",
+              "locations": [{ "offset": 681, "length": 6 }]
+            },
+            {
+              "id": "32",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 750, "length": 5 }]
+            },
+            {
+              "id": "33",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 841, "length": 5 }]
+            },
+            {
+              "id": "34",
+              "infons": {
+                "identifier": "MESH:D001943",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D001943"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D001943",
+                "biotype": "disease",
+                "name": "Breast Neoplasms",
+                "accession": "@DISEASE_Breast_Neoplasms"
+              },
+              "text": "breast cancer",
+              "locations": [{ "offset": 885, "length": 13 }]
+            },
+            {
+              "id": "35",
+              "infons": {
+                "identifier": "MESH:D010748",
+                "type": "Chemical",
+                "valid": true,
+                "normalized": ["D010748"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010748",
+                "biotype": "chemical",
+                "name": "Phosphopeptides",
+                "accession": "@CHEMICAL_Phosphopeptides"
+              },
+              "text": "phosphopeptides",
+              "locations": [{ "offset": 988, "length": 15 }]
+            }
+          ],
+          "relations": []
+        }
+      ],
+      "relations": [
+        {
+          "id": "R1",
+          "infons": {
+            "score": "0.9921",
+            "role1": {
+              "identifier": "MESH:D010748",
+              "type": "Chemical",
+              "valid": true,
+              "normalized": ["D010748"],
+              "database": "ncbi_mesh",
+              "normalized_id": "D010748",
+              "biotype": "chemical",
+              "name": "Phosphopeptides",
+              "accession": "@CHEMICAL_Phosphopeptides"
+            },
+            "role2": {
+              "identifier": "672",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [672],
+              "database": "ncbi_gene",
+              "normalized_id": 672,
+              "biotype": "gene",
+              "name": "BRCA1",
+              "accession": "@GENE_BRCA1"
+            },
+            "type": "Association"
+          },
+          "nodes": [{ "refid": "0", "role": "17,15" }]
+        },
+        {
+          "id": "R2",
+          "infons": {
+            "score": "0.9993",
+            "role1": {
+              "identifier": "MESH:D001943",
+              "type": "Disease",
+              "valid": true,
+              "normalized": ["D001943"],
+              "database": "ncbi_mesh",
+              "normalized_id": "D001943",
+              "biotype": "disease",
+              "name": "Breast Neoplasms",
+              "accession": "@DISEASE_Breast_Neoplasms"
+            },
+            "role2": {
+              "identifier": "672",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [672],
+              "database": "ncbi_gene",
+              "normalized_id": 672,
+              "biotype": "gene",
+              "name": "BRCA1",
+              "accession": "@GENE_BRCA1"
+            },
+            "type": "Association"
+          },
+          "nodes": [{ "refid": "1", "role": "16,15" }]
+        }
+      ],
+      "pmid": 34083286,
+      "pmcid": null,
+      "meta": {},
+      "date": "2021-06-01T00:00:00Z",
+      "journal": "Anticancer Res",
+      "authors": ["Drikos I", "Boutou E", "Kastritis PL", "Vorgias CE"],
+      "relations_display": [
+        { "name": "associate|@CHEMICAL_Phosphopeptides|@GENE_BRCA1" },
+        { "name": "associate|@DISEASE_Breast_Neoplasms|@GENE_BRCA1" }
+      ]
+    }
+  },
+  "34137566": {
+    "searchResult": {
+      "_id": "34137566",
+      "pmid": 34137566,
+      "title": "BRCA 1, 2 mutation and earlier menopause: could BRCA 1,2 be used as predictor of menopause?",
+      "journal": "Minerva Obstet Gynecol",
+      "authors": ["Nikolettos K", "Damaskos C", "Garmpis N", "Nikolettos N"],
+      "date": "2022-04-01T00:00:00Z",
+      "doi": "10.23736/S2724-606X.21.04813-2",
+      "meta_date_publication": "2022 Apr",
+      "meta_volume": "74",
+      "meta_issue": "2",
+      "meta_pages": "165-170",
+      "score": 250.24734,
+      "text_hl": "@<m>GENE_BRCA1</m> @@@BRCA 1, 2@@@ mutation and earlier menopause: could @<m>GENE_BRCA1</m> @@@BRCA 1,2@@@ be used as predictor of menopause?",
+      "citations": {
+        "NLM": "Nikolettos K, Damaskos C, Garmpis N, Nikolettos N. BRCA 1, 2 mutation and earlier menopause: could BRCA 1,2 be used as predictor of menopause? Minerva Obstet Gynecol. 2022 Apr;74(2):165-170. PMID: 34137566",
+        "BibTeX": "@article{34137566, title={BRCA 1, 2 mutation and earlier menopause: could BRCA 1,2 be used as predictor of menopause?}, author={Nikolettos K and Damaskos C and Garmpis N and Nikolettos N}, journal={Minerva Obstet Gynecol}, volume={74}, number={2}, pages={165-170}}"
+      }
+    },
+    "abstract": {
+      "_id": "34137566|None",
+      "id": "34137566",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Minerva Obstet Gynecol. 2022 Apr;74(2):165-170. doi: ",
+            "year": "2022",
+            "type": "title",
+            "authors": "Nikolettos K, Damaskos C, Garmpis N, Nikolettos N"
+          },
+          "offset": 0,
+          "text": "BRCA 1, 2 mutation and earlier menopause: could BRCA 1,2 be used as predictor of menopause?",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "2",
+              "infons": {
+                "identifier": "672;675",
+                "type": "Gene",
+                "ncbi_homologene": "5276;41",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA 1, 2",
+              "locations": [{ "offset": 0, "length": 9 }]
+            },
+            {
+              "id": "3",
+              "infons": {
+                "identifier": "672;675",
+                "type": "Gene",
+                "ncbi_homologene": "5276;41",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA 1,2",
+              "locations": [{ "offset": 48, "length": 8 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 92,
+          "text": "INTRODUCTION: Many studies have shown that BRCA mutation is not only related to cancer but also to ovarian aging. Studies in both human and mice oocytes have shown that Double-strand breaks (DSBs) accumulate with age. EVIDENCE ACQUISITION: A review of the literature was completed through the PubMed database aiming to find articles regarding BRCA 1,2 mutation and if they are related to early menopause in order to use them as predictive biomarkers in the near future. The research used keywords in numerous combinations, such as \"BRCA 1,2 mutation,\" \"menopause,\" \"ovarian reserves,\" \"AMH,\" \"genome-wide association studies,\" and \"biomarkers.\" The literature was limited in this specific topic. The initial research found 16 screened articles, 7 of which were not included because there were not relevant, as far as publications in non-English language. EVIDENCE SYNTHESIS: Genome-wide association studies (GWAS) have found 44 genetic loci that are related to variations when a female is about to have menopause. BRCA1 is involved in these 44 loci that are associated with the age of menopause. This review has gathered all results of literature search about the association between BRCA genes and early menopause. Most of the articles found that women with BRCA mutation have earlier menopause compared to non-carriers. CONCLUSIONS: In conclusion, in the near future BRCA1,2 genes could be used as predictive biomarkers of menopause.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "16",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
+                "ncbi_homologene": "5276",
+                "valid": true,
+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA",
+              "locations": [{ "offset": 135, "length": 4 }]
+            },
+            {
+              "id": "17",
+              "infons": {
+                "identifier": "MESH:D009369",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D009369"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009369",
+                "biotype": "disease",
+                "name": "Neoplasms",
+                "accession": "@DISEASE_Neoplasms"
+              },
+              "text": "cancer",
+              "locations": [{ "offset": 172, "length": 6 }]
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+      "authors": ["Nikolettos K", "Damaskos C", "Garmpis N", "Nikolettos N"],
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+      "pmcid": "PMC8375228",
+      "title": "BRCA1 Antibodies Matter.",
+      "journal": "Int J Biol Sci",
+      "authors": ["Yang J", "Qi L", "Chiang HC", "Yuan B", "Li R", "Hu Y"],
+      "date": "2021-07-25T00:00:00Z",
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+        "NLM": "Yang J, Qi L, Chiang HC, Yuan B, Li R, Hu Y. BRCA1 Antibodies Matter. Int J Biol Sci. 2021;17(12):3239-3254. PMID: 34421362",
+        "BibTeX": "@article{34421362, title={BRCA1 Antibodies Matter.}, author={Yang J and Qi L and Chiang HC and Yuan B and Li R and Hu Y}, journal={Int J Biol Sci}, volume={17}, number={12}, pages={3239-3254}}"
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+            "journal": "Int J Biol Sci. 2021 Jul 25;17(12):3239-3254. doi: 10.7150/ijbs.63115. ",
+            "year": "2021",
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+            "authors": "Yang J, Qi L, Chiang HC, Yuan B, Li R, Hu Y"
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+          "text": "Breast cancer susceptibility gene 1 (BRCA1) encodes a tumor suppressor that is frequently mutated in familial breast and ovarian cancer patients. BRCA1 functions in multiple important cellular processes including DNA damage repair, cell cycle checkpoint activation, protein ubiquitination, chromatin remodeling, transcriptional regulation, as well as R-loop formation and apoptosis. A large number of BRCA1 antibodies have been generated and become commercially available over the past three decades, however, many commercial antibodies are poorly characterized and, when widely used, led to unreliable data. In search of reliable and specific BRCA1 antibodies (Abs), particularly antibodies recognizing mouse BRCA1, we performed a rigorous validation of a number of commercially available anti-BRCA1 antibodies, using proper controls in a panel of validation applications, including Western blot (WB), immunoprecipitation (IP), immunoprecipitation-mass spectrometry (IP-MS), chromatin immunoprecipitation (ChIP) and immunofluorescence (IF). Furthermore, we assessed the specificity of these antibodies to detect mouse BRCA1 protein through the use of testis tissue and mouse embryonic fibroblasts (MEFs) from Brca1+/+ and Brca1Delta11/Delta11 mice. We find that Ab1, D-9, 07-434 (for recognizing human BRCA1) and 287.17, 440621, BR-64 (for recognizing mouse BRCA1) are specific with high quality performance in the indicated assays. We share these results here with the goal of helping the community combat the common challenges associated with anti-BRCA1 antibody specificity and reproducibility and, hopefully, better understanding BRCA1 functions at cellular and tissue levels.",
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+      "title": "Novel mechanisms in alcohol neurodevelopmental disorders via BRCA1 depletion and BRCA1-dependent NADPH oxidase regulation.",
+      "journal": "Redox Biol",
+      "authors": ["Drake DM", "Wells PG"],
+      "date": "2021-09-23T00:00:00Z",
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+        "NLM": "Drake DM, Wells PG. Novel mechanisms in alcohol neurodevelopmental disorders via BRCA1 depletion and BRCA1-dependent NADPH oxidase regulation. Redox Biol. 2021 Sep 23;48():102148. PMID: 34736119",
+        "BibTeX": "@article{34736119, title={Novel mechanisms in alcohol neurodevelopmental disorders via BRCA1 depletion and BRCA1-dependent NADPH oxidase regulation.}, author={Drake DM and Wells PG}, journal={Redox Biol}, volume={48}, pages={102148}}"
+      }
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+              "valid": true,
+              "normalized": [672],
+              "database": "ncbi_gene",
+              "normalized_id": 672,
+              "biotype": "gene",
+              "name": "BRCA1",
+              "accession": "@GENE_BRCA1"
+            },
+            "type": "Association"
+          },
+          "nodes": [{ "refid": "2", "role": "1,0" }]
+        }
+      ],
+      "pmid": 35300412,
+      "pmcid": null,
+      "meta": {},
+      "date": "2022-03-01T00:00:00Z",
+      "journal": "Front Cell Dev Biol",
+      "authors": ["Fu X", "Tan W", "Song Q", "Pei H", "Li J"],
+      "relations_display": [
+        { "name": "associate|@DISEASE_Ovarian_Neoplasms|@GENE_BRCA1" },
+        { "name": "inhibit|@DISEASE_Neoplasms|@GENE_BRCA1" },
+        { "name": "associate|@DISEASE_Breast_Neoplasms|@GENE_BRCA1" }
+      ]
+    }
+  },
+  "36270245": {
+    "searchResult": {
+      "_id": "36270245",
+      "pmid": 36270245,
+      "pmcid": "PMC10035668",
+      "title": "BRCA1 protects against its own fragility",
+      "journal": "Mol Cell",
+      "authors": ["Martin SK", "McVey M"],
+      "date": "2022-10-20T00:00:00Z",
+      "doi": "10.1016/j.molcel.2022.09.023",
+      "meta_date_publication": "2022 Oct 20",
+      "meta_volume": "82",
+      "meta_issue": "20",
+      "meta_pages": "3757-3759",
+      "score": 250.26907,
+      "text_hl": "@<m>GENE_BRCA1</m> @@@BRCA1@@@ protects against its own fragility",
+      "citations": {
+        "NLM": "Martin SK, McVey M. BRCA1 protects against its own fragility Mol Cell. 2022 Oct 20;82(20):3757-3759. PMID: 36270245",
+        "BibTeX": "@article{36270245, title={BRCA1 protects against its own fragility}, author={Martin SK and McVey M}, journal={Mol Cell}, volume={82}, number={20}, pages={3757-3759}}"
+      }
+    },
+    "abstract": {
+      "_id": "36270245|None",
+      "id": "36270245",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Mol Cell. 2022 Oct 20;82(20):3757-3759. doi: 10.1016/j.molcel.2022.09.023.",
+            "year": "2022",
+            "article-id_pmc": "PMC10035668",
+            "type": "title",
+            "authors": "Martin SK, McVey M"
+          },
+          "offset": 0,
+          "text": "BRCA1 protects against its own fragility.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "1",
+              "infons": {
+                "identifier": "672",
+                "type": "Gene",
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+                "valid": true,
+                "normalized": [672],
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+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 0, "length": 5 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 42,
+          "text": "Deshpande et al. (2022) demonstrate that BRCA1, a tumor suppressor tasked with protecting the genome, is encoded by a gene that is intrinsically fragile.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "4",
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+                "normalized": [672],
+                "database": "ncbi_gene",
+                "normalized_id": 672,
+                "biotype": "gene",
+                "name": "BRCA1",
+                "accession": "@GENE_BRCA1"
+              },
+              "text": "BRCA1",
+              "locations": [{ "offset": 83, "length": 5 }]
+            },
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+                "biotype": "disease",
+                "name": "Neoplasms",
+                "accession": "@DISEASE_Neoplasms"
+              },
+              "text": "tumor",
+              "locations": [{ "offset": 92, "length": 5 }]
+            }
+          ],
+          "relations": []
+        }
+      ],
+      "relations": [
+        {
+          "id": "R1",
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+            "score": "0.9162",
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+              "type": "Disease",
+              "valid": true,
+              "normalized": ["D009369"],
+              "database": "ncbi_mesh",
+              "normalized_id": "D009369",
+              "biotype": "disease",
+              "name": "Neoplasms",
+              "accession": "@DISEASE_Neoplasms"
+            },
+            "role2": {
+              "identifier": "672",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [672],
+              "database": "ncbi_gene",
+              "normalized_id": 672,
+              "biotype": "gene",
+              "name": "BRCA1",
+              "accession": "@GENE_BRCA1"
+            },
+            "type": "Negative_Correlation"
+          },
+          "nodes": [{ "refid": "0", "role": "2,1" }]
+        }
+      ],
+      "pmid": 36270245,
+      "pmcid": null,
+      "meta": {},
+      "date": "2022-10-20T00:00:00Z",
+      "journal": "Mol Cell",
+      "authors": ["Martin SK", "McVey M"],
+      "relations_display": [{ "name": "inhibit|@DISEASE_Neoplasms|@GENE_BRCA1" }]
+    }
+  }
+}
diff --git a/src/components/GeneLiteratureCard/fixture.pubtatorResults.TGDS.json b/src/components/GeneLiteratureCard/fixture.pubtatorResults.TGDS.json
new file mode 100644
index 0000000..1e4ee35
--- /dev/null
+++ b/src/components/GeneLiteratureCard/fixture.pubtatorResults.TGDS.json
@@ -0,0 +1,6308 @@
+{
+  "31923704": {
+    "searchResult": {
+      "_id": "31923704",
+      "pmid": 31923704,
+      "pmcid": "PMC10521254",
+      "title": "Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism.",
+      "journal": "Bone",
+      "authors": [
+        "Ehmke N",
+        "Cusmano-Ozog K",
+        "Koenig R",
+        "Holtgrewe M",
+        "Nur B",
+        "Mihci E",
+        "Babcock H",
+        "Gonzaga-Jauregui C",
+        "Overton JD",
+        "Xiao J",
+        "Martinez AF",
+        "Muenke M",
+        "Balzer A",
+        "Jochim J",
+        "El Choubassi N",
+        "Fischer-Zirnsak B",
+        "Huber C",
+        "Kornak U",
+        "Elsea SH",
+        "Cormier-Daire V",
+        "Ferreira CR"
+      ],
+      "date": "2020-04-01T00:00:00Z",
+      "doi": "10.1016/j.bone.2019.115219",
+      "meta_date_publication": "2020 Apr",
+      "meta_volume": "133",
+      "meta_issue": "",
+      "meta_pages": "115219",
+      "score": 243.00061,
+      "text_hl": "Chromosomal analysis after amniocentesis showed a normal karyotype 46,XX. Postnatally, no mutations in @<m>GENE_TGDS</m> @@@TGDS@@@ were identified.",
+      "citations": {
+        "NLM": "Ehmke N, Cusmano-Ozog K, Koenig R, Holtgrewe M, Nur B, Mihci E, Babcock H, Gonzaga-Jauregui C, Overton JD, Xiao J, Martinez AF, Muenke M, Balzer A, Jochim J, El Choubassi N, Fischer-Zirnsak B, Huber C, Kornak U, Elsea SH, Cormier-Daire V, Ferreira CR. Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism. Bone. 2020 Apr;133():115219. PMID: 31923704",
+        "BibTeX": "@article{31923704, title={Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism.}, author={Ehmke N and Cusmano-Ozog K and Koenig R and Holtgrewe M and Nur B and Mihci E and Babcock H and Gonzaga-Jauregui C and Overton JD and Xiao J and Martinez AF and Muenke M and Balzer A and Jochim J and El Choubassi N and Fischer-Zirnsak B and Huber C and Kornak U and Elsea SH and Cormier-Daire V and Ferreira CR}, journal={Bone}, volume={133}, pages={115219}}"
+      }
+    },
+    "abstract": {
+      "_id": "31923704|None",
+      "id": "31923704",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Bone. 2020 Apr;133:115219. doi: 10.1016/j.bone.2019.115219. Epub 2020 Jan 7.",
+            "year": "2020",
+            "type": "title",
+            "authors": "Ehmke N, Cusmano-Ozog K, Koenig R, Holtgrewe M, Nur B, Mihci E, Babcock H, Gonzaga-Jauregui C, Overton JD, Xiao J, Martinez AF, Muenke M, Balzer A, Jochim J, El Choubassi N, Fischer-Zirnsak B, Huber C, Kornak U, Elsea SH, Cormier-Daire V, Ferreira CR"
+          },
+          "offset": 0,
+          "text": "Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "3",
+              "infons": {
+                "identifier": "8942",
+                "type": "Gene",
+                "ncbi_homologene": "2925",
+                "valid": true,
+                "normalized": [8942],
+                "database": "ncbi_gene",
+                "normalized_id": 8942,
+                "biotype": "gene",
+                "name": "KYNU",
+                "accession": "@GENE_KYNU"
+              },
+              "text": "KYNU",
+              "locations": [{ "offset": 22, "length": 4 }]
+            },
+            {
+              "id": "4",
+              "infons": {
+                "identifier": "MESH:D019578",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D019578"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D019578",
+                "biotype": "disease",
+                "name": "Multiple System Atrophy",
+                "accession": "@DISEASE_Multiple_System_Atrophy"
+              },
+              "text": "multisystemic syndrome",
+              "locations": [{ "offset": 35, "length": 22 }]
+            },
+            {
+              "id": "5",
+              "infons": {
+                "identifier": "MESH:D006230",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D006230"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D006230",
+                "biotype": "disease",
+                "name": "Hand Injuries",
+                "accession": "@DISEASE_Hand_Injuries"
+              },
+              "text": "hand hyperphalangism",
+              "locations": [{ "offset": 63, "length": 20 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 85,
+          "text": "Catel-Manzke syndrome is characterized by the combination of Pierre Robin sequence and radial deviation, shortening as well as clinodactyly of the index fingers, due to an accessory ossification center. Mutations in TGDS have been identified as one cause of Catel-Manzke syndrome, but cannot be found as causative in every patient with the clinical diagnosis. We performed a chromosome microarray and/or exome sequencing in three patients with hand hyperphalangism, heart defect, short stature, and mild to severe developmental delay, all of whom were initially given a clinical diagnosis of Catel-Manzke syndrome. In one patient, we detected a large deletion of exons 1-8 and the missense variant c.1282C > T (p.Arg428Trp) in KYNU (NM_003937.2), whereas homozygous missense variants in KYNU were found in the other two patients (c.989G > A (p.Arg330Gln) and c.326G > C (p.Trp109Ser)). Plasma and urine metabolomic analysis of two patients indicated a block along the tryptophan catabolic pathway and urine organic acid analysis showed excretion of xanthurenic acid. Biallelic loss-of-function mutations in KYNU were recently described as a cause of NAD deficiency with vertebral, cardiac, renal and limb defects; however, no hand hyperphalangism was described in those patients, and Catel-Manzke syndrome was not discussed as a differential diagnosis. In conclusion, we present unrelated patients identified with biallelic variants in KYNU leading to kynureninase deficiency and xanthurenic aciduria as a very likely cause of their hyperphalangism, heart defect, short stature, and developmental delay. We suggest performance of urine organic acid analysis in patients with suspected Catel-Manzke syndrome, particularly in those with cardiac or vertebral defects or without mutations in TGDS.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "53",
+              "infons": {
+                "identifier": "OMIM:616145",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["616145"],
+                "database": "omim",
+                "normalized_id": "616145",
+                "biotype": "disease",
+                "name": "616145",
+                "accession": "@DISEASE_616145"
+              },
+              "text": "Catel-Manzke syndrome",
+              "locations": [{ "offset": 85, "length": 21 }]
+            },
+            {
+              "id": "54",
+              "infons": {
+                "identifier": "MESH:D010855",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010855"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010855",
+                "biotype": "disease",
+                "name": "Pierre Robin Syndrome",
+                "accession": "@DISEASE_Pierre_Robin_Syndrome"
+              },
+              "text": "Pierre Robin sequence",
+              "locations": [{ "offset": 146, "length": 21 }]
+            },
+            {
+              "id": "55",
+              "infons": {
+                "identifier": "MESH:D010262",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010262"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010262",
+                "biotype": "disease",
+                "name": "Paraphilic Disorders",
+                "accession": "@DISEASE_Paraphilic_Disorders"
+              },
+              "text": "radial deviation",
+              "locations": [{ "offset": 172, "length": 16 }]
+            },
+            {
+              "id": "56",
+              "infons": {
+                "identifier": "OMIM:616145",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["616145"],
+                "database": "omim",
+                "normalized_id": "616145",
+                "biotype": "disease",
+                "name": "616145",
+                "accession": "@DISEASE_616145"
+              },
+              "text": "clinodactyly of the index fingers",
+              "locations": [{ "offset": 212, "length": 33 }]
+            },
+            {
+              "id": "57",
+              "infons": {
+                "identifier": "23483",
+                "type": "Gene",
+                "ncbi_homologene": "129708",
+                "valid": true,
+                "normalized": [23483],
+                "database": "ncbi_gene",
+                "normalized_id": 23483,
+                "biotype": "gene",
+                "name": "TGDS",
+                "accession": "@GENE_TGDS"
+              },
+              "text": "TGDS",
+              "locations": [{ "offset": 301, "length": 4 }]
+            },
+            {
+              "id": "58",
+              "infons": {
+                "identifier": "OMIM:616145",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["616145"],
+                "database": "omim",
+                "normalized_id": "616145",
+                "biotype": "disease",
+                "name": "616145",
+                "accession": "@DISEASE_616145"
+              },
+              "text": "Catel-Manzke syndrome",
+              "locations": [{ "offset": 343, "length": 21 }]
+            },
+            {
+              "id": "59",
+              "infons": {
+                "identifier": "9606",
+                "type": "Species",
+                "valid": true,
+                "normalized": [9606],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 9606,
+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patient",
+              "locations": [{ "offset": 408, "length": 7 }]
+            },
+            {
+              "id": "60",
+              "infons": {
+                "identifier": "9606",
+                "type": "Species",
+                "valid": true,
+                "normalized": [9606],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 9606,
+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patients",
+              "locations": [{ "offset": 515, "length": 8 }]
+            },
+            {
+              "id": "61",
+              "infons": {
+                "identifier": "MESH:D006230",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D006230"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D006230",
+                "biotype": "disease",
+                "name": "Hand Injuries",
+                "accession": "@DISEASE_Hand_Injuries"
+              },
+              "text": "hand hyperphalangism",
+              "locations": [{ "offset": 529, "length": 20 }]
+            },
+            {
+              "id": "62",
+              "infons": {
+                "identifier": "MESH:D006330",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D006330"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D006330",
+                "biotype": "disease",
+                "name": "Heart Defects Congenital",
+                "accession": "@DISEASE_Heart_Defects_Congenital"
+              },
+              "text": "heart defect",
+              "locations": [{ "offset": 551, "length": 12 }]
+            },
+            {
+              "id": "63",
+              "infons": {
+                "identifier": "MESH:D006130",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D006130"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D006130",
+                "biotype": "disease",
+                "name": "Growth Disorders",
+                "accession": "@DISEASE_Growth_Disorders"
+              },
+              "text": "short stature",
+              "locations": [{ "offset": 565, "length": 13 }]
+            },
+            {
+              "id": "64",
+              "infons": {
+                "identifier": "MESH:D002658",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D002658"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D002658",
+                "biotype": "disease",
+                "name": "Developmental Disabilities",
+                "accession": "@DISEASE_Developmental_Disabilities"
+              },
+              "text": "developmental delay",
+              "locations": [{ "offset": 599, "length": 19 }]
+            },
+            {
+              "id": "65",
+              "infons": {
+                "identifier": "OMIM:616145",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["616145"],
+                "database": "omim",
+                "normalized_id": "616145",
+                "biotype": "disease",
+                "name": "616145",
+                "accession": "@DISEASE_616145"
+              },
+              "text": "Catel-Manzke syndrome",
+              "locations": [{ "offset": 677, "length": 21 }]
+            },
+            {
+              "id": "66",
+              "infons": {
+                "identifier": "9606",
+                "type": "Species",
+                "valid": true,
+                "normalized": [9606],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 9606,
+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patient",
+              "locations": [{ "offset": 707, "length": 7 }]
+            },
+            {
+              "id": "67",
+              "infons": {
+                "identifier": "tmVar:c|SUB|C|1282|T;HGVS:c.1282C>T;VariantGroup:0;CorrespondingGene:8942;RS#:147475752;CorrespondingSpecies:9606;CA#:1897043",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "DNAMutation",
+                "database": "litvar",
+                "hgvs": "c.1282C>T",
+                "gene_ids": [8942],
+                "gene_id": 8942,
+                "rsids": ["rs147475752"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA1897043",
+                "rsid": "rs147475752",
+                "normalized": ["rs147475752##", "#8942#", "CA1897043#rs147475752##"],
+                "normalized_id": "rs147475752##",
+                "biotype": "variant",
+                "name": "c.1282C>T",
+                "accession": "@VARIANT_c.1282C>T_KYNU_human"
+              },
+              "text": "c.1282C > T",
+              "locations": [{ "offset": 783, "length": 11 }]
+            },
+            {
+              "id": "68",
+              "infons": {
+                "identifier": "tmVar:p|SUB|R|428|W;HGVS:p.R428W;VariantGroup:0;CorrespondingGene:8942;RS#:147475752;CorrespondingSpecies:9606;CA#:1897043",
+                "type": "Variant",
+                "valid": true,
+                "subtype": "ProteinMutation",
+                "database": "litvar",
+                "hgvs": "p.R428W",
+                "gene_ids": [8942],
+                "gene_id": 8942,
+                "rsids": ["rs147475752"],
+                "species_ids": [9606],
+                "species_id": 9606,
+                "clingen_id": "CA1897043",
+                "rsid": "rs147475752",
+                "normalized": ["rs147475752##", "#8942#", "CA1897043#rs147475752##"],
+                "normalized_id": "rs147475752##",
+                "biotype": "variant",
+                "name": "p.R428W",
+                "accession": "@VARIANT_c.1282C>T_KYNU_human"
+              },
+              "text": "p.Arg428Trp",
+              "locations": [{ "offset": 796, "length": 11 }]
+            },
+            {
+              "id": "69",
+              "infons": {
+                "identifier": "8942",
+                "type": "Gene",
+                "ncbi_homologene": "2925",
+                "valid": true,
+                "normalized": [8942],
+                "database": "ncbi_gene",
+                "normalized_id": 8942,
+                "biotype": "gene",
+                "name": "KYNU",
+                "accession": "@GENE_KYNU"
+              },
+              "text": "KYNU",
+              "locations": [{ "offset": 812, "length": 4 }]
+            },
+            {
+              "id": "70",
+              "infons": {
+                "type": "Species",
+                "valid": false,
+                "normalized_id": null,
+                "biotype": "species"
+              },
+              "text": "NM_003937.2",
+              "locations": [{ "offset": 818, "length": 11 }]
+            },
+            {
+              "id": "71",
+              "infons": {
+                "identifier": "8942",
+                "type": "Gene",
+                "ncbi_homologene": "2925",
+                "valid": true,
+                "normalized": [8942],
+                "database": "ncbi_gene",
+                "normalized_id": 8942,
+                "biotype": "gene",
+                "name": "KYNU",
+                "accession": "@GENE_KYNU"
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+      "date": "2020-04-01T00:00:00Z",
+      "journal": "Bone",
+      "authors": [
+        "Ehmke N",
+        "Cusmano-Ozog K",
+        "Koenig R",
+        "Holtgrewe M",
+        "Nur B",
+        "Mihci E",
+        "Babcock H",
+        "Gonzaga-Jauregui C",
+        "Overton JD",
+        "Xiao J",
+        "Martinez AF",
+        "Muenke M",
+        "Balzer A",
+        "Jochim J",
+        "El Choubassi N",
+        "Fischer-Zirnsak B",
+        "Huber C",
+        "Kornak U",
+        "Elsea SH",
+        "Cormier-Daire V",
+        "Ferreira CR"
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+        { "name": "associate|@DISEASE_Hand_Injuries|@GENE_KYNU" },
+        { "name": "associate|@DISEASE_Hydroxykynureninuria|@GENE_KYNU" },
+        { "name": "associate|@DISEASE_616145|@GENE_KYNU" },
+        { "name": "associate|@DISEASE_Heart_Defects_Congenital|@GENE_KYNU" },
+        { "name": "associate|@DISEASE_Holt_Oram_syndrome|@GENE_KYNU" }
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+      "journal": "Nucleic Acids Res",
+      "authors": [
+        "Holtgrewe M",
+        "Stolpe O",
+        "Nieminen M",
+        "Mundlos S",
+        "Knaus A",
+        "Kornak U",
+        "Seelow D",
+        "Segebrecht L",
+        "Spielmann M",
+        "Fischer-Zirnsak B",
+        "Boschann F",
+        "Scholl U",
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+        "NLM": "Holtgrewe M, Stolpe O, Nieminen M, Mundlos S, Knaus A, Kornak U, Seelow D, Segebrecht L, Spielmann M, Fischer-Zirnsak B, Boschann F, Scholl U, Ehmke N, Beule D. VarFish: comprehensive DNA variant analysis for diagnostics and research. Nucleic Acids Res. 2020 Jul 2;48(W1):W162-W169. PMID: 32338743",
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+          "text": "VarFish is a user-friendly web application for the quality control, filtering, prioritization, analysis, and user-based annotation of DNA variant data with a focus on rare disease genetics. It is capable of processing variant call files with single or multiple samples. The variants are automatically annotated with population frequencies, molecular impact, and presence in databases such as ClinVar. Further, it provides support for pathogenicity scores including CADD, MutationTaster, and phenotypic similarity scores. Users can filter variants based on these annotations and presumed inheritance pattern and sort the results by these scores. Variants passing the filter are listed with their annotations and many useful link-outs to genome browsers, other gene/variant data portals, and external tools for variant assessment. VarFish allows users to create their own annotations including support for variant assessment following ACMG-AMP guidelines. In close collaboration with medical practitioners, VarFish was designed for variant analysis and prioritization in diagnostic and research settings as described in the software's extensive manual. The user interface has been optimized for supporting these protocols. Users can install VarFish on their own in-house servers where it provides additional lab notebook features for collaborative analysis and allows re-analysis of cases, e.g. after update of genotype or phenotype databases.",
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+      "title": "A Homozygous Deletion of Exon 5 of KYNU Resulting from a Maternal Chromosome 2 Isodisomy (UPD2) Causes Catel-Manzke-Syndrome/VCRL Syndrome.",
+      "journal": "Genes (Basel)",
+      "authors": [
+        "Schüle I",
+        "Berger U",
+        "Matysiak U",
+        "Ruzaike G",
+        "Stiller B",
+        "Pohl M",
+        "Spiekerkoetter U",
+        "Lausch E",
+        "Grünert SC",
+        "Schmidts M"
+      ],
+      "date": "2021-06-07T00:00:00Z",
+      "doi": "10.3390/genes12060879",
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+      "meta_volume": "12",
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+      "text_hl": "The phenotype of patients with VCRL is overlapping with that of @DISEASE_616145 @@@CATMANS@@@ (@DISEASE_616145 @@@Catel-Manzke Syndrome@@@, @DISEASE_616145 @@@CMS@@@) patients which is caused by mutations in the @<m>GENE_TGDS</m> @@@TGDS@@@ gene that encodes for @<m>GENE_TGDS</m> @@@TDP-glucose 4,6-dehydratase@@@. ",
+      "citations": {
+        "NLM": "Schüle I, Berger U, Matysiak U, Ruzaike G, Stiller B, Pohl M, Spiekerkoetter U, Lausch E, Grünert SC, Schmidts M. A Homozygous Deletion of Exon 5 of KYNU Resulting from a Maternal Chromosome 2 Isodisomy (UPD2) Causes Catel-Manzke-Syndrome/VCRL Syndrome. Genes (Basel). 2021 Jun 7;12(6):. PMID: 34200361",
+        "BibTeX": "@article{34200361, title={A Homozygous Deletion of Exon 5 of KYNU Resulting from a Maternal Chromosome 2 Isodisomy (UPD2) Causes Catel-Manzke-Syndrome/VCRL Syndrome.}, author={Schüle I and Berger U and Matysiak U and Ruzaike G and Stiller B and Pohl M and Spiekerkoetter U and Lausch E and Grünert SC and Schmidts M}, journal={Genes (Basel)}, volume={12}, number={6}}"
+      }
+    },
+    "abstract": {
+      "_id": "34200361|None",
+      "id": "34200361",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Genes (Basel). 2021 Jun 7;12(6):879. doi: 10.3390/genes12060879.",
+            "year": "2021",
+            "article-id_pmc": "PMC8227568",
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+            "authors": "Schule I, Berger U, Matysiak U, Ruzaike G, Stiller B, Pohl M, Spiekerkoetter U, Lausch E, Grunert SC, Schmidts M"
+          },
+          "offset": 0,
+          "text": "A Homozygous Deletion of Exon 5 of KYNU Resulting from a Maternal Chromosome 2 Isodisomy (UPD2) Causes Catel-Manzke-Syndrome/VCRL Syndrome.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "5",
+              "infons": {
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+                "normalized": [8942],
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+                "normalized_id": 8942,
+                "biotype": "gene",
+                "name": "KYNU",
+                "accession": "@GENE_KYNU"
+              },
+              "text": "KYNU",
+              "locations": [{ "offset": 35, "length": 4 }]
+            },
+            {
+              "id": "6",
+              "infons": {
+                "identifier": "MESH:D024182",
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+                "valid": true,
+                "normalized": ["D024182"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D024182",
+                "biotype": "disease",
+                "name": "Uniparental Disomy",
+                "accession": "@DISEASE_Uniparental_Disomy"
+              },
+              "text": "Maternal Chromosome 2 Isodisomy",
+              "locations": [{ "offset": 57, "length": 31 }]
+            },
+            {
+              "id": "7",
+              "infons": {
+                "type": "Disease",
+                "valid": false,
+                "normalized_id": null,
+                "biotype": "disease"
+              },
+              "text": "UPD2",
+              "locations": [{ "offset": 90, "length": 4 }]
+            },
+            {
+              "id": "8",
+              "infons": {
+                "identifier": "OMIM:616145",
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+                "valid": true,
+                "normalized": ["616145"],
+                "database": "omim",
+                "normalized_id": "616145",
+                "biotype": "disease",
+                "name": "616145",
+                "accession": "@DISEASE_616145"
+              },
+              "text": "Catel-Manzke-Syndrome",
+              "locations": [{ "offset": 103, "length": 21 }]
+            },
+            {
+              "id": "9",
+              "infons": {
+                "identifier": "MESH:D013577",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D013577"],
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+                "biotype": "disease",
+                "name": "Syndrome",
+                "accession": "@DISEASE_Syndrome"
+              },
+              "text": "VCRL Syndrome",
+              "locations": [{ "offset": 125, "length": 13 }]
+            }
+          ],
+          "relations": []
+        },
+        {
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+          "offset": 140,
+          "text": "Vertebral, Cardiac, Renal and Limb Defect Syndrome (VCRL), is a very rare congenital malformation syndrome. Pathogenic variants in HAAO (3-Hydroxyanthranilate 3,4-dioxygenase), NADSYN1 (NAD+ Synthetase-1) and KYNU (Kynureninase) have been identified in a handful of affected individuals. All three genes encode for enzymes essential for the NAD+ de novo synthesis pathway. Using Trio-Exome analysis and CGH array analysis in combination with long range PCR, we have identified a novel homozygous copy number variant (CNV) encompassing exon 5 of KYNU in an individual presenting with overlapping features of VCRL and Catel-Manzke Syndrome. Interestingly, only the mother, not the father carried the small deletion in a heterozygous state. High-resolution SNP array analysis subsequently delineated a maternal isodisomy of chromosome 2 (UPD2). Increased xanthurenic acid excretion in the urine confirmed the genetic diagnosis. Our findings confirm the clinical, genetic and metabolic phenotype of VCRL1, adding a novel functionally tested disease allele. We also describe the first patient with NAD+ deficiency disorder resulting from a UPD. Furthermore, we provide a comprehensive review of the current literature covering the genetic basis and pathomechanisms for VCRL and Catel-Manzke Syndrome, including possible phenotype/genotype correlations as well as genetic causes of hypoplastic left heart syndrome.",
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+                "name": "Holt-Oram syndrome",
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+              },
+              "text": "Vertebral, Cardiac, Renal and Limb Defect Syndrome",
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+            {
+              "id": "33",
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+            },
+            {
+              "id": "34",
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+                "biotype": "disease",
+                "name": "163000",
+                "accession": "@DISEASE_163000"
+              },
+              "text": "congenital malformation syndrome",
+              "locations": [{ "offset": 214, "length": 32 }]
+            },
+            {
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+            },
+            {
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+                "name": "HAAO",
+                "accession": "@GENE_HAAO"
+              },
+              "text": "3-Hydroxyanthranilate 3,4-dioxygenase",
+              "locations": [{ "offset": 277, "length": 37 }]
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+      "journal": "Genes (Basel)",
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+        "Schüle I",
+        "Berger U",
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+      "_id": "34526359",
+      "pmid": 34526359,
+      "pmcid": "PMC7612071",
+      "title": "Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma.",
+      "journal": "Clin Cancer Res",
+      "authors": [
+        "Ziccheddu B",
+        "Da Vià MC",
+        "Lionetti M",
+        "Maeda A",
+        "Morlupi S",
+        "Dugo M",
+        "Todoerti K",
+        "Oliva S",
+        "D'Agostino M",
+        "Corradini P",
+        "Landgren O",
+        "Iorio F",
+        "Pettine L",
+        "Pompa A",
+        "Manzoni M",
+        "Baldini L",
+        "Neri A",
+        "Maura F",
+        "Bolli N"
+      ],
+      "date": "2021-12-01T00:00:00Z",
+      "doi": "10.1158/1078-0432.CCR-20-4366",
+      "meta_date_publication": "2021 Dec 1",
+      "meta_volume": "27",
+      "meta_issue": "23",
+      "meta_pages": "6479-6490",
+      "score": 206.21944,
+      "text_hl": "S1A and S1B). Among less frequent mutations, @<m>GENE_TGDS</m> @@@TGDS@@@ and @GENE_RB1 @@@RB1@@@ in 13q and the @GENE_MYC @@@MYC@@@ transcriptional regulators @GENE_IRF4 @@@IRF4@@@ and MAX displayed correlation with the transcriptome. ",
+      "citations": {
+        "NLM": "Ziccheddu B, Da Vià MC, Lionetti M, Maeda A, Morlupi S, Dugo M, Todoerti K, Oliva S, D'Agostino M, Corradini P, Landgren O, Iorio F, Pettine L, Pompa A, Manzoni M, Baldini L, Neri A, Maura F, Bolli N. Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma. Clin Cancer Res. 2021 Dec 1;27(23):6479-6490. PMID: 34526359",
+        "BibTeX": "@article{34526359, title={Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma.}, author={Ziccheddu B and Da Vià MC and Lionetti M and Maeda A and Morlupi S and Dugo M and Todoerti K and Oliva S and D'Agostino M and Corradini P and Landgren O and Iorio F and Pettine L and Pompa A and Manzoni M and Baldini L and Neri A and Maura F and Bolli N}, journal={Clin Cancer Res}, volume={27}, number={23}, pages={6479-6490}}"
+      }
+    },
+    "abstract": {
+      "_id": "34526359|None",
+      "id": "34526359",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Clin Cancer Res. 2021 Dec 1;27(23):6479-6490. doi: 10.1158/1078-0432.CCR-20-4366. ",
+            "year": "2021",
+            "article-id_pmc": "PMC7612071",
+            "type": "title",
+            "authors": "Ziccheddu B, Da Via MC, Lionetti M, Maeda A, Morlupi S, Dugo M, Todoerti K, Oliva S, D Agostino M, Corradini P, Landgren O, Iorio F, Pettine L, Pompa A, Manzoni M, Baldini L, Neri A, Maura F, Bolli N"
+          },
+          "offset": 0,
+          "text": "Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "1",
+              "infons": {
+                "identifier": "MESH:D009101",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D009101"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009101",
+                "biotype": "disease",
+                "name": "Multiple Myeloma",
+                "accession": "@DISEASE_Multiple_Myeloma"
+              },
+              "text": "Multiple Myeloma",
+              "locations": [{ "offset": 64, "length": 16 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 82,
+          "text": "PURPOSE: Multiple myeloma is a biologically heterogenous plasma-cell disorder. In this study, we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNA), and chromosomal rearrangements (CR). Moreover, we applied a geno-transcriptomic approach to identify specific biomarkers for personalized treatments. EXPERIMENTAL DESIGN: We analyzed 514 newly diagnosed patients from the IA12 release of the CoMMpass study, accounting for mutations in multiple myeloma driver genes, structural variants, copy-number segments, and raw-transcript counts. We performed an in silico drug sensitivity screen (DSS), interrogating the Cancer Dependency Map (DepMap) dataset after anchoring cell lines to primary tumor samples using the Celligner algorithm. RESULTS: Immunoglobulin translocations, hyperdiploidy and chr(1q)gain/amps were associated with the highest number of deregulated genes. Other CNAs and specific gene mutations had a lower but very distinct impact affecting specific pathways. Many recurrent genes showed a hotspot (HS)-specific effect. The clinical relevance of double-hit multiple myeloma found strong biological bases in our analysis. Biallelic deletions of tumor suppressors and chr(1q)-amplifications showed the greatest impact on gene expression, deregulating pathways related to cell cycle, proliferation, and expression of immunotherapy targets. Moreover, our in silico DSS showed that not only t(11;14) but also chr(1q)gain/amps and CYLD inactivation predicted differential expression of transcripts of the BCL2 axis and response to venetoclax. CONCLUSIONS: The multiple myeloma genomic architecture and transcriptome have a strict connection, led by CNAs and CRs. Gene mutations impacted especially with HS-mutations of oncogenes and biallelic tumor suppressor gene inactivation. Finally, a comprehensive geno-transcriptomic analysis allows the identification of specific deregulated pathways and candidate biomarkers for personalized treatments in multiple myeloma.",
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+                "biotype": "disease",
+                "name": "Multiple Myeloma",
+                "accession": "@DISEASE_Multiple_Myeloma"
+              },
+              "text": "Multiple myeloma",
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+                "name": "Leukemia Plasma Cell",
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+                "biotype": "disease",
+                "name": "Kidney Diseases",
+                "accession": "@DISEASE_Kidney_Diseases"
+              },
+              "text": "copy-number abnormalities",
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+                "biotype": "disease",
+                "name": "Kidney Diseases",
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+                "biotype": "disease",
+                "name": "Chromosome Disorders",
+                "accession": "@DISEASE_Chromosome_Disorders"
+              },
+              "text": "chromosomal",
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+            },
+            {
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+                "biotype": "species",
+                "name": "9606",
+                "accession": null
+              },
+              "text": "patients",
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+            },
+            {
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+                "database": "ncbi_mesh",
+                "normalized_id": "D009101",
+                "biotype": "disease",
+                "name": "Multiple Myeloma",
+                "accession": "@DISEASE_Multiple_Myeloma"
+              },
+              "text": "multiple myeloma",
+              "locations": [{ "offset": 575, "length": 16 }]
+            },
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+                "biotype": "disease",
+                "name": "Neoplasms",
+                "accession": "@DISEASE_Neoplasms"
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+              "text": "Cancer",
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+                "normalized": ["D009369"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009369",
+                "biotype": "disease",
+                "name": "Neoplasms",
+                "accession": "@DISEASE_Neoplasms"
+              },
+              "text": "tumor",
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+                "normalized_id": "D009101",
+                "biotype": "disease",
+                "name": "Multiple Myeloma",
+                "accession": "@DISEASE_Multiple_Myeloma"
+              },
+              "text": "multiple myeloma",
+              "locations": [{ "offset": 1212, "length": 16 }]
+            },
+            {
+              "id": "29",
+              "infons": {
+                "identifier": "MESH:D009369",
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+                "valid": true,
+                "normalized": ["D009369"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009369",
+                "biotype": "disease",
+                "name": "Neoplasms",
+                "accession": "@DISEASE_Neoplasms"
+              },
+              "text": "tumor",
+              "locations": [{ "offset": 1299, "length": 5 }]
+            },
+            {
+              "id": "30",
+              "infons": {
+                "identifier": "1540",
+                "type": "Gene",
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+                "database": "ncbi_gene",
+                "normalized_id": 1540,
+                "biotype": "gene",
+                "name": "CYLD",
+                "accession": "@GENE_CYLD"
+              },
+              "text": "CYLD",
+              "locations": [{ "offset": 1580, "length": 4 }]
+            },
+            {
+              "id": "31",
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+                "valid": true,
+                "normalized": [596],
+                "database": "ncbi_gene",
+                "normalized_id": 596,
+                "biotype": "gene",
+                "name": "BCL2",
+                "accession": "@GENE_BCL2"
+              },
+              "text": "BCL2",
+              "locations": [{ "offset": 1654, "length": 4 }]
+            },
+            {
+              "id": "32",
+              "infons": {
+                "identifier": "MESH:C579720",
+                "type": "Chemical",
+                "valid": true,
+                "normalized": ["C579720"],
+                "database": "ncbi_mesh",
+                "normalized_id": "C579720",
+                "biotype": "chemical",
+                "name": "venetoclax",
+                "accession": "@CHEMICAL_venetoclax"
+              },
+              "text": "venetoclax",
+              "locations": [{ "offset": 1680, "length": 10 }]
+            },
+            {
+              "id": "33",
+              "infons": {
+                "identifier": "MESH:D009101",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D009101"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009101",
+                "biotype": "disease",
+                "name": "Multiple Myeloma",
+                "accession": "@DISEASE_Multiple_Myeloma"
+              },
+              "text": "multiple myeloma",
+              "locations": [{ "offset": 1709, "length": 16 }]
+            },
+            {
+              "id": "34",
+              "infons": {
+                "identifier": "MESH:D009369",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D009369"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009369",
+                "biotype": "disease",
+                "name": "Neoplasms",
+                "accession": "@DISEASE_Neoplasms"
+              },
+              "text": "tumor",
+              "locations": [{ "offset": 1892, "length": 5 }]
+            },
+            {
+              "id": "35",
+              "infons": {
+                "identifier": "MESH:D009101",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D009101"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D009101",
+                "biotype": "disease",
+                "name": "Multiple Myeloma",
+                "accession": "@DISEASE_Multiple_Myeloma"
+              },
+              "text": "multiple myeloma",
+              "locations": [{ "offset": 2097, "length": 16 }]
+            }
+          ],
+          "relations": []
+        }
+      ],
+      "relations": [
+        {
+          "id": "R1",
+          "infons": {
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+              "database": "ncbi_gene",
+              "normalized_id": 1540,
+              "biotype": "gene",
+              "name": "CYLD",
+              "accession": "@GENE_CYLD"
+            },
+            "role2": {
+              "identifier": "596",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [596],
+              "database": "ncbi_gene",
+              "normalized_id": 596,
+              "biotype": "gene",
+              "name": "BCL2",
+              "accession": "@GENE_BCL2"
+            },
+            "type": "Association"
+          },
+          "nodes": [{ "refid": "0", "role": "12,13" }]
+        },
+        {
+          "id": "R2",
+          "infons": {
+            "score": "0.9992",
+            "role1": {
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+              "type": "Chemical",
+              "valid": true,
+              "normalized": ["C579720"],
+              "database": "ncbi_mesh",
+              "normalized_id": "C579720",
+              "biotype": "chemical",
+              "name": "venetoclax",
+              "accession": "@CHEMICAL_venetoclax"
+            },
+            "role2": {
+              "identifier": "1540",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [1540],
+              "database": "ncbi_gene",
+              "normalized_id": 1540,
+              "biotype": "gene",
+              "name": "CYLD",
+              "accession": "@GENE_CYLD"
+            },
+            "type": "Association"
+          },
+          "nodes": [{ "refid": "1", "role": "14,12" }]
+        }
+      ],
+      "pmid": 34526359,
+      "pmcid": null,
+      "meta": {},
+      "date": "2021-12-01T00:00:00Z",
+      "journal": "Clin Cancer Res",
+      "authors": [
+        "Ziccheddu B",
+        "Da Vià MC",
+        "Lionetti M",
+        "Maeda A",
+        "Morlupi S",
+        "Dugo M",
+        "Todoerti K",
+        "Oliva S",
+        "D'Agostino M",
+        "Corradini P",
+        "Landgren O",
+        "Iorio F",
+        "Pettine L",
+        "Pompa A",
+        "Manzoni M",
+        "Baldini L",
+        "Neri A",
+        "Maura F",
+        "Bolli N"
+      ],
+      "relations_display": [
+        { "name": "associate|@GENE_CYLD|@GENE_BCL2" },
+        { "name": "associate|@CHEMICAL_venetoclax|@GENE_CYLD" }
+      ]
+    }
+  },
+  "35415063": {
+    "searchResult": {
+      "_id": "35415063",
+      "pmid": 35415063,
+      "pmcid": "PMC8994080",
+      "title": "The Pathogenesis of Pierre Robin Sequence through a Review of SOX9 and Its Interactions.",
+      "journal": "Plast Reconstr Surg Glob Open",
+      "authors": ["Al-Qattan MM", "Almohrij SA"],
+      "date": "2022-04-08T00:00:00Z",
+      "doi": "10.1097/GOX.0000000000004241",
+      "meta_date_publication": "2022 Apr",
+      "meta_volume": "10",
+      "meta_issue": "4",
+      "meta_pages": "e4241",
+      "score": 208.83943,
+      "text_hl": "...The @<m>GENE_TGDS</m> @@@TGDS@@@ gene encodes the @<m>GENE_TGDS</m> @@@TGDS@@@ protein, which is an enzyme involved in @CHEMICAL_Glucose @@@glucose@@@ metabolism. ",
+      "citations": {
+        "NLM": "Al-Qattan MM, Almohrij SA. The Pathogenesis of Pierre Robin Sequence through a Review of SOX9 and Its Interactions. Plast Reconstr Surg Glob Open. 2022 Apr;10(4):e4241. PMID: 35415063",
+        "BibTeX": "@article{35415063, title={The Pathogenesis of Pierre Robin Sequence through a Review of SOX9 and Its Interactions.}, author={Al-Qattan MM and Almohrij SA}, journal={Plast Reconstr Surg Glob Open}, volume={10}, number={4}, pages={e4241}}"
+      }
+    },
+    "abstract": {
+      "_id": "35415063|None",
+      "id": "35415063",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Plast Reconstr Surg Glob Open. 2022 Apr 8;10(4):e4241. doi: ",
+            "year": "2022",
+            "article-id_pmc": "PMC8994080",
+            "type": "title",
+            "authors": "Al-Qattan MM, Almohrij SA"
+          },
+          "offset": 0,
+          "text": "The Pathogenesis of Pierre Robin Sequence through a Review of SOX9 and Its Interactions.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "1",
+              "infons": {
+                "identifier": "MESH:D010855",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010855"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010855",
+                "biotype": "disease",
+                "name": "Pierre Robin Syndrome",
+                "accession": "@DISEASE_Pierre_Robin_Syndrome"
+              },
+              "text": "Pierre Robin Sequence",
+              "locations": [{ "offset": 20, "length": 21 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 89,
+          "text": "The literature does not offer any review of the pathogenesis of the clinical features of syndromes with Pierre Robin sequence (PRS). The senior author (MMA) proposed a hypothesis that SOX9 and its interactions may play a key role in this pathogenesis. The current review aims to test this hypothesis. Methods: Three literature searches were made: the first aimed to document the main syndromes associated with PRS; and the second was to document the main functions of SOX9 in development; and the third was to investigate if SOX9 and its interactions may play a role in the pathogenesis. Results: SOX9 is the main positive regulator in the development of the mandibular cartilage and it also enhances collagen type II (the main collagen type in cartilage) expression in the mandibular cartilage. Furthermore, SOX9 participates in neural crest development, binds to the exon junction complex, and participates in sex determination. The interactions of SOX9 could explain the pathogenesis of the clinical features of syndromic PRS. These included interactions with collagen type II (in Strickler syndrome), exon junction complex (in Richier-Costa-Periera syndrome), glucose (in Catel-Manzke syndrome), RNA-binding proteins (in TARP syndrome), and the spliceosome (in cerebra-costo-mandibular syndrome). Finally, SOX9 mutations cause campomelic dysplasia. Conclusions: The review supports the hypothesis of the participation of SOX9 in the pathogenesis of the clinical features of syndromic and nonsyndromic PRS. This should guide future research on the topic.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "14",
+              "infons": {
+                "identifier": "MESH:D010855",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010855"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010855",
+                "biotype": "disease",
+                "name": "Pierre Robin Syndrome",
+                "accession": "@DISEASE_Pierre_Robin_Syndrome"
+              },
+              "text": "Pierre Robin sequence",
+              "locations": [{ "offset": 193, "length": 21 }]
+            },
+            {
+              "id": "15",
+              "infons": {
+                "identifier": "MESH:D010855",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010855"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010855",
+                "biotype": "disease",
+                "name": "Pierre Robin Syndrome",
+                "accession": "@DISEASE_Pierre_Robin_Syndrome"
+              },
+              "text": "PRS",
+              "locations": [{ "offset": 216, "length": 3 }]
+            },
+            {
+              "id": "16",
+              "infons": {
+                "identifier": "MESH:D010855",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010855"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010855",
+                "biotype": "disease",
+                "name": "Pierre Robin Syndrome",
+                "accession": "@DISEASE_Pierre_Robin_Syndrome"
+              },
+              "text": "PRS",
+              "locations": [{ "offset": 499, "length": 3 }]
+            },
+            {
+              "id": "17",
+              "infons": {
+                "identifier": "MESH:D010855",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010855"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010855",
+                "biotype": "disease",
+                "name": "Pierre Robin Syndrome",
+                "accession": "@DISEASE_Pierre_Robin_Syndrome"
+              },
+              "text": "PRS",
+              "locations": [{ "offset": 1114, "length": 3 }]
+            },
+            {
+              "id": "18",
+              "infons": {
+                "identifier": "MESH:D013577",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D013577"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D013577",
+                "biotype": "disease",
+                "name": "Syndrome",
+                "accession": "@DISEASE_Syndrome"
+              },
+              "text": "Strickler syndrome",
+              "locations": [{ "offset": 1173, "length": 18 }]
+            },
+            {
+              "id": "19",
+              "infons": {
+                "identifier": "MESH:C535653",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["C535653"],
+                "database": "ncbi_mesh",
+                "normalized_id": "C535653",
+                "biotype": "disease",
+                "name": "Acrokeratoelastoidosis of Costa",
+                "accession": "@DISEASE_Acrokeratoelastoidosis_of_Costa"
+              },
+              "text": "Richier-Costa-Periera syndrome",
+              "locations": [{ "offset": 1220, "length": 30 }]
+            },
+            {
+              "id": "20",
+              "infons": {
+                "identifier": "MESH:D005947",
+                "type": "Chemical",
+                "valid": true,
+                "normalized": ["D005947"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D005947",
+                "biotype": "chemical",
+                "name": "Glucose",
+                "accession": "@CHEMICAL_Glucose"
+              },
+              "text": "glucose",
+              "locations": [{ "offset": 1253, "length": 7 }]
+            },
+            {
+              "id": "21",
+              "infons": {
+                "identifier": "OMIM:616145",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["616145"],
+                "database": "omim",
+                "normalized_id": "616145",
+                "biotype": "disease",
+                "name": "616145",
+                "accession": "@DISEASE_616145"
+              },
+              "text": "Catel-Manzke syndrome",
+              "locations": [{ "offset": 1265, "length": 21 }]
+            },
+            {
+              "id": "22",
+              "infons": {
+                "identifier": "MESH:C536942",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["C536942"],
+                "database": "ncbi_mesh",
+                "normalized_id": "C536942",
+                "biotype": "disease",
+                "name": "TARP syndrome",
+                "accession": "@DISEASE_TARP_syndrome"
+              },
+              "text": "TARP syndrome",
+              "locations": [{ "offset": 1314, "length": 13 }]
+            },
+            {
+              "id": "23",
+              "infons": {
+                "identifier": "MESH:D008338",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D008338"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D008338",
+                "biotype": "disease",
+                "name": "Mandibular Injuries",
+                "accession": "@DISEASE_Mandibular_Injuries"
+              },
+              "text": "cerebra-costo-mandibular syndrome",
+              "locations": [{ "offset": 1354, "length": 33 }]
+            },
+            {
+              "id": "24",
+              "infons": {
+                "identifier": "MESH:D055036",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D055036"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D055036",
+                "biotype": "disease",
+                "name": "Campomelic Dysplasia",
+                "accession": "@DISEASE_Campomelic_Dysplasia"
+              },
+              "text": "campomelic dysplasia",
+              "locations": [{ "offset": 1420, "length": 20 }]
+            },
+            {
+              "id": "25",
+              "infons": {
+                "identifier": "MESH:D010855",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D010855"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D010855",
+                "biotype": "disease",
+                "name": "Pierre Robin Syndrome",
+                "accession": "@DISEASE_Pierre_Robin_Syndrome"
+              },
+              "text": "syndromic and nonsyndromic PRS",
+              "locations": [{ "offset": 1567, "length": 30 }]
+            }
+          ],
+          "relations": []
+        }
+      ],
+      "relations": [],
+      "pmid": 35415063,
+      "pmcid": null,
+      "meta": {},
+      "date": "2022-04-08T00:00:00Z",
+      "journal": "Plast Reconstr Surg Glob Open",
+      "authors": ["Al-Qattan MM", "Almohrij SA"],
+      "relations_display": []
+    }
+  },
+  "36498914": {
+    "searchResult": {
+      "_id": "36498914",
+      "pmid": 36498914,
+      "pmcid": "PMC9741107",
+      "title": "The L-Rhamnose Biosynthetic Pathway in Trichomonas vaginalis: Identification and Characterization of UDP-D-Glucose 4,6-dehydratase.",
+      "journal": "Int J Mol Sci",
+      "authors": [
+        "Gaglianone M",
+        "Laugieri ME",
+        "Rojas AL",
+        "Coppola MR",
+        "Piacente F",
+        "Fiori PL",
+        "Tonetti MG"
+      ],
+      "date": "2022-11-23T00:00:00Z",
+      "doi": "10.3390/ijms232314587",
+      "meta_date_publication": "2022 Nov 23",
+      "meta_volume": "23",
+      "meta_issue": "23",
+      "meta_pages": "",
+      "score": 206.58212,
+      "text_hl": "Thus, in the perspective to use NDP-D-Glc 4,6-dehydratases as pharmacologic targets, further studies will also be required to understand the role of @<m>GENE_TGDS</m> @@@TGDS@@@ in human cells.",
+      "citations": {
+        "NLM": "Gaglianone M, Laugieri ME, Rojas AL, Coppola MR, Piacente F, Fiori PL, Tonetti MG. The L-Rhamnose Biosynthetic Pathway in Trichomonas vaginalis: Identification and Characterization of UDP-D-Glucose 4,6-dehydratase. Int J Mol Sci. 2022 Nov 23;23(23):. PMID: 36498914",
+        "BibTeX": "@article{36498914, title={The L-Rhamnose Biosynthetic Pathway in Trichomonas vaginalis: Identification and Characterization of UDP-D-Glucose 4,6-dehydratase.}, author={Gaglianone M and Laugieri ME and Rojas AL and Coppola MR and Piacente F and Fiori PL and Tonetti MG}, journal={Int J Mol Sci}, volume={23}, number={23}}"
+      }
+    },
+    "abstract": {
+      "_id": "36498914|None",
+      "id": "36498914",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "Int J Mol Sci. 2022 Nov 23;23(23):14587. doi: 10.3390/ijms232314587.",
+            "year": "2022",
+            "article-id_pmc": "PMC9741107",
+            "type": "title",
+            "authors": "Gaglianone M, Laugieri ME, Rojas AL, Coppola MR, Piacente F, Fiori PL, Tonetti MG"
+          },
+          "offset": 0,
+          "text": "The L-Rhamnose Biosynthetic Pathway in Trichomonas vaginalis: Identification and Characterization of UDP-D-Glucose 4,6-dehydratase.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "2",
+              "infons": {
+                "identifier": "MESH:D012210",
+                "type": "Chemical",
+                "valid": true,
+                "normalized": ["D012210"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D012210",
+                "biotype": "chemical",
+                "name": "Rhamnose",
+                "accession": "@CHEMICAL_Rhamnose"
+              },
+              "text": "L-Rhamnose",
+              "locations": [{ "offset": 4, "length": 10 }]
+            },
+            {
+              "id": "3",
+              "infons": {
+                "identifier": "5722",
+                "type": "Species",
+                "valid": true,
+                "normalized": [5722],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 5722,
+                "biotype": "species",
+                "name": "5722",
+                "accession": null
+              },
+              "text": "Trichomonas vaginalis",
+              "locations": [{ "offset": 39, "length": 21 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 132,
+          "text": "Trichomonas vaginalis is the causative agent of one of the most widespread sexually transmitted diseases in the world. The adhesion of the parasite to the vaginal epithelial cells is mediated by specific proteins and by a complex glycan structure, the lipoglycan (TvLG), which covers the pathogen surface. L-rhamnose is an important component of TvLG, comprising up to 40% of the monosaccharides. Thus, the inhibition of its production could lead to a severe alteration in the TvLG structure, making the L-rhamnose biosynthetic pathway an attractive pharmacologic target. We report the identification and characterization of the first committed and limiting step of the L-rhamnose biosynthetic pathway, UDP-D-glucose 4,6-dehydratase (UGD, EC 4.2.1.76). The enzyme shows a strong preference for UDP-D-glucose compared to dTDP-D-glucose; we propose that the mechanism underlying the higher affinity for the UDP-bound substrate is mediated by the differential recognition of ribose versus the deoxyribose of the nucleotide moiety. The identification of the enzymes responsible for the following steps of the L-rhamnose pathway (epimerization and reduction) was more elusive. However, sequence analyses suggest that in T. vaginalis L-rhamnose synthesis proceeds through a mechanism different from the typical eukaryotic pathways, displaying intermediate features between the eukaryotic and prokaryotic pathways and involving separate enzymes for the epimerase and reductase activities, as observed in bacteria. Altogether, these results form the basis for a better understanding of the formation of the complex glycan structures on TvLG and the possible use of L-rhamnose biosynthetic enzymes for the development of selective inhibitors.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "23",
+              "infons": {
+                "identifier": "5722",
+                "type": "Species",
+                "valid": true,
+                "normalized": [5722],
+                "database": "ncbi_taxonomy",
+                "normalized_id": 5722,
+                "biotype": "species",
+                "name": "5722",
+                "accession": null
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+      "pmcid": "PMC9892563",
+      "title": "Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling.",
+      "journal": "Sci Rep",
+      "authors": [
+        "Yoshida K",
+        "Yokota K",
+        "Watanabe K",
+        "Tsuda H",
+        "Matsumoto A",
+        "Mizukami H",
+        "Iwamoto S"
+      ],
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+      "citations": {
+        "NLM": "Yoshida K, Yokota K, Watanabe K, Tsuda H, Matsumoto A, Mizukami H, Iwamoto S. Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling. Sci Rep. 2023 Feb 1;13(1):1843. PMID: 36726016",
+        "BibTeX": "@article{36726016, title={Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling.}, author={Yoshida K and Yokota K and Watanabe K and Tsuda H and Matsumoto A and Mizukami H and Iwamoto S}, journal={Sci Rep}, volume={13}, number={1}, pages={1843}}"
+      }
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+            "authors": "Yoshida K, Yokota K, Watanabe K, Tsuda H, Matsumoto A, Mizukami H, Iwamoto S"
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+          "offset": 0,
+          "text": "Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling.",
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+          "text": "Our previous genome-wide association study to explore genetic loci associated with lean nonalcoholic fatty liver disease (NAFLD) in Japan suggested four candidate loci, which were mapped to chr6, chr7, chr12 and chr13. The present study aimed to identify the locus involved functionally in NAFLD around the association signal observed in chr13. Chromosome conformation capture assay and a database survey suggested the intermolecular interaction among DNA fragments in association signals with the adjacent four coding gene promoters. The four genes were further screened by knockdown (KD) in mice using shRNA delivered by an adeno-associated virus vector (AAV8), and KD of G protein-coupled receptor 180 (Gpr180) showed amelioration of hepatic lipid storage. Gpr180 knockout (KO) mice also showed ameliorated hepatic and plasma lipid levels without influencing glucose metabolism after high-fat diet intake. Transcriptome analyses showed downregulation of mTORC1 signaling and cholesterol homeostasis, which was confirmed by weakened phosphorylation of mTOR and decreased activated SREBP1 in Gpr180KO mice and a human hepatoma cell line (Huh7). AAV8-mediated hepatic rescue of GPR180 expression in KO mice showed recovery of plasma and hepatic lipid levels. In conclusion, ablation of GPR180 ameliorated plasma and hepatic lipid levels, which was mediated by downregulation of mTORC1 signaling.",
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+        "Yoshida K",
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+      "title": "Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens.",
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+        "O'Rourke D",
+        "Gravato-Nobre MJ",
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+        "Pritchett E",
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+        "NLM": "O'Rourke D, Gravato-Nobre MJ, Stroud D, Pritchett E, Barker E, Price RL, Robinson SA, Spiro S, Kuwabara P, Hodgkin J. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. G3 (Bethesda). 2023 May 2;13(5):. PMID: 36911920",
+        "BibTeX": "@article{36911920, title={Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens.}, author={O'Rourke D and Gravato-Nobre MJ and Stroud D and Pritchett E and Barker E and Price RL and Robinson SA and Spiro S and Kuwabara P and Hodgkin J}, journal={G3 (Bethesda)}, volume={13}, number={5}}"
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+            "journal": "G3 (Bethesda). 2023 May 2;13(5):jkad056. doi: 10.1093/g3journal/jkad056.",
+            "year": "2023",
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+                "biotype": "disease",
+                "name": "Bacterial Infections",
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+          "text": "Numerous mutants of the nematode Caenorhabditis elegans with surface abnormalities have been isolated by utilizing their resistance to a variety of bacterial pathogens (Microbacterium nematophilum, Yersinia pseudotuberculosis and two Leucobacter strains), all of which are able to cause disease or death when worms are grown on bacterial lawns containing these pathogens. Previous work led to the identification of nine srf or bus genes; here we report molecular identification and characterization of a further ten surface-affecting genes. Three of these were found to encode factors implicated in glycosylation (srf-2, bus-5, bus-22), like several of those previously reported; srf-2 belongs to the GT92 family of putative galactosyltransferases, and bus-5 is homologous to human TGDS, which is implicated in Catel-Manzke syndrome. Other genes encoded proteins with sequence similarity to phosphatidylinositol phosphatases (bus-6), Patched-related receptors (ptr-15/bus-13), steroid dehydrogenases (dhs-5/bus-21) or glypiation factors (bus-24). Three genes appeared to be nematode-specific (srf-5, bus-10, bus-28). Many mutants exhibited cuticle fragility as revealed by bleach and detergent sensitivity; this fragility was correlated with increased drug sensitivity, as well as with abnormal skiddy locomotion. Most of the genes examined were found to be expressed in epidermal seam cells, which appear to be important for synthesizing nematode surface coat. The results reveal the genetic and biochemical complexity of this critical surface layer, and provide new tools for its analysis.",
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+        "Wredenhagen MS",
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+      "text_hl": "We recruited 37 patients and we identified pathogenic or likely pathogenic variants in @GENE_WNT10A @@@WNT10A@@@, @GENE_EDAR @@@EDAR@@@, @GENE_AMBN @@@AMBN@@@, @GENE_PLOD1 @@@PLOD1@@@, @GENE_TSPEAR @@@TSPEAR@@@, @GENE_PRKAR1A @@@PRKAR1A@@@, @GENE_FAM83H @@@FAM83H@@@, @GENE_PRKACB @@@PRKACB@@@, @GENE_DLX3 @@@DLX3@@@, @GENE_DSPP @@@DSPP@@@, @GENE_BMP2 @@@BMP2@@@, @<m>GENE_TGDS</m> @@@TGDS@@@. Our project led to the establishment of the Quebec @DISEASE_614188 @@@Dental Anomalies@@@ Registry, which will help researchers, medical and dental practitioners alike understand the genetics of @DISEASE_614188 @@@dental anomalies@@@ and facilitate research collaborations into improved standards of care for patients with rare @DISEASE_614188 @@@dental anomalies@@@ and any accompanying @DISEASE_Genetic_Diseases_Inborn @@@genetic diseases@@@.",
+      "citations": {
+        "NLM": "Wredenhagen MS, Goldstein A, Mathieu H, Miranda V, Morali B, Santerre J, Maftei C, Delrue MA, Schmittbuhl M, Vu DD, Moldovan F, Campeau PM. The Quebec Dental Anomalies Registry: Identifying genes for rare disorders. PNAS Nexus. 2023 Jun;2(6):pgad196. PMID: 37361548",
+        "BibTeX": "@article{37361548, title={The Quebec Dental Anomalies Registry: Identifying genes for rare disorders.}, author={Wredenhagen MS and Goldstein A and Mathieu H and Miranda V and Morali B and Santerre J and Maftei C and Delrue MA and Schmittbuhl M and Vu DD and Moldovan F and Campeau PM}, journal={PNAS Nexus}, volume={2}, number={6}, pages={pgad196}}"
+      }
+    },
+    "abstract": {
+      "_id": "37361548|None",
+      "id": "37361548",
+      "infons": {},
+      "passages": [
+        {
+          "infons": {
+            "journal": "PNAS Nexus;2023Jun; 2 (6) 196. doi:10.1093/pnasnexus/pgad196",
+            "year": "2023",
+            "article-id_pmc": "PMC10290489",
+            "type": "title",
+            "authors": "Wredenhagen MS, Goldstein A, Mathieu H, Miranda V, Morali B, Santerre J, Maftei C, Delrue MA, Schmittbuhl M, Vu DD, Moldovan F, Campeau PM, "
+          },
+          "offset": 0,
+          "text": "The Quebec Dental Anomalies Registry: Identifying genes for rare disorders.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "1",
+              "infons": {
+                "identifier": "OMIM:614188",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["614188"],
+                "database": "omim",
+                "normalized_id": "614188",
+                "biotype": "disease",
+                "name": "614188",
+                "accession": "@DISEASE_614188"
+              },
+              "text": "Dental Anomalies",
+              "locations": [{ "offset": 11, "length": 16 }]
+            }
+          ],
+          "relations": []
+        },
+        {
+          "infons": { "type": "abstract" },
+          "offset": 76,
+          "text": "There are more than 900 genetic syndromes associated with oral manifestations. These syndromes can have serious health implications, and left undiagnosed, can hamper treatment and prognosis later in life. About 6.67% of the population will develop a rare disease during their lifetime, some of which are difficult to diagnose. The establishment of a data and tissue bank of rare diseases with oral manifestations in Quebec will help medical professionals identify the genes involved, will improve knowledge on the rare genetic diseases, and will also lead to improved patient management. It will also allow samples and information sharing with other clinicians and investigators. As an example of a condition requiring additional research, dental ankylosis is a condition in which the tooth's cementum fuses to the surrounding alveolar bone. This can be secondary to traumatic injury but is often idiopathic, and the genes involved in the idiopathic cases, if any, are poorly known. To date, patients with both identified and unidentified genetic etiology for their dental anomalies were recruited through dental and genetics clinics for the study. They underwent sequencing of selected genes or exome sequencing depending on the manifestation. We recruited 37 patients and we identified pathogenic or likely pathogenic variants in WNT10A, EDAR, AMBN, PLOD1, TSPEAR, PRKAR1A, FAM83H, PRKACB, DLX3, DSPP, BMP2, TGDS. Our project led to the establishment of the Quebec Dental Anomalies Registry, which will help researchers, medical and dental practitioners alike understand the genetics of dental anomalies and facilitate research collaborations into improved standards of care for patients with rare dental anomalies and any accompanying genetic diseases.",
+          "sentences": [],
+          "annotations": [
+            {
+              "id": "23",
+              "infons": {
+                "identifier": "MESH:D035583",
+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D035583"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D035583",
+                "biotype": "disease",
+                "name": "Rare Diseases",
+                "accession": "@DISEASE_Rare_Diseases"
+              },
+              "text": "rare diseases",
+              "locations": [{ "offset": 450, "length": 13 }]
+            },
+            {
+              "id": "24",
+              "infons": {
+                "identifier": "MESH:D030342",
+                "type": "Disease",
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+                "normalized": ["D030342"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D030342",
+                "biotype": "disease",
+                "name": "Genetic Diseases Inborn",
+                "accession": "@DISEASE_Genetic_Diseases_Inborn"
+              },
+              "text": "genetic diseases",
+              "locations": [{ "offset": 595, "length": 16 }]
+            },
+            {
+              "id": "25",
+              "infons": {
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+                "type": "Disease",
+                "valid": true,
+                "normalized": ["D020254"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D020254",
+                "biotype": "disease",
+                "name": "Tooth Ankylosis",
+                "accession": "@DISEASE_Tooth_Ankylosis"
+              },
+              "text": "dental ankylosis",
+              "locations": [{ "offset": 816, "length": 16 }]
+            },
+            {
+              "id": "26",
+              "infons": {
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+                "valid": true,
+                "normalized": ["D014947"],
+                "database": "ncbi_mesh",
+                "normalized_id": "D014947",
+                "biotype": "disease",
+                "name": "Wounds and Injuries",
+                "accession": "@DISEASE_Wounds_and_Injuries"
+              },
+              "text": "traumatic injury",
+              "locations": [{ "offset": 943, "length": 16 }]
+            },
+            {
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+                "database": "omim",
+                "normalized_id": "614188",
+                "biotype": "disease",
+                "name": "614188",
+                "accession": "@DISEASE_614188"
+              },
+              "text": "dental anomalies",
+              "locations": [{ "offset": 1142, "length": 16 }]
+            },
+            {
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+                "normalized_id": 80326,
+                "biotype": "gene",
+                "name": "WNT10A",
+                "accession": "@GENE_WNT10A"
+              },
+              "text": "WNT10A",
+              "locations": [{ "offset": 1408, "length": 6 }]
+            },
+            {
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+                "normalized_id": 10913,
+                "biotype": "gene",
+                "name": "EDAR",
+                "accession": "@GENE_EDAR"
+              },
+              "text": "EDAR",
+              "locations": [{ "offset": 1416, "length": 4 }]
+            },
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+                "biotype": "gene",
+                "name": "AMBN",
+                "accession": "@GENE_AMBN"
+              },
+              "text": "AMBN",
+              "locations": [{ "offset": 1422, "length": 4 }]
+            },
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+                "normalized_id": 5351,
+                "biotype": "gene",
+                "name": "PLOD1",
+                "accession": "@GENE_PLOD1"
+              },
+              "text": "PLOD1",
+              "locations": [{ "offset": 1428, "length": 5 }]
+            },
+            {
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+                "normalized_id": 54084,
+                "biotype": "gene",
+                "name": "TSPEAR",
+                "accession": "@GENE_TSPEAR"
+              },
+              "text": "TSPEAR",
+              "locations": [{ "offset": 1435, "length": 6 }]
+            },
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+                "biotype": "gene",
+                "name": "PRKAR1A",
+                "accession": "@GENE_PRKAR1A"
+              },
+              "text": "PRKAR1A",
+              "locations": [{ "offset": 1443, "length": 7 }]
+            },
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+                "biotype": "gene",
+                "name": "FAM83H",
+                "accession": "@GENE_FAM83H"
+              },
+              "text": "FAM83H",
+              "locations": [{ "offset": 1452, "length": 6 }]
+            },
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+                "biotype": "gene",
+                "name": "PRKACB",
+                "accession": "@GENE_PRKACB"
+              },
+              "text": "PRKACB",
+              "locations": [{ "offset": 1460, "length": 6 }]
+            },
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+                "normalized_id": 1747,
+                "biotype": "gene",
+                "name": "DLX3",
+                "accession": "@GENE_DLX3"
+              },
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+            },
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+                "biotype": "gene",
+                "name": "DSPP",
+                "accession": "@GENE_DSPP"
+              },
+              "text": "DSPP",
+              "locations": [{ "offset": 1474, "length": 4 }]
+            },
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+                "name": "BMP2",
+                "accession": "@GENE_BMP2"
+              },
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+            },
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+                "name": "TGDS",
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+              },
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+            },
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+                "biotype": "disease",
+                "name": "614188",
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+              },
+              "text": "Dental Anomalies",
+              "locations": [{ "offset": 1543, "length": 16 }]
+            },
+            {
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+              },
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+            },
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+              },
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+                "accession": "@DISEASE_Genetic_Diseases_Inborn"
+              },
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+            }
+          ],
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+        }
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+              "biotype": "gene",
+              "name": "PRKACB",
+              "accession": "@GENE_PRKACB"
+            }
+          },
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+              "biotype": "gene",
+              "name": "AMBN",
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+            }
+          },
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+              "type": "Gene",
+              "valid": true,
+              "normalized": [1834],
+              "database": "ncbi_gene",
+              "normalized_id": 1834,
+              "biotype": "gene",
+              "name": "DSPP",
+              "accession": "@GENE_DSPP"
+            }
+          },
+          "nodes": [{ "refid": "8", "role": "40,37" }]
+        },
+        {
+          "id": "R10",
+          "infons": {
+            "type": "Association",
+            "score": "0.9871",
+            "role1": {
+              "identifier": "OMIM:614188",
+              "type": "Disease",
+              "valid": true,
+              "normalized": ["614188"],
+              "database": "omim",
+              "normalized_id": "614188",
+              "biotype": "disease",
+              "name": "614188",
+              "accession": "@DISEASE_614188"
+            },
+            "role2": {
+              "identifier": "5351",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [5351],
+              "database": "ncbi_gene",
+              "normalized_id": 5351,
+              "biotype": "gene",
+              "name": "PLOD1",
+              "accession": "@GENE_PLOD1"
+            }
+          },
+          "nodes": [{ "refid": "9", "role": "40,31" }]
+        },
+        {
+          "id": "R11",
+          "infons": {
+            "type": "Association",
+            "score": "0.9963",
+            "role1": {
+              "identifier": "OMIM:614188",
+              "type": "Disease",
+              "valid": true,
+              "normalized": ["614188"],
+              "database": "omim",
+              "normalized_id": "614188",
+              "biotype": "disease",
+              "name": "614188",
+              "accession": "@DISEASE_614188"
+            },
+            "role2": {
+              "identifier": "650",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [650],
+              "database": "ncbi_gene",
+              "normalized_id": 650,
+              "biotype": "gene",
+              "name": "BMP2",
+              "accession": "@GENE_BMP2"
+            }
+          },
+          "nodes": [{ "refid": "10", "role": "40,38" }]
+        },
+        {
+          "id": "R12",
+          "infons": {
+            "type": "Association",
+            "score": "0.996",
+            "role1": {
+              "identifier": "OMIM:614188",
+              "type": "Disease",
+              "valid": true,
+              "normalized": ["614188"],
+              "database": "omim",
+              "normalized_id": "614188",
+              "biotype": "disease",
+              "name": "614188",
+              "accession": "@DISEASE_614188"
+            },
+            "role2": {
+              "identifier": "23483",
+              "type": "Gene",
+              "valid": true,
+              "normalized": [23483],
+              "database": "ncbi_gene",
+              "normalized_id": 23483,
+              "biotype": "gene",
+              "name": "TGDS",
+              "accession": "@GENE_TGDS"
+            }
+          },
+          "nodes": [{ "refid": "11", "role": "40,39" }]
+        }
+      ],
+      "pmid": 37361548,
+      "pmcid": null,
+      "meta": {},
+      "date": "2023-06-14T00:00:00Z",
+      "journal": "PNAS Nexus",
+      "authors": [
+        "Wredenhagen MS",
+        "Goldstein A",
+        "Mathieu H",
+        "Miranda V",
+        "Morali B",
+        "Santerre J",
+        "Maftei C",
+        "Delrue MA",
+        "Schmittbuhl M",
+        "Vu DD",
+        "Moldovan F",
+        "Campeau PM"
+      ],
+      "relations_display": [
+        { "name": "associate|@DISEASE_614188|@GENE_WNT10A" },
+        { "name": "associate|@DISEASE_614188|@GENE_FAM83H" },
+        { "name": "associate|@DISEASE_614188|@GENE_PRKAR1A" },
+        { "name": "associate|@DISEASE_614188|@GENE_DLX3" },
+        { "name": "associate|@DISEASE_614188|@GENE_TSPEAR" },
+        { "name": "associate|@DISEASE_614188|@GENE_EDAR" },
+        { "name": "associate|@DISEASE_614188|@GENE_PRKACB" },
+        { "name": "associate|@DISEASE_614188|@GENE_AMBN" },
+        { "name": "associate|@DISEASE_614188|@GENE_DSPP" },
+        { "name": "associate|@DISEASE_614188|@GENE_PLOD1" },
+        { "name": "associate|@DISEASE_614188|@GENE_BMP2" },
+        { "name": "associate|@DISEASE_614188|@GENE_TGDS" }
+      ]
+    }
+  }
+}
diff --git a/src/store/index.ts b/src/store/index.ts
new file mode 100644
index 0000000..c9f6f04
--- /dev/null
+++ b/src/store/index.ts
@@ -0,0 +1 @@
+export * from './types'
diff --git a/src/store/pubtator/index.ts b/src/store/pubtator/index.ts
new file mode 100644
index 0000000..d04e177
--- /dev/null
+++ b/src/store/pubtator/index.ts
@@ -0,0 +1,67 @@
+/**
+ * Store wrapping the PubTator access.
+ */
+import { defineStore } from 'pinia'
+import { ref } from 'vue'
+
+import { PubtatorClient } from '../../api/pubtator'
+import { StoreState } from '../../store/types'
+import { SearchResults } from './types'
+
+export * from './types'
+
+export const usePubtatorStore = defineStore('pubtator', () => {
+  /** The current store state. */
+  const storeState = ref<StoreState>(StoreState.Initial)
+
+  /** The HGNC symbol currently loaded for. */
+  const hgncSymbol = ref<string | undefined>(undefined)
+
+  /** Detailed result information. */
+  const searchResults = ref<SearchResults>({})
+
+  /** Initialize the store for the given HGNC symbol. */
+  const initialize = async (hgncSymbol$?: string, force: boolean = false) => {
+    // Skip if already loaded
+    if (!force && hgncSymbol$ === hgncSymbol.value) {
+      return
+    }
+
+    // Clear against artifacts.
+    clearData()
+
+    storeState.value = StoreState.Loading
+
+    // Bail out if no HGNC symbol is available.
+    if (!hgncSymbol$) {
+      storeState.value = StoreState.Active
+      return
+    }
+
+    // "Just" lookup via PubTator client.
+    const client = new PubtatorClient()
+    try {
+      searchResults.value = await client.performSearch(hgncSymbol$)
+      storeState.value = StoreState.Active
+    } catch (err) {
+      storeState.value = StoreState.Error
+      throw new Error(`Error running PubTator 3 search: ${err}`)
+    }
+  }
+
+  /** Clear the store. */
+  const clearData = () => {
+    storeState.value = StoreState.Initial
+    hgncSymbol.value = undefined
+    searchResults.value = {}
+  }
+
+  /** The current gene Ranking. */
+  return {
+    storeState,
+    hgncSymbol,
+    searchResults,
+    initialize,
+    clearData
+  }
+})
diff --git a/src/store/pubtator/types.ts b/src/store/pubtator/types.ts
new file mode 100644
index 0000000..8f2def8
--- /dev/null
+++ b/src/store/pubtator/types.ts
@@ -0,0 +1,40 @@
+import { SearchResult } from '../../api/pubtator'
+
+/** Enumeration for annotation types */
+export enum AnnotationType {
+  /** Disease */
+  Disease = 'Disease',
+  /** Gene */
+  Gene = 'Gene',
+  /** Chemical */
+  Chemical = 'Chemical',
+  /** Species */
+  Species = 'Species',
+  /** Variant */
+  Variant = 'Variant',
+  /** CellLine */
+  CellLine = 'CellLine'
+}
+
+/** Location of an annotation. */
+export interface AnnotationLocation {
+  /** The offset of the annotation. */
+  offset: number
+  /** The length of the annotation. */
+  length: number
+}
+
+/** One annotation record. */
+export interface Annotation {
+  /** The type of annotation. */
+  type: AnnotationType
+  /** The name of the annotation. */
+  name?: string
+  /** The text of the annotation. */
+  text?: string
+  /** Locations of the annotation */
+  locations: AnnotationLocation[]
+}
+
+/** Search results type. */
+export type SearchResults = { [key: string]: SearchResult }
diff --git a/src/store/types.ts b/src/store/types.ts
new file mode 100644
index 0000000..aef8dd1
--- /dev/null
+++ b/src/store/types.ts
@@ -0,0 +1,15 @@
+/**
+ * Store state enum
+ */
+export enum StoreState {
+  /** Initial state, not loaded yet. */
+  Initial = 'initial',
+  /** Loading state, loading data. */
+  Loading = 'loading',
+  /** Active state, data loaded. */
+  Active = 'active',
+  /** Error state, error loading data. */
+  Error = 'error',
+  /** Redirect state, redirecting to another page. */
+  Redirect = 'redirect'
+}